The Experts below are selected from a list of 1494 Experts worldwide ranked by ideXlab platform
A Agarwal - One of the best experts on this subject based on the ideXlab platform.
-
dexmedetomidine for prevention of early postoperative catheter related Bladder Discomfort in voluntary kidney donors prospective randomized double blind placebo controlled trial
Journal of Anaesthesiology Clinical Pharmacology, 2018Co-Authors: Tapas Kumar Singh, A Agarwal, Devendra Gupta, Sandeep Sahu, Prabhaker MishraAbstract:Background and Aims: Catheter-related Bladder Discomfort (CRBD) has started to gain recognition as a problem in early postoperative care. Dexmedetomidine reduces Bladder contractility via M3 muscarinic receptor antagonism and α-2 receptor agonism, apart from its concomitant therapeutic benefits, such as sedation and sympatholysis, in a postoperative period. We, therefore, evaluated the efficacy of dexmedetomidine in reducing incidence and severity of CRBD. Material and Methods: This prospective, randomized, double-blind, placebo-controlled trial done on 110 voluntary kidney donors for live related kidney transplantations were planned for laparoscopic donor nephrectomy. The donors were of ages 18–60 years, American Society of Anesthesiologists physical status I and II of either sex. The control group received 20 ml normal saline (NS) intravenous (IV) infusion over 15 min, whereas the dexmedetomidine group received dexmedetomidine 1 μg/kg made in 20 ml NS as IV infusion over 15 min. The incidence and severity of CRBD were recorded as primary endpoints up to 12 h in early postoperative period. The incidence of Bladder Discomfort was analysed by Fisher's exact test and severity of Bladder Discomfort by Mann Whitney U test. Results: The incidence of CRBD on arrival at postoperative care unit was 18% in dexmedetomidine group compared to 42% in control group (P Conclusions: Dexmedetomidine 1 μg/kg administered IV to patients 30 min before extubation reduces the incidence and severity of CRBD in early postoperative settings with no adverse effects.
-
Dexmedetomidine for prevention of early postoperative catheter-related Bladder Discomfort in voluntary kidney donors: Prospective, randomized, double-blind, placebo-controlled trial
Wolters Kluwer Medknow Publications, 2018Co-Authors: Tapas Kumar Singh, A Agarwal, Devendra Gupta, Sandeep Sahu, Prabhaker MishraAbstract:Background and Aims: Catheter-related Bladder Discomfort (CRBD) has started to gain recognition as a problem in early postoperative care. Dexmedetomidine reduces Bladder contractility via M3 muscarinic receptor antagonism and α-2 receptor agonism, apart from its concomitant therapeutic benefits, such as sedation and sympatholysis, in a postoperative period. We, therefore, evaluated the efficacy of dexmedetomidine in reducing incidence and severity of CRBD. Material and Methods: This prospective, randomized, double-blind, placebo-controlled trial done on 110 voluntary kidney donors for live related kidney transplantations were planned for laparoscopic donor nephrectomy. The donors were of ages 18–60 years, American Society of Anesthesiologists physical status I and II of either sex. The control group received 20 ml normal saline (NS) intravenous (IV) infusion over 15 min, whereas the dexmedetomidine group received dexmedetomidine 1 μg/kg made in 20 ml NS as IV infusion over 15 min. The incidence and severity of CRBD were recorded as primary endpoints up to 12 h in early postoperative period. The incidence of Bladder Discomfort was analysed by Fisher's exact test and severity of Bladder Discomfort by Mann Whitney U test. Results: The incidence of CRBD on arrival at postoperative care unit was 18% in dexmedetomidine group compared to 42% in control group (P < 0.05). The incidence and severity of CRBD reduced in dexmedetomidine group at 0, 2, and 4 h compared with control group (P < 0.05). Conclusions: Dexmedetomidine 1 μg/kg administered IV to patients 30 min before extubation reduces the incidence and severity of CRBD in early postoperative settings with no adverse effects
-
evaluation of efficacy of amikacin for attenuation of catheter related Bladder Discomfort in patients undergoing percutaneous nephrolithotomy a prospective randomized placebo controlled double blind study
Anesthesia: Essays and Researches, 2016Co-Authors: Ruchi Verma, A Agarwal, Devendra Gupta, Prabhat K Singh, Rafat ShamimAbstract:Context: Catheter-related Bladder Discomfort (CRBD) is the most distressing symptom in patients due to intraoperative urinary catheterization. Amikacin significantly inhibits detrusor contraction evoked by prejunctional stimulation. Aims: The aim of this study is to evaluate the efficacy of amikacin in prevention of CRBD in patients undergoing percutaneous nephrolithotomy. Settings and Design: Study areas were operation theater and postanesthesia care unit of the Department of Anesthesiology, SGPGIMS, Lucknow. Subjects and Methods: One hundred adult patients of either sex were randomly assigned into two groups of fifty each. Patients in control group received normal saline whereas patients in amikacin group received amikacin 10 mg/kg just before induction. Grading of CRBD was done as none, mild, moderate, and severe by a blinded observer at 0, 1, 6, 12, and 24 h after surgery. Statistical Analysis Used: Data were analyzed using Student's t-test and Chi-square test among groups. Incidence of CRBD was compared with Chi-square test whereas severity was analyzed by the test of proportions (Z-test). Visual analog score was compared using Mann–Whitney U-test for surgical site pain. Results: Incidence of CRBD in control group was 66% as compared to 44% observed in amikacin group (P Conclusions: Amikacin can significantly reduce the incidence and severity of CRBD in the first few hours after surgery.
