Blood Flow Disturbance

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Gaëlle Lissorgues - One of the best experts on this subject based on the ideXlab platform.

  • Non-invasive measurement of Blood Flow using magnetic Disturbance method
    2009 International Conference on Biomedical and Pharmaceutical Engineering, 2009
    Co-Authors: Chee Teck Phua, Gaëlle Lissorgues
    Abstract:

    Current laser Doppler method of Blood Flow sensing requires optical contact to the skin, tend to be bulky and have performance subjective to body fluids (e.g. Blood, perspiration) and environmental contaminants (e.g. mud, water). This paper proposes a novel method of noninvasive acquisition of Blood Flow by measuring the magnetic Disturbance created due to Blood Flowing through a localized magnetic field. The proposed system employs a GMR based magnetic sensor and magnet of 3 mm radius, placed on a major Blood vessel. The magnetic field generated by the magnet acts both as the biasing field for the sensor and also the uniform magnetic flux for Blood Flow Disturbance. As such, the system is compact, operates at room temperature and is able to sense through clothing. The signal acquired from the magnetic and optical methods are compared using the post-occlusive reactive hyperaemia test, where measurement results on 6 different healthy subjects are found to have error of less than 5%, showing the successful use of the magnetic method to measure Blood Flow.

Chee Teck Phua - One of the best experts on this subject based on the ideXlab platform.

  • Non-invasive measurement of Blood Flow using magnetic Disturbance method
    2009 International Conference on Biomedical and Pharmaceutical Engineering, 2009
    Co-Authors: Chee Teck Phua, Gaëlle Lissorgues
    Abstract:

    Current laser Doppler method of Blood Flow sensing requires optical contact to the skin, tend to be bulky and have performance subjective to body fluids (e.g. Blood, perspiration) and environmental contaminants (e.g. mud, water). This paper proposes a novel method of noninvasive acquisition of Blood Flow by measuring the magnetic Disturbance created due to Blood Flowing through a localized magnetic field. The proposed system employs a GMR based magnetic sensor and magnet of 3 mm radius, placed on a major Blood vessel. The magnetic field generated by the magnet acts both as the biasing field for the sensor and also the uniform magnetic flux for Blood Flow Disturbance. As such, the system is compact, operates at room temperature and is able to sense through clothing. The signal acquired from the magnetic and optical methods are compared using the post-occlusive reactive hyperaemia test, where measurement results on 6 different healthy subjects are found to have error of less than 5%, showing the successful use of the magnetic method to measure Blood Flow.

Kazutaka Misaka - One of the best experts on this subject based on the ideXlab platform.

  • effects of bacillus subtilis var natto products on symptoms caused by Blood Flow Disturbance in female patients with lifestyle diseases
    International Journal of General Medicine, 2015
    Co-Authors: Masahito Hitosugi, Katsuo Hamada, Kazutaka Misaka
    Abstract:

    The fermented soybean product natto is a popular traditional food in Japan and is considered a health supplement. NKCP®, a natto-derived dietary food supplement whose main component is bacillopeptidase F, has antithrombotic, fibrinolytic, and Blood pressure-lowering effects. We examined whether daily intake of NKCP® effectively improves subjective symptoms in patients with lifestyle diseases in this cross-over, double-blind study. Fermented soya extract with subtilisin NAT (nattokinase) as the main component was used as an active placebo. A 4-week course of NKCP® significantly decreased the visual analog scale (VAS) score for shoulder stiffness from 42.3 to 32.4 (P=0.009), the VAS score for low back pain from 25.5 to 18.8 (P=0.02), and the VAS score for coldness of the extremities from 33.1 to 25.7 (P=0.002). However, no significant difference was found in the VAS score for headache. After a 4-week course of active placebo, no significant changes in the VAS score were found for any symptoms. The significant improvement in the symptoms secondary to Blood Flow Disturbance was caused by the improvement in Blood Flow by NKCP®. The use of dietary supplements based on the Japanese traditional food natto helps to relieve subjective symptoms for patients with lifestyle diseases receiving medical care.

Alexander Brill - One of the best experts on this subject based on the ideXlab platform.

  • von willebrand factor mediated platelet adhesion is critical for deep vein thrombosis in mouse models
    Blood, 2011
    Co-Authors: Alexander Brill, Tobias A Fuchs, Anil K Chauhan, Janie J Yang, Simon F De Meyer, Maria Kollnberger
    Abstract:

    Deep vein thrombosis (DVT) and its complication, pulmonary embolism, are frequent causes of disability and mortality. Although Blood Flow Disturbance is considered an important triggering factor, the mechanism of DVT initiation remains elusive. Here we show that 48-hour Flow restriction in the inferior vena cava (IVC) results in the development of thrombi structurally similar to human deep vein thrombi. von Willebrand factor (VWF)–deficient mice were protected from thrombosis induced by complete (stasis) or partial (stenosis) Flow restriction in the IVC. Mice with half normal VWF levels were also protected in the stenosis model. Besides promoting platelet adhesion, VWF carries Factor VIII. Repeated infusions of recombinant Factor VIII did not rescue thrombosis in VWF−/− mice, indicating that impaired coagulation was not the primary reason for the absence of DVT in VWF−/− mice. Infusion of GPG-290, a mutant glycoprotein Ibα-immunoglobulin chimera that specifically inhibits interaction of the VWF A1 domain with platelets, prevented thrombosis in wild-type mice. Intravital microscopy showed that platelet and leukocyte recruitment in the early stages of DVT was dramatically higher in wild-type than in VWF−/− IVC. Our results demonstrate a pathogenetic role for VWF-platelet interaction in Flow Disturbance-induced venous thrombosis.

Masahiro Oinuma - One of the best experts on this subject based on the ideXlab platform.

  • Blood Flow Disturbance in perforating arteries attributable to aneurysm surgery
    Journal of Neurosurgery, 2007
    Co-Authors: Tatsuya Sasaki, Namio Kodama, Masato Matsumoto, Kyouichi Suzuki, Yutaka Konno, Jun Sakuma, Yuji Endo, Masahiro Oinuma
    Abstract:

    Object The object of this study was to investigate patients with cerebral infarction in the area of the perforating arteries after aneurysm surgery. Methods The authors studied the incidence of cerebral infarction in 1043 patients using computed tomography or magnetic resonance imaging and the affected perforating arteries, clinical symptoms, prognosis, and operative maneuvers resulting in Blood Flow Disturbance. Results Among 46 patients (4.4%) with infarction, the affected perforating arteries were the anterior choroidal artery (AChA) in nine patients, lenticulostriate artery (LSA) in nine patients, hypothalamic artery in two patients, posterior thalamoperforating artery in five patients, perforating artery of the vertebral artery (VA) in three patients, anterior thalamoperforating artery in nine patients, and recurrent artery of Heubner in nine patients. Sequelae persisted in 21 (45.7%) of the 46 patients; 13 (28.3%) had transient symptoms and 12 (26.1%) were asymptomatic. Sequelae developed in all pat...