The Experts below are selected from a list of 222 Experts worldwide ranked by ideXlab platform

Giuseppe Battaglia - One of the best experts on this subject based on the ideXlab platform.

  • controlling surface topology and functionality of electrospun fibers on the nanoscale using amphiphilic block copolymers to direct mesenchymal progenitor cell adhesion
    Biomacromolecules, 2015
    Co-Authors: Priyalakshimi Viswanathan, Efrosyni Themistou, Kamolchanok Ngamkham, Gwendolen C Reilly, Steven P Armes, Giuseppe Battaglia
    Abstract:

    Surface patterning in three dimensions is of great importance in Biomaterials Design for controlling cell behavior. A facile one-step functionalization of biodegradable PDLLA fibers using amphiphilic diblock copolymers is demonstrated here to systematically vary the fiber surface composition. The copolymers comprise a hydrophilic poly[oligo(ethylene glycol) methacrylate] (POEGMA), poly[(2-methacryloyloxy)ethyl phosphorylcholine] (PMPC), or poly[2-(dimethylamino)ethyl methacrylate)] (PDMAEMA) block and a hydrophobic poly(l-lactide) (PLA) block. The block copolymer-modified fibers have increased surface hydrophilicity compared to that of PDLLA fibers. Mixtures of PLA–PMPC and PLA–POEGMA copolymers are utilized to exploit microphase separation of the incompatible hydrophilic PMPC and POEGMA blocks at the fiber surface. Conjugation of an RGD cell-adhesive peptide to one hydrophilic block (POEGMA) using thiol-ene chemistry produces fibers with domains of cell-adhesive (POEGMA) and cell-inert (PMPC) sites, mimi...

  • controlling surface topology and functionality of electrospun fibers on the nanoscale using amphiphilic block copolymers to direct mesenchymal progenitor cell adhesion
    Biomacromolecules, 2015
    Co-Authors: Priyalakshmi Viswanathan, Efrosyni Themistou, Kamolchanok Ngamkham, Gwendolen C Reilly, Steven P Armes, Giuseppe Battaglia
    Abstract:

    Surface patterning in three dimensions is of great importance in Biomaterials Design for controlling cell behavior. A facile one-step functionalization of biodegradable PDLLA fibers using amphiphilic diblock copolymers is demonstrated here to systematically vary the fiber surface composition. The copolymers comprise a hydrophilic poly[oligo(ethylene glycol) methacrylate] (POEGMA), poly[(2-methacryloyloxy)ethyl phosphorylcholine] (PMPC), or poly[2-(dimethylamino)ethyl methacrylate)] (PDMAEMA) block and a hydrophobic poly(l-lactide) (PLA) block. The block copolymer-modified fibers have increased surface hydrophilicity compared to that of PDLLA fibers. Mixtures of PLA-PMPC and PLA-POEGMA copolymers are utilized to exploit microphase separation of the incompatible hydrophilic PMPC and POEGMA blocks at the fiber surface. Conjugation of an RGD cell-adhesive peptide to one hydrophilic block (POEGMA) using thiol-ene chemistry produces fibers with domains of cell-adhesive (POEGMA) and cell-inert (PMPC) sites, mimicking the adhesive properties of the extracellular matrix (ECM). Human mesenchymal progenitor cells (hES-MPs) showed much better adhesion to the fibers with surface-adhesive heterogeneity compared to that to fibers with only adhesive or only inert surface chemistries.

Ian W. Hamley - One of the best experts on this subject based on the ideXlab platform.

  • Small Bioactive Peptides for Biomaterials Design and Therapeutics
    Chemical Reviews, 2017
    Co-Authors: Ian W. Hamley
    Abstract:

    This review is aimed to provide a concise yet extensive survey of key short bioactive peptide sequences for a range of applications ranging from Biomaterials development to peptides with therapeutic uses. The following are considered: cell adhesion motifs, structural peptides, cell-penetrating and tumor-homing peptides, antimicrobial peptides, peptide hormones, growth factors and matrix metalloprotease substrates, neuropeptides, amyloid peptides, antioxidant peptides, peptide affinity tags, anticancer peptides, and others. This review provides a convenient resource, summarizing a broad range of important sequences with great utility as a resource concerning both small peptide drugs and also novel biofunctional peptide-based materials.

Sébastien Lecommandoux - One of the best experts on this subject based on the ideXlab platform.

