The Experts below are selected from a list of 40605 Experts worldwide ranked by ideXlab platform

Ewoudjan Van Hoogdalem - One of the best experts on this subject based on the ideXlab platform.

Klaus Rave - One of the best experts on this subject based on the ideXlab platform.

Claire Turner - One of the best experts on this subject based on the ideXlab platform.

  • potential of breath and skin analysis for monitoring Blood Glucose Concentration in diabetes
    Expert Review of Molecular Diagnostics, 2011
    Co-Authors: Claire Turner
    Abstract:

    The ability to monitor Blood Glucose noninvasively has long been a goal of those with diabetes, due to the pain and inconvenience of current Blood Glucose monitoring devices. This article investigates the potential for monitoring compounds in breath and emitted through skin for inferring Blood Glucose Concentration. Potential markers and an assessment of their suitability for noninvasive monitoring are discussed. The varying technologies developed for monitoring volatile organic compounds in breath and from the skin of diabetics and their suitability for development as a hand-held device is reviewed. The potential exists for the use of breath and skin monitoring as an alternative to Blood Glucose, but it may take years to collect sufficient clinical data for robust correlations to be possible.

  • breath acetone Concentration decreases with Blood Glucose Concentration in type i diabetes mellitus patients during hypoglycaemic clamps
    Journal of Breath Research, 2009
    Co-Authors: Claire Turner, Christopher Walton, Shu Hoashi, Mark L Evans
    Abstract:

    Conventional wisdom is that breath acetone may be markedly elevated in type 1 diabetes, but that this only occurs during poor Blood Glucose control and/or intercurrent illness. In contrast, little is known about breath acetone at more representative everyday Blood Glucose levels in diabetes. We used selected ion flow tube mass spectrometry to monitor the breath of eight patients with type 1 diabetes mellitus during 'insulin clamp' studies in which insulin and Glucose were infused into patients to lower Blood Glucose levels in steps from normal values into the low Glucose (hypoglycaemic) range. The Concentration of acetone in breath and the Blood sugar Concentration of the patients were monitored at each Blood Glucose Concentration. The Blood Glucose level at the start of the study was typically about 6 mM L−1, whereas the breath acetone Concentration at this Blood Glucose level was unexpectedly variable, ranging from 1 part-per-million to 21 ppm, in contrast to what was previously believed, i.e. that type 1 diabetes mellitus is characterized by high acetone levels. In all eight patients, the breath acetone declined linearly with Blood Glucose Concentration.

Andrew J. Chipperfield - One of the best experts on this subject based on the ideXlab platform.

  • A Bayesian network for modelling Blood Glucose Concentration and exercise in type 1 diabetes.
    Statistical methods in medical research, 2014
    Co-Authors: Sean M Ewings, John Joseph Valletta, Sujit K. Sahu, Christopher D. Byrne, Andrew J. Chipperfield
    Abstract:

    This article presents a new statistical approach to analysing the effects of everyday physical activity on Blood Glucose Concentration in people with type 1 diabetes. A physiologically based model of Blood Glucose dynamics is developed to cope with frequently sampled data on food, insulin and habitual physical activity; the model is then converted to a Bayesian network to account for measurement error and variability in the physiological processes. A simulation study is conducted to determine the feasibility of using Markov chain Monte Carlo methods for simultaneous estimation of all model parameters and prediction of Blood Glucose Concentration. Although there are problems with parameter identification in a minority of cases, most parameters can be estimated without bias. Predictive performance is unaffected by parameter misspecification and is insensitive to misleading prior distributions. This article highlights important practical and theoretical issues not previously addressed in the quest for an artificial pancreas as treatment for type 1 diabetes. The proposed methods represent a new paradigm for analysis of deterministic mathematical models of Blood Glucose Concentration.

Vahid Khori - One of the best experts on this subject based on the ideXlab platform.

