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Iris Zalaudek - One of the best experts on this subject based on the ideXlab platform.
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clinical and dermoscopic features of genital pigmented Bowen Disease
Clinical and Experimental Dermatology, 2018Co-Authors: Roberta Giuffrida, Rainer Hofmannwellenhof, Claudio Conforti, Fernanda Simoes Seabra Resende, Hamilko M De Barros, M Uranitsch, F Favero, Teresa Deinlein, Iris ZalaudekAbstract:Pigmented Bowen Disease (pBD) is an uncommon variant of squamous cell carcinoma in situ. Sometimes it can show clinical and dermoscopic features that are seen in other pigmented lesions of the skin and mucosa, making the diagnosis difficult. We report six cases of pBD occurring on the anogenital area, and discuss the importance of dermoscopy for improving the diagnostic accuracy in pBD.
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periungual Bowen Disease mimicking chronic paronychia and diagnosed by dermoscopy
Journal of The American Academy of Dermatology, 2014Co-Authors: Jason Giacomel, Iris Zalaudek, Aimilios Lallas, Giuseppe ArgenzianoAbstract:From th Re U Fund Conf CLINICAL PRESENTATION A 75-year-old woman, with Fitzpatrick skin phototype I/II and a history of nonmelanoma skin cancer presented with a scaly, fissured, erythematous, fairly well demarcated patch involving the periungual skin of the left index finger (Fig 1). The lesion had persisted for[1 year despite the use of antibiotic and corticosteroid ointments. The patient was immunocompetent, an exsmoker, with no reported history of arsenic ingestion, trauma, burns, or ionizing radiation to the site.
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dermoscopy of squamous cell carcinoma and keratoacanthoma
Archives of Dermatology, 2012Co-Authors: Cliff Rosendahl, Iris Zalaudek, Giuseppe Argenziano, Alan Cameron, Philipp Tschandl, Harald KittlerAbstract:Objectives To characterize dermoscopic criteria of squamous cell carcinoma (SCC) and keratoacanthoma and to compare them with other lesions. Design Observer-masked study of consecutive lesions performed from March 1 through December 31, 2011. Setting Primary care skin cancer practice in Brisbane, Australia. Participants A total of 186 patients with 206 lesions. Main Outcome Measures Sensitivity, specificity, predictive values, and odds ratios. Results In a retrospective analysis of 60 invasive SCC and 43 keratoacanthoma cases, keratin, surface scale, blood spots, white structureless zones, white circles, and coiled vessels were commonly found in both types of lesions. We reevaluated the significance of these criteria in 206 raised, nonpigmented lesions (32 SCCs, 29 keratoacanthomas, and 145 other lesions). Central keratin was more common in keratoacanthoma than in SCC (51.2% vs 30.0%, P = .03). Keratin had the highest sensitivity for keratoacanthoma and SCC (79%), and white circles had the highest specificity (87%). When keratoacanthoma and SCC were contrasted with basal cell carcinoma, the positive predictive values of keratin and white circles were 92% and 89%, respectively. When SCC and keratoacanthoma were contrasted with actinic keratosis and Bowen Disease, the positive predictive value of keratin was 50% and that of white circles was 92%. In a multivariate model, white circles, keratin, and blood spots were independent predictors of SCC and keratoacanthoma. White circles had the highest odds ratio in favor of SCC and keratoacanthoma. The interobserver agreement for white circles was good (0.55; 95% CI, 0.44-0.65). Conclusions White circles, keratin, and blood spots are useful clues to differentiate SCC and keratoacanthoma from other raised nonpigmented skin lesions by dermoscopy. The significance of these criteria depends on the clinical context.
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amelanotic hypomelanotic melanoma is dermatoscopy useful for diagnosis
Journal Der Deutschen Dermatologischen Gesellschaft, 2003Co-Authors: Iris Zalaudek, Helmut Kerl, H. Peter Soyer, Giuseppe Argenziano, Rainer HofmannwellenhofAbstract:Background: Amelanotic/hypomelanotic melanoma often leads to delayed clinical diagnosis because its clinical appearance can mimic other hypopigmented skin conditions. Dermatoscopy (dermoscopy, epiluminescence microscopy) is thought to be a helpful diagnostic tool in pigmented skin lesions, but it can be used also in non-pigmented skin tumors due to the recognition of vascular structures not visible to the naked eye. Objective: 7 amelanotic/hypomelanotic melanomas in 6 patients were analyzed in order to define their dermatoscopic findings using standard pattern analysis. Methods: Clinical and dermoscopic images of each lesion were obtained using Dermaphot (Heine Optotechnik, Herrsching, Germany), with 10-fold magnification of the lesion and the color slides were converted to digital format using a Kodak Photo CD system. Results: All 7 amelanotic/hypomelanotic melanomas revealed peculiar dermatoscopic findings, namely, atypical vessels, dotted vessels, and a central pink to white veil. In addition, in 2 patients a slight brownish homogenous pigmentation at the periphery of the lesion was observed. In one case the correct diagnosis was done by an experienced dermatologist using dermatoscopy, whereas in the remaining 6 cases the clinical diagnoses included squamous cell carcinoma, Bowen Disease, pyogenic granuloma and basal cell carcinoma. In 2 of 6 patients amelanotic/hypomelanotic melanoma was associated with a previous history of melanoma. Conclusion: Amelanotic/hypomelanotic melanoma exhibits as a common dermatoscopic denominator atypical vessels, varying in size and shape, usually associated with a central pink to white veil.
