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Blood Product

The Experts below are selected from a list of 48858 Experts worldwide ranked by ideXlab platform

Markus Gerigk – 1st expert on this subject based on the ideXlab platform

  • clinical advantages of using mini bypass systems in terms of Blood Product use postoperative bleeding and air entrainment an in vivo clinical perspective
    European Journal of Cardio-Thoracic Surgery, 2007
    Co-Authors: Matthias Perthel, Andreas Bendisch, Joachim Laas, Lemir Elayoubi, Markus Gerigk

    Abstract:

    Objective: In an effort to minimize the effect of extracorporeal circulation (ECC), mini-bypass is gaining clinical acceptance in routine coronary artery bypass grafting (CABG). These small circuits target combine the clinical advantages of reduced prime, 100% bio-coating and suction Blood separation. We demonstrate that the use of mini-bypass in routine CABG reduces homologous Blood Product use and postoperative bleeding. Our goal was to also demonstrate that these small systems are effective in gaseous microemboli (GME) management as compared to a conventional extracorporeal system. Methods: Prospective, randomized study comparing 30 mini-bypass (Dideco ECC.O TM ) to 30 conventional systems (n = 30, Dideco 903 Avant TM ). Study included CABG cases only, independent of preoperative coagulative status; clinic ethical committee approval and informed patient consent was obtained before initiating study. Results: There were no statistical differences in terms of patient demographics. Statistically significant differences were seen in transfusion frequency (27% of the study group vs 43% in the control group, p = 0.05), transfused volume (133.3 244.5 ml vs 325 483.1 ml, p < 0.05), fresh frozen plasma (0 unit vs 3 units, p < 0.001), postoperative bleeding (301.8 531.9 ml vs 785.5 1000.4 ml, p < 0.05) and GME activity post-arterial filter (0.14 ml vs 5.32 ml, p < 0.05). Conclusions: The adoption of mini-bypass significantly potentially reduces hemodilution, donor Blood usage, postoperative bleeding and exposure to GME in routine CABG patients as compared to the use of conventional extracorporeal circulation circuits. # 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.

  • Clinical advantages of using mini-bypass systems in terms of Blood Product use, postoperative bleeding and air entrainment: an in vivo clinical perspective
    European Journal of Cardio-thoracic Surgery, 2007
    Co-Authors: Matthias Perthel, L'emir El-ayoubi, Andreas Bendisch, Joachim Laas, Markus Gerigk

    Abstract:

    Objective: In an effort to minimize the effect of extracorporeal circulation (ECC), mini-bypass is gaining clinical acceptance in routine coronary artery bypass grafting (CABG). These small circuits target combine the clinical advantages of reduced prime, 100% bio-coating and suction Blood separation. We demonstrate that the use of mini-bypass in routine CABG reduces homologous Blood Product use and postoperative bleeding. Our goal was to also demonstrate that these small systems are effective in gaseous microemboli (GME) management as compared to a conventional extracorporeal system. Methods: Prospective, randomized study comparing 30 mini-bypass (Dideco ECC.O™) to 30 conventional systems (n = 30, Dideco 903 Avant™). Study included CABG cases only, independent of preoperative coagulative status; clinic ethical committee approval and informed patient consent was obtained before initiating study. Results: There were no statistical differences in terms of patient demographics. Statistically significant differences were seen in transfusion frequency (27% of the study group vs 43% in the control group, p = 0.05), transfused volume (133.3 ± 244.5 ml vs 325 ± 483.1 ml, p < 0.05), fresh frozen plasma (0 unit vs 3 units, p < 0.001), postoperative bleeding (301.8 ± 531.9 ml vs 785.5 ± 1000.4 ml, p < 0.05) and GME activity post-arterial filter (0.14 μl vs 5.32 μl, p < 0.05). Conclusions: The adoption of mini-bypass significantly potentially reduces hemodilution, donor Blood usage, postoperative bleeding and exposure to GME in routine CABG patients as compared to the use of conventional extracorporeal circulation circuits. © 2007 European Association for Cardio-Thoracic Surgery.