-
evaluation of intra operative tramadol for prevention of catheter related Bladder Discomfort a prospective randomized double blind study
BJA: British Journal of Anaesthesia, 2008Co-Authors: A Agarwal, Prabhat K Singh, Deepak Gupta, Gitanjali Yadav, Uttam SinghAbstract:Abstract Background Catheter-related Bladder Discomfort (CRBD) is defined as an urge to void or Discomfort in the supra-pubic region; reported postoperatively in patients who have had urinary catheterization intra-operatively. We have evaluated tramadol, a centrally acting opioid analgesic with muscarinic receptor antagonist properties for prevention of CRBD. Methods Fifty-four adults (18–60 yr), ASA physical status I and II of either sex, undergoing elective percutaneous nephro-lithomy were randomly divided into two groups of 27 each. Control (C) group received normal saline (NS; 2 ml), whereas Tramadol (T) group received tramadol 1.5 mg kg−1. All medications were diluted in 2 ml NS and administered 30 min before extubation. Intra-operatively, urinary catherization was performed with a 16 Fr Foley's catheter, and the balloon was inflated with 10 ml distilled water. The CRBD was assessed at 0, 1, 2, and 6 h after patient's arrival in the post-anaesthesia care unit along with total postoperative fentanyl requirement. Severity of CRBD was graded as none, mild, moderate and severe. Data were analysed by one-way anova , Z-test, and Fisher's exact test. P Results Incidence and severity of CRBD was reduced in T group compared with C group at all time points (P sd 26.5)] compared with C group [210 (34.6)] (P Conclusions Tramadol 1.5 mg kg−1 administered i.v. 30 min before extubation decreases the incidence and severity of CRBD and postoperative fentanyl requirement.
-
an evaluation of the efficacy of gabapentin for prevention of catheter related Bladder Discomfort a prospective randomized placebo controlled double blind study
Anesthesia & Analgesia, 2007Co-Authors: A Agarwal, Sanjay Dhiraaj, R Kapoor, Devendra Gupta, Sandeep Pawar, Prabhat K SinghAbstract:BACKGROUND:Catheter-related Bladder Discomfort (CRBD) secondary to catheterization of urinary Bladder is distressing. In the present study, we evaluated gabapentin for preventing CRBD.METHODS:One-hundred and eight consecutive adult patients, ASA physical status I and II, of either sex, undergoing el
Hee Pyoung Park - One of the best experts on this subject based on the ideXlab platform.
-
sevoflurane vs propofol in post operative catheter related Bladder Discomfort a prospective randomized study
Acta Anaesthesiologica Scandinavica, 2017Co-Authors: Hyunchang Kim, Hee Pyoung Park, J Lee, M H Jeong, Kook Hyun LeeAbstract:Background Post-operative catheter-related Bladder Discomfort (CRBD) causes increased emergence agitation. Muscarinic receptor activation is a major mechanism in CRBD development. Experimental studies showed that sevoflurane has anti-muscarinic effects whereas propofol does not. Our hypothesis was that sevoflurane anaesthesia would reduce the incidence of CRBD following Bladder surgery. Methods In total, 82 patients undergoing transurethral Bladder tumour excision (TURBT) were assigned randomly to two groups according to the maintenance anaesthetic agent received: sevoflurane (n = 41) or propofol (n = 41). The incidence of CRBD was evaluated at 0, 1, 6 and 24 h post-operatively. The number of patients treated with a rescue medication (tramadol) for CRBD was noted. Results The incidence of CRBD at post-operative 1 h was lower in the sevoflurane group than that in the propofol group (59% vs. 85%; P = 0.007). The differences in CRBD were 27% and 22% at 0 and 6 h post-operatively (P = 0.008 and 0.047, respectively). CRBD occurred in 27 (66%) patients in the sevoflurane group vs. 38 (93%) in the propofol group from 0 to 24 h post-operatively (P = 0.005). The number of patients treated with tramadol was lower in the sevoflurane group (13 [22%] vs. 22 [54%]; P = 0.044). Conclusion Sevoflurane, as a maintenance in general anaesthesia, decreased the incidence of early post-operative CRBD and tramadol requirements in patients undergoing TURBT, compared with propofol.
