The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Alfredo Ribeiro-da-silva - One of the best experts on this subject based on the ideXlab platform.
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Skin Blood Vessels are simultaneously innervated by sensory, sympathetic, and parasympathetic fibers
The Journal of Comparative Neurology, 2002Co-Authors: Isabella Ruocco, A. Claudio Cuello, André Parent, Alfredo Ribeiro-da-silvaAbstract:Despite the known major role of skin Blood Vessel Innervation in Blood flow control, particularly in disease, little information on the co-Innervation of Blood Vessels by sensory and autonomic fibers and the relationships of these fibers to one another is available. To fill this gap, we performed a light and electron microscopic analysis of the Innervation of skin Vessels by sensory and autonomic fibers by using the rat and monkey lower lips as a model. In rats, double-labeling immunocytochemistry revealed that combinations of fibers immunoreactive for substance P (SP) and dopamine-beta-hydroxylase (DbetaH), SP and vesicular acetylcholine transporter (VAChT), as well as DbetaH and VAChT occurred only around Blood Vessels in the lower dermis. All fiber types travelled in parallel and in close proximity to one another. In the upper dermis, Blood Vessels were innervated by SP-containing fibers only. Although nerve terminals displayed synaptic vesicles, synaptic specializations were never observed, suggesting that, in this territory, these fibers do not establish synaptic contacts. Quantification of the distance between the various immunoreactive terminals and their presumptive targets (smooth muscle cells and endothelial cells) revealed that both sympathetic and parasympathetic fibers were significantly closer to the endothelial cell layer and smooth muscle cells compared with sensory fibers. In monkeys, double-labeling immunocytochemistry was performed for SP-DbetaH and SP-VAChT only. The results obtained are similar to those found in rats; however, the fiber density was greater in monkeys. Our findings suggest that the regulation of skin microcirculation might be the result of the coordinated functions of sensory and autonomic fibers.
Isabella Ruocco - One of the best experts on this subject based on the ideXlab platform.
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Skin Blood Vessels are simultaneously innervated by sensory, sympathetic, and parasympathetic fibers
The Journal of Comparative Neurology, 2002Co-Authors: Isabella Ruocco, A. Claudio Cuello, André Parent, Alfredo Ribeiro-da-silvaAbstract:Despite the known major role of skin Blood Vessel Innervation in Blood flow control, particularly in disease, little information on the co-Innervation of Blood Vessels by sensory and autonomic fibers and the relationships of these fibers to one another is available. To fill this gap, we performed a light and electron microscopic analysis of the Innervation of skin Vessels by sensory and autonomic fibers by using the rat and monkey lower lips as a model. In rats, double-labeling immunocytochemistry revealed that combinations of fibers immunoreactive for substance P (SP) and dopamine-beta-hydroxylase (DbetaH), SP and vesicular acetylcholine transporter (VAChT), as well as DbetaH and VAChT occurred only around Blood Vessels in the lower dermis. All fiber types travelled in parallel and in close proximity to one another. In the upper dermis, Blood Vessels were innervated by SP-containing fibers only. Although nerve terminals displayed synaptic vesicles, synaptic specializations were never observed, suggesting that, in this territory, these fibers do not establish synaptic contacts. Quantification of the distance between the various immunoreactive terminals and their presumptive targets (smooth muscle cells and endothelial cells) revealed that both sympathetic and parasympathetic fibers were significantly closer to the endothelial cell layer and smooth muscle cells compared with sensory fibers. In monkeys, double-labeling immunocytochemistry was performed for SP-DbetaH and SP-VAChT only. The results obtained are similar to those found in rats; however, the fiber density was greater in monkeys. Our findings suggest that the regulation of skin microcirculation might be the result of the coordinated functions of sensory and autonomic fibers.