Matthias Perthel – 2nd expert on this subject based on the ideXlab platform

  • clinical advantages of using mini bypass systems in terms of Blood Product use postoperative bleeding and air entrainment an in vivo clinical perspective
    European Journal of Cardio-Thoracic Surgery, 2007
    Co-Authors: Matthias Perthel, Andreas Bendisch, Joachim Laas, Lemir Elayoubi, Markus Gerigk

    Abstract:

    Objective: In an effort to minimize the effect of extracorporeal circulation (ECC), mini-bypass is gaining clinical acceptance in routine coronary artery bypass grafting (CABG). These small circuits target combine the clinical advantages of reduced prime, 100% bio-coating and suction Blood separation. We demonstrate that the use of mini-bypass in routine CABG reduces homologous Blood Product use and postoperative bleeding. Our goal was to also demonstrate that these small systems are effective in gaseous microemboli (GME) management as compared to a conventional extracorporeal system. Methods: Prospective, randomized study comparing 30 mini-bypass (Dideco ECC.O TM ) to 30 conventional systems (n = 30, Dideco 903 Avant TM ). Study included CABG cases only, independent of preoperative coagulative status; clinic ethical committee approval and informed patient consent was obtained before initiating study. Results: There were no statistical differences in terms of patient demographics. Statistically significant differences were seen in transfusion frequency (27% of the study group vs 43% in the control group, p = 0.05), transfused volume (133.3 244.5 ml vs 325 483.1 ml, p < 0.05), fresh frozen plasma (0 unit vs 3 units, p < 0.001), postoperative bleeding (301.8 531.9 ml vs 785.5 1000.4 ml, p < 0.05) and GME activity post-arterial filter (0.14 ml vs 5.32 ml, p < 0.05). Conclusions: The adoption of mini-bypass significantly potentially reduces hemodilution, donor Blood usage, postoperative bleeding and exposure to GME in routine CABG patients as compared to the use of conventional extracorporeal circulation circuits. # 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.

  • Clinical advantages of using mini-bypass systems in terms of Blood Product use, postoperative bleeding and air entrainment: an in vivo clinical perspective
    European Journal of Cardio-thoracic Surgery, 2007
    Co-Authors: Matthias Perthel, L'emir El-ayoubi, Andreas Bendisch, Joachim Laas, Markus Gerigk

    Abstract:

    Objective: In an effort to minimize the effect of extracorporeal circulation (ECC), mini-bypass is gaining clinical acceptance in routine coronary artery bypass grafting (CABG). These small circuits target combine the clinical advantages of reduced prime, 100% bio-coating and suction Blood separation. We demonstrate that the use of mini-bypass in routine CABG reduces homologous Blood Product use and postoperative bleeding. Our goal was to also demonstrate that these small systems are effective in gaseous microemboli (GME) management as compared to a conventional extracorporeal system. Methods: Prospective, randomized study comparing 30 mini-bypass (Dideco ECC.O™) to 30 conventional systems (n = 30, Dideco 903 Avant™). Study included CABG cases only, independent of preoperative coagulative status; clinic ethical committee approval and informed patient consent was obtained before initiating study. Results: There were no statistical differences in terms of patient demographics. Statistically significant differences were seen in transfusion frequency (27% of the study group vs 43% in the control group, p = 0.05), transfused volume (133.3 ± 244.5 ml vs 325 ± 483.1 ml, p < 0.05), fresh frozen plasma (0 unit vs 3 units, p < 0.001), postoperative bleeding (301.8 ± 531.9 ml vs 785.5 ± 1000.4 ml, p < 0.05) and GME activity post-arterial filter (0.14 μl vs 5.32 μl, p < 0.05). Conclusions: The adoption of mini-bypass significantly potentially reduces hemodilution, donor Blood usage, postoperative bleeding and exposure to GME in routine CABG patients as compared to the use of conventional extracorporeal circulation circuits. © 2007 European Association for Cardio-Thoracic Surgery.

