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Michel Vaubourdolle - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of the GEM® Premier™ 4000: a compact Blood Gas CO-Oximeter and electrolyte Analyzer for point-of-care and laboratory testing
Clinical chemistry and laboratory medicine, 2008Co-Authors: Bénédicte Bénéteau-burnat, Pascal Pernet, Antoine Pilon, Damien Latour, Stéphanie Goujon, Alain Feuillu, Michel VaubourdolleAbstract:Background GEM Premier 4000 (Instrumentation Laboratory), a new Blood Gas/CO-Oximeter/hematocrit/electrolyte/glucose/lactate Analyzer was evaluated. The only reagents required were disposable cartridges (GEM Premier 4000 PAK comprise all components necessary for analysis, including quality controls). Methods The evaluation was performed in two laboratories according to the Valtec protocol guidelines. Analytical performances (imprecision at three levels, linearity, inaccuracy by method comparison using patient samples, interferences) and instrument practicability were compared with three routinely used laboratory Blood Gas Analyzers (ABL 835 and 725, Radiometer; OMNI S, Roche Diagnostics) and the centrifuged microhematocrit method. Results Within-run and between-run imprecision yielded good coefficients of variation values for all parameters. Linearity was satisfactory and within the expected ranges provided by the manufacturer. Method comparisons demonstrated close agreement (Deming's regression correlation coefficients 0.92-1.00). No interferences of lipemia, hyperbilirubinemia and hemolysis were found on CO-Oximetry parameters. Fetal hemoglobin >35% overestimated carboxyhemoglobin measurements, but the magnitude of error was reduced with the fetal hemoglobin correction analysis mode. Conclusion The GEM Premier 4000 analytical performance was validated for all parameters with the accuracy and the reliability of traditional systems. This Blood Gas Analyzer fulfills most of the requirements for both point-of-care and laboratory use.
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evaluation of the Blood Gas Analyzer gem premier 3000
Clinical Chemistry and Laboratory Medicine, 2004Co-Authors: Benedicte Beneteauburnat, Mariechantal Bocque, Anne Lorin, Catherine Martin, Michel VaubourdolleAbstract:During the past few decades, new technologies have allowed the fabrication of miniaturized sensors and the development of Analyzers well designed for point-of-care testing (POCT). They combined the ease-of-use and portability required for POC with the accuracy and the reliability of traditional systems. Instrumentation Laboratory introduced the GEM Premier 3000, a compact and portable system to rapidly analyze pH, pCO2, PO2, Ca2+, Na2+, K+, lactate, glucose and hematocrit, from 135 microl of whole Blood with a simple component: a cartridge, the GEM Premier Pak. The analytical performance was compared with the Radiometer ABL 725 instrument for Blood Gas/ electrolytes/metabolites, and for hematocrit with the centrifuged microhematocrit method. Aqueous quality control materials (Instrumentation Laboratory) were used for precision and recovery studies. The evaluation was performed according to the Valtec protocol, designed by the French Society of Clinical Biology, for imprecision, linearity and accuracy. With-in-run and between-run imprecisions for all the parameters gave good CV values. Linearity was good and results comparison showed close agreement with correlation coefficients between 0.91 and 0.99. The Analyzer is very easy to use; the simplicity and the convenience of only one consumable make the GEM Premier 3000 very suitable for a STAT laboratory or for POCT.
Balasubramanian Venkatesh - One of the best experts on this subject based on the ideXlab platform.
