The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform
Catherine Hirel - One of the best experts on this subject based on the ideXlab platform.
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Bromine–lithium exchange as a straightforward method to obtain meso -tetrakis(4-formylphenyl)porphyrin: a versatile intermediate
Tetrahedron Letters, 2015Co-Authors: Emel Önal, Vefa Ahsen, Jacques Pécaut, Dominique Luneau, Catherine HirelAbstract:Abstract A three step, one-pot Reaction has been developed for the introduction of the formyl functional group to the meso position of porphyrins. Symmetric meso -tetrakis(4-formylphenyl)porphyrin (( CHO) 4 TPPH2 ), an important cornerstone in porphyrin chemistry, was obtained selectively in good yields via bromine–lithium exchange and subsequent Bouveault Reaction. The meso -tetrakis(4-formylphenyl)porphyrin was fully characterized by HR-ESI, UV–vis, NMR, and single crystal X-ray diffraction.
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Bromine-lithium exchange as a straightforward method to obtain meso-tetrakis(4-formylphenyl)porphyrin: a versatile intermediate
Tetrahedron Letters, 2015Co-Authors: Emel Oenal, Vefa Ahsen, Jacques Pécaut, Dominique Luneau, Catherine HirelAbstract:A three step, one-pot Reaction has been developed for the introduction of the formyl functional group to the mesa position of porphyrins. Symmetric meso-tetrakis(4-formylphenyl)porphyrin ((CHO)(4)TPPH2), an important cornerstone in porphyrin chemistry, was obtained selectively in good yields via bromine-lithium exchange and subsequent Bouveault Reaction. The meso-tetrakis(4-formylphenyl)porphyrin was fully characterized by HR-ESI, UV-vis, NMR, and single crystal X-ray diffraction. (C) 2015 Elsevier Ltd. All rights reserved.
Jacques Pécaut - One of the best experts on this subject based on the ideXlab platform.
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Bromine–lithium exchange as a straightforward method to obtain meso -tetrakis(4-formylphenyl)porphyrin: a versatile intermediate
Tetrahedron Letters, 2015Co-Authors: Emel Önal, Vefa Ahsen, Jacques Pécaut, Dominique Luneau, Catherine HirelAbstract:Abstract A three step, one-pot Reaction has been developed for the introduction of the formyl functional group to the meso position of porphyrins. Symmetric meso -tetrakis(4-formylphenyl)porphyrin (( CHO) 4 TPPH2 ), an important cornerstone in porphyrin chemistry, was obtained selectively in good yields via bromine–lithium exchange and subsequent Bouveault Reaction. The meso -tetrakis(4-formylphenyl)porphyrin was fully characterized by HR-ESI, UV–vis, NMR, and single crystal X-ray diffraction.
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Bromine-lithium exchange as a straightforward method to obtain meso-tetrakis(4-formylphenyl)porphyrin: a versatile intermediate
Tetrahedron Letters, 2015Co-Authors: Emel Oenal, Vefa Ahsen, Jacques Pécaut, Dominique Luneau, Catherine HirelAbstract:A three step, one-pot Reaction has been developed for the introduction of the formyl functional group to the mesa position of porphyrins. Symmetric meso-tetrakis(4-formylphenyl)porphyrin ((CHO)(4)TPPH2), an important cornerstone in porphyrin chemistry, was obtained selectively in good yields via bromine-lithium exchange and subsequent Bouveault Reaction. The meso-tetrakis(4-formylphenyl)porphyrin was fully characterized by HR-ESI, UV-vis, NMR, and single crystal X-ray diffraction. (C) 2015 Elsevier Ltd. All rights reserved.
Dominique Luneau - One of the best experts on this subject based on the ideXlab platform.
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Bromine–lithium exchange as a straightforward method to obtain meso -tetrakis(4-formylphenyl)porphyrin: a versatile intermediate
Tetrahedron Letters, 2015Co-Authors: Emel Önal, Vefa Ahsen, Jacques Pécaut, Dominique Luneau, Catherine HirelAbstract:Abstract A three step, one-pot Reaction has been developed for the introduction of the formyl functional group to the meso position of porphyrins. Symmetric meso -tetrakis(4-formylphenyl)porphyrin (( CHO) 4 TPPH2 ), an important cornerstone in porphyrin chemistry, was obtained selectively in good yields via bromine–lithium exchange and subsequent Bouveault Reaction. The meso -tetrakis(4-formylphenyl)porphyrin was fully characterized by HR-ESI, UV–vis, NMR, and single crystal X-ray diffraction.