  • Reduction in Blood Product usage associated with routine use of mini bypass systems in extracorporeal circulation
    Perfusion, 2007
    Co-Authors: Matthias Perthel, L'emir El-ayoubi, Andreas Klingbeil, M. Gerick, Joachim Laas

    Abstract:

    OBJECTIVE: The objective of this study is to investigate the hypothesis that a reduced prime extracorporeal circulation (ECC) system and ensuing reduction in patient hemodilution can affect Blood Product use.\n\nMETHODS: We performed a prospective, randomized study from a group of 60 consecutive coronary artery bypass graft (CABG) patients, comparing Blood Product usage and postoperative bleeding in 30 mini bypass systems (n = 30) to 30 conventional systems (n = 30). The patient demographics in terms of patient weight, height, age, preoperative hemoglobin, preoperative hematocrit, BSA, ejection fraction, and NYHA were not statistically significant.\n\nRESULTS: Blood Product use, including fresh frozen plasma (FFP) and homolgous Blood transfusions was tracked through the operating theater and into the intensive care unit. In the mini bypass group, while no homologous Blood transfusions were given in the OR, 27% of the patients received at least one unit of homologous Blood. In the control group, 43% of the patients received at least one unit of Blood in the OR or in the ICU and there was a stastistically-significant 38% reduction in homologous Blood Product use (p = 0.05). For the patients who received homologous Blood, there was also a significant reduction in transfused volume (0.53 +/- 0.90 units Blood mini bypass vs 1.3 +/- 1.93 units conventional, p < 0.05). In terms of FFP, there was also a stastistically significant difference between the two groups (0 units transfused in mini bypass group vs 3 patients receiving one unit FFP in the control group, p < 0.001). Cumulative postoperative bleeding during the ICU stay was also evaluated, yielding a significant reduction (365 +/- 495 ml mini bypass vs 825 +/- 975 ml conventional, p < 0.05).\n\nCONCLUSION: Mini bypass reduces on-pump hemodilution and, therefore, donor Blood usage in routine CABG patients as compared to conventional ECC circuits and can reduce postoperative bleeding as compared to a traditional system. The mini bypass system is safe in routine clinical use and can manage easily the same number of anastomoses as a traditional system and should be considered a favorable alternative to conventional ECC in all revascularization cases.

Joachim Laas – 3rd expert on this subject based on the ideXlab platform

  • clinical advantages of using mini bypass systems in terms of Blood Product use postoperative bleeding and air entrainment an in vivo clinical perspective
    European Journal of Cardio-Thoracic Surgery, 2007
    Co-Authors: Matthias Perthel, Andreas Bendisch, Joachim Laas, Lemir Elayoubi, Markus Gerigk

    Abstract:

    Objective: In an effort to minimize the effect of extracorporeal circulation (ECC), mini-bypass is gaining clinical acceptance in routine coronary artery bypass grafting (CABG). These small circuits target combine the clinical advantages of reduced prime, 100% bio-coating and suction Blood separation. We demonstrate that the use of mini-bypass in routine CABG reduces homologous Blood Product use and postoperative bleeding. Our goal was to also demonstrate that these small systems are effective in gaseous microemboli (GME) management as compared to a conventional extracorporeal system. Methods: Prospective, randomized study comparing 30 mini-bypass (Dideco ECC.O TM ) to 30 conventional systems (n = 30, Dideco 903 Avant TM ). Study included CABG cases only, independent of preoperative coagulative status; clinic ethical committee approval and informed patient consent was obtained before initiating study. Results: There were no statistical differences in terms of patient demographics. Statistically significant differences were seen in transfusion frequency (27% of the study group vs 43% in the control group, p = 0.05), transfused volume (133.3 244.5 ml vs 325 483.1 ml, p < 0.05), fresh frozen plasma (0 unit vs 3 units, p < 0.001), postoperative bleeding (301.8 531.9 ml vs 785.5 1000.4 ml, p < 0.05) and GME activity post-arterial filter (0.14 ml vs 5.32 ml, p < 0.05). Conclusions: The adoption of mini-bypass significantly potentially reduces hemodilution, donor Blood usage, postoperative bleeding and exposure to GME in routine CABG patients as compared to the use of conventional extracorporeal circulation circuits. # 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.

