The Experts below are selected from a list of 222 Experts worldwide ranked by ideXlab platform

Hongwei Zhang - One of the best experts on this subject based on the ideXlab platform.

  • Low lymphocyte-to-white Blood Cell Ratio and high monocyte-to-white Blood Cell Ratio predict poor prognosis in gastric cancer.
    Oncotarget, 2016
    Co-Authors: Fan Feng, Li Sun, Gaozan Zheng, Shushang Liu, Zhen Liu, Man Guo, Xiao Lian, Daiming Fan, Hongwei Zhang
    Abstract:

    // Fan Feng 1, * , Li Sun 1, * , Gaozan Zheng 1, * , Shushang Liu 1 , Zhen Liu 1 , Guanghui Xu 1 , Man Guo 1 , Xiao Lian 1 , Daiming Fan 1 , Hongwei Zhang 1 1 Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032, Xi’an, Shaanxi, China * These authors have contributed equally to this work Correspondence to: Hongwei Zhang, email: zhanghwfmmu@126.com Keywords: gastric cancer, Blood test, prognosis Received: June 01, 2016     Accepted: November 21, 2016     Published: December 24, 2016 ABSTRACT Previous results regarding the prognostic value of the neutrophil-to-lymphocyte Ratio (NLR) and platelet-to-lymphocyte Ratio (PLR) in gastric cancer are conflicting, and full analysis of other Blood test parameters are lacking. We therefore examined the associations between various Blood test parameters and prognosis in 3243 gastric cancer patients randomly divided into training (n=1621) and validation (n=1622) sets. Optimal cut-off values of 0.663 for neutrophil-to-white Blood Cell Ratio (NWR), 0.288 for lymphocyte-to-white Blood Cell Ratio (LWR), 0.072 for monocyte-to-white Blood Cell Ratio (MWR), 2.604 for NLR, 0.194 for monocyte-to-lymphocyte Ratio (MLR), and 130.675 for PLR were identified in the training set. Univariate and survival analyses revealed that high NWR, low LWR, high MWR, high NLR, high MLR, and high PLR are all associated with a poor prognosis in gastric cancer. However, multivariate analysis revealed that only LWR, and MWR are independent prognostic predictors, and prognostic value increased when LWR and MWR were considered in combination. These findings suggest that low LWR and high MWR are each predictive of a poor prognosis, and exhibit greater prognostic value when considered in combination.

  • Combination of PLR, MLR, MWR, and Tumor Size Could Significantly Increase the Prognostic Value for Gastrointestinal Stromal Tumors.
    Medicine, 2016
    Co-Authors: Fan Feng, Gaozan Zheng, Shushang Liu, Zhen Liu, Man Guo, Xiao Lian, Daiming Fan, Tian Yangzi, Xu Guanghui, Hongwei Zhang
    Abstract:

    Systemic inflammation and immune response were associated with prognosis of tumors. However, data was limited due to the relatively low incidence of gastrointestinal stromal tumors (GISTs). The aim of the present study was to investigate the predictive value of preoperative peripheral Blood Cells in prognosis of GISTs. From September 2008 to July 2015, a total of 274 GIST patients in our department were enrolled in the present study. Clinicopathological features of GISTs were recorded. The association between preoperative peripheral Blood Cells and prognosis of GISTs were analyzed. Tumor location, tumor size, mitotic index, intratumoral necrosis, and National Institutes of Health (NIH) risk category were associated with prognosis of GISTs. High neutrophil-to-lymphocyte Ratio (NLR), monocyte-to-lymphocyte Ratio (MLR), platelet-to-lymphocyte Ratio (PLR), neutrophil-to-white Blood Cell Ratio (NWR), monocyte-to-white Blood Cell Ratio (MWR) and low lymphocyte-to-white Blood Cell Ratio (LWR) was associated with poor prognosis of GISTs (76.2% vs 83.7%, P = 0.010. 70.5% vs 98.7%, P = 0.000. 65.7% vs 96.4%, P = 0.004. 78.5% vs 82.5%, P = 0.044. 73.5% vs 97.8%, P = 0.004. 76.6% vs 83.6%, P = 0.012, respectively). However, tumor size was the only independent risk factor for prognosis according to multivariate analysis (P = 0.006). Tumor location, tumor size, mitotic index, and NIH risk category were significantly correlated with the above-mentioned parameters (all P  5 cm, high MLR, high PLR, and high MWR was significantly lower than the remnant patients (P = 0.010). The peripheral Blood routine test is convenient, reproducible, and inexpensive. High NLR, MLR, PLR, NWR, MWR, and low LWR were associated with poor prognosis of GISTs. The association between the above parameters and prognosis of GISTs may be attributed to their correlation with tumor size, mitotic index, and NIH risk category. The combination of tumor size, MLR, PLR, and MWR could further increase the predictive value of prognosis of GISTs.

