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Bowman Capsule

The Experts below are selected from a list of 15 Experts worldwide ranked by ideXlab platform

Takashi Yokoo – 1st expert on this subject based on the ideXlab platform

  • Bowman Capsule volume and related factors in adults with normal renal function
    Kidney International Reports, 2017
    Co-Authors: Takaya Sasaki, Nobuo Tsuboi, Kotaro Haruhara, Yusuke Okabayashi, Go Kanzaki, Kentaro Koike, Akimitsu Kobayashi, Izumi Yamamoto, Makoto Ogura, Takashi Yokoo

    Abstract:

    Introduction Alterations in glomerular filtration can considerably influence the dynamics and functions of the Bowman Capsule. Despite the potentially important role in maintaining normal renal functions, few studies have focused on Bowman Capsule volume in normal human kidneys. Methods We analyzed specimens from biopsies performed 1 hour after kidney transplantation from living donors without apparent renal disease. The measurements of all cross-sectional areas of the Bowman Capsules and glomerular capillaries were used to estimate the mean Bowman Capsule volume (BV) and glomerular capillary volume (GV) in each subject. The G/B ratio was defined as the ratio of GV to BV. The morphometric findings were examined in relation to the clinical findings in donors just before kidney transplantation. Results We analyzed 37 adults with a mean creatinine clearance of 111 ml/min. The mean BV and GV of these subjects were 6.10 ± 2.46 × 10 6 μm 3 and 3.83 ± 1.52 × 10 6 μm 3 , respectively. Both the BV and GV varied up to 6-fold and were significantly higher in elderly, obese, or hypertensive subjects in comparison to nonelderly, nonobese, or normotensive subjects, whereas the renal function of each subgroup was similar. The G/B ratio (0.63 ± 0.05) was unaffected, and BV and GV were strongly correlated regardless of these clinical factors ( r  = 0.980 [95% confidence interval = 0.961−0.990], P Conclusion In the normal adult kidney, there may be an optimal BV to GV ratio for maintaining effective filtration in a variety of clinical situations, including advanced age, obesity, and hypertension.

Bruno Bordoni – 2nd expert on this subject based on the ideXlab platform

  • “StatPearls” – Anatomy, Abdomen and Pelvis, Bowman Capsule
    , 2020
    Co-Authors: Samuel R. Falkson, Bruno Bordoni

    Abstract:

    Bowman‘s Capsule is a part of the nephron that forms a cup-like sack surrounding the glomerulus. Bowman‘s Capsule encloses a space called “Bowman‘s space,” which represents the beginning of the urinary space and is contiguous with the proximal convoluted tubule of the nephron. Bowman‘s Capsule, Bowman‘s space, and the glomerular capillary network and its supporting architecture can collectively be thought of as composing the glomerulus. There are an estimated 900000 glomeruli within the cortex of a mature human kidney.[1][2]

Takaya Sasaki – 3rd expert on this subject based on the ideXlab platform

  • Bowman Capsule volume and related factors in adults with normal renal function
    Kidney International Reports, 2017
    Co-Authors: Takaya Sasaki, Nobuo Tsuboi, Kotaro Haruhara, Yusuke Okabayashi, Go Kanzaki, Kentaro Koike, Akimitsu Kobayashi, Izumi Yamamoto, Makoto Ogura, Takashi Yokoo

    Abstract:

    Introduction Alterations in glomerular filtration can considerably influence the dynamics and functions of the Bowman Capsule. Despite the potentially important role in maintaining normal renal functions, few studies have focused on Bowman Capsule volume in normal human kidneys. Methods We analyzed specimens from biopsies performed 1 hour after kidney transplantation from living donors without apparent renal disease. The measurements of all cross-sectional areas of the Bowman Capsules and glomerular capillaries were used to estimate the mean Bowman Capsule volume (BV) and glomerular capillary volume (GV) in each subject. The G/B ratio was defined as the ratio of GV to BV. The morphometric findings were examined in relation to the clinical findings in donors just before kidney transplantation. Results We analyzed 37 adults with a mean creatinine clearance of 111 ml/min. The mean BV and GV of these subjects were 6.10 ± 2.46 × 10 6 μm 3 and 3.83 ± 1.52 × 10 6 μm 3 , respectively. Both the BV and GV varied up to 6-fold and were significantly higher in elderly, obese, or hypertensive subjects in comparison to nonelderly, nonobese, or normotensive subjects, whereas the renal function of each subgroup was similar. The G/B ratio (0.63 ± 0.05) was unaffected, and BV and GV were strongly correlated regardless of these clinical factors ( r  = 0.980 [95% confidence interval = 0.961−0.990], P Conclusion In the normal adult kidney, there may be an optimal BV to GV ratio for maintaining effective filtration in a variety of clinical situations, including advanced age, obesity, and hypertension.