  • Clinical advantages of using mini-bypass systems in terms of Blood Product use, postoperative bleeding and air entrainment: an in vivo clinical perspective
    European Journal of Cardio-thoracic Surgery, 2007
    Co-Authors: Matthias Perthel, L'emir El-ayoubi, Andreas Bendisch, Joachim Laas, Markus Gerigk

    Abstract:

    Objective: In an effort to minimize the effect of extracorporeal circulation (ECC), mini-bypass is gaining clinical acceptance in routine coronary artery bypass grafting (CABG). These small circuits target combine the clinical advantages of reduced prime, 100% bio-coating and suction Blood separation. We demonstrate that the use of mini-bypass in routine CABG reduces homologous Blood Product use and postoperative bleeding. Our goal was to also demonstrate that these small systems are effective in gaseous microemboli (GME) management as compared to a conventional extracorporeal system. Methods: Prospective, randomized study comparing 30 mini-bypass (Dideco ECC.O™) to 30 conventional systems (n = 30, Dideco 903 Avant™). Study included CABG cases only, independent of preoperative coagulative status; clinic ethical committee approval and informed patient consent was obtained before initiating study. Results: There were no statistical differences in terms of patient demographics. Statistically significant differences were seen in transfusion frequency (27% of the study group vs 43% in the control group, p = 0.05), transfused volume (133.3 ± 244.5 ml vs 325 ± 483.1 ml, p < 0.05), fresh frozen plasma (0 unit vs 3 units, p < 0.001), postoperative bleeding (301.8 ± 531.9 ml vs 785.5 ± 1000.4 ml, p < 0.05) and GME activity post-arterial filter (0.14 μl vs 5.32 μl, p < 0.05). Conclusions: The adoption of mini-bypass significantly potentially reduces hemodilution, donor Blood usage, postoperative bleeding and exposure to GME in routine CABG patients as compared to the use of conventional extracorporeal circulation circuits. © 2007 European Association for Cardio-Thoracic Surgery.

  • Reduction in Blood Product usage associated with routine use of mini bypass systems in extracorporeal circulation
    Perfusion, 2007
    Co-Authors: Matthias Perthel, L'emir El-ayoubi, Andreas Klingbeil, M. Gerick, Joachim Laas

    Abstract:

    OBJECTIVE: The objective of this study is to investigate the hypothesis that a reduced prime extracorporeal circulation (ECC) system and ensuing reduction in patient hemodilution can affect Blood Product use.\n\nMETHODS: We performed a prospective, randomized study from a group of 60 consecutive coronary artery bypass graft (CABG) patients, comparing Blood Product usage and postoperative bleeding in 30 mini bypass systems (n = 30) to 30 conventional systems (n = 30). The patient demographics in terms of patient weight, height, age, preoperative hemoglobin, preoperative hematocrit, BSA, ejection fraction, and NYHA were not statistically significant.\n\nRESULTS: Blood Product use, including fresh frozen plasma (FFP) and homolgous Blood transfusions was tracked through the operating theater and into the intensive care unit. In the mini bypass group, while no homologous Blood transfusions were given in the OR, 27% of the patients received at least one unit of homologous Blood. In the control group, 43% of the patients received at least one unit of Blood in the OR or in the ICU and there was a stastistically-significant 38% reduction in homologous Blood Product use (p = 0.05). For the patients who received homologous Blood, there was also a significant reduction in transfused volume (0.53 +/- 0.90 units Blood mini bypass vs 1.3 +/- 1.93 units conventional, p < 0.05). In terms of FFP, there was also a stastistically significant difference between the two groups (0 units transfused in mini bypass group vs 3 patients receiving one unit FFP in the control group, p < 0.001). Cumulative postoperative bleeding during the ICU stay was also evaluated, yielding a significant reduction (365 +/- 495 ml mini bypass vs 825 +/- 975 ml conventional, p < 0.05).\n\nCONCLUSION: Mini bypass reduces on-pump hemodilution and, therefore, donor Blood usage in routine CABG patients as compared to conventional ECC circuits and can reduce postoperative bleeding as compared to a traditional system. The mini bypass system is safe in routine clinical use and can manage easily the same number of anastomoses as a traditional system and should be considered a favorable alternative to conventional ECC in all revascularization cases.