The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform

Liu Liegang - One of the best experts on this subject based on the ideXlab platform.

  • effect of deltamethrin on cyp450 activity in rat Brain Microsome
    Modern Preventive Medicine, 1999
    Co-Authors: Liu Liegang
    Abstract:

    The ethoxyresorufin O deethylase(EROD) and benzhloxyresorufin O dealkylatase(BROD) activities in rat Brain were determined by flurophotometry under the treatments of deltamethrin(DM) in vivo and in vitro.The results showed that in vivo,DM could markedly inhibit EROD activity in rat Brain Microsome after rats received DM(12 5mg.kg -1 .d -1 ,ip) for 5 days.The inhibitory rates in whole Brain,cerebral cortex were 32 0% and 37 7% respectively.DM also reduced BROD activity in whole Brain,cerebral cortex and cerebellum,the rates of inhibition were 26 7%,23 8% and 33 3% respectively.However,in vitro,under the concentration of 2×10 -8 ～2×10 -4 mol/L,there were no obvious changes of EROD and BROD activities in rat Brain.So the mechanism by which DM inhibit P450 activity in rat Brain Microsome is related to the fact that DM intervenes in the synthesis of protein.

Lanfranco Corazzi - One of the best experts on this subject based on the ideXlab platform.

  • rat Brain Microsome fluidity as modified by prenatal ethanol administration
    Neurochemical Research, 1993
    Co-Authors: Giuseppe Arienti, Gian Carlo Di Renzo, Ermelando V Cosmi, Enrico Carlini, Lanfranco Corazzi
    Abstract:

    The fluorescence anisotropy (r) of diphenylhexatriene (DPH) and of trimethylamino-diphenylhexatriene (TMA-DPH) as a function of temperature (10° to 54°C) was measured in Brain Microsomes of newborn rats prenatally exposed to ethanol. In this temperature range, the relationship between r and T was linear. The addition of ethanol in vitro to microsomal suspensions influenced the slope of the line of r versus T only when DPH was used as a probe and with high concentrations of the alcohol (≥0.3 M).

Giuseppe Arienti - One of the best experts on this subject based on the ideXlab platform.

  • rat Brain Microsome fluidity as modified by prenatal ethanol administration
    Neurochemical Research, 1993
    Co-Authors: Giuseppe Arienti, Gian Carlo Di Renzo, Ermelando V Cosmi, Enrico Carlini, Lanfranco Corazzi
    Abstract:

    The fluorescence anisotropy (r) of diphenylhexatriene (DPH) and of trimethylamino-diphenylhexatriene (TMA-DPH) as a function of temperature (10° to 54°C) was measured in Brain Microsomes of newborn rats prenatally exposed to ethanol. In this temperature range, the relationship between r and T was linear. The addition of ethanol in vitro to microsomal suspensions influenced the slope of the line of r versus T only when DPH was used as a probe and with high concentrations of the alcohol (≥0.3 M).

Gian Carlo Di Renzo - One of the best experts on this subject based on the ideXlab platform.

  • rat Brain Microsome fluidity as modified by prenatal ethanol administration
    Neurochemical Research, 1993
    Co-Authors: Giuseppe Arienti, Gian Carlo Di Renzo, Ermelando V Cosmi, Enrico Carlini, Lanfranco Corazzi
    Abstract:

    The fluorescence anisotropy (r) of diphenylhexatriene (DPH) and of trimethylamino-diphenylhexatriene (TMA-DPH) as a function of temperature (10° to 54°C) was measured in Brain Microsomes of newborn rats prenatally exposed to ethanol. In this temperature range, the relationship between r and T was linear. The addition of ethanol in vitro to microsomal suspensions influenced the slope of the line of r versus T only when DPH was used as a probe and with high concentrations of the alcohol (≥0.3 M).

Ermelando V Cosmi - One of the best experts on this subject based on the ideXlab platform.

  • rat Brain Microsome fluidity as modified by prenatal ethanol administration
    Neurochemical Research, 1993
    Co-Authors: Giuseppe Arienti, Gian Carlo Di Renzo, Ermelando V Cosmi, Enrico Carlini, Lanfranco Corazzi
    Abstract:

    The fluorescence anisotropy (r) of diphenylhexatriene (DPH) and of trimethylamino-diphenylhexatriene (TMA-DPH) as a function of temperature (10° to 54°C) was measured in Brain Microsomes of newborn rats prenatally exposed to ethanol. In this temperature range, the relationship between r and T was linear. The addition of ethanol in vitro to microsomal suspensions influenced the slope of the line of r versus T only when DPH was used as a probe and with high concentrations of the alcohol (≥0.3 M).