Yi Shao - One of the best experts on this subject based on the ideXlab platform.

  • Systemic Inflammatory Response Syndrome Combined with Pre- and Postoperative White Blood Cell Ratio Is a Better Criterion to Identify Septic Shock Patients After Flexible Ureteroscopic Lithotripsy.
    Journal of endourology, 2020
    Co-Authors: Yi-yong Zhu, Yujia Huo, Shu-jie Xia, Yi Shao
    Abstract:

    Objective: To find out a better criterion to identify septic shock patients after flexible ureteroscopic lithotripsy (FUL). Materials and Methods: In total, 2364 patients who underwent the FUL procedure were enrolled in the study. The demographics and preoperative results of laboratory tests of the patients were collected. The postoperative white Blood Cell (WBC), systemic inflammatory response syndrome (SIRS), and quick sequential (sepsis-related) organ failure assessment score (qSOFA) were assessed 2 hours after FUL. The predictive efficacy was measured by sensitivity, specificity, positive and negative predictive value, and area under the receiver's operating characteristic curve (AUROC). Results: A total of 15 (0.63%) patients developed septic shock. There were 86 (3.64%) patients who were SIRS positive and 69 (2.92%) patients who were qSOFA positive. The pre- and postoperative WBC Ratios in septic shock patients and normal patients were 2.50 ± 1.55 and 0.69 ± 0.24, respectively (p < 0.001). For sensitivity and negative predictive value, all reached 100%. For specificity, qSOFA was 97.70%, SIRS was 96.98%, and SIRS combining pre- and postoperative WBC Ratio (the new criterion) was 99.79%. The new criterion had statistically significant higher specificity than SIRS or qSOFA (p < 0.001 for both), but when comparing SIRS and qSOFA, it had statistically insignificant specificity (p = 0.142). For positive predictive value, qSOFA was 21.73%, SIRS was 17.44%, and the new criterion was 75%. qSOFA and SIRS had similar AUROC (0.989 for qSOFA and 0.985 for SIRS), both lower than the new criterion (AUROC: 0.999). Conclusions: SIRS combined with pre- and postoperative WBC Ratio has a much better specificity and positive predictive value than SIRS or qSOFA alone. It has 99.79% specificity and 75% positive predictive value, and as high as 100% sensitivity and negative predictive value.

  • systemic inflammatory response syndrome combined with pre and postoperative white Blood Cell Ratio is a better criterion to identify septic shock patients after flexible ureteroscopic lithotripsy
    Journal of Endourology, 2020
    Co-Authors: Yi-yong Zhu, Yujia Huo, Shu-jie Xia, Yi Shao
    Abstract:

    Objective: To find out a better criterion to identify septic shock patients after flexible ureteroscopic lithotripsy (FUL). Materials and Methods: In total, 2364 patients who underwent the FUL proc...

Fan Feng - One of the best experts on this subject based on the ideXlab platform.

