The Experts below are selected from a list of 22881 Experts worldwide ranked by ideXlab platform
Renbo An - One of the best experts on this subject based on the ideXlab platform.
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protective effect of ganodermanondiol isolated from the lingzhi mushroom against tert butyl hydroperoxide induced hepatotoxicity through nrf2 mediated antioxidant enzymes
Food and Chemical Toxicology, 2013Co-Authors: Bin Li, Yue Kang, Renbo AnAbstract:Abstract Ganodermanondiol, a Biologically Active Compound, was isolated from the Lingzhi mushroom ( Ganoderma lucidum ). The present study examined the protective effects of ganodermanondiol against tert -butyl hydroperoxide ( t -BHP)-induced hepatotoxicity. Ganodermanondiol protected human liver-derived HepG2 cells through nuclear factor-E2-related factor 2 (Nrf2) pathway-dependent heme oxygenase-1 expressions. Moreover, ganodermanondiol increased cellular glutathione levels and the expression of the glutamine-cysteine ligase gene in a dose-dependent manner. Furthermore, ganodermanondiol exposure enhanced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and its upstream kinase activators, LKB1 and Ca 2+ /calmodulin-dependent protein kinase-II (CaMKII). This study indicates that ganodermanondiol exhibits potent cytoprotective effects on t -BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.
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protective effect of ganodermanondiol isolated from the lingzhi mushroom against tert butyl hydroperoxide induced hepatotoxicity through nrf2 mediated antioxidant enzymes
Food and Chemical Toxicology, 2013Co-Authors: Bin Li, Yue Kang, Renbo AnAbstract:Abstract Ganodermanondiol, a Biologically Active Compound, was isolated from the Lingzhi mushroom ( Ganoderma lucidum ). The present study examined the protective effects of ganodermanondiol against tert -butyl hydroperoxide ( t -BHP)-induced hepatotoxicity. Ganodermanondiol protected human liver-derived HepG2 cells through nuclear factor-E2-related factor 2 (Nrf2) pathway-dependent heme oxygenase-1 expressions. Moreover, ganodermanondiol increased cellular glutathione levels and the expression of the glutamine-cysteine ligase gene in a dose-dependent manner. Furthermore, ganodermanondiol exposure enhanced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and its upstream kinase activators, LKB1 and Ca 2+ /calmodulin-dependent protein kinase-II (CaMKII). This study indicates that ganodermanondiol exhibits potent cytoprotective effects on t -BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.
Bin Li - One of the best experts on this subject based on the ideXlab platform.
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protective effect of ganodermanondiol isolated from the lingzhi mushroom against tert butyl hydroperoxide induced hepatotoxicity through nrf2 mediated antioxidant enzymes
Food and Chemical Toxicology, 2013Co-Authors: Bin Li, Yue Kang, Renbo AnAbstract:Abstract Ganodermanondiol, a Biologically Active Compound, was isolated from the Lingzhi mushroom ( Ganoderma lucidum ). The present study examined the protective effects of ganodermanondiol against tert -butyl hydroperoxide ( t -BHP)-induced hepatotoxicity. Ganodermanondiol protected human liver-derived HepG2 cells through nuclear factor-E2-related factor 2 (Nrf2) pathway-dependent heme oxygenase-1 expressions. Moreover, ganodermanondiol increased cellular glutathione levels and the expression of the glutamine-cysteine ligase gene in a dose-dependent manner. Furthermore, ganodermanondiol exposure enhanced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and its upstream kinase activators, LKB1 and Ca 2+ /calmodulin-dependent protein kinase-II (CaMKII). This study indicates that ganodermanondiol exhibits potent cytoprotective effects on t -BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.
