The Experts below are selected from a list of 4242 Experts worldwide ranked by ideXlab platform

Joe Gates - One of the best experts on this subject based on the ideXlab platform.

Robert Kendall Meyrick - One of the best experts on this subject based on the ideXlab platform.

Robert Meyrick - One of the best experts on this subject based on the ideXlab platform.

Alissa Mittnik - One of the best experts on this subject based on the ideXlab platform.

  • The Beaker phenomenon and the genomic transformation of northwest Europe
    Nature, 2018
    Co-Authors: Inigo Olalde, Selina Brace, Morten E Allentoft, Ian Armit, Kristian Kristiansen, Nadin Rohland, Swapan Mallick, Thomas Booth, Anna Szécsényi-nagy, Alissa Mittnik
    Abstract:

    From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 bc . The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, including 226 individuals associated with Beaker-complex artefacts. We detected limited genetic affinity between Beaker-complex-associated individuals from Iberia and central Europe, and thus exclude migration as an important mechanism of spread between these two regions. However, migration had a key role in the further dissemination of the Beaker complex. We document this phenomenon most clearly in Britain, where the spread of the Beaker complex introduced high levels of steppe-related ancestry and was associated with the replacement of approximately 90% of Britain’s gene pool within a few hundred years, continuing the east-to-west expansion that had brought steppe-related ancestry into central and northern Europe over the previous centuries. Genome-wide data from 400 individuals indicate that the initial spread of the Beaker archaeological complex between Iberia and central Europe was propelled by cultural diffusion, but that its spread into Britain involved a large-scale migration that permanently replaced about ninety per cent of the ancestry in the previously resident population. Bell Beaker refers to a distinctive pottery style found across western and central Europe during the end of the Neolithic. Previous studies have had conflicting results on the origin and mechanisms of spread of the Beaker culture. David Reich and colleagues report genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, from 136 different archaeological sites, and including 226 Beaker-associated individuals. These individuals were highly genetically heterogeneous, which supports a model in which cultural transmission and human migration both had important roles in the spread of the Beaker culture, with the relative balance of these two processes varying by region. Elsewhere in this issue, David Reich and colleagues analyse genome-wide genomic data from 225 individuals who lived in southeastern European and the surrounding regions between 12000 and 500 bc . They analyse these data in combination with previous genomic datasets to update existing models of the early spread of farming into and across Europe.

  • the beaker phenomenon and the genomic transformation of northwest europe
    Nature, 2018
    Co-Authors: Inigo Olalde, Selina Brace, Morten E Allentoft, Ian Armit, Anna Szecsenyinagy, Kristian Kristiansen, Thomas J. Booth, Nadin Rohland, Swapan Mallick, Alissa Mittnik
    Abstract:

    From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, including 226 individuals associated with Beaker-complex artefacts. We detected limited genetic affinity between Beaker-complex-associated individuals from Iberia and central Europe, and thus exclude migration as an important mechanism of spread between these two regions. However, migration had a key role in the further dissemination of the Beaker complex. We document this phenomenon most clearly in Britain, where the spread of the Beaker complex introduced high levels of steppe-related ancestry and was associated with the replacement of approximately 90% of Britain’s gene pool within a few hundred years, continuing the east-to-west expansion that had brought steppe-related ancestry into central and northern Europe over the previous centuries.

Laurine M Bow - One of the best experts on this subject based on the ideXlab platform.

  • p039 the bumpy road to epic beaker implementation
    Human Immunology, 2018
    Co-Authors: Maureen Miller, Laurine M Bow
    Abstract:

    Our lab has reported discrete results into Epic EMR since the initial Epic Go Live allowing for access to electronic data for clinical and research use. YNHH initiated the LIS update from SoftLab to Epic Beaker in 2016. This update dramatically changed our workflow. Initially, the Epic Beaker team set up our lab with a workaround to report results back into Epic without completing the standard Beaker sample workflow. Generic sample labels and incomplete specimen collection information often led to confusion and samples were redrawn or orders were automatically canceled in Epic before results were posted to the EMR. In 2017, a project was initiated to incorporate the HLA lab into the Epic Beaker workflow. This project faced three primary challenges. First, Beaker lacked support for Epic order panels with multiple tests and sample types, which were initially set up to improve efficiency when ordering multiple concurrent tests. As a solution, these panels were split into orders based on the various tube types necessary to perform the test and order sets were created in Beaker. The second challenge was the Beaker required update of the HL7 orders and results interfaces to support the data transfer between Epic and HistoTrac. The final hurdle was that every result message needed to be updated with the Beaker sample ID. This prompted the HLA Lab to consolidate our Epic orders removing organ specificity and reducing orders from 28 to 10 unique order codes. Furthermore, Beaker enforced a one to one relationship between orders and results. To accommodate this rule, SystemLink added status logic to the results message. All results are sent as preliminary until the last outstanding test result is signed off in HistoTrac and sent as final. Prior to the HLA lab Go Live the Epic team trained the sample collection staff to process our orders with the standard Beaker workflow, updated the clinicians with an Epic splash screen message, and trained the HLA staff to receive samples in Beaker before processing in HistoTrac. All Epic outstanding orders, standing orders and preference lists were updated by the Epic consolidation team. Post-Go Live optimization has included filing results for all pre-Go Live outstanding tests in HistoTrac, and identifying sample collection sites needing updated order transmittal rules which add the Beaker sample ID at collection. As a result of the Epic Beaker implementation order specific labels are printed for all samples, sample status is updated in real time, and samples are processed with the standard Beaker workflow.