-
the effect of sevoflurane versus desflurane on postoperative catheter related Bladder Discomfort in patients undergoing transurethral excision of a Bladder tumour a randomized controlled trial
Canadian Journal of Anaesthesia-journal Canadien D Anesthesie, 2016Co-Authors: Hyunchang Kim, Youngjin Lim, Won Pyo Hong, Hee Pyoung ParkAbstract:Catheter-related Bladder Discomfort (CRBD) due to an indwelling urinary catheter can cause postoperative distress, and the mechanism underlying CRBD is linked to the activation of muscarinic receptors. Inhalation of anesthetic agents, such as sevoflurane and desflurane, has differential inhibitory effects on muscarinic receptors. We aimed to compare the effect of intraoperative sevoflurane vs desflurane inhalation on postoperative CRBD. Eighty-nine patients undergoing transurethral resection of a Bladder tumour (TURBT) were randomly allocated to two groups. The sevoflurane group (n = 45) and the desflurane group (n = 44) received the respective inhalational agents for maintenance of general anesthesia. The incidence and severity (mild/moderate/severe) of CRBD were assessed at zero, one, six, and 24 hr postoperatively. Catheter-related Bladder Discomfort during the first 24 hr postoperatively occurred in 34/45 (76%) patients receiving sevoflurane compared with 41/44 (93%) patients receiving desflurane [absolute difference 18%; 95% confidence interval [CI], 2 to 33; P = 0.039]. The differences in the rate of CRBD between the sevoflurane and desflurane groups at zero, one, and six hours postoperatively were 24% (95% CI, 7 to 40; P = 0.012), 33% (95% CI, 15 to 49; P = 0.001), and 26% (95% CI, 6 to 43; P = 0.019), respectively. The incidence of moderate to severe CRBD and the number of patients treated with tramadol for CRBD were comparable between the two groups. As a maintenance agent of general anesthesia, sevoflurane reduced the incidence of early postoperative CRBD in patients undergoing TURBT when compared with desflurane. The protocol for this clinical trial was registered at ClinicalTrials.gov (NCT02096224).
-
the effect of intraoperative dexmedetomidine on postoperative catheter related Bladder Discomfort in patients undergoing transurethral Bladder tumour resection a double blind randomised study
European Journal of Anaesthesiology, 2015Co-Authors: Hyunchang Kim, Young-tae Jeon, Yonghun Lee, Jungwon Hwang, Youngjin Lim, Jungeun Park, Hee Pyoung ParkAbstract:BACKGROUNDCatheter-related Bladder Discomfort (CRBD) due to an indwelling urinary catheter causes postoperative distress. Dexmedetomidine is used as an anaesthetic adjuvant during general anaesthesia and has an antimuscarinic effect, which may be beneficial for the prevention and treatment of CRBD.O
-
effect of glycopyrrolate versus atropine coadministered with neostigmine for reversal of rocuronium on postoperative catheter related Bladder Discomfort in patients undergoing transurethral resection of Bladder tumor a prospective randomized study
Journal of Anesthesia, 2015Co-Authors: Hyunchang Kim, Sunmin Lim, Hyungseok Seo, Hee Pyoung ParkAbstract:Background Muscarinic receptors are involved in the mechanism of postoperative catheter-related Bladder Discomfort (CRBD). Glycopyrrolate and atropine as adjuncts to reversal of neuromuscular blockers have differential inhibitory effects on muscarinic receptors. This study was conducted to compare the effect of glycopyrrolate versus atropine on postoperative CRBD in patients undergoing transurethral resection of a Bladder tumor (TURBT).