  • Low lymphocyte-to-white Blood Cell Ratio and high monocyte-to-white Blood Cell Ratio predict poor prognosis in gastric cancer.
    Oncotarget, 2016
    Co-Authors: Fan Feng, Li Sun, Gaozan Zheng, Shushang Liu, Zhen Liu, Man Guo, Xiao Lian, Daiming Fan, Hongwei Zhang
    Abstract:

    // Fan Feng 1, * , Li Sun 1, * , Gaozan Zheng 1, * , Shushang Liu 1 , Zhen Liu 1 , Guanghui Xu 1 , Man Guo 1 , Xiao Lian 1 , Daiming Fan 1 , Hongwei Zhang 1 1 Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032, Xi’an, Shaanxi, China * These authors have contributed equally to this work Correspondence to: Hongwei Zhang, email: zhanghwfmmu@126.com Keywords: gastric cancer, Blood test, prognosis Received: June 01, 2016     Accepted: November 21, 2016     Published: December 24, 2016 ABSTRACT Previous results regarding the prognostic value of the neutrophil-to-lymphocyte Ratio (NLR) and platelet-to-lymphocyte Ratio (PLR) in gastric cancer are conflicting, and full analysis of other Blood test parameters are lacking. We therefore examined the associations between various Blood test parameters and prognosis in 3243 gastric cancer patients randomly divided into training (n=1621) and validation (n=1622) sets. Optimal cut-off values of 0.663 for neutrophil-to-white Blood Cell Ratio (NWR), 0.288 for lymphocyte-to-white Blood Cell Ratio (LWR), 0.072 for monocyte-to-white Blood Cell Ratio (MWR), 2.604 for NLR, 0.194 for monocyte-to-lymphocyte Ratio (MLR), and 130.675 for PLR were identified in the training set. Univariate and survival analyses revealed that high NWR, low LWR, high MWR, high NLR, high MLR, and high PLR are all associated with a poor prognosis in gastric cancer. However, multivariate analysis revealed that only LWR, and MWR are independent prognostic predictors, and prognostic value increased when LWR and MWR were considered in combination. These findings suggest that low LWR and high MWR are each predictive of a poor prognosis, and exhibit greater prognostic value when considered in combination.

  • Combination of PLR, MLR, MWR, and Tumor Size Could Significantly Increase the Prognostic Value for Gastrointestinal Stromal Tumors.
    Medicine, 2016
    Co-Authors: Fan Feng, Gaozan Zheng, Shushang Liu, Zhen Liu, Man Guo, Xiao Lian, Daiming Fan, Tian Yangzi, Xu Guanghui, Hongwei Zhang
    Abstract:

    Systemic inflammation and immune response were associated with prognosis of tumors. However, data was limited due to the relatively low incidence of gastrointestinal stromal tumors (GISTs). The aim of the present study was to investigate the predictive value of preoperative peripheral Blood Cells in prognosis of GISTs. From September 2008 to July 2015, a total of 274 GIST patients in our department were enrolled in the present study. Clinicopathological features of GISTs were recorded. The association between preoperative peripheral Blood Cells and prognosis of GISTs were analyzed. Tumor location, tumor size, mitotic index, intratumoral necrosis, and National Institutes of Health (NIH) risk category were associated with prognosis of GISTs. High neutrophil-to-lymphocyte Ratio (NLR), monocyte-to-lymphocyte Ratio (MLR), platelet-to-lymphocyte Ratio (PLR), neutrophil-to-white Blood Cell Ratio (NWR), monocyte-to-white Blood Cell Ratio (MWR) and low lymphocyte-to-white Blood Cell Ratio (LWR) was associated with poor prognosis of GISTs (76.2% vs 83.7%, P = 0.010. 70.5% vs 98.7%, P = 0.000. 65.7% vs 96.4%, P = 0.004. 78.5% vs 82.5%, P = 0.044. 73.5% vs 97.8%, P = 0.004. 76.6% vs 83.6%, P = 0.012, respectively). However, tumor size was the only independent risk factor for prognosis according to multivariate analysis (P = 0.006). Tumor location, tumor size, mitotic index, and NIH risk category were significantly correlated with the above-mentioned parameters (all P  5 cm, high MLR, high PLR, and high MWR was significantly lower than the remnant patients (P = 0.010). The peripheral Blood routine test is convenient, reproducible, and inexpensive. High NLR, MLR, PLR, NWR, MWR, and low LWR were associated with poor prognosis of GISTs. The association between the above parameters and prognosis of GISTs may be attributed to their correlation with tumor size, mitotic index, and NIH risk category. The combination of tumor size, MLR, PLR, and MWR could further increase the predictive value of prognosis of GISTs.

