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Ian N. Morrison - One of the best experts on this subject based on the ideXlab platform.

  • Fetal assessment based on fetal Biophysical Profile scoring
    American Journal of Obstetrics and Gynecology, 1998
    Co-Authors: Frank A. Manning, Christopher Harman, Nabeel Bondaji, Oscar Casiro, Savas Menticoglou, Ian N. Morrison, David J. Berck
    Abstract:

    Abstract OBJECTIVE: The intent of this comparative clinical study was fourfold: (1) to determine the incidence of cerebral palsy in a large obstetric population, (2) to compare the incidence of cerebral palsy in patients at high risk referred for and managed according to the fetal Biophysical Profile score result with the incidence among unreferred and untested patients, (3) to determine the relationship, if any, between the last fetal Biophysical Profile score and the incidence of cerebral palsy, and (4) to categorize cases of cerebral palsy according to the clinical parameters and the probable time and nature of the damaging insult. STUDY DESIGN: In this retrospective 5-year comparative study (1987 to 1991) the incidence of cerebral palsy was determined by analysis of International Classification of Diseases, Ninth Revision, –coded related medical services. The clinical records were then sought and reviewed in index cases and obstetric, neonatal, and postnatal clinical data were abstracted. Cross-correlation with partial registries was done to confirm completeness of capture of index cases. The population of referred high-risk patients who received serial fetal Biophysical Profile scoring and were managed according to test results was determined by review of a prospective computer-stored database and by review of patient log books. The population of untested patients was calculated as the residual of total cases minus tested cases. The rate of cerebral palsy for all patients and for the tested and untested population was calculated and compared. The tested and untested perinates were compared for birth age, weight, and assigned timing or etiology of cerebral palsy. In the tested population the distribution of test results by last recorded Biophysical Profile score was determined and the relationship between the last test result and cerebral palsy and predictive accuracy parameters of the fetal Biophysical Profile score were calculated. RESULTS: The incidence of cerebral palsy among the 84,947 live births was 3.68 per 1000 live births (313 cases). The rate of cerebral palsy in the 26,290 referred high-risk tested patients was 1.33 per 1000 (35 cases) compared with a rate of 4.74 per 1000 live births in the 58,657 untested mixed low-risk/high-risk patients (278 cases). These differences were highly significant. A significant declining trend in the annual incidence of cerebral palsy was observed in the total population and the untested population, whereas the rate in the tested population remained relatively constant over the 5-year study interval. The differences in the cerebral palsy rate between the tested and untested population were not related to differences in gestational age, birth weight, or assigned timing or etiology category. In the tested population the relationship between the incidence of cerebral palsy and the last test fetal Biophysical Profile score was inverse, exponential, and highly significant. CONCLUSIONS: Antepartum assessment by fetal Biophysical Profile scoring is associated with a significant reduction in the incidence of cerebral palsy compared with untested patients. The relationship between the last test score and the incidence of cerebral palsy is inverse and exponential, suggesting that antenatal asphyxia is an important and potentially avoidable cause of cerebral palsy. (Am J Obstet Gynecol 1998;178:696-706.)

  • fetal Biophysical Profile score vi correlation with antepartum umbilical venous fetal ph
    American Journal of Obstetrics and Gynecology, 1993
    Co-Authors: Frank A. Manning, Christopher Harman, Savas Menticoglou, R.j.m. Snijders, Kypros H. Nicolaides, Ian N. Morrison
    Abstract:

    OBJECTIVE:: Our objective was to determine the relationship, if any, between the fetal Biophysical Profile score and antepartum umbilical venous pH. STUDY DESIGN: This was a prospective observational study conducted concurrently in two centers and involving two discrete high-risk groups of fetuses. Fetal Biophysical Profile scores were compared with umbilical venous pH values measured in blood obtained by immediate cordocentesis. A total of 493 paired observations of Biophysical Profile score and pH were made; 104 observations were of fetuses with intrauterine growth retardation and 389 observations were of fetuses with alloimmune anemia. RESULTS: In both data sets there was a highly significant linear correlation between Biophysical Profile score and umbilical venous pH. Poor Biophysical Profile score performance (a score of 0 of 10) was always associated with a pH 7.20 when the Biophysical Profile score was 10 of 10. Sequenced sensitivity of short-term Biophysical variables in the detection of acidemia was observed. CONCLUSION: The fetal Biophysical Profile score accurately predicts antepartum umbilical venous pH.