Jeffrey L Medeiros - One of the best experts on this subject based on the ideXlab platform.
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pagetoid Bowen Disease
Archives of Pathology & Laboratory Medicine, 2009Co-Authors: John D. Williamson, Maria I Colome, Alberto G Ayala, Aysegul A Sahin, Jeffrey L MedeirosAbstract:Abstract Bowen Disease is a variant of squamous cell carcinoma in situ. In some cases a pagetoid growth pattern can be observed with cytologically atypical clear cells arranged singly and in nests....
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pagetoid Bowen Disease a report of 2 cases that express cytokeratin 7
Archives of Pathology & Laboratory Medicine, 2000Co-Authors: Maria I Colome, John D. Williamson, Alberto G Ayala, Aysegul A Sahin, Jeffrey L MedeirosAbstract:○ Bowen Disease is a variant of squamous cell carcinoma in situ. In some cases a pagetoid growth pattern can be observed with cytologically atypical clear cells arranged singly and in nests. The differential diagnosis of pagetoid Bowen Disease includes primarily Paget Disease and malignant melanoma in situ, as well as other less common entities. Two cases of pagetoid Bowen Disease are described, one in a 65-year-old man with a thigh lesion and the other in a 25-year-old man with a lesion in the penile/scrotal region. Neither patient had clinical evidence of an internal malignant neoplasm. In both cases, the neoplastic cells were positive for cytokeratin (CK) 7 and CK 19 and were negative for CK 18, CK 20, carcinoembryonic antigen, GCDFP-15, c-erbB2, S100, and HMB-45. In aggregate, these findings support the diagnosis of pagetoid Bowen Disease. Previously, others have shown that CK 7 is an almost invariable marker of Paget Disease. Thus, we report these two cases to illustrate that CK 7 can be expressed by pagetoid Bowen Disease and should not be a cause of confusion in the differential diagnosis.
John D. Williamson - One of the best experts on this subject based on the ideXlab platform.
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pagetoid Bowen Disease
Archives of Pathology & Laboratory Medicine, 2009Co-Authors: John D. Williamson, Maria I Colome, Alberto G Ayala, Aysegul A Sahin, Jeffrey L MedeirosAbstract:Abstract Bowen Disease is a variant of squamous cell carcinoma in situ. In some cases a pagetoid growth pattern can be observed with cytologically atypical clear cells arranged singly and in nests....
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pagetoid Bowen Disease a report of 2 cases that express cytokeratin 7
Archives of Pathology & Laboratory Medicine, 2000Co-Authors: Maria I Colome, John D. Williamson, Alberto G Ayala, Aysegul A Sahin, Jeffrey L MedeirosAbstract:○ Bowen Disease is a variant of squamous cell carcinoma in situ. In some cases a pagetoid growth pattern can be observed with cytologically atypical clear cells arranged singly and in nests. The differential diagnosis of pagetoid Bowen Disease includes primarily Paget Disease and malignant melanoma in situ, as well as other less common entities. Two cases of pagetoid Bowen Disease are described, one in a 65-year-old man with a thigh lesion and the other in a 25-year-old man with a lesion in the penile/scrotal region. Neither patient had clinical evidence of an internal malignant neoplasm. In both cases, the neoplastic cells were positive for cytokeratin (CK) 7 and CK 19 and were negative for CK 18, CK 20, carcinoembryonic antigen, GCDFP-15, c-erbB2, S100, and HMB-45. In aggregate, these findings support the diagnosis of pagetoid Bowen Disease. Previously, others have shown that CK 7 is an almost invariable marker of Paget Disease. Thus, we report these two cases to illustrate that CK 7 can be expressed by pagetoid Bowen Disease and should not be a cause of confusion in the differential diagnosis.
C B Bunker - One of the best experts on this subject based on the ideXlab platform.
