The Experts below are selected from a list of 102 Experts worldwide ranked by ideXlab platform
Fingermann Matías - One of the best experts on this subject based on the ideXlab platform.
-
Caracterización molecular y funcional de la respuesta de la acidez en Bordetella bronchiseptica : Posible rol en la infección persistente
'Universidad Nacional de La Plata', 2011Co-Authors: Fingermann MatíasAbstract:El presente trabajo de tesis se ha focalizado en el estudio del comportamiento de Bordetella bronchiseptica frente a una condición de estrés ambiental como lo es la acidez. La elección de esta temática responde a que este patógeno respiratorio, capaz de inducir un conjunto de enfermedades denominadas Bordetellosis, enfrenta y sobrelleva esta condición de estrés durante su ciclo de vida. La capacidad de resistir a a condiciones de acidez podría permitir a B. bronchiseptica inducir estadíos crónicos de la enfermedad, los cuales garantizan no sólo la sobrevida del patógeno dentro del huésped sino posibilitan la continuación de la circulación del mismo dentro de una población. Este estadío de cronicidad constituye por ello un problema para la salud. La profundización de este conocimiento relacionado a la sobrevida de B. bronchiseptica en condiciones de estrés, contriburía a un mejor manejo sanitario de este patógeno, capaz de inducir enfermedades en un amplio rango de huéspedes que incluye al hombre. En este contexto, en mi trabajo de tesis doctoral he abordado los siguientes objetivos específicos: • Evaluación del crecimiento de B. bronchiseptica en diferentes condiciones de acidez. Determinación de los valores de pH límite para el crecimiento • Evaluación de la capacidad B. bronchiseptica de desarrollar una respuesta de tolerancia a la acidez (ATR). • Impacto de los fenotipos virulento y avirulento de B. bronchiseptica en el proceso de resistencia/adaptación a la condición de estrés estudiada. • Identificación de componentes proteicos asociados al proceso de resistencia/adaptación mediante espectrometría de masas del tipo UV-MALDI TOF y TOF/TOF. Análisis proteómico de expresión diferencial 2D-PAGE. • Análisis y discusión del posible rol de los marcadores de respuesta a la acidificación del medio encontrados sobre el ciclo biológico del patógeno.Facultad de Ciencias Exacta
-
Caracterización molecular y funcional de la respuesta de la acidez en Bordetella bronchiseptica : Posible rol en la infección persistente
2011Co-Authors: Fingermann MatíasAbstract:El presente trabajo de tesis se ha focalizado en el estudio del comportamiento de Bordetella bronchiseptica frente a una condición de estrés ambiental como lo es la acidez. La elección de esta temática responde a que este patógeno respiratorio, capaz de inducir un conjunto de enfermedades denominadas Bordetellosis, enfrenta y sobrelleva esta condición de estrés durante su ciclo de vida. La capacidad de resistir a a condiciones de acidez podría permitir a B. bronchiseptica inducir estadíos crónicos de la enfermedad, los cuales garantizan no sólo la sobrevida del patógeno dentro del huésped sino posibilitan la continuación de la circulación del mismo dentro de una población. Este estadío de cronicidad constituye por ello un problema para la salud. La profundización de este conocimiento relacionado a la sobrevida de B. bronchiseptica en condiciones de estrés, contriburía a un mejor manejo sanitario de este patógeno, capaz de inducir enfermedades en un amplio rango de huéspedes que incluye al hombre. En este contexto, en mi trabajo de tesis doctoral he abordado los siguientes objetivos específicos: • Evaluación del crecimiento de B. bronchiseptica en diferentes condiciones de acidez. Determinación de los valores de pH límite para el crecimiento • Evaluación de la capacidad B. bronchiseptica de desarrollar una respuesta de tolerancia a la acidez (ATR). • Impacto de los fenotipos virulento y avirulento de B. bronchiseptica en el proceso de resistencia/adaptación a la condición de estrés estudiada. • Identificación de componentes proteicos asociados al proceso de resistencia/adaptación mediante espectrometría de masas del tipo UV-MALDI TOF y TOF/TOF. Análisis proteómico de expresión diferencial 2D-PAGE. • Análisis y discusión del posible rol de los marcadores de respuesta a la acidificación del medio encontrados sobre el ciclo biológico del patógeno.Departamento de Ciencias Biológica
Cécile Clercx - One of the best experts on this subject based on the ideXlab platform.
-
Comparison of C-reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia.