Yi-yong Zhu - One of the best experts on this subject based on the ideXlab platform.

  • Systemic Inflammatory Response Syndrome Combined with Pre- and Postoperative White Blood Cell Ratio Is a Better Criterion to Identify Septic Shock Patients After Flexible Ureteroscopic Lithotripsy.
    Journal of endourology, 2020
    Co-Authors: Yi-yong Zhu, Yujia Huo, Shu-jie Xia, Yi Shao
    Abstract:

    Objective: To find out a better criterion to identify septic shock patients after flexible ureteroscopic lithotripsy (FUL). Materials and Methods: In total, 2364 patients who underwent the FUL procedure were enrolled in the study. The demographics and preoperative results of laboratory tests of the patients were collected. The postoperative white Blood Cell (WBC), systemic inflammatory response syndrome (SIRS), and quick sequential (sepsis-related) organ failure assessment score (qSOFA) were assessed 2 hours after FUL. The predictive efficacy was measured by sensitivity, specificity, positive and negative predictive value, and area under the receiver's operating characteristic curve (AUROC). Results: A total of 15 (0.63%) patients developed septic shock. There were 86 (3.64%) patients who were SIRS positive and 69 (2.92%) patients who were qSOFA positive. The pre- and postoperative WBC Ratios in septic shock patients and normal patients were 2.50 ± 1.55 and 0.69 ± 0.24, respectively (p < 0.001). For sensitivity and negative predictive value, all reached 100%. For specificity, qSOFA was 97.70%, SIRS was 96.98%, and SIRS combining pre- and postoperative WBC Ratio (the new criterion) was 99.79%. The new criterion had statistically significant higher specificity than SIRS or qSOFA (p < 0.001 for both), but when comparing SIRS and qSOFA, it had statistically insignificant specificity (p = 0.142). For positive predictive value, qSOFA was 21.73%, SIRS was 17.44%, and the new criterion was 75%. qSOFA and SIRS had similar AUROC (0.989 for qSOFA and 0.985 for SIRS), both lower than the new criterion (AUROC: 0.999). Conclusions: SIRS combined with pre- and postoperative WBC Ratio has a much better specificity and positive predictive value than SIRS or qSOFA alone. It has 99.79% specificity and 75% positive predictive value, and as high as 100% sensitivity and negative predictive value.

  • systemic inflammatory response syndrome combined with pre and postoperative white Blood Cell Ratio is a better criterion to identify septic shock patients after flexible ureteroscopic lithotripsy
    Journal of Endourology, 2020
    Co-Authors: Yi-yong Zhu, Yujia Huo, Shu-jie Xia, Yi Shao
    Abstract:

    Objective: To find out a better criterion to identify septic shock patients after flexible ureteroscopic lithotripsy (FUL). Materials and Methods: In total, 2364 patients who underwent the FUL proc...

Gaozan Zheng - One of the best experts on this subject based on the ideXlab platform.

  • Low lymphocyte-to-white Blood Cell Ratio and high monocyte-to-white Blood Cell Ratio predict poor prognosis in gastric cancer.
    Oncotarget, 2016
    Co-Authors: Fan Feng, Li Sun, Gaozan Zheng, Shushang Liu, Zhen Liu, Man Guo, Xiao Lian, Daiming Fan, Hongwei Zhang
    Abstract:

