Blood Clot Retraction - Explore the Science & Experts | ideXlab

Scan Science and Technology

Contact Leading Edge Experts & Companies

Blood Clot Retraction

The Experts below are selected from a list of 69 Experts worldwide ranked by ideXlab platform

Jianping Fu – One of the best experts on this subject based on the ideXlab platform.

  • a miniaturized hemoretractometer for Blood Clot Retraction testing
    Small, 2016
    Co-Authors: Zida Li, Xiang Li, Brendan M Mccracken, Yue Shao, Kevin R Ward, Jianping Fu

    Abstract:

    Blood coagulation is a critical hemostatic process that must be properly regulated to maintain a delicate balance between bleeding and Clotting. Disorders of Blood coagulation can expose patients to the risk of either bleeding disorders or thrombotic diseases. Coagulation diagnostics using whole Blood is very promising for assessing the complexity of the coagulation system and for global measurements of hemostasis. Despite the clinic values that existing whole Blood coagulation tests have demonstrated, these systems have significant limitations that diminish their potential for point-of-care applications. Here, recent advancements in device miniaturization using functional soft materials are leveraged to develop a miniaturized Clot Retraction force assay device termed mHemoRetractoMeter (mHRM). The mHRM is capable of precise measurements of dynamic Clot Retraction forces in real time using minute amounts of whole Blood. To further demonstrate the clinical utility of the mHRM, systematic studies are conducted using the mHRM to examine the effects of assay temperature, treatments of Clotting agents, and pro- and anti-coagulant drugs on Clot Retraction force developments of whole Blood samples. The mHRM’s low fabrication cost, small size, and consumption of only minute amounts of Blood samples make the technology promising as a point-of-care tool for future coagulation monitoring.

  • Clot Retraction a miniaturized hemoretractometer for Blood Clot Retraction testing small 29 2016
    Small, 2016
    Co-Authors: Zida Li, Xiang Li, Brendan M Mccracken, Yue Shao, Kevin R Ward, Jianping Fu

    Abstract:

    : Whole Blood coagulation testing provides valuable diagnostic information on diseases such as bleeding disorders, heart attack, deep venous thrombosis, etc. On page 3926, J. Fu and co-workers develop a miniaturized hemoretractometer to measure Clot contraction upon Blood coagulation with good reproducibility and robustness. This device design shows great application potential in point-of-care testing. Photo credit: David Peyer from University of Michigan.

  • Clot Retraction: A Miniaturized Hemoretractometer for Blood Clot Retraction Testing (Small 29/2016)
    Small, 2016
    Co-Authors: Zida Li, Xiang Li, Brendan M Mccracken, Yue Shao, Kevin R Ward, Jianping Fu

    Abstract:

    : Whole Blood coagulation testing provides valuable diagnostic information on diseases such as bleeding disorders, heart attack, deep venous thrombosis, etc. On page 3926, J. Fu and co-workers develop a miniaturized hemoretractometer to measure Clot contraction upon Blood coagulation with good reproducibility and robustness. This device design shows great application potential in point-of-care testing. Photo credit: David Peyer from University of Michigan.

Zida Li – One of the best experts on this subject based on the ideXlab platform.

  • a miniaturized hemoretractometer for Blood Clot Retraction testing
    Small, 2016
    Co-Authors: Zida Li, Xiang Li, Brendan M Mccracken, Yue Shao, Kevin R Ward, Jianping Fu

    Abstract:

    Blood coagulation is a critical hemostatic process that must be properly regulated to maintain a delicate balance between bleeding and Clotting. Disorders of Blood coagulation can expose patients to the risk of either bleeding disorders or thrombotic diseases. Coagulation diagnostics using whole Blood is very promising for assessing the complexity of the coagulation system and for global measurements of hemostasis. Despite the clinic values that existing whole Blood coagulation tests have demonstrated, these systems have significant limitations that diminish their potential for point-of-care applications. Here, recent advancements in device miniaturization using functional soft materials are leveraged to develop a miniaturized Clot Retraction force assay device termed mHemoRetractoMeter (mHRM). The mHRM is capable of precise measurements of dynamic Clot Retraction forces in real time using minute amounts of whole Blood. To further demonstrate the clinical utility of the mHRM, systematic studies are conducted using the mHRM to examine the effects of assay temperature, treatments of Clotting agents, and pro- and anti-coagulant drugs on Clot Retraction force developments of whole Blood samples. The mHRM’s low fabrication cost, small size, and consumption of only minute amounts of Blood samples make the technology promising as a point-of-care tool for future coagulation monitoring.

