The Experts below are selected from a list of 156 Experts worldwide ranked by ideXlab platform

Rami I. Aqeilan - One of the best experts on this subject based on the ideXlab platform.

  • Role of the WWOX tumor suppressor gene in Bone homeostasis and the pathogenesis of osteosarcoma.
    American journal of cancer research, 2011
    Co-Authors: Del Mare S, Kyle C. Kurek, Gary S. Stein, Jane B. Lian, Rami I. Aqeilan
    Abstract:

    Osteosarcoma is the most common primary Bone malignancy in children with unknown etiology and often with poor clinical outcome. In recent years, a critical role has emerged for the WW domain-containing oxidoreductase (WWOX) in osteosarcoma and Bone biology. WWOX is a tumor suppressor that is deleted or attenuated in most human tumors. Wwox-deficient mice develop osteosarcoma and a Bone Metabolic Disease characterized by hypocalcemia and osteopenia. Studies of human osteosarcomas have revealed that the WWOX gene is deleted in 30% of cases and WWOX protein is absent or reduced in ~60% of tumors. Further, WWOX levels are attenuated in the majority of osteosarcoma cells, in which ectopic expression is associated with reduced proliferation, migration, invasion and tumorigenicity. At the molecular level, WWOX associates with RUNX2 and suppresses its transcriptional activity in osteoblasts and in cancer cells. This review provides new insights on the current knowledge of the spectrum of WWOX activities and future directions for the role of WWOX in Bone biology and osteosarcoma.

  • Review Article Role of the WWOX tumor suppressor gene in Bone homeo- stasis and the pathogenesis of osteosarcoma
    2011
    Co-Authors: Sara Del Mare, Kyle C. Kurek, Gary S. Stein, Jane B. Lian, Rami I. Aqeilan
    Abstract:

    Osteosarcoma is the most common primary Bone malignancy in children with unknown etiology and often with poor clinical outcome. In recent years, a critical role has emerged for the WW domain-containing oxidoreductase (WWOX) in osteosarcoma and Bone biology. WWOX is a tumor suppressor that is deleted or attenuated in most hu- man tumors. Wwox-deficient mice develop osteosarcoma and a Bone Metabolic Disease characterized by hypocalce- mia and osteopenia. Studies of human osteosarcomas have revealed that the WWOX gene is deleted in 30% of cases and WWOX protein is absent or reduced in ~60% of tumors. Further, WWOX levels are attenuated in the majority of osteosarcoma cells, in which ectopic expression is associated with reduced proliferation, migration, invasion and tumorigenicity. At the molecular level, WWOX associates with RUNX2 and suppresses its transcriptional activity in osteoblasts and in cancer cells. This review provides new insights on the current knowledge of the spectrum of WWOX activities and future directions for the role of WWOX in Bone biology and osteosarcoma.

Del Mare S - One of the best experts on this subject based on the ideXlab platform.

  • Role of the WWOX tumor suppressor gene in Bone homeostasis and the pathogenesis of osteosarcoma.
    American journal of cancer research, 2011
    Co-Authors: Del Mare S, Kyle C. Kurek, Gary S. Stein, Jane B. Lian, Rami I. Aqeilan
    Abstract:

    Osteosarcoma is the most common primary Bone malignancy in children with unknown etiology and often with poor clinical outcome. In recent years, a critical role has emerged for the WW domain-containing oxidoreductase (WWOX) in osteosarcoma and Bone biology. WWOX is a tumor suppressor that is deleted or attenuated in most human tumors. Wwox-deficient mice develop osteosarcoma and a Bone Metabolic Disease characterized by hypocalcemia and osteopenia. Studies of human osteosarcomas have revealed that the WWOX gene is deleted in 30% of cases and WWOX protein is absent or reduced in ~60% of tumors. Further, WWOX levels are attenuated in the majority of osteosarcoma cells, in which ectopic expression is associated with reduced proliferation, migration, invasion and tumorigenicity. At the molecular level, WWOX associates with RUNX2 and suppresses its transcriptional activity in osteoblasts and in cancer cells. This review provides new insights on the current knowledge of the spectrum of WWOX activities and future directions for the role of WWOX in Bone biology and osteosarcoma.

