The Experts below are selected from a list of 234 Experts worldwide ranked by ideXlab platform
A. M. Cunha - One of the best experts on this subject based on the ideXlab platform.
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Dynamic mechanical properties of hydroxyapatite-reinforced and porous starch-based degradable Biomaterials.
Journal of materials science. Materials in medicine, 1999Co-Authors: João F. Mano, R. L. Reis, Cláudia M. Vaz, S.c. Mendes, A. M. CunhaAbstract:It has been shown that blends of starch with a poly(ethylene-vinyl-alcohol) copolymer, EVOH, designated as SEVA-C, present an interesting combination of mechanical, degradation and biocompatible properties, specially when filled with hydroxyapatite (HA). Consequently, they may find a range of applications in the Biomaterials Field. This work evaluated the influence of HA fillers and of blowing agents (used to produce porous architectures) over the viscoelastic properties of SEVA-C polymers, as seen by dynamic mechanical analysis (DMA), in order to speculate on their performances when withstanding cyclic loading in the body. The composite materials presented a promising performance under dynamic mechanical solicitation conditions. Two relaxations were found being attributed to the starch and EVOH phases. The EVOH relaxation process may be very useful in vivo improving the implants performance under cyclic loading. DMA results also showed that it is possible to produce SEVA-C compact surface/porous core architectures with a mechanical performance similar to that of SEVA-C dense materials. This may allow for the use of these materials as bone replacements or scaffolds that must withstand loads when implanted.
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Characterization of two biodegradable polymers of potential application within the Biomaterials Field
Journal of Materials Science: Materials in Medicine, 1995Co-Authors: R. L. Reis, A. M. CunhaAbstract:An extensive characterization of two biodegradable polymers that may constitute an alternative, if one is aiming at orthopaedic applications, to the currently used poly(glicolic acid), poly(lactic acid) or polyhydroxybutyrate was carried out. A cellulose acetate and three different grades of a novel starch based polymer were studied. The characterization included: tensile and instrumented impact tests, rheological measurements, scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transformed infra-red spectroscopy (FTIR), differential scanning calorimetry (DSC), and long-term degradation trials in Hank's solution. The results show that both polymers, specially the starch based one, present a great potential for biomedical applications, on which adequate mechanical properties associated to a controlled degradation rate are required. © 1995 Chapman & Hall.
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Characterization of two biodegradable polymers of potential application within the Biomaterials Field
Journal of Materials Science: Materials in Medicine, 1995Co-Authors: R. L. Reis, A. M. CunhaAbstract:An extensive characterization of two biodegradable polymers that may constitute an alternative, if one is aiming at orthopaedic applications, to the currently used poly(glicolic acid), poly(lactic acid) or polyhydroxybutyrate was carried out. A cellulose acetate and three different grades of a novel starch based polymer were studied. The characterization included: tensile and instrumented impact tests, rheological measurements, scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transformed infra-red spectroscopy (FTIR), differential scanning calorimetry (DSC), and long-term degradation trials in Hank's solution. The results show tha both polymers, on wich adequate mechanical properties associated to a controlled degradation rate are required
R. L. Reis - One of the best experts on this subject based on the ideXlab platform.
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Microparticulate release systems based on natural origin materials.
Advances in experimental medicine and biology, 2004Co-Authors: Gabriel A. Silva, Filipa J. Costa, Nuno M. Neves, R. L. ReisAbstract:It has been a long path for particulate systems in biomedical applications. Since long time ago that these micron and nanosize systems synthesised from the most varied materials find application in the Biomaterials Field, mainly as drug delivery carrier systems. The aim of drug delivery systems is to facilitate the dosage and duration of the drug effect, causing the minimal harm to the patient and improving human health1,2. Typically, they allow for the reduction of the dosage frequency3 and are non-toxic4. Back in time, these systems designed for the controlled delivery of drugs were found extremely promising for several applications, such as the delivery of insulin5–8, contraceptives9–12, cancer therapeutics13–16 among others17.