Journal of veterinary internal medicine, 2021Co-Authors: Aude Morgane Canonne, Frédéric Billen, Maud Menard, Christelle Maurey, Ghita Benchrekroun, Nina Fernandes Rodrigues, Cécile ClercxAbstract:BACKGROUND C-reactive protein (CRP) is a well-known acute-phase protein in dogs that may discriminate bacterial bronchopneumonia from other pulmonary conditions. Bronchopneumonia caused by Bordetella bronchiseptica (Bb) is common but the associated increase in CRP concentration in naturally infected dogs has not been fully explored. OBJECTIVE To compare CRP concentrations of dogs with Bb infection, with or without radiographic pulmonary lesions, to dogs with aspiration bronchopneumonia (ABP). ANIMALS Sixteen dogs with Bb infection and 36 dogs with ABP. METHODS Retrospective study. C-reactive protein concentrations and thoracic radiographs were available for each dog. RESULTS Eleven dogs with Bb infection had alveolar lesions. In all dogs, CRP concentration was mildly increased (14-38 mg/L). In the 5 dogs without alveolar lesions, CRP concentration was within the reference range in all but 1 dog, in which it was slightly increased. Median CRP concentration was significantly higher in dogs with alveolar lesions (20 mg/L) compared with dogs without alveolar lesions (5 mg/L; p < .002). In dogs with Bb infection, median duration of clinical signs was not different between dogs with normal CRP concentration and dogs with increased concentration. In dogs with Bb infection either with or without alveolar lessions, median CRP concentration was significantly lower (20 mg/L) than in dogs with ABP (118 mg/L; p < .001). CONCLUSIONS AND CLINICAL IMPORTANCE In contrast to dogs with APB, CRP was not a good marker for the diagnosis of dogs suspected to have Bordetellosis. Confirmation of Bb infection still requires lower airway sampling.
-
Comparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia
'Wiley', 2021Co-Authors: Aude Morgane Canonne, Frédéric Billen, Maud Menard, Christelle Maurey, Ghita Benchrekroun, Nina Fernandes Rodrigues, Cécile ClercxAbstract:Abstract Background C‐reactive protein (CRP) is a well‐known acute‐phase protein in dogs that may discriminate bacterial bronchopneumonia from other pulmonary conditions. Bronchopneumonia caused by Bordetella bronchiseptica (Bb) is common but the associated increase in CRP concentration in naturally infected dogs has not been fully explored. Objective To compare CRP concentrations of dogs with Bb infection, with or without radiographic pulmonary lesions, to dogs with aspiration bronchopneumonia (ABP). Animals Sixteen dogs with Bb infection and 36 dogs with ABP. Methods Retrospective study. C‐reactive protein concentrations and thoracic radiographs were available for each dog. Results Eleven dogs with Bb infection had alveolar lesions. In all dogs, CRP concentration was mildly increased (14‐38 mg/L). In the 5 dogs without alveolar lesions, CRP concentration was within the reference range in all but 1 dog, in which it was slightly increased. Median CRP concentration was significantly higher in dogs with alveolar lesions (20 mg/L) compared with dogs without alveolar lesions (5 mg/L; p < .002). In dogs with Bb infection, median duration of clinical signs was not different between dogs with normal CRP concentration and dogs with increased concentration. In dogs with Bb infection either with or without alveolar lessions, median CRP concentration was significantly lower (20 mg/L) than in dogs with ABP (118 mg/L; p < .001). Conclusions and Clinical Importance In contrast to dogs with APB, CRP was not a good marker for the diagnosis of dogs suspected to have Bordetellosis. Confirmation of Bb infection still requires lower airway sampling
Aude Morgane Canonne - One of the best experts on this subject based on the ideXlab platform.
-
Comparison of C-reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia.
Journal of veterinary internal medicine, 2021Co-Authors: Aude Morgane Canonne, Frédéric Billen, Maud Menard, Christelle Maurey, Ghita Benchrekroun, Nina Fernandes Rodrigues, Cécile ClercxAbstract:BACKGROUND C-reactive protein (CRP) is a well-known acute-phase protein in dogs that may discriminate bacterial bronchopneumonia from other pulmonary conditions. Bronchopneumonia caused by Bordetella bronchiseptica (Bb) is common but the associated increase in CRP concentration in naturally infected dogs has not been fully explored. OBJECTIVE To compare CRP concentrations of dogs with Bb infection, with or without radiographic pulmonary lesions, to dogs with aspiration bronchopneumonia (ABP). ANIMALS Sixteen dogs with Bb infection and 36 dogs with ABP. METHODS Retrospective study. C-reactive protein concentrations and thoracic radiographs were available for each dog. RESULTS Eleven dogs with Bb infection had alveolar lesions. In all dogs, CRP concentration was mildly increased (14-38 mg/L). In the 5 dogs without alveolar lesions, CRP concentration was within the reference range in all but 1 dog, in which it was slightly increased. Median CRP concentration was significantly higher in dogs with alveolar lesions (20 mg/L) compared with dogs without alveolar lesions (5 mg/L; p < .002). In dogs with Bb infection, median duration of clinical signs was not different between dogs with normal CRP concentration and dogs with increased concentration. In dogs with Bb infection either with or without alveolar lessions, median CRP concentration was significantly lower (20 mg/L) than in dogs with ABP (118 mg/L; p < .001). CONCLUSIONS AND CLINICAL IMPORTANCE In contrast to dogs with APB, CRP was not a good marker for the diagnosis of dogs suspected to have Bordetellosis. Confirmation of Bb infection still requires lower airway sampling.