Jane B. Lian - One of the best experts on this subject based on the ideXlab platform.

  • Role of the WWOX tumor suppressor gene in Bone homeostasis and the pathogenesis of osteosarcoma.
    American journal of cancer research, 2011
    Co-Authors: Del Mare S, Kyle C. Kurek, Gary S. Stein, Jane B. Lian, Rami I. Aqeilan
    Abstract:

    Osteosarcoma is the most common primary Bone malignancy in children with unknown etiology and often with poor clinical outcome. In recent years, a critical role has emerged for the WW domain-containing oxidoreductase (WWOX) in osteosarcoma and Bone biology. WWOX is a tumor suppressor that is deleted or attenuated in most human tumors. Wwox-deficient mice develop osteosarcoma and a Bone Metabolic Disease characterized by hypocalcemia and osteopenia. Studies of human osteosarcomas have revealed that the WWOX gene is deleted in 30% of cases and WWOX protein is absent or reduced in ~60% of tumors. Further, WWOX levels are attenuated in the majority of osteosarcoma cells, in which ectopic expression is associated with reduced proliferation, migration, invasion and tumorigenicity. At the molecular level, WWOX associates with RUNX2 and suppresses its transcriptional activity in osteoblasts and in cancer cells. This review provides new insights on the current knowledge of the spectrum of WWOX activities and future directions for the role of WWOX in Bone biology and osteosarcoma.

  • Review Article Role of the WWOX tumor suppressor gene in Bone homeo- stasis and the pathogenesis of osteosarcoma
    2011
    Co-Authors: Sara Del Mare, Kyle C. Kurek, Gary S. Stein, Jane B. Lian, Rami I. Aqeilan
    Abstract:

    Osteosarcoma is the most common primary Bone malignancy in children with unknown etiology and often with poor clinical outcome. In recent years, a critical role has emerged for the WW domain-containing oxidoreductase (WWOX) in osteosarcoma and Bone biology. WWOX is a tumor suppressor that is deleted or attenuated in most hu- man tumors. Wwox-deficient mice develop osteosarcoma and a Bone Metabolic Disease characterized by hypocalce- mia and osteopenia. Studies of human osteosarcomas have revealed that the WWOX gene is deleted in 30% of cases and WWOX protein is absent or reduced in ~60% of tumors. Further, WWOX levels are attenuated in the majority of osteosarcoma cells, in which ectopic expression is associated with reduced proliferation, migration, invasion and tumorigenicity. At the molecular level, WWOX associates with RUNX2 and suppresses its transcriptional activity in osteoblasts and in cancer cells. This review provides new insights on the current knowledge of the spectrum of WWOX activities and future directions for the role of WWOX in Bone biology and osteosarcoma.

Gary S. Stein - One of the best experts on this subject based on the ideXlab platform.

  • Role of the WWOX tumor suppressor gene in Bone homeostasis and the pathogenesis of osteosarcoma.
    American journal of cancer research, 2011
    Co-Authors: Del Mare S, Kyle C. Kurek, Gary S. Stein, Jane B. Lian, Rami I. Aqeilan
    Abstract:

    Osteosarcoma is the most common primary Bone malignancy in children with unknown etiology and often with poor clinical outcome. In recent years, a critical role has emerged for the WW domain-containing oxidoreductase (WWOX) in osteosarcoma and Bone biology. WWOX is a tumor suppressor that is deleted or attenuated in most human tumors. Wwox-deficient mice develop osteosarcoma and a Bone Metabolic Disease characterized by hypocalcemia and osteopenia. Studies of human osteosarcomas have revealed that the WWOX gene is deleted in 30% of cases and WWOX protein is absent or reduced in ~60% of tumors. Further, WWOX levels are attenuated in the majority of osteosarcoma cells, in which ectopic expression is associated with reduced proliferation, migration, invasion and tumorigenicity. At the molecular level, WWOX associates with RUNX2 and suppresses its transcriptional activity in osteoblasts and in cancer cells. This review provides new insights on the current knowledge of the spectrum of WWOX activities and future directions for the role of WWOX in Bone biology and osteosarcoma.