  • Fetal Biophysical Profile score: VI. Correlation with antepartum umbilical venous fetal pH*
    American Journal of Obstetrics and Gynecology, 1993
    Co-Authors: Frank A. Manning, Christopher Harman, Savas Menticoglou, R.j.m. Snijders, Kypros H. Nicolaides, Ian N. Morrison
    Abstract:

    OBJECTIVE:: Our objective was to determine the relationship, if any, between the fetal Biophysical Profile score and antepartum umbilical venous pH. STUDY DESIGN: This was a prospective observational study conducted concurrently in two centers and involving two discrete high-risk groups of fetuses. Fetal Biophysical Profile scores were compared with umbilical venous pH values measured in blood obtained by immediate cordocentesis. A total of 493 paired observations of Biophysical Profile score and pH were made; 104 observations were of fetuses with intrauterine growth retardation and 389 observations were of fetuses with alloimmune anemia. RESULTS: In both data sets there was a highly significant linear correlation between Biophysical Profile score and umbilical venous pH. Poor Biophysical Profile score performance (a score of 0 of 10) was always associated with a pH 7.20 when the Biophysical Profile score was 10 of 10. Sequenced sensitivity of short-term Biophysical variables in the detection of acidemia was observed. CONCLUSION: The fetal Biophysical Profile score accurately predicts antepartum umbilical venous pH.

Frank A. Manning - One of the best experts on this subject based on the ideXlab platform.

  • fetal death after normal Biophysical Profile score an eighteen year experience
    American Journal of Obstetrics and Gynecology, 1999
    Co-Authors: Ashlesha K Dayal, Frank A. Manning, David J. Berck, George M Mussalli, Cecilia Avila, Christopher R Harman, Savas Menticoglou
    Abstract:

    Abstract Objective: It was our goal to determine the false-negative rate of the Biophysical Profile, characterize an 18-year variation in the false-negative rate, examine the relationship between the last normal Biophysical Profile score and death, and compare the false-negative rate of 2 disparate populations. Study Design: Biophysical Profile scores of 86,955 patients at 2 medical centers were collected and recorded prospectively. All perinatal deaths occurring within 1 week of a normal score were similarly recorded. The annual false-negative rate, the cumulative false-negative rate, and the ratio of false-negative results in cases of subsequent fetal death to the perinatal mortality rate were calculated. Results: There were 65 fetal deaths among 86,955 fetuses. Over an 18-year study period at one institution, the false-negative rate varied but not significantly. The cumulative false-negative rate was 0.708 per 1000 at one medical center studied and 2.289 per 1000 at the other center. The average interval between last normal score and fetal death was 3.62 days and did not vary significantly between the medical centers. Conclusions: False-negative results in cases of subsequent fetal death reflect events that are subsequent to the last normal test result. Fetomaternal hemorrhage was the single most identifiable fetal cause of false-negative results in cases of subsequent fetal death. The ratio of the false-negative rate in cases of subsequent fetal death to the perinatal mortality rate should be used as a more objective approach to reporting this value, because the false-negative rate likely reflects the underlying perinatal mortality. (Am J Obstet Gynecol 1999;181:1231-6.)

  • Fetal Biophysical Profile.
    Obstetrics and Gynecology Clinics of North America, 1999
    Co-Authors: Frank A. Manning
    Abstract:

    This article begins with an outline of the theoretic basis of the fetal Biophysical Profile, the method for the Biophysical Profile score (BPS), and the timing and frequency of testing. The article further discusses the clinical management based on test scores; modified methods of the BPS; and clinical application, predictive accuracy, and impact on outcome of BPS. The authors specifically examine the relationship between BPS and cerebral palsy. They conclude with a discussion of adult sequelae and fetal adaptation to asphyxia.