A. Claudio Cuello - One of the best experts on this subject based on the ideXlab platform.
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Skin Blood Vessels are simultaneously innervated by sensory, sympathetic, and parasympathetic fibers
The Journal of Comparative Neurology, 2002Co-Authors: Isabella Ruocco, A. Claudio Cuello, André Parent, Alfredo Ribeiro-da-silvaAbstract:Despite the known major role of skin Blood Vessel Innervation in Blood flow control, particularly in disease, little information on the co-Innervation of Blood Vessels by sensory and autonomic fibers and the relationships of these fibers to one another is available. To fill this gap, we performed a light and electron microscopic analysis of the Innervation of skin Vessels by sensory and autonomic fibers by using the rat and monkey lower lips as a model. In rats, double-labeling immunocytochemistry revealed that combinations of fibers immunoreactive for substance P (SP) and dopamine-beta-hydroxylase (DbetaH), SP and vesicular acetylcholine transporter (VAChT), as well as DbetaH and VAChT occurred only around Blood Vessels in the lower dermis. All fiber types travelled in parallel and in close proximity to one another. In the upper dermis, Blood Vessels were innervated by SP-containing fibers only. Although nerve terminals displayed synaptic vesicles, synaptic specializations were never observed, suggesting that, in this territory, these fibers do not establish synaptic contacts. Quantification of the distance between the various immunoreactive terminals and their presumptive targets (smooth muscle cells and endothelial cells) revealed that both sympathetic and parasympathetic fibers were significantly closer to the endothelial cell layer and smooth muscle cells compared with sensory fibers. In monkeys, double-labeling immunocytochemistry was performed for SP-DbetaH and SP-VAChT only. The results obtained are similar to those found in rats; however, the fiber density was greater in monkeys. Our findings suggest that the regulation of skin microcirculation might be the result of the coordinated functions of sensory and autonomic fibers.
André Parent - One of the best experts on this subject based on the ideXlab platform.
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Skin Blood Vessels are simultaneously innervated by sensory, sympathetic, and parasympathetic fibers
The Journal of Comparative Neurology, 2002Co-Authors: Isabella Ruocco, A. Claudio Cuello, André Parent, Alfredo Ribeiro-da-silvaAbstract:Despite the known major role of skin Blood Vessel Innervation in Blood flow control, particularly in disease, little information on the co-Innervation of Blood Vessels by sensory and autonomic fibers and the relationships of these fibers to one another is available. To fill this gap, we performed a light and electron microscopic analysis of the Innervation of skin Vessels by sensory and autonomic fibers by using the rat and monkey lower lips as a model. In rats, double-labeling immunocytochemistry revealed that combinations of fibers immunoreactive for substance P (SP) and dopamine-beta-hydroxylase (DbetaH), SP and vesicular acetylcholine transporter (VAChT), as well as DbetaH and VAChT occurred only around Blood Vessels in the lower dermis. All fiber types travelled in parallel and in close proximity to one another. In the upper dermis, Blood Vessels were innervated by SP-containing fibers only. Although nerve terminals displayed synaptic vesicles, synaptic specializations were never observed, suggesting that, in this territory, these fibers do not establish synaptic contacts. Quantification of the distance between the various immunoreactive terminals and their presumptive targets (smooth muscle cells and endothelial cells) revealed that both sympathetic and parasympathetic fibers were significantly closer to the endothelial cell layer and smooth muscle cells compared with sensory fibers. In monkeys, double-labeling immunocytochemistry was performed for SP-DbetaH and SP-VAChT only. The results obtained are similar to those found in rats; however, the fiber density was greater in monkeys. Our findings suggest that the regulation of skin microcirculation might be the result of the coordinated functions of sensory and autonomic fibers.
Sture Forsgren - One of the best experts on this subject based on the ideXlab platform.
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Distribution of general (PGP 9.5) and sensory (substance P/CGRP) Innervations in the human patellar tendon
Knee Surgery Sports Traumatology Arthroscopy, 2006Co-Authors: Patrik Danielson, Håkan Alfredson, Sture ForsgrenAbstract:There is no information on the pattern of Blood Vessel Innervation, and in principle no information on Innervation in general, in the human patellar tendon. In the present study, biopsies from the proximal part of normal and pain-free patellar tendons (11 men, mean age 33 years) were examined. The specimens were evaluated by using antibodies against the general nerve marker protein gene-product 9.5 (PGP 9.5) and the sensory neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP), and immunohistochemistry. It was observed that the arteries, and to some extent the small Vessels, in the loose paratendinous connective tissue were supplied with PGP 9.5- as well as SP- and CGRP-Innervations. There was a marked PGP 9.5-like immunoreaction (LI), and to some extent also SP- and CGRP-LI, in the large nerve fascicles in this tissue. In the tendon tissue proper, PGP 9.5-LI was detected in nerve fibers located in the vicinity of some of the Blood Vessels and in thin nerve fascicles. There was a low degree of SP- and CGRP-Innervation in the tendon tissue proper. The observations give a morphologic correlate for the occurrence of nerve-mediated effects in the patellar tendon. Particularly it seems as if there is a marked nerve-mediated regulation of the Blood Vessels supplying the tendon, at the level where they course in the loose paratendinous connective tissue.