    // Fan Feng 1, * , Li Sun 1, * , Gaozan Zheng 1, * , Shushang Liu 1 , Zhen Liu 1 , Guanghui Xu 1 , Man Guo 1 , Xiao Lian 1 , Daiming Fan 1 , Hongwei Zhang 1 1 Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032, Xi’an, Shaanxi, China * These authors have contributed equally to this work Correspondence to: Hongwei Zhang, email: zhanghwfmmu@126.com Keywords: gastric cancer, Blood test, prognosis Received: June 01, 2016     Accepted: November 21, 2016     Published: December 24, 2016 ABSTRACT Previous results regarding the prognostic value of the neutrophil-to-lymphocyte Ratio (NLR) and platelet-to-lymphocyte Ratio (PLR) in gastric cancer are conflicting, and full analysis of other Blood test parameters are lacking. We therefore examined the associations between various Blood test parameters and prognosis in 3243 gastric cancer patients randomly divided into training (n=1621) and validation (n=1622) sets. Optimal cut-off values of 0.663 for neutrophil-to-white Blood Cell Ratio (NWR), 0.288 for lymphocyte-to-white Blood Cell Ratio (LWR), 0.072 for monocyte-to-white Blood Cell Ratio (MWR), 2.604 for NLR, 0.194 for monocyte-to-lymphocyte Ratio (MLR), and 130.675 for PLR were identified in the training set. Univariate and survival analyses revealed that high NWR, low LWR, high MWR, high NLR, high MLR, and high PLR are all associated with a poor prognosis in gastric cancer. However, multivariate analysis revealed that only LWR, and MWR are independent prognostic predictors, and prognostic value increased when LWR and MWR were considered in combination. These findings suggest that low LWR and high MWR are each predictive of a poor prognosis, and exhibit greater prognostic value when considered in combination.

  • Combination of PLR, MLR, MWR, and Tumor Size Could Significantly Increase the Prognostic Value for Gastrointestinal Stromal Tumors.
    Medicine, 2016
    Co-Authors: Fan Feng, Gaozan Zheng, Shushang Liu, Zhen Liu, Man Guo, Xiao Lian, Daiming Fan, Tian Yangzi, Xu Guanghui, Hongwei Zhang
    Abstract:

    Systemic inflammation and immune response were associated with prognosis of tumors. However, data was limited due to the relatively low incidence of gastrointestinal stromal tumors (GISTs). The aim of the present study was to investigate the predictive value of preoperative peripheral Blood Cells in prognosis of GISTs. From September 2008 to July 2015, a total of 274 GIST patients in our department were enrolled in the present study. Clinicopathological features of GISTs were recorded. The association between preoperative peripheral Blood Cells and prognosis of GISTs were analyzed. Tumor location, tumor size, mitotic index, intratumoral necrosis, and National Institutes of Health (NIH) risk category were associated with prognosis of GISTs. High neutrophil-to-lymphocyte Ratio (NLR), monocyte-to-lymphocyte Ratio (MLR), platelet-to-lymphocyte Ratio (PLR), neutrophil-to-white Blood Cell Ratio (NWR), monocyte-to-white Blood Cell Ratio (MWR) and low lymphocyte-to-white Blood Cell Ratio (LWR) was associated with poor prognosis of GISTs (76.2% vs 83.7%, P = 0.010. 70.5% vs 98.7%, P = 0.000. 65.7% vs 96.4%, P = 0.004. 78.5% vs 82.5%, P = 0.044. 73.5% vs 97.8%, P = 0.004. 76.6% vs 83.6%, P = 0.012, respectively). However, tumor size was the only independent risk factor for prognosis according to multivariate analysis (P = 0.006). Tumor location, tumor size, mitotic index, and NIH risk category were significantly correlated with the above-mentioned parameters (all P  5 cm, high MLR, high PLR, and high MWR was significantly lower than the remnant patients (P = 0.010). The peripheral Blood routine test is convenient, reproducible, and inexpensive. High NLR, MLR, PLR, NWR, MWR, and low LWR were associated with poor prognosis of GISTs. The association between the above parameters and prognosis of GISTs may be attributed to their correlation with tumor size, mitotic index, and NIH risk category. The combination of tumor size, MLR, PLR, and MWR could further increase the predictive value of prognosis of GISTs.