  • Fetal assessment based on fetal Biophysical Profile scoring
    American Journal of Obstetrics and Gynecology, 1998
    Co-Authors: Frank A. Manning, Christopher Harman, Nabeel Bondaji, Oscar Casiro, Savas Menticoglou, Ian N. Morrison, David J. Berck
    Abstract:

    Abstract OBJECTIVE: The intent of this comparative clinical study was fourfold: (1) to determine the incidence of cerebral palsy in a large obstetric population, (2) to compare the incidence of cerebral palsy in patients at high risk referred for and managed according to the fetal Biophysical Profile score result with the incidence among unreferred and untested patients, (3) to determine the relationship, if any, between the last fetal Biophysical Profile score and the incidence of cerebral palsy, and (4) to categorize cases of cerebral palsy according to the clinical parameters and the probable time and nature of the damaging insult. STUDY DESIGN: In this retrospective 5-year comparative study (1987 to 1991) the incidence of cerebral palsy was determined by analysis of International Classification of Diseases, Ninth Revision, –coded related medical services. The clinical records were then sought and reviewed in index cases and obstetric, neonatal, and postnatal clinical data were abstracted. Cross-correlation with partial registries was done to confirm completeness of capture of index cases. The population of referred high-risk patients who received serial fetal Biophysical Profile scoring and were managed according to test results was determined by review of a prospective computer-stored database and by review of patient log books. The population of untested patients was calculated as the residual of total cases minus tested cases. The rate of cerebral palsy for all patients and for the tested and untested population was calculated and compared. The tested and untested perinates were compared for birth age, weight, and assigned timing or etiology of cerebral palsy. In the tested population the distribution of test results by last recorded Biophysical Profile score was determined and the relationship between the last test result and cerebral palsy and predictive accuracy parameters of the fetal Biophysical Profile score were calculated. RESULTS: The incidence of cerebral palsy among the 84,947 live births was 3.68 per 1000 live births (313 cases). The rate of cerebral palsy in the 26,290 referred high-risk tested patients was 1.33 per 1000 (35 cases) compared with a rate of 4.74 per 1000 live births in the 58,657 untested mixed low-risk/high-risk patients (278 cases). These differences were highly significant. A significant declining trend in the annual incidence of cerebral palsy was observed in the total population and the untested population, whereas the rate in the tested population remained relatively constant over the 5-year study interval. The differences in the cerebral palsy rate between the tested and untested population were not related to differences in gestational age, birth weight, or assigned timing or etiology category. In the tested population the relationship between the incidence of cerebral palsy and the last test fetal Biophysical Profile score was inverse, exponential, and highly significant. CONCLUSIONS: Antepartum assessment by fetal Biophysical Profile scoring is associated with a significant reduction in the incidence of cerebral palsy compared with untested patients. The relationship between the last test score and the incidence of cerebral palsy is inverse and exponential, suggesting that antenatal asphyxia is an important and potentially avoidable cause of cerebral palsy. (Am J Obstet Gynecol 1998;178:696-706.)

  • fetal Biophysical Profile score vi correlation with antepartum umbilical venous fetal ph
    American Journal of Obstetrics and Gynecology, 1993
    Co-Authors: Frank A. Manning, Christopher Harman, Savas Menticoglou, R.j.m. Snijders, Kypros H. Nicolaides, Ian N. Morrison
    Abstract:

    OBJECTIVE:: Our objective was to determine the relationship, if any, between the fetal Biophysical Profile score and antepartum umbilical venous pH. STUDY DESIGN: This was a prospective observational study conducted concurrently in two centers and involving two discrete high-risk groups of fetuses. Fetal Biophysical Profile scores were compared with umbilical venous pH values measured in blood obtained by immediate cordocentesis. A total of 493 paired observations of Biophysical Profile score and pH were made; 104 observations were of fetuses with intrauterine growth retardation and 389 observations were of fetuses with alloimmune anemia. RESULTS: In both data sets there was a highly significant linear correlation between Biophysical Profile score and umbilical venous pH. Poor Biophysical Profile score performance (a score of 0 of 10) was always associated with a pH 7.20 when the Biophysical Profile score was 10 of 10. Sequenced sensitivity of short-term Biophysical variables in the detection of acidemia was observed. CONCLUSION: The fetal Biophysical Profile score accurately predicts antepartum umbilical venous pH.

