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L M A Akkermans - One of the best experts on this subject based on the ideXlab platform.
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motilin induces gall Bladder Emptying and antral contractions in the fasted state in humans
Gut, 1998Co-Authors: Y C Luiking, Inge Depoortere, T L Peeters, V B Nieuwenhuijs, G P Van Berge Henegouwen, M F J Stolk, Piero Portincasa, L M A AkkermansAbstract:Background —Animal studies have shown that motilin affects gall Bladder motility. In humans, no effect has been shown, but erythromycin, a motilin receptor agonist, induces gall Bladder Emptying. Aims —To explore the effect of increasing doses of exogenous motilin on gall Bladder volume and antral contractility in the fasted state in humans. Methods —After an overnight fast, eight healthy men received increasing intravenous doses of Leu 13 -motilin (KW-5139) or 0.9% NaCl in a double blind, randomised fashion. Gall Bladder volume and antral contraction frequency were determined by ultrasonography. Results —Infusion of motilin increased plasma motilin levels. Motilin induced a reduction in gall Bladder volume of 8.0 (5.0)%, 17.1 (5.0)%, 18.5 (4.7)%, and 16.1 (4.9)% of baseline volume at the end of infusion of 2, 4, ,8 and 16 pmol/kg/min respectively, compared with mean stable gall Bladder volumes during placebo infusion (p Conclusions —Exogenous motilin reducted fasting gall Bladder volume and increased antral contractions. After reaching maximal reduction, the gall Bladder volume did not decrease further during continuous motilin infusion at higher doses and stayed at the same reduced volume. The degree of gall Bladder volume reduction during motilin infusion mimicked gall Bladder Emptying preceding antral phase III activity of the migrating motor complex in humans. This study indicates that motilin may play a physiological role in the regulation of gall Bladder Emptying in the fasted state.
Steven G Docimo - One of the best experts on this subject based on the ideXlab platform.
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can ultrasonography or uroflowmetry predict which children with voiding dysfunction will have recurrent urinary tract infections
The Journal of Urology, 2005Co-Authors: Nader Shaikh, Sameem Abedin, Steven G DocimoAbstract:ABSTRACTPurpose:: It has been suggested that in children with voiding dysfunction improper Bladder Emptying contributes to recurrent urinary tract infections (UTIs) and progressive renal scarring. Incomplete Bladder Emptying may be related to Bladder-sphincter dyssynergia. Ultrasonography and uroflowmetry are used in the initial evaluation of many children with voiding dysfunction. We determine in children with voiding dysfunction whether incomplete Bladder Emptying has an important role in the pathogenesis of urinary tract infections and whether abnormal ultrasonography or uroflowmetry can predict which children are at increased risk of recurrent UTIs.Materials and Methods:: In this retrospective cohort study charts of 148 consecutive patients diagnosed with voiding dysfunction were reviewed for information regarding residual urine volumes on initial post-void ultrasound and the number of urinary tract infections on followup. Initial uroflowmetry curves were blindly reevaluated for this study.Results:: C...
M F J Stolk - One of the best experts on this subject based on the ideXlab platform.
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severe impairment of postprandial cholecystokinin release and gall Bladder Emptying and high risk of gallstone formation in acromegalic patients during sandostatin lar
Alimentary Pharmacology & Therapeutics, 2001Co-Authors: A Moschetta, M F J Stolk, Piero Portincasa, Jens F Rehfeld, P Th H J Slee, H P F Koppeschaar, K J Van Erpecum, G P VanbergehenegouwenAbstract:Background: Acromegalic patients treated three times daily with subcutaneous injections of the somatostatin analogue octreotide frequently develop gallstones, due to suppressed cholecystokinin release and impaired gall-Bladder Emptying. Aim: To elucidate the effects of a new long-acting octreotide formulation (Sandostatin LAR) on gall-Bladder Emptying, cholecystokinin release and gallstone formation. Methods: Postprandial gall-Bladder and gastric Emptying were determined by ultrasonography and cholecystokinin release was measured in seven patients on days 0, 14, 28, and 75 (Sandostatin LAR, 20 mg intramuscularly on days 1, 30, and 60). Results: During treatment, fasting gall-Bladder volumes increased from 26.5 ± 3.2 mL to 61.4 ± 7.5 mL, but postprandial cholecystokinin release and gall-Bladder Emptying (from 63.9 ± 3.8% to 12.3 ± 3.5%) were severely suppressed. Gallstones formed in six out of seven patients within 8 months of treatment. Gastric Emptying did not change during the therapy. Conclusions: The risk of gallstone formation is greatly increased during Sandostatin LAR. This is probably related to profound suppression of cholecystokinin release and gall-Bladder Emptying.