  • Future Directions at the Frontier of Polymer Science and Biology.
    Biomacromolecules, 2019
    Co-Authors: Sébastien Lecommandoux, Zhiyuan Zhong, Harm-anton Klok, Timothy J. Deming
    Abstract:

    The field of polymer science has continuously grown over the past century, since the discovery of polymers. Macromolecules are nowadays an essential piece of our life and are found in large range of different applications, from construction, materials, composites, food, health and personal care, among others. The research field is rather matured and structured, with a unique balance between fundamental research and more applied science, with a great involvement of companies. Many important challenges are still to be addressed, especially when polymers are considered at the interface with biology. This is exactly what a journal such as Biomacromolecules is focusing on since two decades now. 1 During Spring 2018, the first Bordeaux Polymer Conference (BPC 2018) 2 gathered the top specialists from all over the world, offering them the opportunity to present their most recent research findings and to discuss the latest ideas, discoveries and innovations in the field of Polymer Science and Engineering. This first edition, which gathered 600 participants, was organized by the Laboratoire de Chimie des Polymeres Organiques (LCPO) 3 in Bordeaux on May 28-31, 2018. Several symposia were featured, covering most of the different aspects of polymer science, including (1) Polymerization mechanism and catalysis, (2) Macromolecular engineering, (3) Green polymers, (4) Polymer self-assembly and (5) Interactions of polymers in life sciences and electronics. This Special Issue includes 25 papers (4 reviews and 21 original research manuscripts) that were presented at BPC 2018. These papers are covering a wide range of research topics of interest to the readership of Biomacromolecules, including Biomaterials Design, renewable materials, polymer micelles and vesicles, nanoparticles, hydrogels and nanogels for nanomedicine, green approaches for polymer Design, biobased nanocomposites, biosourced amphiphiles, biocompatible and functional emulsions, macromolecular engineering for biomaterial Design, DNA- and protein-based bioconjugates, Design of polymer interface for controlled interaction with living organisms, bioadhesives, antimicrobial polymers and surfaces. Altogether, these contributions are providing a brilliant overview of the current state-of-the-art in the field and are highlighting exciting future emerging challenges and opportunities at the frontier of polymer science and life science, in a broad manner.

  • Future Directions at the Frontier of Polymer Science and Biology
    Biomacromolecules, 2019
    Co-Authors: Sébastien Lecommandoux, Zhiyuan Zhong, Harm-anton Klok, Timothy Deming
    Abstract:

    The field of polymer science has continuously grown over the past century, since the discovery of polymers. Macromolecules are nowadays an essential piece of our life and are found in large range of different applications, from construction, materials, composites, food, health and personal care, among others. The research field is rather matured and structured, with a unique balance between fundamental research and more applied science, with a great involvement of companies. Many important challenges are still to be addressed, especially when polymers are considered at the interface with biology. This is exactly what a journal such as Biomacromolecules is focusing on since two decades now. 1 During Spring 2018, the first Bordeaux Polymer Conference (BPC 2018) 2 gathered the top specialists from all over the world, offering them the opportunity to present their most recent research findings and to discuss the latest ideas, discoveries and innovations in the field of Polymer Science and Engineering. This first edition, which gathered 600 participants, was organized by the Laboratoire de Chimie des Polymères Organiques (LCPO) 3 in Bordeaux on May 28-31, 2018. Several symposia were featured, covering most of the different aspects of polymer science, including (1) Polymerization mechanism and catalysis, (2) Macromolecular engineering, (3) Green polymers, (4) Polymer self-assembly and (5) Interactions of polymers in life sciences and electronics. This Special Issue includes 25 papers (4 reviews and 21 original research manuscripts) that were presented at BPC 2018. These papers are covering a wide range of research topics of interest to the readership of Biomacromolecules, including Biomaterials Design, renewable materials, polymer micelles and vesicles, nanoparticles, hydrogels and nanogels for nanomedicine, green approaches for polymer Design, biobased nanocomposites, biosourced amphiphiles, biocompatible and functional emulsions, macromolecular engineering for biomaterial Design, DNA- and protein-based bioconjugates, Design of polymer interface for controlled interaction with living organisms, bioadhesives, antimicrobial polymers and surfaces. Altogether, these contributions are providing a brilliant overview of the current state-of-the-art in the field and are highlighting exciting future emerging challenges and opportunities at the frontier of polymer science and life science, in a broad manner.

Timothy Deming - One of the best experts on this subject based on the ideXlab platform.