  • Fetal Biophysical Profile score: VI. Correlation with antepartum umbilical venous fetal pH*
    American Journal of Obstetrics and Gynecology, 1993
    Co-Authors: Frank A. Manning, Christopher Harman, Savas Menticoglou, R.j.m. Snijders, Kypros H. Nicolaides, Ian N. Morrison
    Abstract:

    OBJECTIVE:: Our objective was to determine the relationship, if any, between the fetal Biophysical Profile score and antepartum umbilical venous pH. STUDY DESIGN: This was a prospective observational study conducted concurrently in two centers and involving two discrete high-risk groups of fetuses. Fetal Biophysical Profile scores were compared with umbilical venous pH values measured in blood obtained by immediate cordocentesis. A total of 493 paired observations of Biophysical Profile score and pH were made; 104 observations were of fetuses with intrauterine growth retardation and 389 observations were of fetuses with alloimmune anemia. RESULTS: In both data sets there was a highly significant linear correlation between Biophysical Profile score and umbilical venous pH. Poor Biophysical Profile score performance (a score of 0 of 10) was always associated with a pH 7.20 when the Biophysical Profile score was 10 of 10. Sequenced sensitivity of short-term Biophysical variables in the detection of acidemia was observed. CONCLUSION: The fetal Biophysical Profile score accurately predicts antepartum umbilical venous pH.

Savas Menticoglou - One of the best experts on this subject based on the ideXlab platform.

  • fetal death after normal Biophysical Profile score an eighteen year experience
    American Journal of Obstetrics and Gynecology, 1999
    Co-Authors: Ashlesha K Dayal, Frank A. Manning, David J. Berck, George M Mussalli, Cecilia Avila, Christopher R Harman, Savas Menticoglou
    Abstract:

    Abstract Objective: It was our goal to determine the false-negative rate of the Biophysical Profile, characterize an 18-year variation in the false-negative rate, examine the relationship between the last normal Biophysical Profile score and death, and compare the false-negative rate of 2 disparate populations. Study Design: Biophysical Profile scores of 86,955 patients at 2 medical centers were collected and recorded prospectively. All perinatal deaths occurring within 1 week of a normal score were similarly recorded. The annual false-negative rate, the cumulative false-negative rate, and the ratio of false-negative results in cases of subsequent fetal death to the perinatal mortality rate were calculated. Results: There were 65 fetal deaths among 86,955 fetuses. Over an 18-year study period at one institution, the false-negative rate varied but not significantly. The cumulative false-negative rate was 0.708 per 1000 at one medical center studied and 2.289 per 1000 at the other center. The average interval between last normal score and fetal death was 3.62 days and did not vary significantly between the medical centers. Conclusions: False-negative results in cases of subsequent fetal death reflect events that are subsequent to the last normal test result. Fetomaternal hemorrhage was the single most identifiable fetal cause of false-negative results in cases of subsequent fetal death. The ratio of the false-negative rate in cases of subsequent fetal death to the perinatal mortality rate should be used as a more objective approach to reporting this value, because the false-negative rate likely reflects the underlying perinatal mortality. (Am J Obstet Gynecol 1999;181:1231-6.)

  • Fetal assessment based on fetal Biophysical Profile scoring
    American Journal of Obstetrics and Gynecology, 1998
    Co-Authors: Frank A. Manning, Christopher Harman, Nabeel Bondaji, Oscar Casiro, Savas Menticoglou, Ian N. Morrison, David J. Berck
    Abstract:

    Abstract OBJECTIVE: The intent of this comparative clinical study was fourfold: (1) to determine the incidence of cerebral palsy in a large obstetric population, (2) to compare the incidence of cerebral palsy in patients at high risk referred for and managed according to the fetal Biophysical Profile score result with the incidence among unreferred and untested patients, (3) to determine the relationship, if any, between the last fetal Biophysical Profile score and the incidence of cerebral palsy, and (4) to categorize cases of cerebral palsy according to the clinical parameters and the probable time and nature of the damaging insult. STUDY DESIGN: In this retrospective 5-year comparative study (1987 to 1991) the incidence of cerebral palsy was determined by analysis of International Classification of Diseases, Ninth Revision, –coded related medical services. The clinical records were then sought and reviewed in index cases and obstetric, neonatal, and postnatal clinical data were abstracted. Cross-correlation with partial registries was done to confirm completeness of capture of index cases. The population of referred high-risk patients who received serial fetal Biophysical Profile scoring and were managed according to test results was determined by review of a prospective computer-stored database and by review of patient log books. The population of untested patients was calculated as the residual of total cases minus tested cases. The rate of cerebral palsy for all patients and for the tested and untested population was calculated and compared. The tested and untested perinates were compared for birth age, weight, and assigned timing or etiology of cerebral palsy. In the tested population the distribution of test results by last recorded Biophysical Profile score was determined and the relationship between the last test result and cerebral palsy and predictive accuracy parameters of the fetal Biophysical Profile score were calculated. RESULTS: The incidence of cerebral palsy among the 84,947 live births was 3.68 per 1000 live births (313 cases). The rate of cerebral palsy in the 26,290 referred high-risk tested patients was 1.33 per 1000 (35 cases) compared with a rate of 4.74 per 1000 live births in the 58,657 untested mixed low-risk/high-risk patients (278 cases). These differences were highly significant. A significant declining trend in the annual incidence of cerebral palsy was observed in the total population and the untested population, whereas the rate in the tested population remained relatively constant over the 5-year study interval. The differences in the cerebral palsy rate between the tested and untested population were not related to differences in gestational age, birth weight, or assigned timing or etiology category. In the tested population the relationship between the incidence of cerebral palsy and the last test fetal Biophysical Profile score was inverse, exponential, and highly significant. CONCLUSIONS: Antepartum assessment by fetal Biophysical Profile scoring is associated with a significant reduction in the incidence of cerebral palsy compared with untested patients. The relationship between the last test score and the incidence of cerebral palsy is inverse and exponential, suggesting that antenatal asphyxia is an important and potentially avoidable cause of cerebral palsy. (Am J Obstet Gynecol 1998;178:696-706.)

  • fetal Biophysical Profile score vi correlation with antepartum umbilical venous fetal ph
    American Journal of Obstetrics and Gynecology, 1993
    Co-Authors: Frank A. Manning, Christopher Harman, Savas Menticoglou, R.j.m. Snijders, Kypros H. Nicolaides, Ian N. Morrison
    Abstract:

    OBJECTIVE:: Our objective was to determine the relationship, if any, between the fetal Biophysical Profile score and antepartum umbilical venous pH. STUDY DESIGN: This was a prospective observational study conducted concurrently in two centers and involving two discrete high-risk groups of fetuses. Fetal Biophysical Profile scores were compared with umbilical venous pH values measured in blood obtained by immediate cordocentesis. A total of 493 paired observations of Biophysical Profile score and pH were made; 104 observations were of fetuses with intrauterine growth retardation and 389 observations were of fetuses with alloimmune anemia. RESULTS: In both data sets there was a highly significant linear correlation between Biophysical Profile score and umbilical venous pH. Poor Biophysical Profile score performance (a score of 0 of 10) was always associated with a pH 7.20 when the Biophysical Profile score was 10 of 10. Sequenced sensitivity of short-term Biophysical variables in the detection of acidemia was observed. CONCLUSION: The fetal Biophysical Profile score accurately predicts antepartum umbilical venous pH.

  • Fetal Biophysical Profile score: VI. Correlation with antepartum umbilical venous fetal pH*
    American Journal of Obstetrics and Gynecology, 1993
    Co-Authors: Frank A. Manning, Christopher Harman, Savas Menticoglou, R.j.m. Snijders, Kypros H. Nicolaides, Ian N. Morrison
    Abstract:

    OBJECTIVE:: Our objective was to determine the relationship, if any, between the fetal Biophysical Profile score and antepartum umbilical venous pH. STUDY DESIGN: This was a prospective observational study conducted concurrently in two centers and involving two discrete high-risk groups of fetuses. Fetal Biophysical Profile scores were compared with umbilical venous pH values measured in blood obtained by immediate cordocentesis. A total of 493 paired observations of Biophysical Profile score and pH were made; 104 observations were of fetuses with intrauterine growth retardation and 389 observations were of fetuses with alloimmune anemia. RESULTS: In both data sets there was a highly significant linear correlation between Biophysical Profile score and umbilical venous pH. Poor Biophysical Profile score performance (a score of 0 of 10) was always associated with a pH 7.20 when the Biophysical Profile score was 10 of 10. Sequenced sensitivity of short-term Biophysical variables in the detection of acidemia was observed. CONCLUSION: The fetal Biophysical Profile score accurately predicts antepartum umbilical venous pH.