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protective effect of ganodermanondiol isolated from the lingzhi mushroom against tert butyl hydroperoxide induced hepatotoxicity through nrf2 mediated antioxidant enzymes
Food and Chemical Toxicology, 2013Co-Authors: Bin Li, Yue Kang, Renbo AnAbstract:Abstract Ganodermanondiol, a Biologically Active Compound, was isolated from the Lingzhi mushroom ( Ganoderma lucidum ). The present study examined the protective effects of ganodermanondiol against tert -butyl hydroperoxide ( t -BHP)-induced hepatotoxicity. Ganodermanondiol protected human liver-derived HepG2 cells through nuclear factor-E2-related factor 2 (Nrf2) pathway-dependent heme oxygenase-1 expressions. Moreover, ganodermanondiol increased cellular glutathione levels and the expression of the glutamine-cysteine ligase gene in a dose-dependent manner. Furthermore, ganodermanondiol exposure enhanced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and its upstream kinase activators, LKB1 and Ca 2+ /calmodulin-dependent protein kinase-II (CaMKII). This study indicates that ganodermanondiol exhibits potent cytoprotective effects on t -BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.
Zonghai Shen - One of the best experts on this subject based on the ideXlab platform.
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Chemical Composition and Biological Activity of Star Anise Illicium verum Extracts Against Maize Weevil, Sitophilus zeamais Adults
Journal of Insect Science, 2014Co-Authors: Mao-ye Li, Yan-zhang Huang, Shi-guang Li, Yu-jie He, Zonghai ShenAbstract:Abstract This study aims to develop eco-friendly botanical pesticides. Dried fruits of star anise (Illicium verum Hook.f. (Austrobaileyales: Schisandraceae)) were extracted with methyl alcohol (MA), ethyl acetate (EA), and petroleum ether (PE) at 25°C. The constituents were determined by gas chromatography-mass spectrometry, and the repellency and contact toxicity of the extracts against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae) adults were tested. Fortyfour Compounds, whose concentrations were more than 0.2%, were separated and identified from the MA, EA, and PE extracts. The extraction yields of trans-anethole, the most abundant Biologically Active Compound in I. verum, were 9.7%, 7.5%, and 10.1% in the MA, EA, and PE extracts, respectively. Repellency increased with increasing extract dose. The average repellency rate of the extracts against S. zeamais adults peaked at 125.79 μg/cm2 72 hr after treatment. The percentage repellency of the EA extract reached 76.9%, making it a class IV r...
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Chemical Composition and Biological Activity of Star Anise Illicium verum Extracts Against Maize Weevil, Sitophilus zeamais Adults
Journal of Insect Science, 2014Co-Authors: Mao-ye Li, Yan-zhang Huang, Shi-guang Li, Yu-jie He, Zonghai ShenAbstract:Abstract This study aims to develop eco-friendly botanical pesticides. Dried fruits of star anise (Illicium verum Hook.f. (Austrobaileyales: Schisandraceae)) were extracted with methyl alcohol (MA), ethyl acetate (EA), and petroleum ether (PE) at 25°C. The constituents were determined by gas chromatography-mass spectrometry, and the repellency and contact toxicity of the extracts against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae) adults were tested. Fortyfour Compounds, whose concentrations were more than 0.2%, were separated and identified from the MA, EA, and PE extracts. The extraction yields of trans-anethole, the most abundant Biologically Active Compound in I. verum, were 9.7%, 7.5%, and 10.1% in the MA, EA, and PE extracts, respectively. Repellency increased with increasing extract dose. The average repellency rate of the extracts against S. zeamais adults peaked at 125.79 μg/cm2 72 hr after treatment. The percentage repellency of the EA extract reached 76.9%, making it a class IV r...
Yue Kang - One of the best experts on this subject based on the ideXlab platform.
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protective effect of ganodermanondiol isolated from the lingzhi mushroom against tert butyl hydroperoxide induced hepatotoxicity through nrf2 mediated antioxidant enzymes
Food and Chemical Toxicology, 2013Co-Authors: Bin Li, Yue Kang, Renbo AnAbstract:Abstract Ganodermanondiol, a Biologically Active Compound, was isolated from the Lingzhi mushroom ( Ganoderma lucidum ). The present study examined the protective effects of ganodermanondiol against tert -butyl hydroperoxide ( t -BHP)-induced hepatotoxicity. Ganodermanondiol protected human liver-derived HepG2 cells through nuclear factor-E2-related factor 2 (Nrf2) pathway-dependent heme oxygenase-1 expressions. Moreover, ganodermanondiol increased cellular glutathione levels and the expression of the glutamine-cysteine ligase gene in a dose-dependent manner. Furthermore, ganodermanondiol exposure enhanced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and its upstream kinase activators, LKB1 and Ca 2+ /calmodulin-dependent protein kinase-II (CaMKII). This study indicates that ganodermanondiol exhibits potent cytoprotective effects on t -BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.
