The Experts below are selected from a list of 123 Experts worldwide ranked by ideXlab platform

Bertrand Napoleon - One of the best experts on this subject based on the ideXlab platform.

  • Endoscopic ultrasound-guided needle-based confocal laser endomicroscopy in solid pancreatic masses.
    Endoscopy, 2016
    Co-Authors: Marc Giovannini, Fabrice Caillol, Geneviève Monges, Flora Poizat, Anne-isabelle Lemaistre, Bertrand Pujol, Damien Lucidarme, Laurent Palazzo, Bertrand Napoleon
    Abstract:

    Background and study aims: The differential diagnosis of solid pancreatic masses by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is currently suboptimal in centers that are not equipped with rapid on-site evaluation. Needle-based confocal laser endomicroscopy (nCLE) enables real-time in vivo microscopic imaging during endoscopy. This study aimed to describe nCLE interpretation criteria for the characterization of pancreatic masses, with histopathological correlation, and to perform the first validation of these criteria. Patients and methods: A total of 40 patients were evaluated by EUS-FNA combined with nCLE for the diagnosis of pancreatic masses. Final diagnosis was based on EUS-FNA histology and follow-up at 1 year. Five unblinded examiners defined nCLE criteria for adenocarcinoma, chronic pancreatitis, and neuroendocrine tumor (NET) using a set of video sequences from 14 patients with confirmed pathology (Step 1). These criteria were retrospectively validated by four independent, blinded examiners using sequences from 32 patients (Step 2). Results: nCLE criteria were described for adenocarcinoma (dark Cell aggregates, irregular vessels with leakages of fluorescein), chronic pancreatitis (residual regular glandular pancreatic structures), and NET (Black Cell aggregates surrounded by vessels and fibrotic areas). These criteria correlated with the histological features of the corresponding lesions. In the validation review, a conclusive nCLE result was obtained in 75 % of cases (96 % correct). Statistical evaluation provided promising results, with high specificity, and negative and positive predictive values for all types of pancreatic masses. Conclusion: Considering the low negative predictive value of EUS-FNA, nCLE could help to rule out malignancy after a previous inconclusive EUS-FNA. Larger studies are required to confirm these findings and to establish the role of nCLE in the diagnosis of pancreatic masses. Trial registration: ClinicalTrials.gov (NCT01563133).

S. Suresh Babu - One of the best experts on this subject based on the ideXlab platform.

  • High Speed Parallel Prefix Novel Ladner Fischer Adder
    International Journal of Research, 2017
    Co-Authors: K.krishna Kumari, S. Suresh Babu
    Abstract:

    A parallel-prefix adder gives the best performance in VLSI design. However, performance of Ladner-Fischer adder through Black Cell takes large area. So, gray Cell can be replaced instead of Black Cell which gives the Efficiency in Ladner-Fischer Adder. The proposed system consists of three stages of operations they are pre-processing stage, carry generation stage, post-processing stage. The pre-processing stage focuses on propagate and generate, carry generation stage focuses on carry generation and post-processing stage focuses on final result. In ripple carry adder each bit of addition operation is waited for the previous bit addition operation. In efficient Ladner - Fischer adder, addition operation does not wait for previous bit addition operation and modification is done at gate level to improve the speed and to decreases the area.

Palli Srinivas - One of the best experts on this subject based on the ideXlab platform.

  • Design of High Speed Truncated Parallel Prefix Adder
    International Journal of Research, 2017
    Co-Authors: Mutyam Maruthi Lakshmana Rao, Palli Srinivas
    Abstract:

    : In this paper discussed about a carry skip adder (CSKA) structure with P.P.A compared with the conventional adder. A parallel-prefix adder gives the best performance in VLSI design. However, performance of P.P.A adder through Black Cell takes huge memory. So, gray Cell can be replaced instead of Black Cell which gives the Efficiency in P.P. Adder. The proposed system consists of three stages of operations they are pre-processing stage, carry generation stage, post-processing stage. The pre-processing stage focuses on propagate and generate, carry generation stage focuses on carry skip generation and post-processing stage focuses on final result

Marc Giovannini - One of the best experts on this subject based on the ideXlab platform.

  • Endoscopic ultrasound-guided needle-based confocal laser endomicroscopy in solid pancreatic masses.
    Endoscopy, 2016
    Co-Authors: Marc Giovannini, Fabrice Caillol, Geneviève Monges, Flora Poizat, Anne-isabelle Lemaistre, Bertrand Pujol, Damien Lucidarme, Laurent Palazzo, Bertrand Napoleon
    Abstract:

    Background and study aims: The differential diagnosis of solid pancreatic masses by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is currently suboptimal in centers that are not equipped with rapid on-site evaluation. Needle-based confocal laser endomicroscopy (nCLE) enables real-time in vivo microscopic imaging during endoscopy. This study aimed to describe nCLE interpretation criteria for the characterization of pancreatic masses, with histopathological correlation, and to perform the first validation of these criteria. Patients and methods: A total of 40 patients were evaluated by EUS-FNA combined with nCLE for the diagnosis of pancreatic masses. Final diagnosis was based on EUS-FNA histology and follow-up at 1 year. Five unblinded examiners defined nCLE criteria for adenocarcinoma, chronic pancreatitis, and neuroendocrine tumor (NET) using a set of video sequences from 14 patients with confirmed pathology (Step 1). These criteria were retrospectively validated by four independent, blinded examiners using sequences from 32 patients (Step 2). Results: nCLE criteria were described for adenocarcinoma (dark Cell aggregates, irregular vessels with leakages of fluorescein), chronic pancreatitis (residual regular glandular pancreatic structures), and NET (Black Cell aggregates surrounded by vessels and fibrotic areas). These criteria correlated with the histological features of the corresponding lesions. In the validation review, a conclusive nCLE result was obtained in 75 % of cases (96 % correct). Statistical evaluation provided promising results, with high specificity, and negative and positive predictive values for all types of pancreatic masses. Conclusion: Considering the low negative predictive value of EUS-FNA, nCLE could help to rule out malignancy after a previous inconclusive EUS-FNA. Larger studies are required to confirm these findings and to establish the role of nCLE in the diagnosis of pancreatic masses. Trial registration: ClinicalTrials.gov (NCT01563133).

Palaparthi. Bujjibabu - One of the best experts on this subject based on the ideXlab platform.

  • Flexible Dsp Accelerator Architecture Exploiting Using Parallel Prefix Adder
    International Journal of Research, 2017
    Co-Authors: Gonuguntla. Mounika, Palaparthi. Bujjibabu
    Abstract:

    A parallel-prefix adder gives the best performance in VLSI design. However, performance of existed adder through Black Cell takes huge memory. So, gray Cell can be replaced instead of Black Cell which gives the Efficiency in proposed Adder. The proposed system consists of three stages of operations they are pre-processing stage, carry generation stage, post-processing stage. The pre-processing stage focuses on propagate and generate, carry generation stage focuses on carry generation and post-processing stage focuses on final result. In ripple carry adder each bit of addition operation is waited for the previous bit addition operation. In efficient proposed adder, addition operation does not wait for previous bit addition operation and modification is done at gate level to improve the speed and to decreases the memory used. Key Words: Parallel Prefix Adder, Kogge stone Adder, Carry Select Adder