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Bernard Malissen - One of the best experts on this subject based on the ideXlab platform.

  • constant replenishment from circulating monocytes maintains the Macrophage pool in the intestine of adult mice
    Nature Immunology, 2014
    Co-Authors: Calum C Bain, Alberto Bravoblas, Charlotte L Scott, Elisa Gomez Perdiguero, Frederic Geissmann, Sandrine Henri, Bernard Malissen
    Abstract:

    Many tissue-resident Macrophages are derived from embryonic precursors. Mowat and colleagues show that embryonic precursor cells seed gut tissues but at weaning transition to a Bone marrow–derived Macrophage population that requires continual replenishment.

  • Constant replenishment from circulating monocytes maintains the Macrophage pool in the intestine of adult mice
    Nature Immunology, 2014
    Co-Authors: Calum C Bain, Charlotte L Scott, Frederic Geissmann, Sandrine Henri, Bernard Malissen, Alberto Bravo-blas, Elisa Gomez Perdiguero, Lisa C Osborne, David Artis, Allan Mci Mowat
    Abstract:

    Many tissue-resident Macrophages are derived from embryonic precursors. Mowat and colleagues show that embryonic precursor cells seed gut tissues but at weaning transition to a Bone marrow–derived Macrophage population that requires continual replenishment. The paradigm that Macrophages that reside in steady-state tissues are derived from embryonic precursors has never been investigated in the intestine, which contains the largest pool of Macrophages. Using fate-mapping models and monocytopenic mice, together with Bone marrow chimera and parabiotic models, we found that embryonic precursor cells seeded the intestinal mucosa and demonstrated extensive in situ proliferation during the neonatal period. However, these cells did not persist in the intestine of adult mice. Instead, they were replaced around the time of weaning by the chemokine receptor CCR2–dependent influx of Ly6C^hi monocytes that differentiated locally into mature, anti-inflammatory Macrophages. This process was driven largely by the microbiota and had to be continued throughout adult life to maintain a normal intestinal Macrophage pool.

Calum C Bain - One of the best experts on this subject based on the ideXlab platform.

  • constant replenishment from circulating monocytes maintains the Macrophage pool in the intestine of adult mice
    Nature Immunology, 2014
    Co-Authors: Calum C Bain, Alberto Bravoblas, Charlotte L Scott, Elisa Gomez Perdiguero, Frederic Geissmann, Sandrine Henri, Bernard Malissen
    Abstract:

    Many tissue-resident Macrophages are derived from embryonic precursors. Mowat and colleagues show that embryonic precursor cells seed gut tissues but at weaning transition to a Bone marrow–derived Macrophage population that requires continual replenishment.

  • Constant replenishment from circulating monocytes maintains the Macrophage pool in the intestine of adult mice
    Nature Immunology, 2014
    Co-Authors: Calum C Bain, Charlotte L Scott, Frederic Geissmann, Sandrine Henri, Bernard Malissen, Alberto Bravo-blas, Elisa Gomez Perdiguero, Lisa C Osborne, David Artis, Allan Mci Mowat
    Abstract:

    Many tissue-resident Macrophages are derived from embryonic precursors. Mowat and colleagues show that embryonic precursor cells seed gut tissues but at weaning transition to a Bone marrow–derived Macrophage population that requires continual replenishment. The paradigm that Macrophages that reside in steady-state tissues are derived from embryonic precursors has never been investigated in the intestine, which contains the largest pool of Macrophages. Using fate-mapping models and monocytopenic mice, together with Bone marrow chimera and parabiotic models, we found that embryonic precursor cells seeded the intestinal mucosa and demonstrated extensive in situ proliferation during the neonatal period. However, these cells did not persist in the intestine of adult mice. Instead, they were replaced around the time of weaning by the chemokine receptor CCR2–dependent influx of Ly6C^hi monocytes that differentiated locally into mature, anti-inflammatory Macrophages. This process was driven largely by the microbiota and had to be continued throughout adult life to maintain a normal intestinal Macrophage pool.

Charlotte L Scott - One of the best experts on this subject based on the ideXlab platform.

  • constant replenishment from circulating monocytes maintains the Macrophage pool in the intestine of adult mice
    Nature Immunology, 2014
    Co-Authors: Calum C Bain, Alberto Bravoblas, Charlotte L Scott, Elisa Gomez Perdiguero, Frederic Geissmann, Sandrine Henri, Bernard Malissen
    Abstract:

    Many tissue-resident Macrophages are derived from embryonic precursors. Mowat and colleagues show that embryonic precursor cells seed gut tissues but at weaning transition to a Bone marrow–derived Macrophage population that requires continual replenishment.