-
effect of glycopyrrolate versus atropine coadministered with neostigmine for reversal of rocuronium on postoperative catheter related Bladder Discomfort in patients undergoing transurethral resection of Bladder tumor a prospective randomized study
Journal of Anesthesia, 2015Co-Authors: Hyunchang Kim, Sunmin Lim, Hyungseok Seo, Hee Pyoung ParkAbstract:Muscarinic receptors are involved in the mechanism of postoperative catheter-related Bladder Discomfort (CRBD). Glycopyrrolate and atropine as adjuncts to reversal of neuromuscular blockers have differential inhibitory effects on muscarinic receptors. This study was conducted to compare the effect of glycopyrrolate versus atropine on postoperative CRBD in patients undergoing transurethral resection of a Bladder tumor (TURBT). Seventy-four patients undergoing TURBT were randomly allocated to receive either glycopyrrolate 10 μg/kg (glycopyrrolate group, n = 37) or atropine 15 μg/kg (atropine group, n = 37) in combination with neostigmine 25 μg/kg at the end of surgery for reversal of neuromuscular blockade. The incidence and severity (mild/moderate/severe) of CRBD were assessed at 0, 1, 6, and 24 h postoperatively. Tramadol 50–100 mg was administered intravenously if the patients complained of moderate or severe CRBD. The incidence of CRBD was significantly lower in the glycopyrrolate group than in the atropine group at 0 h (65 % vs. 89 %, p = 0.025) and 1 h (54 % vs. 89 %, p = 0.002) postoperatively. The severity of postoperative CRBD was less severe in the glycopyrrolate group than in the atropine group at 0 h (p = 0.013) and 1 h (p = 0.006). Fewer patients required tramadol in the glycopyrrolate group than in the atropine group (3 % vs. 12 %, p = 0.024). Glycopyrrolate as an adjunct to reversal of neuromuscular blockers decreased the incidence of early postoperative CRBD and postoperative tramadol requirements in patients undergoing TURBT when compared to atropine.
Prabhat K Singh - One of the best experts on this subject based on the ideXlab platform.
-
evaluation of efficacy of amikacin for attenuation of catheter related Bladder Discomfort in patients undergoing percutaneous nephrolithotomy a prospective randomized placebo controlled double blind study
Anesthesia: Essays and Researches, 2016Co-Authors: Ruchi Verma, A Agarwal, Devendra Gupta, Prabhat K Singh, Rafat ShamimAbstract:Context: Catheter-related Bladder Discomfort (CRBD) is the most distressing symptom in patients due to intraoperative urinary catheterization. Amikacin significantly inhibits detrusor contraction evoked by prejunctional stimulation. Aims: The aim of this study is to evaluate the efficacy of amikacin in prevention of CRBD in patients undergoing percutaneous nephrolithotomy. Settings and Design: Study areas were operation theater and postanesthesia care unit of the Department of Anesthesiology, SGPGIMS, Lucknow. Subjects and Methods: One hundred adult patients of either sex were randomly assigned into two groups of fifty each. Patients in control group received normal saline whereas patients in amikacin group received amikacin 10 mg/kg just before induction. Grading of CRBD was done as none, mild, moderate, and severe by a blinded observer at 0, 1, 6, 12, and 24 h after surgery. Statistical Analysis Used: Data were analyzed using Student's t-test and Chi-square test among groups. Incidence of CRBD was compared with Chi-square test whereas severity was analyzed by the test of proportions (Z-test). Visual analog score was compared using Mann–Whitney U-test for surgical site pain. Results: Incidence of CRBD in control group was 66% as compared to 44% observed in amikacin group (P Conclusions: Amikacin can significantly reduce the incidence and severity of CRBD in the first few hours after surgery.
-
evaluation of intra operative tramadol for prevention of catheter related Bladder Discomfort a prospective randomized double blind study
BJA: British Journal of Anaesthesia, 2008Co-Authors: A Agarwal, Prabhat K Singh, Deepak Gupta, Gitanjali Yadav, Uttam SinghAbstract:Abstract Background Catheter-related Bladder Discomfort (CRBD) is defined as an urge to void or Discomfort in the supra-pubic region; reported postoperatively in patients who have had urinary catheterization intra-operatively. We have evaluated tramadol, a centrally acting opioid analgesic with muscarinic receptor antagonist properties for prevention of CRBD. Methods Fifty-four adults (18–60 yr), ASA physical status I and II of either sex, undergoing elective percutaneous nephro-lithomy were randomly divided into two groups of 27 each. Control (C) group received normal saline (NS; 2 ml), whereas Tramadol (T) group received tramadol 1.5 mg kg−1. All medications were diluted in 2 ml NS and administered 30 min before extubation. Intra-operatively, urinary catherization was performed with a 16 Fr Foley's catheter, and the balloon was inflated with 10 ml distilled water. The CRBD was assessed at 0, 1, 2, and 6 h after patient's arrival in the post-anaesthesia care unit along with total postoperative fentanyl requirement. Severity of CRBD was graded as none, mild, moderate and severe. Data were analysed by one-way anova , Z-test, and Fisher's exact test. P Results Incidence and severity of CRBD was reduced in T group compared with C group at all time points (P sd 26.5)] compared with C group [210 (34.6)] (P Conclusions Tramadol 1.5 mg kg−1 administered i.v. 30 min before extubation decreases the incidence and severity of CRBD and postoperative fentanyl requirement.
