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Marta Vicario - One of the best experts on this subject based on the ideXlab platform.

  • Hyaluronic Acid Combined with Serum Rich in Growth Factors in Corneal Epithelial Defects
    MDPI AG, 2019
    Co-Authors: Carlota Suárez-barrio, Jaime Etxebarria, Raquel Hernáez-moya, Marina Del Val-alonso, Maddalen Rodriguez-astigarraga, Arantza Urkaregi, Vanesa Freire, María-celia Morales, Juan Antonio Durán, Marta Vicario
    Abstract:

    The aim of this study is to assess if an adhesive biopolymer, sodium hyaluronate (NaHA), has synergistic effects with s-PRGF (a serum derived from plasma rich in growth factors and a Blood Derivative that has already shown efficacy in corneal epithelial wound healing), to reduce time of healing or posology. In vitro proliferation and migration studies, both in human corneal epithelial (HCE) cells and in rabbit primary corneal epithelial (RPCE) cultures, were carried out. In addition, we performed studies of corneal wound healing in vivo in rabbits treated with s-PRGF, NaHA, or the combination of both. We performed immunohistochemistry techniques (CK3, CK15, Ki67, ß4 integrin, ZO-1, α-SMA) in rabbit corneas 7 and 30 days after a surgically induced epithelial defect. In vitro results show that the combination of NaHA and s-PRGF offers the worst proliferation rates in both HCE and RPCE cells. Addition of NaHA to s-PRGF diminishes the re-epithelializing capability of s-PRGF. In vivo, all treatments, given twice a day, showed equivalent efficacy in corneal epithelial healing. We conclude that the combined use of s-PRGF and HaNA as an adhesive biopolymer does not improve the efficacy of s-PRGF alone in the wound healing of corneal epithelial defects

Vicario Marta - One of the best experts on this subject based on the ideXlab platform.

  • Hyaluronic Acid Combined with Serum Rich in Growth Factors in Corneal Epithelial Defects
    'MDPI AG', 2019
    Co-Authors: Suárez Barrio Carlota, Etxebarria Jaime, Hernáez Moya Raquel, Del Val Alonso Marina, Rodríguez Astigarraga Maddalen, Urkaregi Etxepare Arantza, Freire Vallejo Vanesa, Morales González, María Celia, Durán De La Colina, Juan Antonio, Vicario Marta
    Abstract:

    The aim of this study is to assess if an adhesive biopolymer, sodium hyaluronate (NaHA), has synergistic effects with s-PRGF (a serum derived from plasma rich in growth factors and a Blood Derivative that has already shown efficacy in corneal epithelial wound healing), to reduce time of healing or posology. In vitro proliferation and migration studies, both in human corneal epithelial (HCE) cells and in rabbit primary corneal epithelial (RPCE) cultures, were carried out. In addition, we performed studies of corneal wound healing in vivo in rabbits treated with s-PRGF, NaHA, or the combination of both. We performed immunohistochemistry techniques (CK3, CK15, Ki67, SS4 integrin, ZO-1, alpha-SMA) in rabbit corneas 7 and 30 days after a surgically induced epithelial defect. In vitro results show that the combination of NaHA and s-PRGF offers the worst proliferation rates in both HCE and RPCE cells. Addition of NaHA to s-PRGF diminishes the re-epithelializing capability of s-PRGF. In vivo, all treatments, given twice a day, showed equivalent efficacy in corneal epithelial healing. We conclude that the combined use of s-PRGF and HaNA as an adhesive biopolymer does not improve the efficacy of s-PRGF alone in the wound healing of corneal epithelial defects.Research study supported by grants from the University of the Basque Country UPV/EHU-Instituto Clinico Quirurgico de Oftalmologia ICQO (US16/23), and from the Basque Foundation for Health Research and Innovation BIOEF (BIO14/TP/002)

Carlota Suárez-barrio - One of the best experts on this subject based on the ideXlab platform.

  • Hyaluronic Acid Combined with Serum Rich in Growth Factors in Corneal Epithelial Defects
    MDPI AG, 2019
    Co-Authors: Carlota Suárez-barrio, Jaime Etxebarria, Raquel Hernáez-moya, Marina Del Val-alonso, Maddalen Rodriguez-astigarraga, Arantza Urkaregi, Vanesa Freire, María-celia Morales, Juan Antonio Durán, Marta Vicario
    Abstract:

