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Jrg Kuipers - One of the best experts on this subject based on the ideXlab platform.
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Body-Fluid Compartment VOLUMES IN CHRONICALLY HYPOXEMIC LAMBS
Pediatric Research, 1993Co-Authors: M Dalinghaus, Jwc Gratama, Jh Koers, A. M. Gerding, Kj Meuzelaar, M Vandeberg, Wg Zijlstra, Jrg KuipersAbstract:Chronic hypoxemia is associated with a decreased growth rate and a decreased rate of cell division. In lambs with experimental cyanotic heart disease, the gain in Body mass was decreased. In this study, we determined to what extent the lower Body mass in these lambs was related to alterations in Body Fluid Compartment volumes, specifically whether intracellular volume was decreased. Therefore, Fluid Compartment volumes were studied in nine lambs, after 3 to 4 wk of experimental cyanotic heart disease, and in 13 control lambs. Hypoxemic lambs had a lower arterial oxygen saturation (65 +/- 11 versus 91 +/- 2%, p
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Body Fluid Compartment volumes in chronically hypoxemic lambs
Pediatric Research, 1993Co-Authors: M Dalinghaus, Jwc Gratama, Jh Koers, A. M. Gerding, Kj Meuzelaar, M Vandeberg, Wg Zijlstra, Jrg KuipersAbstract:Chronic hypoxemia is associated with a decreased growth rate and a decreased rate of cell division. In lambs with experimental cyanotic heart disease, the gain in Body mass was decreased. In this study, we determined to what extent the lower Body mass in these lambs was related to alterations in Body Fluid Compartment volumes, specifically whether intracellular volume was decreased. Therefore, Fluid Compartment volumes were studied in nine lambs, after 3 to 4 wk of experimental cyanotic heart disease, and in 13 control lambs. Hypoxemic lambs had a lower arterial oxygen saturation (65 +/- 11 versus 91 +/- 2%, p <0.001) and a higher Hb concentration (142 +/- 16 versus 101 +/- 8 g . L-1, p <0.001). The lower Body mass in hypoxemic lambs (10.5 +/- 2.3 versus 13.0 +/- 2.8 kg) could be mainly accounted for by a decrease in intracellular water volume (4.7 +/- 1.3 versus 6.6 +/- 1.5 L, p <0.01). Total Body water (753 +/- 27 versus 780 +/- 40 mL . kg-1) and extracellular water volume (307 +/- 25 versus 277 +/- 15 mL . kg-1) in hypoxemic lambs were not significantly different from those in control lambs, but intracellular water volume was decreased (445 +/- 27 versus 501 +/- 35 mL . kg-1, p <0.01). The ratio of extracellular to intracellular water volume was higher in hypoxemic lambs (0.69 +/- 0.10 versus 0.55 +/- 0.04, p <0.01). Blood volume was increased in hypoxemic lambs (121 +/- 29 versus 79 +/- 15 mL . kg-1, p <0.01), mainly due to an increased total red cell volume (48 +/- 12 versus 22 +/- 8 mL . kg-1, p <0.001). We conclude that the lower Body mass in hypoxemic lambs is mainly related to a lower intracellular water volume. These results and the increased ratio of extracellular to intracellular water volume can be explained by assuming a decreased growth of the intracellular Compartment. In addition, a part of the (decreased) growth in hypoxemic lambs must be expended on increased erythropoiesis.
M Dalinghaus - One of the best experts on this subject based on the ideXlab platform.