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motilin induces gall Bladder Emptying and antral contractions in the fasted state in humans
Gut, 1998Co-Authors: Y C Luiking, Inge Depoortere, T L Peeters, V B Nieuwenhuijs, G P Van Berge Henegouwen, M F J Stolk, Piero Portincasa, L M A AkkermansAbstract:Background —Animal studies have shown that motilin affects gall Bladder motility. In humans, no effect has been shown, but erythromycin, a motilin receptor agonist, induces gall Bladder Emptying. Aims —To explore the effect of increasing doses of exogenous motilin on gall Bladder volume and antral contractility in the fasted state in humans. Methods —After an overnight fast, eight healthy men received increasing intravenous doses of Leu 13 -motilin (KW-5139) or 0.9% NaCl in a double blind, randomised fashion. Gall Bladder volume and antral contraction frequency were determined by ultrasonography. Results —Infusion of motilin increased plasma motilin levels. Motilin induced a reduction in gall Bladder volume of 8.0 (5.0)%, 17.1 (5.0)%, 18.5 (4.7)%, and 16.1 (4.9)% of baseline volume at the end of infusion of 2, 4, ,8 and 16 pmol/kg/min respectively, compared with mean stable gall Bladder volumes during placebo infusion (p Conclusions —Exogenous motilin reducted fasting gall Bladder volume and increased antral contractions. After reaching maximal reduction, the gall Bladder volume did not decrease further during continuous motilin infusion at higher doses and stayed at the same reduced volume. The degree of gall Bladder volume reduction during motilin infusion mimicked gall Bladder Emptying preceding antral phase III activity of the migrating motor complex in humans. This study indicates that motilin may play a physiological role in the regulation of gall Bladder Emptying in the fasted state.
Piero Portincasa - One of the best experts on this subject based on the ideXlab platform.
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severe impairment of postprandial cholecystokinin release and gall Bladder Emptying and high risk of gallstone formation in acromegalic patients during sandostatin lar
Alimentary Pharmacology & Therapeutics, 2001Co-Authors: A Moschetta, M F J Stolk, Piero Portincasa, Jens F Rehfeld, P Th H J Slee, H P F Koppeschaar, K J Van Erpecum, G P VanbergehenegouwenAbstract:Background: Acromegalic patients treated three times daily with subcutaneous injections of the somatostatin analogue octreotide frequently develop gallstones, due to suppressed cholecystokinin release and impaired gall-Bladder Emptying. Aim: To elucidate the effects of a new long-acting octreotide formulation (Sandostatin LAR) on gall-Bladder Emptying, cholecystokinin release and gallstone formation. Methods: Postprandial gall-Bladder and gastric Emptying were determined by ultrasonography and cholecystokinin release was measured in seven patients on days 0, 14, 28, and 75 (Sandostatin LAR, 20 mg intramuscularly on days 1, 30, and 60). Results: During treatment, fasting gall-Bladder volumes increased from 26.5 ± 3.2 mL to 61.4 ± 7.5 mL, but postprandial cholecystokinin release and gall-Bladder Emptying (from 63.9 ± 3.8% to 12.3 ± 3.5%) were severely suppressed. Gallstones formed in six out of seven patients within 8 months of treatment. Gastric Emptying did not change during the therapy. Conclusions: The risk of gallstone formation is greatly increased during Sandostatin LAR. This is probably related to profound suppression of cholecystokinin release and gall-Bladder Emptying.
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motilin induces gall Bladder Emptying and antral contractions in the fasted state in humans
Gut, 1998Co-Authors: Y C Luiking, Inge Depoortere, T L Peeters, V B Nieuwenhuijs, G P Van Berge Henegouwen, M F J Stolk, Piero Portincasa, L M A AkkermansAbstract:Background —Animal studies have shown that motilin affects gall Bladder motility. In humans, no effect has been shown, but erythromycin, a motilin receptor agonist, induces gall Bladder Emptying. Aims —To explore the effect of increasing doses of exogenous motilin on gall Bladder volume and antral contractility in the fasted state in humans. Methods —After an overnight fast, eight healthy men received increasing intravenous doses of Leu 13 -motilin (KW-5139) or 0.9% NaCl in a double blind, randomised fashion. Gall Bladder volume and antral contraction frequency were determined by ultrasonography. Results —Infusion of motilin increased plasma motilin levels. Motilin induced a reduction in gall Bladder volume of 8.0 (5.0)%, 17.1 (5.0)%, 18.5 (4.7)%, and 16.1 (4.9)% of baseline volume at the end of infusion of 2, 4, ,8 and 16 pmol/kg/min respectively, compared with mean stable gall Bladder volumes during placebo infusion (p Conclusions —Exogenous motilin reducted fasting gall Bladder volume and increased antral contractions. After reaching maximal reduction, the gall Bladder volume did not decrease further during continuous motilin infusion at higher doses and stayed at the same reduced volume. The degree of gall Bladder volume reduction during motilin infusion mimicked gall Bladder Emptying preceding antral phase III activity of the migrating motor complex in humans. This study indicates that motilin may play a physiological role in the regulation of gall Bladder Emptying in the fasted state.
Bjorn Wullt - One of the best experts on this subject based on the ideXlab platform.
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escherichia coli 83972 bacteriuria protects against recurrent lower urinary tract infections in patients with incomplete Bladder Emptying
The Journal of Urology, 2010Co-Authors: Fredrik Sunden, Lars Hakansson, Eva Ljunggren, Bjorn WulltAbstract:Purpose: We determined if the deliberate establishment of asymptomatic bacteriuria with Escherichia coli 83972 in patients with incomplete Bladder Emptying and recurrent urinary tract infection protects against recurrence.Materials and Methods: In phase 1 of the study the patients were randomized to blinded inoculations with E. coli 83972 or saline. Crossover occurred after monitoring for 12 months or after a urinary tract infection. The outcome was the time to the first urinary tract infection in patients with and without E. coli 83972 bacteriuria. In phase 2 patients were subjected to additional blinded inoculations to extend periods with and without E. coli 83972 bacteriuria. The outcome was the number of urinary tract infections during 12 months with and 12 months without E. coli 83972 bacteriuria.Results: A total of 20 patients completed the study. In phase 1 the time to the first urinary tract infection was longer with than without E. coli 83972 bacteriuria (median 11.3 vs 5.7 months, sign test p = ...