-
Comparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia
'Wiley', 2021Co-Authors: Aude Morgane Canonne, Frédéric Billen, Maud Menard, Christelle Maurey, Ghita Benchrekroun, Nina Fernandes Rodrigues, Cécile ClercxAbstract:Abstract Background C‐reactive protein (CRP) is a well‐known acute‐phase protein in dogs that may discriminate bacterial bronchopneumonia from other pulmonary conditions. Bronchopneumonia caused by Bordetella bronchiseptica (Bb) is common but the associated increase in CRP concentration in naturally infected dogs has not been fully explored. Objective To compare CRP concentrations of dogs with Bb infection, with or without radiographic pulmonary lesions, to dogs with aspiration bronchopneumonia (ABP). Animals Sixteen dogs with Bb infection and 36 dogs with ABP. Methods Retrospective study. C‐reactive protein concentrations and thoracic radiographs were available for each dog. Results Eleven dogs with Bb infection had alveolar lesions. In all dogs, CRP concentration was mildly increased (14‐38 mg/L). In the 5 dogs without alveolar lesions, CRP concentration was within the reference range in all but 1 dog, in which it was slightly increased. Median CRP concentration was significantly higher in dogs with alveolar lesions (20 mg/L) compared with dogs without alveolar lesions (5 mg/L; p < .002). In dogs with Bb infection, median duration of clinical signs was not different between dogs with normal CRP concentration and dogs with increased concentration. In dogs with Bb infection either with or without alveolar lessions, median CRP concentration was significantly lower (20 mg/L) than in dogs with ABP (118 mg/L; p < .001). Conclusions and Clinical Importance In contrast to dogs with APB, CRP was not a good marker for the diagnosis of dogs suspected to have Bordetellosis. Confirmation of Bb infection still requires lower airway sampling
Nina Fernandes Rodrigues - One of the best experts on this subject based on the ideXlab platform.
-
Comparison of C-reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia.
Journal of veterinary internal medicine, 2021Co-Authors: Aude Morgane Canonne, Frédéric Billen, Maud Menard, Christelle Maurey, Ghita Benchrekroun, Nina Fernandes Rodrigues, Cécile ClercxAbstract:BACKGROUND C-reactive protein (CRP) is a well-known acute-phase protein in dogs that may discriminate bacterial bronchopneumonia from other pulmonary conditions. Bronchopneumonia caused by Bordetella bronchiseptica (Bb) is common but the associated increase in CRP concentration in naturally infected dogs has not been fully explored. OBJECTIVE To compare CRP concentrations of dogs with Bb infection, with or without radiographic pulmonary lesions, to dogs with aspiration bronchopneumonia (ABP). ANIMALS Sixteen dogs with Bb infection and 36 dogs with ABP. METHODS Retrospective study. C-reactive protein concentrations and thoracic radiographs were available for each dog. RESULTS Eleven dogs with Bb infection had alveolar lesions. In all dogs, CRP concentration was mildly increased (14-38 mg/L). In the 5 dogs without alveolar lesions, CRP concentration was within the reference range in all but 1 dog, in which it was slightly increased. Median CRP concentration was significantly higher in dogs with alveolar lesions (20 mg/L) compared with dogs without alveolar lesions (5 mg/L; p < .002). In dogs with Bb infection, median duration of clinical signs was not different between dogs with normal CRP concentration and dogs with increased concentration. In dogs with Bb infection either with or without alveolar lessions, median CRP concentration was significantly lower (20 mg/L) than in dogs with ABP (118 mg/L; p < .001). CONCLUSIONS AND CLINICAL IMPORTANCE In contrast to dogs with APB, CRP was not a good marker for the diagnosis of dogs suspected to have Bordetellosis. Confirmation of Bb infection still requires lower airway sampling.
