The Experts below are selected from a list of 15 Experts worldwide ranked by ideXlab platform
Takashi Yokoo - One of the best experts on this subject based on the ideXlab platform.
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Bowman Capsule volume and related factors in adults with normal renal function
Kidney International Reports, 2017Co-Authors: Takaya Sasaki, Nobuo Tsuboi, Kotaro Haruhara, Yusuke Okabayashi, Go Kanzaki, Kentaro Koike, Akimitsu Kobayashi, Izumi Yamamoto, Makoto Ogura, Takashi YokooAbstract:Introduction Alterations in glomerular filtration can considerably influence the dynamics and functions of the Bowman Capsule. Despite the potentially important role in maintaining normal renal functions, few studies have focused on Bowman Capsule volume in normal human kidneys. Methods We analyzed specimens from biopsies performed 1 hour after kidney transplantation from living donors without apparent renal disease. The measurements of all cross-sectional areas of the Bowman Capsules and glomerular capillaries were used to estimate the mean Bowman Capsule volume (BV) and glomerular capillary volume (GV) in each subject. The G/B ratio was defined as the ratio of GV to BV. The morphometric findings were examined in relation to the clinical findings in donors just before kidney transplantation. Results We analyzed 37 adults with a mean creatinine clearance of 111 ml/min. The mean BV and GV of these subjects were 6.10 ± 2.46 × 10 6 μm 3 and 3.83 ± 1.52 × 10 6 μm 3 , respectively. Both the BV and GV varied up to 6-fold and were significantly higher in elderly, obese, or hypertensive subjects in comparison to nonelderly, nonobese, or normotensive subjects, whereas the renal function of each subgroup was similar. The G/B ratio (0.63 ± 0.05) was unaffected, and BV and GV were strongly correlated regardless of these clinical factors ( r = 0.980 [95% confidence interval = 0.961−0.990], P Conclusion In the normal adult kidney, there may be an optimal BV to GV ratio for maintaining effective filtration in a variety of clinical situations, including advanced age, obesity, and hypertension.
Bruno Bordoni - One of the best experts on this subject based on the ideXlab platform.
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"StatPearls" - Anatomy, Abdomen and Pelvis, Bowman Capsule
2020Co-Authors: Samuel R. Falkson, Bruno BordoniAbstract:Bowman's Capsule is a part of the nephron that forms a cup-like sack surrounding the glomerulus. Bowman's Capsule encloses a space called "Bowman's space," which represents the beginning of the urinary space and is contiguous with the proximal convoluted tubule of the nephron. Bowman's Capsule, Bowman's space, and the glomerular capillary network and its supporting architecture can collectively be thought of as composing the glomerulus. There are an estimated 900000 glomeruli within the cortex of a mature human kidney.[1][2]
Takaya Sasaki - One of the best experts on this subject based on the ideXlab platform.
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Bowman Capsule volume and related factors in adults with normal renal function
Kidney International Reports, 2017Co-Authors: Takaya Sasaki, Nobuo Tsuboi, Kotaro Haruhara, Yusuke Okabayashi, Go Kanzaki, Kentaro Koike, Akimitsu Kobayashi, Izumi Yamamoto, Makoto Ogura, Takashi YokooAbstract:Introduction Alterations in glomerular filtration can considerably influence the dynamics and functions of the Bowman Capsule. Despite the potentially important role in maintaining normal renal functions, few studies have focused on Bowman Capsule volume in normal human kidneys. Methods We analyzed specimens from biopsies performed 1 hour after kidney transplantation from living donors without apparent renal disease. The measurements of all cross-sectional areas of the Bowman Capsules and glomerular capillaries were used to estimate the mean Bowman Capsule volume (BV) and glomerular capillary volume (GV) in each subject. The G/B ratio was defined as the ratio of GV to BV. The morphometric findings were examined in relation to the clinical findings in donors just before kidney transplantation. Results We analyzed 37 adults with a mean creatinine clearance of 111 ml/min. The mean BV and GV of these subjects were 6.10 ± 2.46 × 10 6 μm 3 and 3.83 ± 1.52 × 10 6 μm 3 , respectively. Both the BV and GV varied up to 6-fold and were significantly higher in elderly, obese, or hypertensive subjects in comparison to nonelderly, nonobese, or normotensive subjects, whereas the renal function of each subgroup was similar. The G/B ratio (0.63 ± 0.05) was unaffected, and BV and GV were strongly correlated regardless of these clinical factors ( r = 0.980 [95% confidence interval = 0.961−0.990], P Conclusion In the normal adult kidney, there may be an optimal BV to GV ratio for maintaining effective filtration in a variety of clinical situations, including advanced age, obesity, and hypertension.