  • Review Article Role of the WWOX tumor suppressor gene in Bone homeo- stasis and the pathogenesis of osteosarcoma
    2011
    Co-Authors: Sara Del Mare, Kyle C. Kurek, Gary S. Stein, Jane B. Lian, Rami I. Aqeilan
    Abstract:

    Osteosarcoma is the most common primary Bone malignancy in children with unknown etiology and often with poor clinical outcome. In recent years, a critical role has emerged for the WW domain-containing oxidoreductase (WWOX) in osteosarcoma and Bone biology. WWOX is a tumor suppressor that is deleted or attenuated in most hu- man tumors. Wwox-deficient mice develop osteosarcoma and a Bone Metabolic Disease characterized by hypocalce- mia and osteopenia. Studies of human osteosarcomas have revealed that the WWOX gene is deleted in 30% of cases and WWOX protein is absent or reduced in ~60% of tumors. Further, WWOX levels are attenuated in the majority of osteosarcoma cells, in which ectopic expression is associated with reduced proliferation, migration, invasion and tumorigenicity. At the molecular level, WWOX associates with RUNX2 and suppresses its transcriptional activity in osteoblasts and in cancer cells. This review provides new insights on the current knowledge of the spectrum of WWOX activities and future directions for the role of WWOX in Bone biology and osteosarcoma.

Kyle C. Kurek - One of the best experts on this subject based on the ideXlab platform.

  • Role of the WWOX tumor suppressor gene in Bone homeostasis and the pathogenesis of osteosarcoma.
    American journal of cancer research, 2011
    Co-Authors: Del Mare S, Kyle C. Kurek, Gary S. Stein, Jane B. Lian, Rami I. Aqeilan
    Abstract:

    Osteosarcoma is the most common primary Bone malignancy in children with unknown etiology and often with poor clinical outcome. In recent years, a critical role has emerged for the WW domain-containing oxidoreductase (WWOX) in osteosarcoma and Bone biology. WWOX is a tumor suppressor that is deleted or attenuated in most human tumors. Wwox-deficient mice develop osteosarcoma and a Bone Metabolic Disease characterized by hypocalcemia and osteopenia. Studies of human osteosarcomas have revealed that the WWOX gene is deleted in 30% of cases and WWOX protein is absent or reduced in ~60% of tumors. Further, WWOX levels are attenuated in the majority of osteosarcoma cells, in which ectopic expression is associated with reduced proliferation, migration, invasion and tumorigenicity. At the molecular level, WWOX associates with RUNX2 and suppresses its transcriptional activity in osteoblasts and in cancer cells. This review provides new insights on the current knowledge of the spectrum of WWOX activities and future directions for the role of WWOX in Bone biology and osteosarcoma.

  • Review Article Role of the WWOX tumor suppressor gene in Bone homeo- stasis and the pathogenesis of osteosarcoma
    2011
    Co-Authors: Sara Del Mare, Kyle C. Kurek, Gary S. Stein, Jane B. Lian, Rami I. Aqeilan
    Abstract:

    Osteosarcoma is the most common primary Bone malignancy in children with unknown etiology and often with poor clinical outcome. In recent years, a critical role has emerged for the WW domain-containing oxidoreductase (WWOX) in osteosarcoma and Bone biology. WWOX is a tumor suppressor that is deleted or attenuated in most hu- man tumors. Wwox-deficient mice develop osteosarcoma and a Bone Metabolic Disease characterized by hypocalce- mia and osteopenia. Studies of human osteosarcomas have revealed that the WWOX gene is deleted in 30% of cases and WWOX protein is absent or reduced in ~60% of tumors. Further, WWOX levels are attenuated in the majority of osteosarcoma cells, in which ectopic expression is associated with reduced proliferation, migration, invasion and tumorigenicity. At the molecular level, WWOX associates with RUNX2 and suppresses its transcriptional activity in osteoblasts and in cancer cells. This review provides new insights on the current knowledge of the spectrum of WWOX activities and future directions for the role of WWOX in Bone biology and osteosarcoma.