-
Comparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia
'Wiley', 2021Co-Authors: Aude Morgane Canonne, Frédéric Billen, Maud Menard, Christelle Maurey, Ghita Benchrekroun, Nina Fernandes Rodrigues, Cécile ClercxAbstract:Abstract Background C‐reactive protein (CRP) is a well‐known acute‐phase protein in dogs that may discriminate bacterial bronchopneumonia from other pulmonary conditions. Bronchopneumonia caused by Bordetella bronchiseptica (Bb) is common but the associated increase in CRP concentration in naturally infected dogs has not been fully explored. Objective To compare CRP concentrations of dogs with Bb infection, with or without radiographic pulmonary lesions, to dogs with aspiration bronchopneumonia (ABP). Animals Sixteen dogs with Bb infection and 36 dogs with ABP. Methods Retrospective study. C‐reactive protein concentrations and thoracic radiographs were available for each dog. Results Eleven dogs with Bb infection had alveolar lesions. In all dogs, CRP concentration was mildly increased (14‐38 mg/L). In the 5 dogs without alveolar lesions, CRP concentration was within the reference range in all but 1 dog, in which it was slightly increased. Median CRP concentration was significantly higher in dogs with alveolar lesions (20 mg/L) compared with dogs without alveolar lesions (5 mg/L; p < .002). In dogs with Bb infection, median duration of clinical signs was not different between dogs with normal CRP concentration and dogs with increased concentration. In dogs with Bb infection either with or without alveolar lessions, median CRP concentration was significantly lower (20 mg/L) than in dogs with ABP (118 mg/L; p < .001). Conclusions and Clinical Importance In contrast to dogs with APB, CRP was not a good marker for the diagnosis of dogs suspected to have Bordetellosis. Confirmation of Bb infection still requires lower airway sampling
Ghita Benchrekroun - One of the best experts on this subject based on the ideXlab platform.
-
Comparison of C-reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia.
Journal of veterinary internal medicine, 2021Co-Authors: Aude Morgane Canonne, Frédéric Billen, Maud Menard, Christelle Maurey, Ghita Benchrekroun, Nina Fernandes Rodrigues, Cécile ClercxAbstract:BACKGROUND C-reactive protein (CRP) is a well-known acute-phase protein in dogs that may discriminate bacterial bronchopneumonia from other pulmonary conditions. Bronchopneumonia caused by Bordetella bronchiseptica (Bb) is common but the associated increase in CRP concentration in naturally infected dogs has not been fully explored. OBJECTIVE To compare CRP concentrations of dogs with Bb infection, with or without radiographic pulmonary lesions, to dogs with aspiration bronchopneumonia (ABP). ANIMALS Sixteen dogs with Bb infection and 36 dogs with ABP. METHODS Retrospective study. C-reactive protein concentrations and thoracic radiographs were available for each dog. RESULTS Eleven dogs with Bb infection had alveolar lesions. In all dogs, CRP concentration was mildly increased (14-38 mg/L). In the 5 dogs without alveolar lesions, CRP concentration was within the reference range in all but 1 dog, in which it was slightly increased. Median CRP concentration was significantly higher in dogs with alveolar lesions (20 mg/L) compared with dogs without alveolar lesions (5 mg/L; p < .002). In dogs with Bb infection, median duration of clinical signs was not different between dogs with normal CRP concentration and dogs with increased concentration. In dogs with Bb infection either with or without alveolar lessions, median CRP concentration was significantly lower (20 mg/L) than in dogs with ABP (118 mg/L; p < .001). CONCLUSIONS AND CLINICAL IMPORTANCE In contrast to dogs with APB, CRP was not a good marker for the diagnosis of dogs suspected to have Bordetellosis. Confirmation of Bb infection still requires lower airway sampling.
-
Comparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia
'Wiley', 2021Co-Authors: Aude Morgane Canonne, Frédéric Billen, Maud Menard, Christelle Maurey, Ghita Benchrekroun, Nina Fernandes Rodrigues, Cécile ClercxAbstract:Abstract Background C‐reactive protein (CRP) is a well‐known acute‐phase protein in dogs that may discriminate bacterial bronchopneumonia from other pulmonary conditions. Bronchopneumonia caused by Bordetella bronchiseptica (Bb) is common but the associated increase in CRP concentration in naturally infected dogs has not been fully explored. Objective To compare CRP concentrations of dogs with Bb infection, with or without radiographic pulmonary lesions, to dogs with aspiration bronchopneumonia (ABP). Animals Sixteen dogs with Bb infection and 36 dogs with ABP. Methods Retrospective study. C‐reactive protein concentrations and thoracic radiographs were available for each dog. Results Eleven dogs with Bb infection had alveolar lesions. In all dogs, CRP concentration was mildly increased (14‐38 mg/L). In the 5 dogs without alveolar lesions, CRP concentration was within the reference range in all but 1 dog, in which it was slightly increased. Median CRP concentration was significantly higher in dogs with alveolar lesions (20 mg/L) compared with dogs without alveolar lesions (5 mg/L; p < .002). In dogs with Bb infection, median duration of clinical signs was not different between dogs with normal CRP concentration and dogs with increased concentration. In dogs with Bb infection either with or without alveolar lessions, median CRP concentration was significantly lower (20 mg/L) than in dogs with ABP (118 mg/L; p < .001). Conclusions and Clinical Importance In contrast to dogs with APB, CRP was not a good marker for the diagnosis of dogs suspected to have Bordetellosis. Confirmation of Bb infection still requires lower airway sampling