Christopher Harman - One of the best experts on this subject based on the ideXlab platform.

  • Fetal assessment based on fetal Biophysical Profile scoring
    American Journal of Obstetrics and Gynecology, 1998
    Co-Authors: Frank A. Manning, Christopher Harman, Nabeel Bondaji, Oscar Casiro, Savas Menticoglou, Ian N. Morrison, David J. Berck
    Abstract:

    Abstract OBJECTIVE: The intent of this comparative clinical study was fourfold: (1) to determine the incidence of cerebral palsy in a large obstetric population, (2) to compare the incidence of cerebral palsy in patients at high risk referred for and managed according to the fetal Biophysical Profile score result with the incidence among unreferred and untested patients, (3) to determine the relationship, if any, between the last fetal Biophysical Profile score and the incidence of cerebral palsy, and (4) to categorize cases of cerebral palsy according to the clinical parameters and the probable time and nature of the damaging insult. STUDY DESIGN: In this retrospective 5-year comparative study (1987 to 1991) the incidence of cerebral palsy was determined by analysis of International Classification of Diseases, Ninth Revision, –coded related medical services. The clinical records were then sought and reviewed in index cases and obstetric, neonatal, and postnatal clinical data were abstracted. Cross-correlation with partial registries was done to confirm completeness of capture of index cases. The population of referred high-risk patients who received serial fetal Biophysical Profile scoring and were managed according to test results was determined by review of a prospective computer-stored database and by review of patient log books. The population of untested patients was calculated as the residual of total cases minus tested cases. The rate of cerebral palsy for all patients and for the tested and untested population was calculated and compared. The tested and untested perinates were compared for birth age, weight, and assigned timing or etiology of cerebral palsy. In the tested population the distribution of test results by last recorded Biophysical Profile score was determined and the relationship between the last test result and cerebral palsy and predictive accuracy parameters of the fetal Biophysical Profile score were calculated. RESULTS: The incidence of cerebral palsy among the 84,947 live births was 3.68 per 1000 live births (313 cases). The rate of cerebral palsy in the 26,290 referred high-risk tested patients was 1.33 per 1000 (35 cases) compared with a rate of 4.74 per 1000 live births in the 58,657 untested mixed low-risk/high-risk patients (278 cases). These differences were highly significant. A significant declining trend in the annual incidence of cerebral palsy was observed in the total population and the untested population, whereas the rate in the tested population remained relatively constant over the 5-year study interval. The differences in the cerebral palsy rate between the tested and untested population were not related to differences in gestational age, birth weight, or assigned timing or etiology category. In the tested population the relationship between the incidence of cerebral palsy and the last test fetal Biophysical Profile score was inverse, exponential, and highly significant. CONCLUSIONS: Antepartum assessment by fetal Biophysical Profile scoring is associated with a significant reduction in the incidence of cerebral palsy compared with untested patients. The relationship between the last test score and the incidence of cerebral palsy is inverse and exponential, suggesting that antenatal asphyxia is an important and potentially avoidable cause of cerebral palsy. (Am J Obstet Gynecol 1998;178:696-706.)

  • fetal Biophysical Profile score vi correlation with antepartum umbilical venous fetal ph
    American Journal of Obstetrics and Gynecology, 1993
    Co-Authors: Frank A. Manning, Christopher Harman, Savas Menticoglou, R.j.m. Snijders, Kypros H. Nicolaides, Ian N. Morrison
    Abstract:

    OBJECTIVE:: Our objective was to determine the relationship, if any, between the fetal Biophysical Profile score and antepartum umbilical venous pH. STUDY DESIGN: This was a prospective observational study conducted concurrently in two centers and involving two discrete high-risk groups of fetuses. Fetal Biophysical Profile scores were compared with umbilical venous pH values measured in blood obtained by immediate cordocentesis. A total of 493 paired observations of Biophysical Profile score and pH were made; 104 observations were of fetuses with intrauterine growth retardation and 389 observations were of fetuses with alloimmune anemia. RESULTS: In both data sets there was a highly significant linear correlation between Biophysical Profile score and umbilical venous pH. Poor Biophysical Profile score performance (a score of 0 of 10) was always associated with a pH 7.20 when the Biophysical Profile score was 10 of 10. Sequenced sensitivity of short-term Biophysical variables in the detection of acidemia was observed. CONCLUSION: The fetal Biophysical Profile score accurately predicts antepartum umbilical venous pH.