  • Future Directions at the Frontier of Polymer Science and Biology
    Biomacromolecules, 2019
    Co-Authors: Sébastien Lecommandoux, Zhiyuan Zhong, Harm-anton Klok, Timothy Deming
    Abstract:

    The field of polymer science has continuously grown over the past century, since the discovery of polymers. Macromolecules are nowadays an essential piece of our life and are found in large range of different applications, from construction, materials, composites, food, health and personal care, among others. The research field is rather matured and structured, with a unique balance between fundamental research and more applied science, with a great involvement of companies. Many important challenges are still to be addressed, especially when polymers are considered at the interface with biology. This is exactly what a journal such as Biomacromolecules is focusing on since two decades now. 1 During Spring 2018, the first Bordeaux Polymer Conference (BPC 2018) 2 gathered the top specialists from all over the world, offering them the opportunity to present their most recent research findings and to discuss the latest ideas, discoveries and innovations in the field of Polymer Science and Engineering. This first edition, which gathered 600 participants, was organized by the Laboratoire de Chimie des Polymères Organiques (LCPO) 3 in Bordeaux on May 28-31, 2018. Several symposia were featured, covering most of the different aspects of polymer science, including (1) Polymerization mechanism and catalysis, (2) Macromolecular engineering, (3) Green polymers, (4) Polymer self-assembly and (5) Interactions of polymers in life sciences and electronics. This Special Issue includes 25 papers (4 reviews and 21 original research manuscripts) that were presented at BPC 2018. These papers are covering a wide range of research topics of interest to the readership of Biomacromolecules, including Biomaterials Design, renewable materials, polymer micelles and vesicles, nanoparticles, hydrogels and nanogels for nanomedicine, green approaches for polymer Design, biobased nanocomposites, biosourced amphiphiles, biocompatible and functional emulsions, macromolecular engineering for biomaterial Design, DNA- and protein-based bioconjugates, Design of polymer interface for controlled interaction with living organisms, bioadhesives, antimicrobial polymers and surfaces. Altogether, these contributions are providing a brilliant overview of the current state-of-the-art in the field and are highlighting exciting future emerging challenges and opportunities at the frontier of polymer science and life science, in a broad manner.

Timothy J. Deming - One of the best experts on this subject based on the ideXlab platform.

  • Future Directions at the Frontier of Polymer Science and Biology.
    Biomacromolecules, 2019
    Co-Authors: Sébastien Lecommandoux, Zhiyuan Zhong, Harm-anton Klok, Timothy J. Deming
    Abstract:

    The field of polymer science has continuously grown over the past century, since the discovery of polymers. Macromolecules are nowadays an essential piece of our life and are found in large range of different applications, from construction, materials, composites, food, health and personal care, among others. The research field is rather matured and structured, with a unique balance between fundamental research and more applied science, with a great involvement of companies. Many important challenges are still to be addressed, especially when polymers are considered at the interface with biology. This is exactly what a journal such as Biomacromolecules is focusing on since two decades now. 1 During Spring 2018, the first Bordeaux Polymer Conference (BPC 2018) 2 gathered the top specialists from all over the world, offering them the opportunity to present their most recent research findings and to discuss the latest ideas, discoveries and innovations in the field of Polymer Science and Engineering. This first edition, which gathered 600 participants, was organized by the Laboratoire de Chimie des Polymeres Organiques (LCPO) 3 in Bordeaux on May 28-31, 2018. Several symposia were featured, covering most of the different aspects of polymer science, including (1) Polymerization mechanism and catalysis, (2) Macromolecular engineering, (3) Green polymers, (4) Polymer self-assembly and (5) Interactions of polymers in life sciences and electronics. This Special Issue includes 25 papers (4 reviews and 21 original research manuscripts) that were presented at BPC 2018. These papers are covering a wide range of research topics of interest to the readership of Biomacromolecules, including Biomaterials Design, renewable materials, polymer micelles and vesicles, nanoparticles, hydrogels and nanogels for nanomedicine, green approaches for polymer Design, biobased nanocomposites, biosourced amphiphiles, biocompatible and functional emulsions, macromolecular engineering for biomaterial Design, DNA- and protein-based bioconjugates, Design of polymer interface for controlled interaction with living organisms, bioadhesives, antimicrobial polymers and surfaces. Altogether, these contributions are providing a brilliant overview of the current state-of-the-art in the field and are highlighting exciting future emerging challenges and opportunities at the frontier of polymer science and life science, in a broad manner.