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Body-Fluid Compartment VOLUMES IN CHRONICALLY HYPOXEMIC LAMBS
Pediatric Research, 1993Co-Authors: M Dalinghaus, Jwc Gratama, Jh Koers, A. M. Gerding, Kj Meuzelaar, M Vandeberg, Wg Zijlstra, Jrg KuipersAbstract:Chronic hypoxemia is associated with a decreased growth rate and a decreased rate of cell division. In lambs with experimental cyanotic heart disease, the gain in Body mass was decreased. In this study, we determined to what extent the lower Body mass in these lambs was related to alterations in Body Fluid Compartment volumes, specifically whether intracellular volume was decreased. Therefore, Fluid Compartment volumes were studied in nine lambs, after 3 to 4 wk of experimental cyanotic heart disease, and in 13 control lambs. Hypoxemic lambs had a lower arterial oxygen saturation (65 +/- 11 versus 91 +/- 2%, p
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Body Fluid Compartment volumes in chronically hypoxemic lambs
Pediatric Research, 1993Co-Authors: M Dalinghaus, Jwc Gratama, Jh Koers, A. M. Gerding, Kj Meuzelaar, M Vandeberg, Wg Zijlstra, Jrg KuipersAbstract:Chronic hypoxemia is associated with a decreased growth rate and a decreased rate of cell division. In lambs with experimental cyanotic heart disease, the gain in Body mass was decreased. In this study, we determined to what extent the lower Body mass in these lambs was related to alterations in Body Fluid Compartment volumes, specifically whether intracellular volume was decreased. Therefore, Fluid Compartment volumes were studied in nine lambs, after 3 to 4 wk of experimental cyanotic heart disease, and in 13 control lambs. Hypoxemic lambs had a lower arterial oxygen saturation (65 +/- 11 versus 91 +/- 2%, p <0.001) and a higher Hb concentration (142 +/- 16 versus 101 +/- 8 g . L-1, p <0.001). The lower Body mass in hypoxemic lambs (10.5 +/- 2.3 versus 13.0 +/- 2.8 kg) could be mainly accounted for by a decrease in intracellular water volume (4.7 +/- 1.3 versus 6.6 +/- 1.5 L, p <0.01). Total Body water (753 +/- 27 versus 780 +/- 40 mL . kg-1) and extracellular water volume (307 +/- 25 versus 277 +/- 15 mL . kg-1) in hypoxemic lambs were not significantly different from those in control lambs, but intracellular water volume was decreased (445 +/- 27 versus 501 +/- 35 mL . kg-1, p <0.01). The ratio of extracellular to intracellular water volume was higher in hypoxemic lambs (0.69 +/- 0.10 versus 0.55 +/- 0.04, p <0.01). Blood volume was increased in hypoxemic lambs (121 +/- 29 versus 79 +/- 15 mL . kg-1, p <0.01), mainly due to an increased total red cell volume (48 +/- 12 versus 22 +/- 8 mL . kg-1, p <0.001). We conclude that the lower Body mass in hypoxemic lambs is mainly related to a lower intracellular water volume. These results and the increased ratio of extracellular to intracellular water volume can be explained by assuming a decreased growth of the intracellular Compartment. In addition, a part of the (decreased) growth in hypoxemic lambs must be expended on increased erythropoiesis.
Jwc Gratama - One of the best experts on this subject based on the ideXlab platform.
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Body-Fluid Compartment VOLUMES IN CHRONICALLY HYPOXEMIC LAMBS
Pediatric Research, 1993Co-Authors: M Dalinghaus, Jwc Gratama, Jh Koers, A. M. Gerding, Kj Meuzelaar, M Vandeberg, Wg Zijlstra, Jrg KuipersAbstract:Chronic hypoxemia is associated with a decreased growth rate and a decreased rate of cell division. In lambs with experimental cyanotic heart disease, the gain in Body mass was decreased. In this study, we determined to what extent the lower Body mass in these lambs was related to alterations in Body Fluid Compartment volumes, specifically whether intracellular volume was decreased. Therefore, Fluid Compartment volumes were studied in nine lambs, after 3 to 4 wk of experimental cyanotic heart disease, and in 13 control lambs. Hypoxemic lambs had a lower arterial oxygen saturation (65 +/- 11 versus 91 +/- 2%, p
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Body Fluid Compartment volumes in chronically hypoxemic lambs
