The Experts below are selected from a list of 338676 Experts worldwide ranked by ideXlab platform
Xiangli Liu - One of the best experts on this subject based on the ideXlab platform.
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A simple method for estimating in vitro air-Tissue and in vivo Blood-Tissue partition coefficients
Chemosphere, 2014Co-Authors: Michael H. Abraham, Joelle M. R. Gola, Adam Ibrahim, William E. Acree, Xiangli LiuAbstract:A simple method is reported for the estimation of in vivo air-Tissue partition coefficients of VOCs and of in vitro Blood-Tissue partition coefficients for volatile organic compounds and other compounds. Linear free energy relationships for Tissues such as brain, muscle, liver, lung, kidney, heart, skin and fat are available and once the Abraham descriptors are known for a compound, no more than simple arithmetic is required to estimate air-Tissue and Blood-Tissue partitions.
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The prediction of Blood–Tissue partitions, water–skin partitions and skin permeation for agrochemicals
Pest management science, 2013Co-Authors: Michael H. Abraham, Joelle M. R. Gola, Adam Ibrahim, William E. Acree, Xiangli LiuAbstract:BACKGROUND There is considerable interest in the Blood–Tissue distribution of agrochemicals, and a number of researchers have developed experimental methods for in vitro distribution. These methods involve the determination of saline–Blood and saline–Tissue partitions; not only are they indirect, but they do not yield the required in vivo distribution. RESULTS The authors set out equations for gas–Tissue and Blood–Tissue distribution, for partition from water into skin and for permeation from water through human skin. Together with Abraham descriptors for the agrochemicals, these equations can be used to predict values for all of these processes. The present predictions compare favourably with experimental in vivo Blood–Tissue distribution where available. The predictions require no more than simple arithmetic. CONCLUSIONS The present method represents a much easier and much more economic way of estimating Blood–Tissue partitions than the method that uses saline–Blood and saline–Tissue partitions. It has the added advantages of yielding the required in vivo partitions and being easily extended to the prediction of partition of agrochemicals from water into skin and permeation from water through skin. © 2013 Society of Chemical Industry
William E. Acree - One of the best experts on this subject based on the ideXlab platform.
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Using Water-Solvent Systems To Estimate In Vivo Blood-Tissue Partition Coefficients
Chemistry Central journal, 2015Co-Authors: Caitlin E. Derricott, William E. Acree, Emily A. Knight, Andrew S. I. D. LangAbstract:Background Blood–Tissue partition coefficients indicate how a chemical will distribute throughout the body and are an important part of any pharmacokinetic study. They can be used to assess potential toxicological effects from exposure to chemicals and the efficacy of potential novel drugs designed to target certain organs or the central nervous system. In vivo measurement of Blood–Tissue partition coefficients is often complicated, time-consuming, and relatively expensive, so developing in vitro systems that approximate in vivo ones is desirable. We have determined such systems for Tissues such as brain, muscle, liver, lung, kidney, heart, skin, and fat.
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A simple method for estimating in vitro air-Tissue and in vivo Blood-Tissue partition coefficients
Chemosphere, 2014Co-Authors: Michael H. Abraham, Joelle M. R. Gola, Adam Ibrahim, William E. Acree, Xiangli LiuAbstract:A simple method is reported for the estimation of in vivo air-Tissue partition coefficients of VOCs and of in vitro Blood-Tissue partition coefficients for volatile organic compounds and other compounds. Linear free energy relationships for Tissues such as brain, muscle, liver, lung, kidney, heart, skin and fat are available and once the Abraham descriptors are known for a compound, no more than simple arithmetic is required to estimate air-Tissue and Blood-Tissue partitions.
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The prediction of Blood–Tissue partitions, water–skin partitions and skin permeation for agrochemicals
Pest management science, 2013Co-Authors: Michael H. Abraham, Joelle M. R. Gola, Adam Ibrahim, William E. Acree, Xiangli LiuAbstract:BACKGROUND There is considerable interest in the Blood–Tissue distribution of agrochemicals, and a number of researchers have developed experimental methods for in vitro distribution. These methods involve the determination of saline–Blood and saline–Tissue partitions; not only are they indirect, but they do not yield the required in vivo distribution. RESULTS The authors set out equations for gas–Tissue and Blood–Tissue distribution, for partition from water into skin and for permeation from water through human skin. Together with Abraham descriptors for the agrochemicals, these equations can be used to predict values for all of these processes. The present predictions compare favourably with experimental in vivo Blood–Tissue distribution where available. The predictions require no more than simple arithmetic. CONCLUSIONS The present method represents a much easier and much more economic way of estimating Blood–Tissue partitions than the method that uses saline–Blood and saline–Tissue partitions. It has the added advantages of yielding the required in vivo partitions and being easily extended to the prediction of partition of agrochemicals from water into skin and permeation from water through skin. © 2013 Society of Chemical Industry
Michael H. Abraham - One of the best experts on this subject based on the ideXlab platform.
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A simple method for estimating in vitro air-Tissue and in vivo Blood-Tissue partition coefficients
Chemosphere, 2014Co-Authors: Michael H. Abraham, Joelle M. R. Gola, Adam Ibrahim, William E. Acree, Xiangli LiuAbstract:A simple method is reported for the estimation of in vivo air-Tissue partition coefficients of VOCs and of in vitro Blood-Tissue partition coefficients for volatile organic compounds and other compounds. Linear free energy relationships for Tissues such as brain, muscle, liver, lung, kidney, heart, skin and fat are available and once the Abraham descriptors are known for a compound, no more than simple arithmetic is required to estimate air-Tissue and Blood-Tissue partitions.
