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Manish Patel - One of the best experts on this subject based on the ideXlab platform.
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Biotransformation of organic sulfides vii a predictive model for sulfoxidation by helminthosporium species nrrl 4671
Tetrahedron-asymmetry, 1997Co-Authors: Herbert L Holland, Frances M Brown, Brett G Larsen, Gingipalli Lakshmaiah, Manish PatelAbstract:Abstract The fungus Helminthosporium species NRRL 4671 converts a wide range of prochiral sulfides to the corresponding chiral sulfoxides, the majority of which have ( S ) configuration at sulfur. The formation of a series of chiral cyclopentyl alkyl, cyclohexyl alkyl, benzyl alkyl, and methyl alkyl sulfoxides by Biotransformation of the corresponding sulfides using Helminthosporium species is described. The analysis of over 90 such Biotransformations has resulted in the development of a model based on restrictive space descriptors that has been used to rationalize these reactions, and that is proposed as a predictor of the outcome of Helminthosporium -catalyzed sulfoxidations.
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Biotransformation of organic sulfides—VII. A predictive model for sulfoxidation by Helminthosporium species NRRL 4671
Tetrahedron-asymmetry, 1997Co-Authors: Herbert L Holland, Frances M Brown, Brett G Larsen, Gingipalli Lakshmaiah, Manish PatelAbstract:Abstract The fungus Helminthosporium species NRRL 4671 converts a wide range of prochiral sulfides to the corresponding chiral sulfoxides, the majority of which have ( S ) configuration at sulfur. The formation of a series of chiral cyclopentyl alkyl, cyclohexyl alkyl, benzyl alkyl, and methyl alkyl sulfoxides by Biotransformation of the corresponding sulfides using Helminthosporium species is described. The analysis of over 90 such Biotransformations has resulted in the development of a model based on restrictive space descriptors that has been used to rationalize these reactions, and that is proposed as a predictor of the outcome of Helminthosporium -catalyzed sulfoxidations.
Herbert L Holland - One of the best experts on this subject based on the ideXlab platform.
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Formation of single diastereomers of β-hydroxy sulfoxides by Biotransformation of β-ketosulfides using Helminthosporium species NRRL 4671
Canadian Journal of Chemistry, 2002Co-Authors: Herbert L Holland, Nancy J. Ihasz, Brendan J LounsberyAbstract:Single Biotransformations of 1-(phenylthio)-2-propanone and 1-(p-methoxyphenylthio)-2-propanone by the fungus Helminthosporium species NRRL 4671 resulted in both sulfur oxidation to the sulfoxide and carbonyl reduction to the alcohol. The corresponding (SS,SC)-1-sulfinyl-2-propanols were obtained as single diastereomers following simple crystallization.Key words: biocatalysis, Biotransformation, carbonyl reduction, Helminthosporium sp. NRRL 4671, sulfoxidation.
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Biotransformation of organic sulfides vii a predictive model for sulfoxidation by helminthosporium species nrrl 4671
Tetrahedron-asymmetry, 1997Co-Authors: Herbert L Holland, Frances M Brown, Brett G Larsen, Gingipalli Lakshmaiah, Manish PatelAbstract:Abstract The fungus Helminthosporium species NRRL 4671 converts a wide range of prochiral sulfides to the corresponding chiral sulfoxides, the majority of which have ( S ) configuration at sulfur. The formation of a series of chiral cyclopentyl alkyl, cyclohexyl alkyl, benzyl alkyl, and methyl alkyl sulfoxides by Biotransformation of the corresponding sulfides using Helminthosporium species is described. The analysis of over 90 such Biotransformations has resulted in the development of a model based on restrictive space descriptors that has been used to rationalize these reactions, and that is proposed as a predictor of the outcome of Helminthosporium -catalyzed sulfoxidations.
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Biotransformation of organic sulfides—VII. A predictive model for sulfoxidation by Helminthosporium species NRRL 4671
Tetrahedron-asymmetry, 1997Co-Authors: Herbert L Holland, Frances M Brown, Brett G Larsen, Gingipalli Lakshmaiah, Manish PatelAbstract:Abstract The fungus Helminthosporium species NRRL 4671 converts a wide range of prochiral sulfides to the corresponding chiral sulfoxides, the majority of which have ( S ) configuration at sulfur. The formation of a series of chiral cyclopentyl alkyl, cyclohexyl alkyl, benzyl alkyl, and methyl alkyl sulfoxides by Biotransformation of the corresponding sulfides using Helminthosporium species is described. The analysis of over 90 such Biotransformations has resulted in the development of a model based on restrictive space descriptors that has been used to rationalize these reactions, and that is proposed as a predictor of the outcome of Helminthosporium -catalyzed sulfoxidations.
Brett G Larsen - One of the best experts on this subject based on the ideXlab platform.
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Biotransformation of organic sulfides vii a predictive model for sulfoxidation by helminthosporium species nrrl 4671
Tetrahedron-asymmetry, 1997Co-Authors: Herbert L Holland, Frances M Brown, Brett G Larsen, Gingipalli Lakshmaiah, Manish PatelAbstract:Abstract The fungus Helminthosporium species NRRL 4671 converts a wide range of prochiral sulfides to the corresponding chiral sulfoxides, the majority of which have ( S ) configuration at sulfur. The formation of a series of chiral cyclopentyl alkyl, cyclohexyl alkyl, benzyl alkyl, and methyl alkyl sulfoxides by Biotransformation of the corresponding sulfides using Helminthosporium species is described. The analysis of over 90 such Biotransformations has resulted in the development of a model based on restrictive space descriptors that has been used to rationalize these reactions, and that is proposed as a predictor of the outcome of Helminthosporium -catalyzed sulfoxidations.