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protective effect of ganodermanondiol isolated from the lingzhi mushroom against tert butyl hydroperoxide induced hepatotoxicity through nrf2 mediated antioxidant enzymes
Food and Chemical Toxicology, 2013Co-Authors: Bin Li, Yue Kang, Renbo AnAbstract:Abstract Ganodermanondiol, a Biologically Active Compound, was isolated from the Lingzhi mushroom ( Ganoderma lucidum ). The present study examined the protective effects of ganodermanondiol against tert -butyl hydroperoxide ( t -BHP)-induced hepatotoxicity. Ganodermanondiol protected human liver-derived HepG2 cells through nuclear factor-E2-related factor 2 (Nrf2) pathway-dependent heme oxygenase-1 expressions. Moreover, ganodermanondiol increased cellular glutathione levels and the expression of the glutamine-cysteine ligase gene in a dose-dependent manner. Furthermore, ganodermanondiol exposure enhanced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and its upstream kinase activators, LKB1 and Ca 2+ /calmodulin-dependent protein kinase-II (CaMKII). This study indicates that ganodermanondiol exhibits potent cytoprotective effects on t -BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.
Mao-ye Li - One of the best experts on this subject based on the ideXlab platform.
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Chemical Composition and Biological Activity of Star Anise Illicium verum Extracts Against Maize Weevil, Sitophilus zeamais Adults
Journal of Insect Science, 2014Co-Authors: Mao-ye Li, Yan-zhang Huang, Shi-guang Li, Yu-jie He, Zonghai ShenAbstract:Abstract This study aims to develop eco-friendly botanical pesticides. Dried fruits of star anise (Illicium verum Hook.f. (Austrobaileyales: Schisandraceae)) were extracted with methyl alcohol (MA), ethyl acetate (EA), and petroleum ether (PE) at 25°C. The constituents were determined by gas chromatography-mass spectrometry, and the repellency and contact toxicity of the extracts against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae) adults were tested. Fortyfour Compounds, whose concentrations were more than 0.2%, were separated and identified from the MA, EA, and PE extracts. The extraction yields of trans-anethole, the most abundant Biologically Active Compound in I. verum, were 9.7%, 7.5%, and 10.1% in the MA, EA, and PE extracts, respectively. Repellency increased with increasing extract dose. The average repellency rate of the extracts against S. zeamais adults peaked at 125.79 μg/cm2 72 hr after treatment. The percentage repellency of the EA extract reached 76.9%, making it a class IV r...
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Chemical Composition and Biological Activity of Star Anise Illicium verum Extracts Against Maize Weevil, Sitophilus zeamais Adults
Journal of Insect Science, 2014Co-Authors: Mao-ye Li, Yan-zhang Huang, Shi-guang Li, Yu-jie He, Zonghai ShenAbstract:Abstract This study aims to develop eco-friendly botanical pesticides. Dried fruits of star anise (Illicium verum Hook.f. (Austrobaileyales: Schisandraceae)) were extracted with methyl alcohol (MA), ethyl acetate (EA), and petroleum ether (PE) at 25°C. The constituents were determined by gas chromatography-mass spectrometry, and the repellency and contact toxicity of the extracts against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae) adults were tested. Fortyfour Compounds, whose concentrations were more than 0.2%, were separated and identified from the MA, EA, and PE extracts. The extraction yields of trans-anethole, the most abundant Biologically Active Compound in I. verum, were 9.7%, 7.5%, and 10.1% in the MA, EA, and PE extracts, respectively. Repellency increased with increasing extract dose. The average repellency rate of the extracts against S. zeamais adults peaked at 125.79 μg/cm2 72 hr after treatment. The percentage repellency of the EA extract reached 76.9%, making it a class IV r...