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Biodegradable Polyurethane

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T G Van Kooten – 1st expert on this subject based on the ideXlab platform

  • A long-termin vitro biocompatibility study of a Biodegradable Polyurethane and its degradation products
    Journal of Biomedical Materials Research Part A, 2020
    Co-Authors: B Van Minnen, M B M Van Leeuwen, B Stegenga, T G Van Kooten

    Abstract:

    The biological safety of degradation products from degradable biomaterials is very important. In this study a new method is proposed to test the cytotoxicity of these degradation products with the aim to save time, laboratory animals, and research funds. A Biodegradable Polyurethane (PU) foam was subjected to this test method. The PU had soft segments of DL-lactide/is an element of-caprolactone and hard segments synthesized from butanediol and 1,4-butane-diiosocyanate. Copolymer foams without urethane segments, consisting of DL-lactide/is an element of-caprolactone, were tested as well. Accumulated degradation products were collected by degrading the foams in distilled water at 60 degrees C up to 52 weeks. Cell-culture medium was prepared from powder medium with this water. In different tests the cytotoxicity of this medium was established. The first signs of cytotoxicity were observed after 3-5 weeks of degradation. This accounts for both materials and reestablishes the good short-term biocompatibility of these materials. The PU showed more toxicity toward the end stages of degradation in comparison with the copolymer. This is probably related to the accumulation of degradation products of the urethane segments. In the in vivo situation the degradation of the PU and the metabolism and excretion of degradation products may differ. Therefore, long-term in vivo studies will have to establish whether these in vitro results are representative for the in vivo behavior of the degrading PU. (c) 2005 Wiley Periodicals, Inc

  • a long term in vitro biocompatibility study of a Biodegradable Polyurethane and its degradation products
    Journal of Biomedical Materials Research Part A, 2006
    Co-Authors: B Van Minnen, M B M Van Leeuwen, Boudewijn Stegenga, T G Van Kooten

    Abstract:

    The biological safety of degradation products from degradable biomaterials is very important. In this study a new method is proposed to test the cytotoxicity of these degradation products with the aim to save time, laboratory animals, and research funds. A Biodegradable Polyurethane (PU) foam was subjected to this test method. The PU had soft segments of DL-lactide/is an element of-caprolactone and hard segments synthesized from butanediol and 1,4-butane-diiosocyanate. Copolymer foams without urethane segments, consisting of DL-lactide/is an element of-caprolactone, were tested as well. Accumulated degradation products were collected by degrading the foams in distilled water at 60 degrees C up to 52 weeks. Cell-culture medium was prepared from powder medium with this water. In different tests the cytotoxicity of this medium was established. The first signs of cytotoxicity were observed after 3-5 weeks of degradation. This accounts for both materials and reestablishes the good short-term biocompatibility of these materials. The PU showed more toxicity toward the end stages of degradation in comparison with the copolymer. This is probably related to the accumulation of degradation products of the urethane segments. In the in vivo situation the degradation of the PU and the metabolism and excretion of degradation products may differ. Therefore, long-term in vivo studies will have to establish whether these in vitro results are representative for the in vivo behavior of the degrading PU. (c) 2005 Wiley Periodicals, Inc.

  • short term in vitro and in vivo biocompatibility of a Biodegradable Polyurethane foam based on 1 4 butanediisocyanate
    Journal of Materials Science: Materials in Medicine, 2005
    Co-Authors: B Van Minnen, M B M Van Leeuwen, B Stegenga, J Zuidema, C E Hissink, T G Van Kooten

    Abstract:

    In this study short-term in vitro and in vivo biocompatibility apects of a Biodegradable Polyurethane (PU) foam were evaluated. The PU consists of hard urethane segments and amorphous soft segments based on a copolyester of dl-lactide and e-caprolactone. The urethane segments are of uniform length and synthesized with 1,4-butanediisocyanate. The foam has good mechanical properties and will be used for tissue regeneration applications. Degradation tests were carried out in a buffer solution for twelve weeks. Cytotoxicity was determined using extract and direct contact test methods with incubation periods varying form 24 to 72 h. The foam was implanted subcutaneously for one, four and twelve weeks and the tissue response to the material was histologically evaluated.