-
an evaluation of the efficacy of gabapentin for prevention of catheter related Bladder Discomfort a prospective randomized placebo controlled double blind study
Anesthesia & Analgesia, 2007Co-Authors: A Agarwal, Sanjay Dhiraaj, R Kapoor, Devendra Gupta, Sandeep Pawar, Prabhat K SinghAbstract:BACKGROUND:Catheter-related Bladder Discomfort (CRBD) secondary to catheterization of urinary Bladder is distressing. In the present study, we evaluated gabapentin for preventing CRBD.METHODS:One-hundred and eight consecutive adult patients, ASA physical status I and II, of either sex, undergoing el
-
ketamine for treatment of catheter related Bladder Discomfort a prospective randomized placebo controlled and double blind study
BJA: British Journal of Anaesthesia, 2006Co-Authors: A Agarwal, Sanjay Dhiraaj, M Tandon, Deepak Gupta, Mukesh Kumar, Prabhat K SinghAbstract:Background Intraoperative urinary catheterization might cause postoperative catheter related Bladder Discomfort (CRBD). We evaluated the efficacy of ketamine as a treatment modality for CRBD. Methods Fifty-four, ASA physical status I and II, male and female adult patients, having CRBD after elective percutaneous nephrolithotomy were randomized into two equal groups of 27 each. In the postoperative period, patients who complained of CRBD received medication depending upon group allocation. Group 1 (Control) received placebo, Group II (Ketamine) received i.v. ketamine 250 μg kg−1. After induction of anaesthesia patients were catheterized with a 16 Fr Foley's catheter and the balloon was inflated with 10 ml distilled water. Grading of CRBD was done as none, mild, moderate and severe by a blinded observer at 0, 1, 2 and 6 h after operation. Results Ketamine reduced the incidence of CRBD (P Conclusion I.V. ketamine (250 μg kg−1) is an effective treatment for reducing the incidence and severity of postoperative CRBD.
-
the efficacy of tolterodine for prevention of catheter related Bladder Discomfort a prospective randomized placebo controlled double blind study
Anesthesia & Analgesia, 2005Co-Authors: A Agarwal, Sanjay Dhiraaj, Vinay Singhal, R Kapoor, Mehdi Raza, Aneesh Srivastava, Devendra Gupta, Prabhat K Singh, Chandra Kant Pandey, Uttam SinghAbstract:Bladder Discomfort secondary to an indwelling urinary catheter is distressing, particularly for patients awakening from anesthesia. We sought to discover the incidence and severity of Bladder Discomfort in patients who were catheterized intraoperatively and to evaluate the efficacy of tolterodine, a
Devendra Gupta - One of the best experts on this subject based on the ideXlab platform.
-
dexmedetomidine for prevention of early postoperative catheter related Bladder Discomfort in voluntary kidney donors prospective randomized double blind placebo controlled trial
Journal of Anaesthesiology Clinical Pharmacology, 2018Co-Authors: Tapas Kumar Singh, A Agarwal, Devendra Gupta, Sandeep Sahu, Prabhaker MishraAbstract:Background and Aims: Catheter-related Bladder Discomfort (CRBD) has started to gain recognition as a problem in early postoperative care. Dexmedetomidine reduces Bladder contractility via M3 muscarinic receptor antagonism and α-2 receptor agonism, apart from its concomitant therapeutic benefits, such as sedation and sympatholysis, in a postoperative period. We, therefore, evaluated the efficacy of dexmedetomidine in reducing incidence and severity of CRBD. Material and Methods: This prospective, randomized, double-blind, placebo-controlled trial done on 110 voluntary kidney donors for live related kidney transplantations were planned for laparoscopic donor nephrectomy. The donors were of ages 18–60 years, American Society of Anesthesiologists physical status I and II of either sex. The control group received 20 ml normal saline (NS) intravenous (IV) infusion over 15 min, whereas the dexmedetomidine group received dexmedetomidine 1 μg/kg made in 20 ml NS as IV infusion over 15 min. The incidence and severity of CRBD were recorded as primary endpoints up to 12 h in early postoperative period. The incidence of Bladder Discomfort was analysed by Fisher's exact test and severity of Bladder Discomfort by Mann Whitney U test. Results: The incidence of CRBD on arrival at postoperative care unit was 18% in dexmedetomidine group compared to 42% in control group (P Conclusions: Dexmedetomidine 1 μg/kg administered IV to patients 30 min before extubation reduces the incidence and severity of CRBD in early postoperative settings with no adverse effects.