  • the protective activity of urtica dioica leaves on Blood Glucose Concentration and beta cells in streptozotocin diabetic rats
    Pakistan Journal of Biological Sciences, 2007
    Co-Authors: Mohammad Jafar Golalipour, Vahid Khori
    Abstract:

    This study was done to determine the protective activity of the hydroalcholic extract of Urtica dioica leaves on Hyperglycemia and P-cells in hyperglycemic rats. Thirty Wistar rats were allocated in groups of normal, Diabetic and treatment. Hyperglycemia in Rats induced by 80 mg kg-1 streptozotocin. In treatment group, animals received hydroalcholic extract of Urtica dioica 100 mg kg-1 day-1 for five days, intraperitoneally and then hyperglycemia induced by streptozotocin. The Blood Glucose Concentration was measured by using a Glucometer in 1st, 3rd and 5th weeks. In the end of 5th weeks the animals in each group were sacrificed by anesthesia and whole pancreas in three groups extracted and fixed in bouin's fluid and stained by chromealum hematoxiline-phloxine and beta cells were counted in three groups by Olympus microscope. Mean±SE of Blood Glucose Concentrations in the end of fifth weeks were 99.4±5.0,454.7±34.5 and 303.6±100.6 in control, diabetic and treatment groups, respectively (p<0.05). The percentages of β-cells in control, diabetic and treatment groups were 73.6, 1.9 and 22.9%, respectively. The percentage of P-cells in treatment group comparing with diabetic group was significant (p<0.05). This study showed that the protective administration of hydroalcholic extract of Urtica dioica has hypoglycemic effect and protective activity of P-cells of langerhans in hyperglycemic rats. © 2007 Asian Network for Scientific Information.

  • The protective activity of Urtica dioica leaves on Blood Glucose Concentration and beta-cells in streptozotocin-diabetic rats.
    Pakistan Journal of Biological Sciences, 2007
    Co-Authors: Mohammad Jafar Golalipour, Vahid Khori
    Abstract:

    This study was done to determine the protective activity of the hydroalcholic extract of Urtica dioica leaves on Hyperglycemia and P-cells in hyperglycemic rats. Thirty Wistar rats were allocated in groups of normal, Diabetic and treatment. Hyperglycemia in Rats induced by 80 mg kg-1 streptozotocin. In treatment group, animals received hydroalcholic extract of Urtica dioica 100 mg kg-1 day-1 for five days, intraperitoneally and then hyperglycemia induced by streptozotocin. The Blood Glucose Concentration was measured by using a Glucometer in 1st, 3rd and 5th weeks. In the end of 5th weeks the animals in each group were sacrificed by anesthesia and whole pancreas in three groups extracted and fixed in bouin's fluid and stained by chromealum hematoxiline-phloxine and beta cells were counted in three groups by Olympus microscope. Mean±SE of Blood Glucose Concentrations in the end of fifth weeks were 99.4±5.0,454.7±34.5 and 303.6±100.6 in control, diabetic and treatment groups, respectively (p

  • the protective activity of urtica dioica leaves on Blood Glucose Concentration and beta cells in streptozotocin diabetic rats
    Pakistan Journal of Biological Sciences, 2007
    Co-Authors: Mohammad Jafar Golalipour, Vahid Khori
    Abstract:

    This study was done to determine the protective activity of the hydroalcholic extract of Urtica dioica leaves on Hyperglycemia and beta-cells in hyperglycemic rats. Thirty Wistar rats were allocated in groups of normal, Diabetic and treatment. Hyperglycemia in Rats induced by 80 mg kg(-1) streptozotocin. In treatment group, animals received hydroalcholic extract of Urtica dioica 100 mg kg(-1) day(-1) for five days, intraperitoneally and then hyperglycemia induced by streptozotocin. The Blood Glucose Concentration was measured by using a Glucometer in 1st, 3rd and 5th weeks. In the end of 5th weeks the animals in each group were sacrificed by anesthesia and whole pancreas in three groups extracted and fixed in bouin's fluid and stained by chromealum hematoxiline-phloxine and beta cells were counted in three groups by Olympus microscope. Mean +/- SE of Blood Glucose Concentrations in the end of fifth weeks were 99.4 +/-5.0, 454.7 +/- 34.5 and 303.6 +/- 100.6 in control, diabetic and treatment groups, respectively (p < 0.05). The percentages of beta-cells in control, diabetic and treatment groups were 73.6, 1.9 and 22.9%, respectively. The percentage of beta-cells in treatment group comparing with diabetic group was significant (p < 0.05). This study showed that the protective administration of hydroalcholic extract of Urtica dioica has hypoglycemic effect and protective activity of beta-cells of langerhans in hyperglycemic rats.