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dermatoscopic findings of penile intraepithelial neoplasia Bowenoid papulosis Bowen Disease and erythroplasia of queyrat
Australasian Journal of Dermatology, 2019Co-Authors: Sulin Chan, Richard Watchorn, Evangelia Panagou, Evdoxia Panou, Eugene Lh Ong, Kara Heelan, Aiman Haider, Alex Freeman, C B BunkerAbstract:BACKGROUND/OBJECTIVES The clinical diagnosis of penile intraepithelial neoplasia is challenging. No specific dermoscopic criteria for penile intraepithelial neoplasia have been described in the literature. This study aimed to describe and evaluate the dermoscopic features of penile intraepithelial neoplasia. METHODS Clinical and dermoscopic images of 11 patients with histopathologically confirmed penile intraepithelial neoplasia were recorded and evaluated. RESULTS The most frequent dermoscopic features were the presence of structureless areas (100%, structureless pink 72.7%) and vascular structures (81.8%), particularly dotted vessels (72.7%). Other findings included the absence of a pigment network (100%); scale (45.5%); scar-like areas (45.5%); erosions (27.3%); and pigmentation consisting of brown-grey dots and globules (27.3%). CONCLUSIONS The dermoscopic features that characterise penile intraepithelial neoplasia are structureless pink areas and a prominent vascular pattern (mainly clustered dotted vessels). Dermoscopy is a useful tool that can aid in the diagnosis and surveillance of penile intraepithelial neoplasia.
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circumcision and genital dermatoses
Archives of Dermatology, 2000Co-Authors: Eleanor Mallon, D Hawkins, M Dinneen, N Francis, L Fearfield, Roger Newson, C B BunkerAbstract:Context It is well recognized that the presence of a foreskin predisposes to penile carcinoma and sexually transmitted infections. We have investigated the relationship between the presence or absence of the foreskin and penile dermatoses. Objective To determine whether there is an association between circumcision and penile dermatoses. Design A retrospective case control study of patients attending the department of dermatology with genital skin conditions. Subjects The study population consisted of 357 male patients referred for diagnosis and management of genital skin Disease. The control population consisted of 305 male patients without genital skin Disease attending the general dermatology clinics over a 4-month period. Main Outcome Measures The relationship between circumcision and the presence or absence of skin Disease involving the penis was investigated. The rate of circumcision in the general male dermatology population was determined. Results The most common diagnoses were psoriasis (n=94), penile infections (n=58), lichen sclerosus (n=52), lichen planus (n=39), seborrheic dermatitis (n=29), and Zoon balanitis (n=27). Less common diagnoses included squamous cell carcinoma (n=4), Bowenoid papulosis (n=3), and Bowen Disease (n=3). The age-adjusted odds ratio for all penile skin Diseases associated with presence of the foreskin was 3.24 (95% confidence interval, 2.26-4.64). All patients with Zoon balanitis, Bowenoid papulosis, and nonspecific balanoposthitis were uncircumcised. Lichen sclerosus was diagnosed in only 1 circumcised patient. Most patients with psoriasis, lichen planus, and seborrheic eczema (72%, 69%, and 72%, respectively) were uncircumcised at presentation. The majority of men with penile infections (84%) were uncircumcised. Conclusions Most cases of inflammatory dermatoses were diagnosed in uncircumcised men, suggesting that circumcision protects against inflammatory dermatoses. The presence of the foreskin may promote inflammation by a koebnerization phenomenon, or the presence of infectious agents, as yet unidentified, may induce inflammation. The data suggest that circumcision prevents or protects against common infective penile dermatoses.
Ehnis A Perez - One of the best experts on this subject based on the ideXlab platform.
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Bowen Disease of the nail unit a retrospective study of 12 cases and their association with human papillomaviruses
Journal of The European Academy of Dermatology and Venereology, 2016Co-Authors: Delphine Lydie Perruchoud, C Varonier, Eckart Haneke, Robert E Hunger, Helmut Beltraminelli, Luca Borradori, Ehnis A PerezAbstract:BACKGROUND Bowen Disease is the most frequent nail malignancy, usually seen as a verrucous plaque of the nail in men. OBJECTIVE To characterize the affected patient population, the clinical manifestations, the diagnostic delay and diagnostic steps, and presence of human papilloma virus (HPV) infection. METHODS We retrospectively evaluated all cases of Bowen Disease of the nail unit over a period of 9 years. Data were obtained from our electronic database. Human papilloma virus genotype was assessed in biopsy specimens by polymerase chain reaction (PCR) sequencing. RESULTS We identified 12 cases of Bowen Disease of the nail unit in 10 patients. Mean age at onset was 52 years, with a male predominance of 90%. The thumb and middle finger were the most frequently affected (66%). Fifty percent of the lesions presented as periungual and subungual verrucous tumours. Patients sought medical evaluation after a mean delay of 5.7 years; histopathological diagnosis was made after a mean delay of 3.2 years. HPV infection was identified in 75% of the cases. CONCLUSIONS Any recently appeared verrucous lesion of the nail unit in men above the age of 40 years should raise the suspicion of Bowen Disease and lead to further histopathological diagnostic procedures.