-
Dexmedetomidine for prevention of early postoperative catheter-related Bladder Discomfort in voluntary kidney donors: Prospective, randomized, double-blind, placebo-controlled trial
Wolters Kluwer Medknow Publications, 2018Co-Authors: Tapas Kumar Singh, A Agarwal, Devendra Gupta, Sandeep Sahu, Prabhaker MishraAbstract:Background and Aims: Catheter-related Bladder Discomfort (CRBD) has started to gain recognition as a problem in early postoperative care. Dexmedetomidine reduces Bladder contractility via M3 muscarinic receptor antagonism and α-2 receptor agonism, apart from its concomitant therapeutic benefits, such as sedation and sympatholysis, in a postoperative period. We, therefore, evaluated the efficacy of dexmedetomidine in reducing incidence and severity of CRBD. Material and Methods: This prospective, randomized, double-blind, placebo-controlled trial done on 110 voluntary kidney donors for live related kidney transplantations were planned for laparoscopic donor nephrectomy. The donors were of ages 18–60 years, American Society of Anesthesiologists physical status I and II of either sex. The control group received 20 ml normal saline (NS) intravenous (IV) infusion over 15 min, whereas the dexmedetomidine group received dexmedetomidine 1 μg/kg made in 20 ml NS as IV infusion over 15 min. The incidence and severity of CRBD were recorded as primary endpoints up to 12 h in early postoperative period. The incidence of Bladder Discomfort was analysed by Fisher's exact test and severity of Bladder Discomfort by Mann Whitney U test. Results: The incidence of CRBD on arrival at postoperative care unit was 18% in dexmedetomidine group compared to 42% in control group (P < 0.05). The incidence and severity of CRBD reduced in dexmedetomidine group at 0, 2, and 4 h compared with control group (P < 0.05). Conclusions: Dexmedetomidine 1 μg/kg administered IV to patients 30 min before extubation reduces the incidence and severity of CRBD in early postoperative settings with no adverse effects
-
evaluation of efficacy of amikacin for attenuation of catheter related Bladder Discomfort in patients undergoing percutaneous nephrolithotomy a prospective randomized placebo controlled double blind study
Anesthesia: Essays and Researches, 2016Co-Authors: Ruchi Verma, A Agarwal, Devendra Gupta, Prabhat K Singh, Rafat ShamimAbstract:Context: Catheter-related Bladder Discomfort (CRBD) is the most distressing symptom in patients due to intraoperative urinary catheterization. Amikacin significantly inhibits detrusor contraction evoked by prejunctional stimulation. Aims: The aim of this study is to evaluate the efficacy of amikacin in prevention of CRBD in patients undergoing percutaneous nephrolithotomy. Settings and Design: Study areas were operation theater and postanesthesia care unit of the Department of Anesthesiology, SGPGIMS, Lucknow. Subjects and Methods: One hundred adult patients of either sex were randomly assigned into two groups of fifty each. Patients in control group received normal saline whereas patients in amikacin group received amikacin 10 mg/kg just before induction. Grading of CRBD was done as none, mild, moderate, and severe by a blinded observer at 0, 1, 6, 12, and 24 h after surgery. Statistical Analysis Used: Data were analyzed using Student's t-test and Chi-square test among groups. Incidence of CRBD was compared with Chi-square test whereas severity was analyzed by the test of proportions (Z-test). Visual analog score was compared using Mann–Whitney U-test for surgical site pain. Results: Incidence of CRBD in control group was 66% as compared to 44% observed in amikacin group (P Conclusions: Amikacin can significantly reduce the incidence and severity of CRBD in the first few hours after surgery.