William R. Wagner – 2nd expert on this subject based on the ideXlab platform

  • thiol click modification of cyclic disulfide containing Biodegradable Polyurethane urea elastomers
    Biomacromolecules, 2015
    Co-Authors: Jun Fang, Sangho Ye, Jing Wang, Ting Zhao, Xiumei Mo, William R. Wagner

    Abstract:

    Although the thiol click reaction is an attractive tool for postpolymerization modification of thiolmers, thiol groups are easily oxidized, limiting the potential for covalent immobilization of bioactive molecules. In this study, a series of Biodegradable Polyurethane elastomers incorporating stable cyclic disulfide groups was developed and characterized. These poly(ester urethane)urea (PEUU-SS) polymers were based on polycaprolactone diol (PCL), oxidized dl-dithiothreitol (O-DTT), lysine diisocyanate (LDI), or butyl diisocyanate (BDI), with chain extension by putrescine. The ratio of O-DTT:PCL was altered to investigate different levels of potential functionalization. PEG acrylate was employed to study the mechanism and availability of both bulk and surface click modification of PEUU-SS polymers. All synthesized PEUU-SS polymers were elastic with breaking strengths of 38–45 MPa, while the PEUU-SS(LDI) polymers were more amorphous, possessing lower moduli and relatively small permanent deformations versus…

  • Biodegradable Polyurethane ureas with variable polyester or polycarbonate soft segments effects of crystallinity molecular weight and composition on mechanical properties
    Biomacromolecules, 2011
    Co-Authors: Yi Hong, Devin M. Nelson, Joseph E. Pichamuthu, Cory E. Leeson, William R. Wagner

    Abstract:

    Biodegradable Polyurethane urea (PUU) elastomers are ideal candidates for fabricating tissue engineering scaffolds with mechanical properties akin to strong and resilient soft tissues. PUU with a crystalline poly(e-caprolactone) (PCL) macrodiol soft segment (SS) showed good elasticity and resilience at small strains (<50%) but showed poor resilience under large strains because of stress-induced crystallization of the PCL segments, with a permanent set of 677 ± 30% after tensile failure. To obtain softer and more resilient PUUs, we used noncrystalline poly(trimethylene carbonate) (PTMC) or poly(δ-valerolactone-co-e-caprolactone) (PVLCL) macrodiols of different molecular weights as SSs that were reacted with 1,4-diisocyanatobutane and chain extended with 1,4-diaminobutane. Mechanical properties of the PUUs were characterized by tensile testing with static or cyclic loading and dynamic mechanical analysis. All of the PUUs synthesized showed large elongations at break (800–1400%) and high tensile strength (30...

  • Biodegradable Polyurethane Ureas with Variable Polyester or Polycarbonate Soft Segments: Effects of Crystallinity, Molecular Weight, and Composition on Mechanical Properties
    Biomacromolecules, 2011
    Co-Authors: Zuwei Ma, Yi Hong, Devin M. Nelson, Joseph E. Pichamuthu, Cory E. Leeson, William R. Wagner

    Abstract:

    Biodegradable Polyurethane urea (PUU) elastomers are ideal candidates for fabricating tissue engineering scaffolds with mechanical properties akin to strong and resilient soft tissues. PUU with a crystalline poly(e-caprolactone) (PCL) macrodiol soft segment (SS) showed good elasticity and resilience at small strains (

B Van Minnen – 3rd expert on this subject based on the ideXlab platform

  • A long-termin vitro biocompatibility study of a Biodegradable Polyurethane and its degradation products
    Journal of Biomedical Materials Research Part A, 2020
    Co-Authors: B Van Minnen, M B M Van Leeuwen, B Stegenga, T G Van Kooten