  • Constant replenishment from circulating monocytes maintains the Macrophage pool in the intestine of adult mice
    Nature Immunology, 2014
    Co-Authors: Calum C Bain, Charlotte L Scott, Frederic Geissmann, Sandrine Henri, Bernard Malissen, Alberto Bravo-blas, Elisa Gomez Perdiguero, Lisa C Osborne, David Artis, Allan Mci Mowat
    Abstract:

    Many tissue-resident Macrophages are derived from embryonic precursors. Mowat and colleagues show that embryonic precursor cells seed gut tissues but at weaning transition to a Bone marrow–derived Macrophage population that requires continual replenishment. The paradigm that Macrophages that reside in steady-state tissues are derived from embryonic precursors has never been investigated in the intestine, which contains the largest pool of Macrophages. Using fate-mapping models and monocytopenic mice, together with Bone marrow chimera and parabiotic models, we found that embryonic precursor cells seeded the intestinal mucosa and demonstrated extensive in situ proliferation during the neonatal period. However, these cells did not persist in the intestine of adult mice. Instead, they were replaced around the time of weaning by the chemokine receptor CCR2–dependent influx of Ly6C^hi monocytes that differentiated locally into mature, anti-inflammatory Macrophages. This process was driven largely by the microbiota and had to be continued throughout adult life to maintain a normal intestinal Macrophage pool.

Allan Mci Mowat - One of the best experts on this subject based on the ideXlab platform.

  • Constant replenishment from circulating monocytes maintains the Macrophage pool in the intestine of adult mice
    Nature Immunology, 2014
    Co-Authors: Calum C Bain, Charlotte L Scott, Frederic Geissmann, Sandrine Henri, Bernard Malissen, Alberto Bravo-blas, Elisa Gomez Perdiguero, Lisa C Osborne, David Artis, Allan Mci Mowat
    Abstract:

    Many tissue-resident Macrophages are derived from embryonic precursors. Mowat and colleagues show that embryonic precursor cells seed gut tissues but at weaning transition to a Bone marrow–derived Macrophage population that requires continual replenishment. The paradigm that Macrophages that reside in steady-state tissues are derived from embryonic precursors has never been investigated in the intestine, which contains the largest pool of Macrophages. Using fate-mapping models and monocytopenic mice, together with Bone marrow chimera and parabiotic models, we found that embryonic precursor cells seeded the intestinal mucosa and demonstrated extensive in situ proliferation during the neonatal period. However, these cells did not persist in the intestine of adult mice. Instead, they were replaced around the time of weaning by the chemokine receptor CCR2–dependent influx of Ly6C^hi monocytes that differentiated locally into mature, anti-inflammatory Macrophages. This process was driven largely by the microbiota and had to be continued throughout adult life to maintain a normal intestinal Macrophage pool.

Lynn Soong - One of the best experts on this subject based on the ideXlab platform.

  • sand fly saliva enhances leishmania amazonensis infection by modulating interleukin 10 production
    Infection and Immunity, 2004
    Co-Authors: Nilufer B Norsworthy, Dia Elnaiem, Gregory C Lanzaro, Lynn Soong
    Abstract:

    After transmission through the bite of female sand flies, Leishmania spp. can cause a broad spectrum of disease manifestations collectively known as leishmaniases. L. amazonensis is endemic in South America, where it causes cutaneous, diffuse cutaneous, and visceral leishmaniasis. In this study, we have provided evidence that salivary gland extracts (SGE) of Lutzomyia longipalpis enhances L. amazonensis infection. BALB/c mice infected intradermally in the ear with 105 metacyclic promastigotes of L. amazonensis together with SGE (equivalent to 0.5 gland) showed an early onset of disease and larger lesions that contained ∼3-log-units more parasites than did controls. To determine the potential mechanism underlying this enhancement, we assessed cytokine production via reverse transcriptase PCR and enzyme-linked immunosorbent assay. Mice coinjected with parasites and SGE displayed higher levels of interleukin-10 (IL-10) mRNA in the ear tissues, as well as higher levels of IL-10 in supernatants of restimulated draining lymph node (LN) cells, than did controls. Flow cytometric analysis revealed high frequencies of IL-10-producing CD4+ and CD8+ T cells in the draining LN of mice coinjected with the parasite and SGE. In addition, we examined Bone marrow derived-Macrophage cultures and detected increased IL-10 but decreased nitric oxide (NO) production in cells exposed to SGE prior to infection with L. amazonensis. Together, these results imply that the sand fly saliva facilitates Leishmania evasion of the host immune system by modulating IL-10 production.