    The aim of this study is to assess if an adhesive biopolymer, sodium hyaluronate (NaHA), has synergistic effects with s-PRGF (a serum derived from plasma rich in growth factors and a Blood Derivative that has already shown efficacy in corneal epithelial wound healing), to reduce time of healing or posology. In vitro proliferation and migration studies, both in human corneal epithelial (HCE) cells and in rabbit primary corneal epithelial (RPCE) cultures, were carried out. In addition, we performed studies of corneal wound healing in vivo in rabbits treated with s-PRGF, NaHA, or the combination of both. We performed immunohistochemistry techniques (CK3, CK15, Ki67, ß4 integrin, ZO-1, α-SMA) in rabbit corneas 7 and 30 days after a surgically induced epithelial defect. In vitro results show that the combination of NaHA and s-PRGF offers the worst proliferation rates in both HCE and RPCE cells. Addition of NaHA to s-PRGF diminishes the re-epithelializing capability of s-PRGF. In vivo, all treatments, given twice a day, showed equivalent efficacy in corneal epithelial healing. We conclude that the combined use of s-PRGF and HaNA as an adhesive biopolymer does not improve the efficacy of s-PRGF alone in the wound healing of corneal epithelial defects

Suárez Barrio Carlota - One of the best experts on this subject based on the ideXlab platform.

  • Hyaluronic Acid Combined with Serum Rich in Growth Factors in Corneal Epithelial Defects
    'MDPI AG', 2019
    Co-Authors: Suárez Barrio Carlota, Etxebarria Jaime, Hernáez Moya Raquel, Del Val Alonso Marina, Rodríguez Astigarraga Maddalen, Urkaregi Etxepare Arantza, Freire Vallejo Vanesa, Morales González, María Celia, Durán De La Colina, Juan Antonio, Vicario Marta
    Abstract:

    The aim of this study is to assess if an adhesive biopolymer, sodium hyaluronate (NaHA), has synergistic effects with s-PRGF (a serum derived from plasma rich in growth factors and a Blood Derivative that has already shown efficacy in corneal epithelial wound healing), to reduce time of healing or posology. In vitro proliferation and migration studies, both in human corneal epithelial (HCE) cells and in rabbit primary corneal epithelial (RPCE) cultures, were carried out. In addition, we performed studies of corneal wound healing in vivo in rabbits treated with s-PRGF, NaHA, or the combination of both. We performed immunohistochemistry techniques (CK3, CK15, Ki67, SS4 integrin, ZO-1, alpha-SMA) in rabbit corneas 7 and 30 days after a surgically induced epithelial defect. In vitro results show that the combination of NaHA and s-PRGF offers the worst proliferation rates in both HCE and RPCE cells. Addition of NaHA to s-PRGF diminishes the re-epithelializing capability of s-PRGF. In vivo, all treatments, given twice a day, showed equivalent efficacy in corneal epithelial healing. We conclude that the combined use of s-PRGF and HaNA as an adhesive biopolymer does not improve the efficacy of s-PRGF alone in the wound healing of corneal epithelial defects.Research study supported by grants from the University of the Basque Country UPV/EHU-Instituto Clinico Quirurgico de Oftalmologia ICQO (US16/23), and from the Basque Foundation for Health Research and Innovation BIOEF (BIO14/TP/002)

Kismali Erkan - One of the best experts on this subject based on the ideXlab platform.

  • Effect of Injectable Platelet-Rich Fibrin on Diced Cartilage's Viability in Rhinoplasty
    'Georg Thieme Verlag KG', 2019
    Co-Authors: Gode Sercan, Ozturk Arin, Berber Veysel, Kismali Erkan
    Abstract:

    ###EgeUn###Diced cartilage is one of the most widely used camouflage technique in rhinoplasty. Its variable resorption rate creates issues in postoperative time period. Platelet-rich fibrin is an autologous concentrated Blood Derivative containing growth factors that accelerate tissue healing. The authors evaluate the effect of injectable platelet-rich fibrin (I-PRF) on the viability of diced cartilage, which has been used for dorsum camouflage in rhinoplasty. Forty patients were randomly divided into two groups based on dorsal camouflage grafts: diced cartilage with I-PRF (study group) and diced cartilage without I-PRF (control group). Cartilage graft thickness was measured by linear superficial tissue ultrasound at the postoperative first week and the third month in both groups. The mean cartilage graft thickness loss between the first-week and third-month ultrasound measurements was 0.58 +/- 0.21mm in the study group and 0.82 +/- 0.35mm in the control group. There was significant volume loss in the control group. I-PRF was successful in reducing the resorption rate of diced cartilage on nasal dorsum by either increasing the viability or keeping its form. Sticky cartilage is an easily applicable and reliable technique that may be used to camouflage dorsal irregularities in rhinoplasty.European Acad Facial Plast Sur