    Abstract:

    The biological safety of degradation products from degradable biomaterials is very important. In this study a new method is proposed to test the cytotoxicity of these degradation products with the aim to save time, laboratory animals, and research funds. A Biodegradable Polyurethane (PU) foam was subjected to this test method. The PU had soft segments of DL-lactide/is an element of-caprolactone and hard segments synthesized from butanediol and 1,4-butane-diiosocyanate. Copolymer foams without urethane segments, consisting of DL-lactide/is an element of-caprolactone, were tested as well. Accumulated degradation products were collected by degrading the foams in distilled water at 60 degrees C up to 52 weeks. Cell-culture medium was prepared from powder medium with this water. In different tests the cytotoxicity of this medium was established. The first signs of cytotoxicity were observed after 3-5 weeks of degradation. This accounts for both materials and reestablishes the good short-term biocompatibility of these materials. The PU showed more toxicity toward the end stages of degradation in comparison with the copolymer. This is probably related to the accumulation of degradation products of the urethane segments. In the in vivo situation the degradation of the PU and the metabolism and excretion of degradation products may differ. Therefore, long-term in vivo studies will have to establish whether these in vitro results are representative for the in vivo behavior of the degrading PU. (c) 2005 Wiley Periodicals, Inc

  • a long term in vitro biocompatibility study of a Biodegradable Polyurethane and its degradation products
    Journal of Biomedical Materials Research Part A, 2006
    Co-Authors: B Van Minnen, M B M Van Leeuwen, Boudewijn Stegenga, T G Van Kooten

    Abstract:

    The biological safety of degradation products from degradable biomaterials is very important. In this study a new method is proposed to test the cytotoxicity of these degradation products with the aim to save time, laboratory animals, and research funds. A Biodegradable Polyurethane (PU) foam was subjected to this test method. The PU had soft segments of DL-lactide/is an element of-caprolactone and hard segments synthesized from butanediol and 1,4-butane-diiosocyanate. Copolymer foams without urethane segments, consisting of DL-lactide/is an element of-caprolactone, were tested as well. Accumulated degradation products were collected by degrading the foams in distilled water at 60 degrees C up to 52 weeks. Cell-culture medium was prepared from powder medium with this water. In different tests the cytotoxicity of this medium was established. The first signs of cytotoxicity were observed after 3-5 weeks of degradation. This accounts for both materials and reestablishes the good short-term biocompatibility of these materials. The PU showed more toxicity toward the end stages of degradation in comparison with the copolymer. This is probably related to the accumulation of degradation products of the urethane segments. In the in vivo situation the degradation of the PU and the metabolism and excretion of degradation products may differ. Therefore, long-term in vivo studies will have to establish whether these in vitro results are representative for the in vivo behavior of the degrading PU. (c) 2005 Wiley Periodicals, Inc.

  • short term in vitro and in vivo biocompatibility of a Biodegradable Polyurethane foam based on 1 4 butanediisocyanate
    Journal of Materials Science: Materials in Medicine, 2005
    Co-Authors: B Van Minnen, M B M Van Leeuwen, B Stegenga, J Zuidema, C E Hissink, T G Van Kooten

    Abstract:

    In this study short-term in vitro and in vivo biocompatibility apects of a Biodegradable Polyurethane (PU) foam were evaluated. The PU consists of hard urethane segments and amorphous soft segments based on a copolyester of dl-lactide and e-caprolactone. The urethane segments are of uniform length and synthesized with 1,4-butanediisocyanate. The foam has good mechanical properties and will be used for tissue regeneration applications. Degradation tests were carried out in a buffer solution for twelve weeks. Cytotoxicity was determined using extract and direct contact test methods with incubation periods varying form 24 to 72 h. The foam was implanted subcutaneously for one, four and twelve weeks and the tissue response to the material was histologically evaluated.