Pediatric Research, 1993Co-Authors: M Dalinghaus, Jwc Gratama, Jh Koers, A. M. Gerding, Kj Meuzelaar, M Vandeberg, Wg Zijlstra, Jrg KuipersAbstract:Chronic hypoxemia is associated with a decreased growth rate and a decreased rate of cell division. In lambs with experimental cyanotic heart disease, the gain in Body mass was decreased. In this study, we determined to what extent the lower Body mass in these lambs was related to alterations in Body Fluid Compartment volumes, specifically whether intracellular volume was decreased. Therefore, Fluid Compartment volumes were studied in nine lambs, after 3 to 4 wk of experimental cyanotic heart disease, and in 13 control lambs. Hypoxemic lambs had a lower arterial oxygen saturation (65 +/- 11 versus 91 +/- 2%, p <0.001) and a higher Hb concentration (142 +/- 16 versus 101 +/- 8 g . L-1, p <0.001). The lower Body mass in hypoxemic lambs (10.5 +/- 2.3 versus 13.0 +/- 2.8 kg) could be mainly accounted for by a decrease in intracellular water volume (4.7 +/- 1.3 versus 6.6 +/- 1.5 L, p <0.01). Total Body water (753 +/- 27 versus 780 +/- 40 mL . kg-1) and extracellular water volume (307 +/- 25 versus 277 +/- 15 mL . kg-1) in hypoxemic lambs were not significantly different from those in control lambs, but intracellular water volume was decreased (445 +/- 27 versus 501 +/- 35 mL . kg-1, p <0.01). The ratio of extracellular to intracellular water volume was higher in hypoxemic lambs (0.69 +/- 0.10 versus 0.55 +/- 0.04, p <0.01). Blood volume was increased in hypoxemic lambs (121 +/- 29 versus 79 +/- 15 mL . kg-1, p <0.01), mainly due to an increased total red cell volume (48 +/- 12 versus 22 +/- 8 mL . kg-1, p <0.001). We conclude that the lower Body mass in hypoxemic lambs is mainly related to a lower intracellular water volume. These results and the increased ratio of extracellular to intracellular water volume can be explained by assuming a decreased growth of the intracellular Compartment. In addition, a part of the (decreased) growth in hypoxemic lambs must be expended on increased erythropoiesis.
Jh Koers - One of the best experts on this subject based on the ideXlab platform.
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Body-Fluid Compartment VOLUMES IN CHRONICALLY HYPOXEMIC LAMBS
Pediatric Research, 1993Co-Authors: M Dalinghaus, Jwc Gratama, Jh Koers, A. M. Gerding, Kj Meuzelaar, M Vandeberg, Wg Zijlstra, Jrg KuipersAbstract:Chronic hypoxemia is associated with a decreased growth rate and a decreased rate of cell division. In lambs with experimental cyanotic heart disease, the gain in Body mass was decreased. In this study, we determined to what extent the lower Body mass in these lambs was related to alterations in Body Fluid Compartment volumes, specifically whether intracellular volume was decreased. Therefore, Fluid Compartment volumes were studied in nine lambs, after 3 to 4 wk of experimental cyanotic heart disease, and in 13 control lambs. Hypoxemic lambs had a lower arterial oxygen saturation (65 +/- 11 versus 91 +/- 2%, p
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Body Fluid Compartment volumes in chronically hypoxemic lambs
Pediatric Research, 1993Co-Authors: M Dalinghaus, Jwc Gratama, Jh Koers, A. M. Gerding, Kj Meuzelaar, M Vandeberg, Wg Zijlstra, Jrg KuipersAbstract:Chronic hypoxemia is associated with a decreased growth rate and a decreased rate of cell division. In lambs with experimental cyanotic heart disease, the gain in Body mass was decreased. In this study, we determined to what extent the lower Body mass in these lambs was related to alterations in Body Fluid Compartment volumes, specifically whether intracellular volume was decreased. Therefore, Fluid Compartment volumes were studied in nine lambs, after 3 to 4 wk of experimental cyanotic heart disease, and in 13 control lambs. Hypoxemic lambs had a lower arterial oxygen saturation (65 +/- 11 versus 91 +/- 2%, p <0.001) and a higher Hb concentration (142 +/- 16 versus 101 +/- 8 g . L-1, p <0.001). The lower Body mass in hypoxemic lambs (10.5 +/- 2.3 versus 13.0 +/- 2.8 kg) could be mainly accounted for by a decrease in intracellular water volume (4.7 +/- 1.3 versus 6.6 +/- 1.5 L, p <0.01). Total Body water (753 +/- 27 versus 780 +/- 40 mL . kg-1) and extracellular water volume (307 +/- 25 versus 277 +/- 15 mL . kg-1) in hypoxemic lambs were not significantly different from those in control lambs, but intracellular water volume was decreased (445 +/- 27 versus 501 +/- 35 mL . kg-1, p <0.01). The ratio of extracellular to intracellular water volume was higher in hypoxemic lambs (0.69 +/- 0.10 versus 0.55 +/- 0.04, p <0.01). Blood volume was increased in hypoxemic lambs (121 +/- 29 versus 79 +/- 15 mL . kg-1, p <0.01), mainly due to an increased total red cell volume (48 +/- 12 versus 22 +/- 8 mL . kg-1, p <0.001). We conclude that the lower Body mass in hypoxemic lambs is mainly related to a lower intracellular water volume. These results and the increased ratio of extracellular to intracellular water volume can be explained by assuming a decreased growth of the intracellular Compartment. In addition, a part of the (decreased) growth in hypoxemic lambs must be expended on increased erythropoiesis.