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Biotransformation of organic sulfides—VII. A predictive model for sulfoxidation by Helminthosporium species NRRL 4671
Tetrahedron-asymmetry, 1997Co-Authors: Herbert L Holland, Frances M Brown, Brett G Larsen, Gingipalli Lakshmaiah, Manish PatelAbstract:Abstract The fungus Helminthosporium species NRRL 4671 converts a wide range of prochiral sulfides to the corresponding chiral sulfoxides, the majority of which have ( S ) configuration at sulfur. The formation of a series of chiral cyclopentyl alkyl, cyclohexyl alkyl, benzyl alkyl, and methyl alkyl sulfoxides by Biotransformation of the corresponding sulfides using Helminthosporium species is described. The analysis of over 90 such Biotransformations has resulted in the development of a model based on restrictive space descriptors that has been used to rationalize these reactions, and that is proposed as a predictor of the outcome of Helminthosporium -catalyzed sulfoxidations.
Gingipalli Lakshmaiah - One of the best experts on this subject based on the ideXlab platform.
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Biotransformation of organic sulfides vii a predictive model for sulfoxidation by helminthosporium species nrrl 4671
Tetrahedron-asymmetry, 1997Co-Authors: Herbert L Holland, Frances M Brown, Brett G Larsen, Gingipalli Lakshmaiah, Manish PatelAbstract:Abstract The fungus Helminthosporium species NRRL 4671 converts a wide range of prochiral sulfides to the corresponding chiral sulfoxides, the majority of which have ( S ) configuration at sulfur. The formation of a series of chiral cyclopentyl alkyl, cyclohexyl alkyl, benzyl alkyl, and methyl alkyl sulfoxides by Biotransformation of the corresponding sulfides using Helminthosporium species is described. The analysis of over 90 such Biotransformations has resulted in the development of a model based on restrictive space descriptors that has been used to rationalize these reactions, and that is proposed as a predictor of the outcome of Helminthosporium -catalyzed sulfoxidations.
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Biotransformation of organic sulfides—VII. A predictive model for sulfoxidation by Helminthosporium species NRRL 4671
Tetrahedron-asymmetry, 1997Co-Authors: Herbert L Holland, Frances M Brown, Brett G Larsen, Gingipalli Lakshmaiah, Manish PatelAbstract:Abstract The fungus Helminthosporium species NRRL 4671 converts a wide range of prochiral sulfides to the corresponding chiral sulfoxides, the majority of which have ( S ) configuration at sulfur. The formation of a series of chiral cyclopentyl alkyl, cyclohexyl alkyl, benzyl alkyl, and methyl alkyl sulfoxides by Biotransformation of the corresponding sulfides using Helminthosporium species is described. The analysis of over 90 such Biotransformations has resulted in the development of a model based on restrictive space descriptors that has been used to rationalize these reactions, and that is proposed as a predictor of the outcome of Helminthosporium -catalyzed sulfoxidations.
Frances M Brown - One of the best experts on this subject based on the ideXlab platform.
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Biotransformation of organic sulfides vii a predictive model for sulfoxidation by helminthosporium species nrrl 4671
Tetrahedron-asymmetry, 1997Co-Authors: Herbert L Holland, Frances M Brown, Brett G Larsen, Gingipalli Lakshmaiah, Manish PatelAbstract:Abstract The fungus Helminthosporium species NRRL 4671 converts a wide range of prochiral sulfides to the corresponding chiral sulfoxides, the majority of which have ( S ) configuration at sulfur. The formation of a series of chiral cyclopentyl alkyl, cyclohexyl alkyl, benzyl alkyl, and methyl alkyl sulfoxides by Biotransformation of the corresponding sulfides using Helminthosporium species is described. The analysis of over 90 such Biotransformations has resulted in the development of a model based on restrictive space descriptors that has been used to rationalize these reactions, and that is proposed as a predictor of the outcome of Helminthosporium -catalyzed sulfoxidations.
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Biotransformation of organic sulfides—VII. A predictive model for sulfoxidation by Helminthosporium species NRRL 4671
Tetrahedron-asymmetry, 1997Co-Authors: Herbert L Holland, Frances M Brown, Brett G Larsen, Gingipalli Lakshmaiah, Manish PatelAbstract:Abstract The fungus Helminthosporium species NRRL 4671 converts a wide range of prochiral sulfides to the corresponding chiral sulfoxides, the majority of which have ( S ) configuration at sulfur. The formation of a series of chiral cyclopentyl alkyl, cyclohexyl alkyl, benzyl alkyl, and methyl alkyl sulfoxides by Biotransformation of the corresponding sulfides using Helminthosporium species is described. The analysis of over 90 such Biotransformations has resulted in the development of a model based on restrictive space descriptors that has been used to rationalize these reactions, and that is proposed as a predictor of the outcome of Helminthosporium -catalyzed sulfoxidations.