-
an evaluation of the efficacy of gabapentin for prevention of catheter related Bladder Discomfort a prospective randomized placebo controlled double blind study
Anesthesia & Analgesia, 2007Co-Authors: A Agarwal, Sanjay Dhiraaj, R Kapoor, Devendra Gupta, Sandeep Pawar, Prabhat K SinghAbstract:BACKGROUND:Catheter-related Bladder Discomfort (CRBD) secondary to catheterization of urinary Bladder is distressing. In the present study, we evaluated gabapentin for preventing CRBD.METHODS:One-hundred and eight consecutive adult patients, ASA physical status I and II, of either sex, undergoing el
-
the efficacy of tolterodine for prevention of catheter related Bladder Discomfort a prospective randomized placebo controlled double blind study
Anesthesia & Analgesia, 2005Co-Authors: A Agarwal, Sanjay Dhiraaj, Vinay Singhal, R Kapoor, Mehdi Raza, Aneesh Srivastava, Devendra Gupta, Prabhat K Singh, Chandra Kant Pandey, Uttam SinghAbstract:Bladder Discomfort secondary to an indwelling urinary catheter is distressing, particularly for patients awakening from anesthesia. We sought to discover the incidence and severity of Bladder Discomfort in patients who were catheterized intraoperatively and to evaluate the efficacy of tolterodine, a
Hyunchang Kim - One of the best experts on this subject based on the ideXlab platform.
-
effect of chlorpheniramine administration on postoperative catheter related Bladder Discomfort in patients undergoing transurethral excision of Bladder tumor a prospective randomized study
Journal of Anesthesia, 2021Co-Authors: Hyub Huh, Suk Woo Lee, Jang Eun Cho, Hyunchang KimAbstract:Catheter-related Bladder Discomfort (CRBD) is postoperative distress caused by a urinary catheter. CRBD is related to muscarinic receptor activation. Chlorpheniramine has antimuscarinic properties. Hence, this investigation was undertaken to evaluate the efficacy of chlorpheniramine in preventing CRBD in patients undergoing transurethral resection of Bladder tumor (TURBT). Seventy-six patients scheduled for TURBT under general anesthesia were assigned into two groups. In the chlorpheniramine group (n = 38), 100 ml normal saline containing 0.1 mg/kg chlorpheniramine was infused after general anesthesia induction. In the control group (n = 38), 100 ml normal saline alone was infused. The incidence and severity of CRBD were assessed at 1, 6, and 24 h postoperatively. The 1-h postoperative incidence of CRBD was lower in the chlorpheniramine group based on the unadjusted analysis [16 (42%) vs. 28 (74%), risk difference 32%, 95% confidence interval 8–51, p = 0.005]. After adjusting the size of the urinary catheter, post hoc analysis showed that the 1-h postoperative incidence of CRBD was lower in the chlorpheniramine group (p = 0.004). The CRBD severity score was lower in the chlorpheniramine group at 1 and 6 h after operation based on the unadjusted analysis (p = 0.012 and p = 0.007, respectively). After adjusting the urinary catheter size, post hoc analysis showed that 1- and 6-h CRBD severity score was lower in the chlorpheniramine group (p = 0.012 and p = 0.008, respectively). The incidence of rescue medication was lower in the chlorpheniramine group [10 (26%) vs. 20 (53%), risk difference 26%, 95% confidence interval 3–47, p = 0.019]. The overall incidence of complications such as nausea, vomiting, dry mouth, flushing, dizziness, and blurred vision was comparable between the two groups. Chlorpheniramine administration significantly reduces the incidence and severity of CRBD in the patients undergoing TURBT. KCT0004880 ( https://cris.nih.go.kr/ )
-
sevoflurane vs propofol in post operative catheter related Bladder Discomfort a prospective randomized study
Acta Anaesthesiologica Scandinavica, 2017Co-Authors: Hyunchang Kim, Hee Pyoung Park, J Lee, M H Jeong, Kook Hyun LeeAbstract:Background Post-operative catheter-related Bladder Discomfort (CRBD) causes increased emergence agitation. Muscarinic receptor activation is a major mechanism in CRBD development. Experimental studies showed that sevoflurane has anti-muscarinic effects whereas propofol does not. Our hypothesis was that sevoflurane anaesthesia would reduce the incidence of CRBD following Bladder surgery. Methods In total, 82 patients undergoing transurethral Bladder tumour excision (TURBT) were assigned randomly to two groups according to the maintenance anaesthetic agent received: sevoflurane (n = 41) or propofol (n = 41). The incidence of CRBD was evaluated at 0, 1, 6 and 24 h post-operatively. The number of patients treated with a rescue medication (tramadol) for CRBD was noted. Results The incidence of CRBD at post-operative 1 h was lower in the sevoflurane group than that in the propofol group (59% vs. 85%; P = 0.007). The differences in CRBD were 27% and 22% at 0 and 6 h post-operatively (P = 0.008 and 0.047, respectively). CRBD occurred in 27 (66%) patients in the sevoflurane group vs. 38 (93%) in the propofol group from 0 to 24 h post-operatively (P = 0.005). The number of patients treated with tramadol was lower in the sevoflurane group (13 [22%] vs. 22 [54%]; P = 0.044). Conclusion Sevoflurane, as a maintenance in general anaesthesia, decreased the incidence of early post-operative CRBD and tramadol requirements in patients undergoing TURBT, compared with propofol.