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carbon dioxide and oxygen partial pressure measurements in the cerebrospinal fluid in a conventional Blood Gas Analyzer analysis of bias and precision
Journal of the Neurological Sciences, 1997Co-Authors: Balasubramanian Venkatesh, Robert J BootsAbstract:Cerebrospinal fluid (CSF) Gas tension measurements have been used as a marker of cerebral oxygenation in animal models and in human studies. Discrepancies in the measurement of PCO2 and PO2 in non-Blood solutions by standard Blood Gas Analyzers have been described. The CSF is a physiological non-Blood fluid with an ability to carry only dissolved O2 or CO2. The aim of this experiment was to determine the bias and precision of CSF pCO2 and pO2 measurements of a contemporary Blood Gas Analyzer and a continuous Gas sensor. CSF from human patients was tonometered to known PCO2 and PO2 using standard calibration Gases in a bubble tonometer. Following equilibration, a continuous measurement of the partial pressure of Gases in the CSF in the tonometer solution was made using a calibrated Paratrend 7 Gas sensor (Biomedical Sensors, Bucks., UK) inserted into the equilibration chamber of the tonometer and continuous CSF pH, PCO2 and PO2 measurements recorded at 1-min intervals. After equilibration, a 3-ml CSF sample was aspirated anaerobically from the tonometer and analysed in duplicate using an ABL 620 (Radiometer, Copenhagen) Blood Gas analyser. The measured pCO2 and pO2 from the ABL 620 Blood Gas analyser and the Paratrend 7 sensor were paired with the expected values to calculate bias and precision. Small offsets in PCO2 and large offsets in PO2 measurement were seen with the ABL 620 Blood Gas analyser. This study brings into question clinical decisions based on CSF PO2 measurements. The implications for calibrating CSF sensors against CSF Gas measurements are discussed.
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a multiparameter sensor for continuous intra arterial Blood Gas monitoring a prospective evaluation
Critical Care Medicine, 1994Co-Authors: Balasubramanian Venkatesh, Thomas Clutton H Brock, Stuart P HendryAbstract:Objective: To compare measurements of arterial Blood Gases made by a new continuous intra-arterial Blood Gas monitor with measurements in a standard Blood Gas Analyzer in patients in the general and cardiac intensive care units. Design: Criterion standard study. Setting: The cardiac surgical and the general medical intensive care units of a tertiary referral center. Patients: Thirteen consecutive patients requiring mechanical ventilation and Blood Gas monitoring. Interventions: All patients had a Blood Gas sensor placed through a 20-gauge cannula inserted into the radial artery. The duration of monitoring ranged from 9.42 to 117.45 hrs
Michael Suleiman - One of the best experts on this subject based on the ideXlab platform.
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hand held Blood Gas Analyzer is accurate in the critical care setting
Critical Care Medicine, 1996Co-Authors: Gary P Zaloga, Pamela R Roberts, Kimberly Latg Black, Jean T Santamauro, Emily Klase, Michael SuleimanAbstract:Objective : To determine the accuracy of a new, portable, battery-powered Blood Gas Analyzer when used by nonlaboratory-trained clinicians in the critical care setting. Design : Prospective analysis of Blood samples from critically ill patients. Setting : Large tertiary critical care unit. Patients : Heterogeneous group of medical and surgical critically ill patients. Interventions : None. Measurements and Main Results : Two hundred thirty-nine split Blood samples from intensive care patients were analyzed by clinicians in the critical care environment using a new, portable, battery-powered Blood Gas Analyzer (Immediate Response Mobile Analyzer [IRMA], Diametrics Medical, St. Paul, MN). Near-patient measurements were compared with measurements obtained by laboratory technologists using an IL-1312 Blood Gas Analyzer (Instrumentation Laboratories, Lexington, MA) in an established near-patient critical care laboratory. Precision and coefficients of variation were also determined using repeated testing of quality control samples at three levels of pH, Po 2 , and Pco 2 . There was good agreement between IRMA determinations and the laboratory. Correlation coefficients ranged from 0.96 to 0.99. Bias and precision (±2 SD), respectively, were 0.02 and 0.036 units for pH, -0.3 torr (-0.04 kPa) and 7.2 torr (0.96 kPa) for Pco 2 , and -3.9 torr (-0.52 kPa) and 13.8 torr (1.8 kPa) for Po 2 . Precision on repeated testing of quality control samples ranged from 0.022 to 0.04 units for a pH of 7.2 to 7.6, 1.2 to 4.6 torr (0.16 to 0.61 kPa) for a Pco 2 of 20 to 60 torr (2.7 to 8 kPa), and 3.0 to 7.4 torr (0.40 to 0.99 kPa) for a Po 2 of 70 to 160 torr (9.3 to 21.3 kPa). Coefficients of variation ranged from 0.15% to 0.28% for a pH of 7.2 to 7.6, 2.0% to 3.7% for a Pco 2 of 20 to 60 torr (2.7 to 8.0 kPa), and 1.7% to 3.6% for a Po 2 of 70 to 160 torr (9.3 to 21.3 kPa). Mean turnaround time was 16.5 ± 10.1 mins for the near-patient laboratory and 2 ± 0.5 mins for IRMA. Conclusions : IRMA is accurate and reproducible when used in the clinical setting by nonlaboratory-trained individuals. Nonlaboratory-trained individuals can obtain laboratory results in the critical care setting comparable with the results obtained by trained laboratory technologists. Bedside laboratory testing decreases turnaround time compared with a near-patient laboratory.