A. M. Gerding - One of the best experts on this subject based on the ideXlab platform.
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Body-Fluid Compartment VOLUMES IN CHRONICALLY HYPOXEMIC LAMBS
Pediatric Research, 1993Co-Authors: M Dalinghaus, Jwc Gratama, Jh Koers, A. M. Gerding, Kj Meuzelaar, M Vandeberg, Wg Zijlstra, Jrg KuipersAbstract:Chronic hypoxemia is associated with a decreased growth rate and a decreased rate of cell division. In lambs with experimental cyanotic heart disease, the gain in Body mass was decreased. In this study, we determined to what extent the lower Body mass in these lambs was related to alterations in Body Fluid Compartment volumes, specifically whether intracellular volume was decreased. Therefore, Fluid Compartment volumes were studied in nine lambs, after 3 to 4 wk of experimental cyanotic heart disease, and in 13 control lambs. Hypoxemic lambs had a lower arterial oxygen saturation (65 +/- 11 versus 91 +/- 2%, p
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Body Fluid Compartment volumes in chronically hypoxemic lambs
Pediatric Research, 1993Co-Authors: M Dalinghaus, Jwc Gratama, Jh Koers, A. M. Gerding, Kj Meuzelaar, M Vandeberg, Wg Zijlstra, Jrg KuipersAbstract:Chronic hypoxemia is associated with a decreased growth rate and a decreased rate of cell division. In lambs with experimental cyanotic heart disease, the gain in Body mass was decreased. In this study, we determined to what extent the lower Body mass in these lambs was related to alterations in Body Fluid Compartment volumes, specifically whether intracellular volume was decreased. Therefore, Fluid Compartment volumes were studied in nine lambs, after 3 to 4 wk of experimental cyanotic heart disease, and in 13 control lambs. Hypoxemic lambs had a lower arterial oxygen saturation (65 +/- 11 versus 91 +/- 2%, p <0.001) and a higher Hb concentration (142 +/- 16 versus 101 +/- 8 g . L-1, p <0.001). The lower Body mass in hypoxemic lambs (10.5 +/- 2.3 versus 13.0 +/- 2.8 kg) could be mainly accounted for by a decrease in intracellular water volume (4.7 +/- 1.3 versus 6.6 +/- 1.5 L, p <0.01). Total Body water (753 +/- 27 versus 780 +/- 40 mL . kg-1) and extracellular water volume (307 +/- 25 versus 277 +/- 15 mL . kg-1) in hypoxemic lambs were not significantly different from those in control lambs, but intracellular water volume was decreased (445 +/- 27 versus 501 +/- 35 mL . kg-1, p <0.01). The ratio of extracellular to intracellular water volume was higher in hypoxemic lambs (0.69 +/- 0.10 versus 0.55 +/- 0.04, p <0.01). Blood volume was increased in hypoxemic lambs (121 +/- 29 versus 79 +/- 15 mL . kg-1, p <0.01), mainly due to an increased total red cell volume (48 +/- 12 versus 22 +/- 8 mL . kg-1, p <0.001). We conclude that the lower Body mass in hypoxemic lambs is mainly related to a lower intracellular water volume. These results and the increased ratio of extracellular to intracellular water volume can be explained by assuming a decreased growth of the intracellular Compartment. In addition, a part of the (decreased) growth in hypoxemic lambs must be expended on increased erythropoiesis.