-
the effect of sevoflurane versus desflurane on postoperative catheter related Bladder Discomfort in patients undergoing transurethral excision of a Bladder tumour a randomized controlled trial
Canadian Journal of Anaesthesia-journal Canadien D Anesthesie, 2016Co-Authors: Hyunchang Kim, Youngjin Lim, Won Pyo Hong, Hee Pyoung ParkAbstract:Catheter-related Bladder Discomfort (CRBD) due to an indwelling urinary catheter can cause postoperative distress, and the mechanism underlying CRBD is linked to the activation of muscarinic receptors. Inhalation of anesthetic agents, such as sevoflurane and desflurane, has differential inhibitory effects on muscarinic receptors. We aimed to compare the effect of intraoperative sevoflurane vs desflurane inhalation on postoperative CRBD. Eighty-nine patients undergoing transurethral resection of a Bladder tumour (TURBT) were randomly allocated to two groups. The sevoflurane group (n = 45) and the desflurane group (n = 44) received the respective inhalational agents for maintenance of general anesthesia. The incidence and severity (mild/moderate/severe) of CRBD were assessed at zero, one, six, and 24 hr postoperatively. Catheter-related Bladder Discomfort during the first 24 hr postoperatively occurred in 34/45 (76%) patients receiving sevoflurane compared with 41/44 (93%) patients receiving desflurane [absolute difference 18%; 95% confidence interval [CI], 2 to 33; P = 0.039]. The differences in the rate of CRBD between the sevoflurane and desflurane groups at zero, one, and six hours postoperatively were 24% (95% CI, 7 to 40; P = 0.012), 33% (95% CI, 15 to 49; P = 0.001), and 26% (95% CI, 6 to 43; P = 0.019), respectively. The incidence of moderate to severe CRBD and the number of patients treated with tramadol for CRBD were comparable between the two groups. As a maintenance agent of general anesthesia, sevoflurane reduced the incidence of early postoperative CRBD in patients undergoing TURBT when compared with desflurane. The protocol for this clinical trial was registered at ClinicalTrials.gov (NCT02096224).
-
the effect of intraoperative dexmedetomidine on postoperative catheter related Bladder Discomfort in patients undergoing transurethral Bladder tumour resection a double blind randomised study
European Journal of Anaesthesiology, 2015Co-Authors: Hyunchang Kim, Young-tae Jeon, Yonghun Lee, Jungwon Hwang, Youngjin Lim, Jungeun Park, Hee Pyoung ParkAbstract:BACKGROUNDCatheter-related Bladder Discomfort (CRBD) due to an indwelling urinary catheter causes postoperative distress. Dexmedetomidine is used as an anaesthetic adjuvant during general anaesthesia and has an antimuscarinic effect, which may be beneficial for the prevention and treatment of CRBD.O
-
effect of glycopyrrolate versus atropine coadministered with neostigmine for reversal of rocuronium on postoperative catheter related Bladder Discomfort in patients undergoing transurethral resection of Bladder tumor a prospective randomized study
Journal of Anesthesia, 2015Co-Authors: Hyunchang Kim, Sunmin Lim, Hyungseok Seo, Hee Pyoung ParkAbstract:Background Muscarinic receptors are involved in the mechanism of postoperative catheter-related Bladder Discomfort (CRBD). Glycopyrrolate and atropine as adjuncts to reversal of neuromuscular blockers have differential inhibitory effects on muscarinic receptors. This study was conducted to compare the effect of glycopyrrolate versus atropine on postoperative CRBD in patients undergoing transurethral resection of a Bladder tumor (TURBT).