  • Clot Retraction a miniaturized hemoretractometer for Blood Clot Retraction testing small 29 2016
    Small, 2016
    Co-Authors: Zida Li, Xiang Li, Brendan M Mccracken, Yue Shao, Kevin R Ward, Jianping Fu

    Abstract:

    : Whole Blood coagulation testing provides valuable diagnostic information on diseases such as bleeding disorders, heart attack, deep venous thrombosis, etc. On page 3926, J. Fu and co-workers develop a miniaturized hemoretractometer to measure Clot contraction upon Blood coagulation with good reproducibility and robustness. This device design shows great application potential in point-of-care testing. Photo credit: David Peyer from University of Michigan.

  • Clot Retraction: A Miniaturized Hemoretractometer for Blood Clot Retraction Testing (Small 29/2016)
    Small, 2016
    Co-Authors: Zida Li, Xiang Li, Brendan M Mccracken, Yue Shao, Kevin R Ward, Jianping Fu

    Abstract:

    : Whole Blood coagulation testing provides valuable diagnostic information on diseases such as bleeding disorders, heart attack, deep venous thrombosis, etc. On page 3926, J. Fu and co-workers develop a miniaturized hemoretractometer to measure Clot contraction upon Blood coagulation with good reproducibility and robustness. This device design shows great application potential in point-of-care testing. Photo credit: David Peyer from University of Michigan.

Valerie Tutwiler – One of the best experts on this subject based on the ideXlab platform.

  • interplay of platelet contractility and elasticity of fibrin erythrocytes in Blood Clot Retraction
    Biophysical Journal, 2017
    Co-Authors: Valerie Tutwiler, Hailong Wang, Rustem I Litvinov, John W Weisel, Vivek B Shenoy

    Abstract:

    Abstract Blood Clot contraction (Retraction) is driven by platelet-generated forces propagated by the fibrin network and results in Clot shrinkage and deformation of erythrocytes. To elucidate the mechanical nature of this process, we developed a model that combines an active contractile motor element with passive viscoelastic elements. Despite its importance for thrombosis and wound healing, Clot contraction is poorly understood. This model predicts how Clot contraction occurs due to active contractile platelets interacting with a viscoelastic material, rather than to the poroelastic nature of fibrin, and explains the observed dynamics of Clot size, ultrastructure, and measured forces. Mechanically passive erythrocytes and fibrin are present in series and parallel to active contractile cells. This mechanical interplay induces compressive and tensile resistance, resulting in increased contractile force and a reduced extent of contraction in the presence of erythrocytes. This experimentally validated model provides the fundamental mechanical basis for understanding contraction of Blood Clots.

  • Interplay of Platelet Contractility and Elasticity of Fibrin/Erythrocytes in Blood Clot Retraction
    Biophysical Journal, 2017
    Co-Authors: Valerie Tutwiler, Hailong Wang, Rustem I Litvinov, John W Weisel, Vivek B Shenoy

    Abstract:

    Abstract Blood Clot contraction (Retraction) is driven by platelet-generated forces propagated by the fibrin network and results in Clot shrinkage and deformation of erythrocytes. To elucidate the mechanical nature of this process, we developed a model that combines an active contractile motor element with passive viscoelastic elements. Despite its importance for thrombosis and wound healing, Clot contraction is poorly understood. This model predicts how Clot contraction occurs due to active contractile platelets interacting with a viscoelastic material, rather than to the poroelastic nature of fibrin, and explains the observed dynamics of Clot size, ultrastructure, and measured forces. Mechanically passive erythrocytes and fibrin are present in series and parallel to active contractile cells. This mechanical interplay induces compressive and tensile resistance, resulting in increased contractile force and a reduced extent of contraction in the presence of erythrocytes. This experimentally validated model provides the fundamental mechanical basis for understanding contraction of Blood Clots.