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Dynamic mechanical properties of hydroxyapatite-reinforced and porous starch-based degradable Biomaterials.
Journal of materials science. Materials in medicine, 1999Co-Authors: João F. Mano, R. L. Reis, Cláudia M. Vaz, S.c. Mendes, A. M. CunhaAbstract:It has been shown that blends of starch with a poly(ethylene-vinyl-alcohol) copolymer, EVOH, designated as SEVA-C, present an interesting combination of mechanical, degradation and biocompatible properties, specially when filled with hydroxyapatite (HA). Consequently, they may find a range of applications in the Biomaterials Field. This work evaluated the influence of HA fillers and of blowing agents (used to produce porous architectures) over the viscoelastic properties of SEVA-C polymers, as seen by dynamic mechanical analysis (DMA), in order to speculate on their performances when withstanding cyclic loading in the body. The composite materials presented a promising performance under dynamic mechanical solicitation conditions. Two relaxations were found being attributed to the starch and EVOH phases. The EVOH relaxation process may be very useful in vivo improving the implants performance under cyclic loading. DMA results also showed that it is possible to produce SEVA-C compact surface/porous core architectures with a mechanical performance similar to that of SEVA-C dense materials. This may allow for the use of these materials as bone replacements or scaffolds that must withstand loads when implanted.
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Characterization of two biodegradable polymers of potential application within the Biomaterials Field
Journal of Materials Science: Materials in Medicine, 1995Co-Authors: R. L. Reis, A. M. CunhaAbstract:An extensive characterization of two biodegradable polymers that may constitute an alternative, if one is aiming at orthopaedic applications, to the currently used poly(glicolic acid), poly(lactic acid) or polyhydroxybutyrate was carried out. A cellulose acetate and three different grades of a novel starch based polymer were studied. The characterization included: tensile and instrumented impact tests, rheological measurements, scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transformed infra-red spectroscopy (FTIR), differential scanning calorimetry (DSC), and long-term degradation trials in Hank's solution. The results show that both polymers, specially the starch based one, present a great potential for biomedical applications, on which adequate mechanical properties associated to a controlled degradation rate are required. © 1995 Chapman & Hall.
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Characterization of two biodegradable polymers of potential application within the Biomaterials Field
Journal of Materials Science: Materials in Medicine, 1995Co-Authors: R. L. Reis, A. M. CunhaAbstract:An extensive characterization of two biodegradable polymers that may constitute an alternative, if one is aiming at orthopaedic applications, to the currently used poly(glicolic acid), poly(lactic acid) or polyhydroxybutyrate was carried out. A cellulose acetate and three different grades of a novel starch based polymer were studied. The characterization included: tensile and instrumented impact tests, rheological measurements, scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transformed infra-red spectroscopy (FTIR), differential scanning calorimetry (DSC), and long-term degradation trials in Hank's solution. The results show tha both polymers, on wich adequate mechanical properties associated to a controlled degradation rate are required
Kenneth A. Dawson - One of the best experts on this subject based on the ideXlab platform.
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Protein-nanoparticle interactions
Nano Today, 2008Co-Authors: Iseult Lynch, Kenneth A. DawsonAbstract:The key role of protein-nanoparticle interactions in nanomedicine and nanotoxicity has begun to emerge recently with the development of the idea of the nanoparticle-protein ‘corona’. This dynamic layer of proteins (and other biomolecules) adsorbs to nanoparticle surfaces immediately upon contact with living systems. While within the Biomaterials Field the role of adsorbed molecules in cellular responses is acknowledged, there are several new issues at stake where nanoparticles are concerned. We show here that highly selective protein adsorption, added to the fact that particles can reach subcellular locations, results in significant new potential impacts for nanoparticles on protein interactions and cellular behavior.
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Molecular basis of cell-biomaterial interaction: insights gained from transcriptomic and proteomic studies.