  • Fetal Biophysical Profile score: VI. Correlation with antepartum umbilical venous fetal pH*
    American Journal of Obstetrics and Gynecology, 1993
    Co-Authors: Frank A. Manning, Christopher Harman, Savas Menticoglou, R.j.m. Snijders, Kypros H. Nicolaides, Ian N. Morrison
    Abstract:

    OBJECTIVE:: Our objective was to determine the relationship, if any, between the fetal Biophysical Profile score and antepartum umbilical venous pH. STUDY DESIGN: This was a prospective observational study conducted concurrently in two centers and involving two discrete high-risk groups of fetuses. Fetal Biophysical Profile scores were compared with umbilical venous pH values measured in blood obtained by immediate cordocentesis. A total of 493 paired observations of Biophysical Profile score and pH were made; 104 observations were of fetuses with intrauterine growth retardation and 389 observations were of fetuses with alloimmune anemia. RESULTS: In both data sets there was a highly significant linear correlation between Biophysical Profile score and umbilical venous pH. Poor Biophysical Profile score performance (a score of 0 of 10) was always associated with a pH 7.20 when the Biophysical Profile score was 10 of 10. Sequenced sensitivity of short-term Biophysical variables in the detection of acidemia was observed. CONCLUSION: The fetal Biophysical Profile score accurately predicts antepartum umbilical venous pH.

Kypros H. Nicolaides - One of the best experts on this subject based on the ideXlab platform.

  • fetal Biophysical Profile score vi correlation with antepartum umbilical venous fetal ph
    American Journal of Obstetrics and Gynecology, 1993
    Co-Authors: Frank A. Manning, Christopher Harman, Savas Menticoglou, R.j.m. Snijders, Kypros H. Nicolaides, Ian N. Morrison
    Abstract:

    OBJECTIVE:: Our objective was to determine the relationship, if any, between the fetal Biophysical Profile score and antepartum umbilical venous pH. STUDY DESIGN: This was a prospective observational study conducted concurrently in two centers and involving two discrete high-risk groups of fetuses. Fetal Biophysical Profile scores were compared with umbilical venous pH values measured in blood obtained by immediate cordocentesis. A total of 493 paired observations of Biophysical Profile score and pH were made; 104 observations were of fetuses with intrauterine growth retardation and 389 observations were of fetuses with alloimmune anemia. RESULTS: In both data sets there was a highly significant linear correlation between Biophysical Profile score and umbilical venous pH. Poor Biophysical Profile score performance (a score of 0 of 10) was always associated with a pH 7.20 when the Biophysical Profile score was 10 of 10. Sequenced sensitivity of short-term Biophysical variables in the detection of acidemia was observed. CONCLUSION: The fetal Biophysical Profile score accurately predicts antepartum umbilical venous pH.

  • Fetal Biophysical Profile score: VI. Correlation with antepartum umbilical venous fetal pH*
    American Journal of Obstetrics and Gynecology, 1993
    Co-Authors: Frank A. Manning, Christopher Harman, Savas Menticoglou, R.j.m. Snijders, Kypros H. Nicolaides, Ian N. Morrison
    Abstract:

    OBJECTIVE:: Our objective was to determine the relationship, if any, between the fetal Biophysical Profile score and antepartum umbilical venous pH. STUDY DESIGN: This was a prospective observational study conducted concurrently in two centers and involving two discrete high-risk groups of fetuses. Fetal Biophysical Profile scores were compared with umbilical venous pH values measured in blood obtained by immediate cordocentesis. A total of 493 paired observations of Biophysical Profile score and pH were made; 104 observations were of fetuses with intrauterine growth retardation and 389 observations were of fetuses with alloimmune anemia. RESULTS: In both data sets there was a highly significant linear correlation between Biophysical Profile score and umbilical venous pH. Poor Biophysical Profile score performance (a score of 0 of 10) was always associated with a pH 7.20 when the Biophysical Profile score was 10 of 10. Sequenced sensitivity of short-term Biophysical variables in the detection of acidemia was observed. CONCLUSION: The fetal Biophysical Profile score accurately predicts antepartum umbilical venous pH.