Donna J. Lager - One of the best experts on this subject based on the ideXlab platform.
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An Immunophenotypic Comparison of Metanephric Metaplasia of Bowman Capsular Epithelium With Metanephric Adenoma, Wilms Tumor, and Renal Development A Case Report and Review of the Literature
American Journal of Clinical Pathology, 2004Co-Authors: Edgar G. Fischer, J. Aidan Carney, Scott R. Anderson, Edward C. Klatt, Donna J. LagerAbstract:Metanephric metaplasia of the parietal epithelium of the Bowman Capsule is a rare pathologic finding of unknown pathogenesis that has occurred in patients with widespread malignant neoplasms of various types. We report this finding in a 25-year-old woman with partial expression of the Carney triad who died of a disseminated gastrointestinal stromal tumor, specifically a gastric stromal sarcoma. The metaplasia involved both kidneys diffusely. It originated in the parietal epithelium of the Bowman Capsule, extended into the proximal tubules, and focally surrounded the glomeruli in a semicircular manner. Immunohistochemical analysis revealed that the cells of metanephric metaplasia expressed the Wilms tumor gene product, bcl-2 protein, and CD57 and cytokeratin 7 and keratin AE1/AE3 focally, but not CD56. This immunophenotype parallels that of metanephric adenoma, Wilms tumor, and nephrogenic rests and overlaps with antigen expression in certain periods of renal development.
Kotaro Haruhara - One of the best experts on this subject based on the ideXlab platform.
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Bowman Capsule volume and related factors in adults with normal renal function
Kidney International Reports, 2017Co-Authors: Takaya Sasaki, Nobuo Tsuboi, Kotaro Haruhara, Yusuke Okabayashi, Go Kanzaki, Kentaro Koike, Akimitsu Kobayashi, Izumi Yamamoto, Makoto Ogura, Takashi YokooAbstract:Introduction Alterations in glomerular filtration can considerably influence the dynamics and functions of the Bowman Capsule. Despite the potentially important role in maintaining normal renal functions, few studies have focused on Bowman Capsule volume in normal human kidneys. Methods We analyzed specimens from biopsies performed 1 hour after kidney transplantation from living donors without apparent renal disease. The measurements of all cross-sectional areas of the Bowman Capsules and glomerular capillaries were used to estimate the mean Bowman Capsule volume (BV) and glomerular capillary volume (GV) in each subject. The G/B ratio was defined as the ratio of GV to BV. The morphometric findings were examined in relation to the clinical findings in donors just before kidney transplantation. Results We analyzed 37 adults with a mean creatinine clearance of 111 ml/min. The mean BV and GV of these subjects were 6.10 ± 2.46 × 10 6 μm 3 and 3.83 ± 1.52 × 10 6 μm 3 , respectively. Both the BV and GV varied up to 6-fold and were significantly higher in elderly, obese, or hypertensive subjects in comparison to nonelderly, nonobese, or normotensive subjects, whereas the renal function of each subgroup was similar. The G/B ratio (0.63 ± 0.05) was unaffected, and BV and GV were strongly correlated regardless of these clinical factors ( r = 0.980 [95% confidence interval = 0.961−0.990], P Conclusion In the normal adult kidney, there may be an optimal BV to GV ratio for maintaining effective filtration in a variety of clinical situations, including advanced age, obesity, and hypertension.