R. P. Dellinger - One of the best experts on this subject based on the ideXlab platform.
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Initial evaluation of a new intra-arterial Blood Gas system in humans.
Critical care medicine, 1993Co-Authors: J. L. Zimmerman, R. P. DellingerAbstract:OBJECTIVE To evaluate the in vivo performance of a continuous intra-arterial Blood Gas monitor as compared with in vitro arterial Blood Gases for measurements of PaO2, PaCO2, and arterial pH. DESIGN Consecutive patient enrollment. SETTING Medical intensive care unit of a county teaching hospital. PATIENTS Five critically ill patients. INTERVENTIONS All patients had a fiberoptic sensor placed through a 20-gauge cannula inserted into the radial artery. Sensor and arterial Blood Gas measurements were monitored up to 68 hrs. Arterial Blood Gases were analyzed on two Blood Gas Analyzers. MEASUREMENTS AND MAIN RESULTS A total of 104 arterial Blood Gases were obtained for comparison of sensor measurements with Blood Gas Analyzer values. Comparison of the sensor values with the Blood Gas Analyzer values showed bias and precision values of -0.021 and 0.037 for arterial pH, 1.74 and 6.06 torr (0.23 and 0.81 kPa) for PaCO2, and -5.89 and 13.19 torr (-0.79 and 1.76 kPa) for PaO2, respectively. Comparison of the two Blood Gas Analyzer measurements showed bias and precision values of -0.030 and 0.010 for arterial pH, 1.96 and 2.55 torr (0.26 and 0.34 kPa) for PaCO2, and -5.77 and 17.15 torr (-0.77 and 2.29 kPa) for PaO2, respectively. No complications attributable to the sensor were detected. CONCLUSIONS The performance of this fiberoptic continuous intra-arterial Blood Gas monitor is comparable to that of Blood Gas Analyzers and compares favorably with previously reported studies utilizing other sensors in reliably and reproducibly approximating PaO2, PaCO2, and arterial pH values. This monitoring capability was accomplished with no patient morbidity. Further study is indicated to confirm these initial results and to establish the role of a continuous intra-arterial Blood Gas monitor in critically ill patients.
Stuart P Hendry - One of the best experts on this subject based on the ideXlab platform.
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a multiparameter sensor for continuous intra arterial Blood Gas monitoring a prospective evaluation
Critical Care Medicine, 1994Co-Authors: Balasubramanian Venkatesh, Thomas Clutton H Brock, Stuart P HendryAbstract:Objective: To compare measurements of arterial Blood Gases made by a new continuous intra-arterial Blood Gas monitor with measurements in a standard Blood Gas Analyzer in patients in the general and cardiac intensive care units. Design: Criterion standard study. Setting: The cardiac surgical and the general medical intensive care units of a tertiary referral center. Patients: Thirteen consecutive patients requiring mechanical ventilation and Blood Gas monitoring. Interventions: All patients had a Blood Gas sensor placed through a 20-gauge cannula inserted into the radial artery. The duration of monitoring ranged from 9.42 to 117.45 hrs