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The prediction of Blood–Tissue partitions, water–skin partitions and skin permeation for agrochemicals
Pest management science, 2013Co-Authors: Michael H. Abraham, Joelle M. R. Gola, Adam Ibrahim, William E. Acree, Xiangli LiuAbstract:BACKGROUND There is considerable interest in the Blood–Tissue distribution of agrochemicals, and a number of researchers have developed experimental methods for in vitro distribution. These methods involve the determination of saline–Blood and saline–Tissue partitions; not only are they indirect, but they do not yield the required in vivo distribution. RESULTS The authors set out equations for gas–Tissue and Blood–Tissue distribution, for partition from water into skin and for permeation from water through human skin. Together with Abraham descriptors for the agrochemicals, these equations can be used to predict values for all of these processes. The present predictions compare favourably with experimental in vivo Blood–Tissue distribution where available. The predictions require no more than simple arithmetic. CONCLUSIONS The present method represents a much easier and much more economic way of estimating Blood–Tissue partitions than the method that uses saline–Blood and saline–Tissue partitions. It has the added advantages of yielding the required in vivo partitions and being easily extended to the prediction of partition of agrochemicals from water into skin and permeation from water through skin. © 2013 Society of Chemical Industry
Adam Ibrahim - One of the best experts on this subject based on the ideXlab platform.
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A simple method for estimating in vitro air-Tissue and in vivo Blood-Tissue partition coefficients
Chemosphere, 2014Co-Authors: Michael H. Abraham, Joelle M. R. Gola, Adam Ibrahim, William E. Acree, Xiangli LiuAbstract:A simple method is reported for the estimation of in vivo air-Tissue partition coefficients of VOCs and of in vitro Blood-Tissue partition coefficients for volatile organic compounds and other compounds. Linear free energy relationships for Tissues such as brain, muscle, liver, lung, kidney, heart, skin and fat are available and once the Abraham descriptors are known for a compound, no more than simple arithmetic is required to estimate air-Tissue and Blood-Tissue partitions.
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The prediction of Blood–Tissue partitions, water–skin partitions and skin permeation for agrochemicals
Pest management science, 2013Co-Authors: Michael H. Abraham, Joelle M. R. Gola, Adam Ibrahim, William E. Acree, Xiangli LiuAbstract:BACKGROUND There is considerable interest in the Blood–Tissue distribution of agrochemicals, and a number of researchers have developed experimental methods for in vitro distribution. These methods involve the determination of saline–Blood and saline–Tissue partitions; not only are they indirect, but they do not yield the required in vivo distribution. RESULTS The authors set out equations for gas–Tissue and Blood–Tissue distribution, for partition from water into skin and for permeation from water through human skin. Together with Abraham descriptors for the agrochemicals, these equations can be used to predict values for all of these processes. The present predictions compare favourably with experimental in vivo Blood–Tissue distribution where available. The predictions require no more than simple arithmetic. CONCLUSIONS The present method represents a much easier and much more economic way of estimating Blood–Tissue partitions than the method that uses saline–Blood and saline–Tissue partitions. It has the added advantages of yielding the required in vivo partitions and being easily extended to the prediction of partition of agrochemicals from water into skin and permeation from water through skin. © 2013 Society of Chemical Industry
Joelle M. R. Gola - One of the best experts on this subject based on the ideXlab platform.
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A simple method for estimating in vitro air-Tissue and in vivo Blood-Tissue partition coefficients
Chemosphere, 2014Co-Authors: Michael H. Abraham, Joelle M. R. Gola, Adam Ibrahim, William E. Acree, Xiangli LiuAbstract:A simple method is reported for the estimation of in vivo air-Tissue partition coefficients of VOCs and of in vitro Blood-Tissue partition coefficients for volatile organic compounds and other compounds. Linear free energy relationships for Tissues such as brain, muscle, liver, lung, kidney, heart, skin and fat are available and once the Abraham descriptors are known for a compound, no more than simple arithmetic is required to estimate air-Tissue and Blood-Tissue partitions.
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The prediction of Blood–Tissue partitions, water–skin partitions and skin permeation for agrochemicals
Pest management science, 2013Co-Authors: Michael H. Abraham, Joelle M. R. Gola, Adam Ibrahim, William E. Acree, Xiangli LiuAbstract:BACKGROUND There is considerable interest in the Blood–Tissue distribution of agrochemicals, and a number of researchers have developed experimental methods for in vitro distribution. These methods involve the determination of saline–Blood and saline–Tissue partitions; not only are they indirect, but they do not yield the required in vivo distribution. RESULTS The authors set out equations for gas–Tissue and Blood–Tissue distribution, for partition from water into skin and for permeation from water through human skin. Together with Abraham descriptors for the agrochemicals, these equations can be used to predict values for all of these processes. The present predictions compare favourably with experimental in vivo Blood–Tissue distribution where available. The predictions require no more than simple arithmetic. CONCLUSIONS The present method represents a much easier and much more economic way of estimating Blood–Tissue partitions than the method that uses saline–Blood and saline–Tissue partitions. It has the added advantages of yielding the required in vivo partitions and being easily extended to the prediction of partition of agrochemicals from water into skin and permeation from water through skin. © 2013 Society of Chemical Industry