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Bromine-lithium exchange as a straightforward method to obtain meso-tetrakis(4-formylphenyl)porphyrin: a versatile intermediate
Tetrahedron Letters, 2015Co-Authors: Emel Oenal, Vefa Ahsen, Jacques Pécaut, Dominique Luneau, Catherine HirelAbstract:A three step, one-pot Reaction has been developed for the introduction of the formyl functional group to the mesa position of porphyrins. Symmetric meso-tetrakis(4-formylphenyl)porphyrin ((CHO)(4)TPPH2), an important cornerstone in porphyrin chemistry, was obtained selectively in good yields via bromine-lithium exchange and subsequent Bouveault Reaction. The meso-tetrakis(4-formylphenyl)porphyrin was fully characterized by HR-ESI, UV-vis, NMR, and single crystal X-ray diffraction. (C) 2015 Elsevier Ltd. All rights reserved.
Vefa Ahsen - One of the best experts on this subject based on the ideXlab platform.
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Bromine–lithium exchange as a straightforward method to obtain meso -tetrakis(4-formylphenyl)porphyrin: a versatile intermediate
Tetrahedron Letters, 2015Co-Authors: Emel Önal, Vefa Ahsen, Jacques Pécaut, Dominique Luneau, Catherine HirelAbstract:Abstract A three step, one-pot Reaction has been developed for the introduction of the formyl functional group to the meso position of porphyrins. Symmetric meso -tetrakis(4-formylphenyl)porphyrin (( CHO) 4 TPPH2 ), an important cornerstone in porphyrin chemistry, was obtained selectively in good yields via bromine–lithium exchange and subsequent Bouveault Reaction. The meso -tetrakis(4-formylphenyl)porphyrin was fully characterized by HR-ESI, UV–vis, NMR, and single crystal X-ray diffraction.
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Bromine-lithium exchange as a straightforward method to obtain meso-tetrakis(4-formylphenyl)porphyrin: a versatile intermediate
Tetrahedron Letters, 2015Co-Authors: Emel Oenal, Vefa Ahsen, Jacques Pécaut, Dominique Luneau, Catherine HirelAbstract:A three step, one-pot Reaction has been developed for the introduction of the formyl functional group to the mesa position of porphyrins. Symmetric meso-tetrakis(4-formylphenyl)porphyrin ((CHO)(4)TPPH2), an important cornerstone in porphyrin chemistry, was obtained selectively in good yields via bromine-lithium exchange and subsequent Bouveault Reaction. The meso-tetrakis(4-formylphenyl)porphyrin was fully characterized by HR-ESI, UV-vis, NMR, and single crystal X-ray diffraction. (C) 2015 Elsevier Ltd. All rights reserved.
Christine Anne Louise Watson - One of the best experts on this subject based on the ideXlab platform.
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Development of a Scaleable Synthesis of a Geminal Dimethyl Tertiary Amine as an Inhaled Muscarinic Antagonist for the Treatment of COPD
Organic Process Research & Development, 2012Co-Authors: Barry Richard Dillon, Dannielle F. Roberts, David A. Entwistle, Glossop Paul Alan, Craig J. Knight, Daniel Laity, Kim James, Céline F. B. Praquin, Strang Ross Sinclair, Christine Anne Louise WatsonAbstract:An efficient and scalable process for the synthesis of muscarinic antagonist, PF-3635659 1, is described, illustrating redesign of an analogue-targeted synthesis which contained a scale-limiting rhodium-activated C–H amination step. The final route includes a reproducible modified Bouveault Reaction which has not previously been reported on a substrate of this complexity, or on such a scale with over 5 kg of the requisite gem-dimethylamine prepared via this methodology.
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Development of a Scaleable Synthesis of a Geminal Dimethyl Tertiary Amine as an Inhaled Muscarinic Antagonist for the Treatment of COPD
2012Co-Authors: Barry Richard Dillon, Dannielle F. Roberts, David A. Entwistle, Daniel Laity, Kim James, Céline F. B. Praquin, Paul A. Glossop, Craig J. Knight, Ross S. Strang, Christine Anne Louise WatsonAbstract:An efficient and scalable process for the synthesis of muscarinic antagonist, PF-3635659 1, is described, illustrating redesign of an analogue-targeted synthesis which contained a scale-limiting rhodium-activated C–H amination step. The final route includes a reproducible modified Bouveault Reaction which has not previously been reported on a substrate of this complexity, or on such a scale with over 5 kg of the requisite gem-dimethylamine prepared via this methodology