Biomaterials, 2006Co-Authors: William M. Gallagher, Iseult Lynch, Lorcan T. Allen, Ian S. Miller, Stephen C. Penney, Darran P. O'connor, Stephen R. Pennington, Alan K. Keenan, Kenneth A. DawsonAbstract:With the growing interest in clinical interventions that involve medical devices, the role for new Biomaterials in modern medicine is currently expanding at a phenomenal rate. Failure of most implant materials stems from an inability to predict and control biological phenomena, such as protein adsorption and cell interaction, resulting in an inappropriate host response to the materials. Contemporary advances in biological investigation are starting to shift focus in the Biomaterials Field, in particular with the advent of high-throughput methodologies for gene and protein expression profiling. Here, we examine the role that emerging transcriptomic and proteomic technologies could play in relation to biomaterial development and usage. Moreover, a number of studies are highlighted which have utilized such approaches in order to try to create a deeper understanding of cell-biomaterial interactions and, hence, improve our ability to predict and control the biocompatibility of new materials.
Josephine B. Allen - One of the best experts on this subject based on the ideXlab platform.
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Let's Talk About Sex-Biological Sex Is Underreported in Biomaterial Studies.
Advanced healthcare materials, 2020Co-Authors: Bryan D. James, Paxton Guerin, Josephine B. AllenAbstract:Precision medicine aims to better individualize healthcare. It requires that Biomaterials be designed for the physiological characteristics of a specific patient. To make this a reality, Biomaterials research and development must address differences of biological sex. More specifically, Biomaterials should be designed with properties optimized and appropriate for male and female patients. In analyzing research articles from seven prominent Biomaterials journals, sex as a biological variable is missing from an overwhelming majority of in vitro biomaterial studies. From the survey, the reporting of the sex of primary cell cultures happened only 10.3% of the time. Contributing to this trend is that commercial vendors bias cell lines toward one sex or another by not disclosing information of cell line sex at the time of purchase; researchers do not communicate this pertinent information in published studies; and many journal policies have little to no requirements for reporting cell line characteristics. Omitting this valuable information leads to a gap in the understanding of sex-specific cell-biomaterial interactions and it creates a bias in research findings towards one sex or another. To curb this concerning trend and make precision Biomaterials a reality will require the Biomaterials Field to "talk about sex" by reporting cell sex more broadly.
Iseult Lynch - One of the best experts on this subject based on the ideXlab platform.
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Protein-nanoparticle interactions
Nano Today, 2008Co-Authors: Iseult Lynch, Kenneth A. DawsonAbstract:The key role of protein-nanoparticle interactions in nanomedicine and nanotoxicity has begun to emerge recently with the development of the idea of the nanoparticle-protein ‘corona’. This dynamic layer of proteins (and other biomolecules) adsorbs to nanoparticle surfaces immediately upon contact with living systems. While within the Biomaterials Field the role of adsorbed molecules in cellular responses is acknowledged, there are several new issues at stake where nanoparticles are concerned. We show here that highly selective protein adsorption, added to the fact that particles can reach subcellular locations, results in significant new potential impacts for nanoparticles on protein interactions and cellular behavior.
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Molecular basis of cell-biomaterial interaction: insights gained from transcriptomic and proteomic studies.
Biomaterials, 2006Co-Authors: William M. Gallagher, Iseult Lynch, Lorcan T. Allen, Ian S. Miller, Stephen C. Penney, Darran P. O'connor, Stephen R. Pennington, Alan K. Keenan, Kenneth A. DawsonAbstract:With the growing interest in clinical interventions that involve medical devices, the role for new Biomaterials in modern medicine is currently expanding at a phenomenal rate. Failure of most implant materials stems from an inability to predict and control biological phenomena, such as protein adsorption and cell interaction, resulting in an inappropriate host response to the materials. Contemporary advances in biological investigation are starting to shift focus in the Biomaterials Field, in particular with the advent of high-throughput methodologies for gene and protein expression profiling. Here, we examine the role that emerging transcriptomic and proteomic technologies could play in relation to biomaterial development and usage. Moreover, a number of studies are highlighted which have utilized such approaches in order to try to create a deeper understanding of cell-biomaterial interactions and, hence, improve our ability to predict and control the biocompatibility of new materials.