The Experts below are selected from a list of 837 Experts worldwide ranked by ideXlab platform

Masafumi Ito - One of the best experts on this subject based on the ideXlab platform.

  • M (2012) Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxid Med Cell Longev doi: 10.1155/2012/353152
    2020
    Co-Authors: Kinji Ohno, Mikako Ito, Masatoshi Ichihara, Masafumi Ito, Marcos Dias Pereira
    Abstract:

    Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson's disease and three models of Alzheimer's disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson's disease; ischemia/reperfusion of spinal cord, heart, lung, liver, kidney, and intestine; transplantation of lung, heart, kidney, and intestine. Six human diseases have been studied to date: diabetes mellitus type 2, metabolic syndrome, hemodialysis, inflammatory and mitochondrial myopathies, Brain Stem Infarction, and radiation-induced adverse effects. Two enigmas, however, remain to be solved. First, no dose-response effect is observed. Rodents and humans are able to take a small amount of hydrogen by drinking hydrogen-rich water, but marked effects are observed. Second, intestinal bacteria in humans and rodents produce a large amount of hydrogen, but an addition of a small amount of hydrogen exhibits marked effects. Further studies are required to elucidate molecular bases of prominent hydrogen effects and to determine the optimal frequency, amount, and method of hydrogen administration for each human disease

  • molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases
    Oxidative Medicine and Cellular Longevity, 2012
    Co-Authors: Kinji Ohno, Mikako Ito, Masatoshi Ichihara, Masafumi Ito
    Abstract:

    Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson's disease and three models of Alzheimer's disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson's disease; ischemia/reperfusion of spinal cord, heart, lung, liver, kidney, and intestine; transplantation of lung, heart, kidney, and intestine. Six human diseases have been studied to date: diabetes mellitus type 2, metabolic syndrome, hemodialysis, inflammatory and mitochondrial myopathies, Brain Stem Infarction, and radiation-induced adverse effects. Two enigmas, however, remain to be solved. First, no dose-response effect is observed. Rodents and humans are able to take a small amount of hydrogen by drinking hydrogen-rich water, but marked effects are observed. Second, intestinal bacteria in humans and rodents produce a large amount of hydrogen, but an addition of a small amount of hydrogen exhibits marked effects. Further studies are required to elucidate molecular bases of prominent hydrogen effects and to determine the optimal frequency, amount, and method of hydrogen administration for each human disease.

Peter Stoeter - One of the best experts on this subject based on the ideXlab platform.

  • a new method to investigate Brain Stem structural functional correlations using digital post processing mri reliability in ischemic internuclear ophthalmoplegia
    European Journal of Neurology, 2001
    Co-Authors: J J Marx, Sabine Fitzek, Clemens Fitzek, P P Urban, Peter Stoeter, F Thoemke, Goran Vucurevic, A Mikagruettner, H C Hopf
    Abstract:

    We investigated the reliability of a new digital post-processing magnetic resonance imaging (MRI) technique in ischemic Brain Stem lesions to identify relations of the lesion to anatomical Brain Stem structures. The target was a medial longitudinal fasciculus (MLF) lesion, which was evident from ipsilateral internuclear ophthalmoplegia (INO). Sixteen patients with acute unilateral INO and an isolated acute Brain Stem lesion in T2- and EPI-diffusion weighted MRI within 2 days after the onset of symptoms were studied. The MRI slice direction was parallel and perpendicular to a slice selection of a stereotactic anatomical atlas. The individual slices were normalized and projected in the digitalized atlas. The eye movement disorder was monitored by electro-oculography. In all patients with clinical or subclinical electro-oculographically documented INO and MRI proven Brain Stem Infarction the lesion covered or at least partially overlapped the ipsilateral MLF at one or more atlas levels. We conclude that digital post-processing MRI with normalizing and projecting Brain Stem lesions in an anatomical atlas is a reliable method to demonstrate the anatomical structures involved by the lesion. Combined with electrophysiological Brain Stem testing, this method may be a useful tool to identify incompletely understood pathways mediating Brain Stem reflexes or the generators of evoked potentials.

  • time course of lesion development in patients with acute Brain Stem Infarction and correlation with nihss score
    European Journal of Radiology, 2001
    Co-Authors: Sabine Fitzek, Clemens Fitzek, P P Urban, Juergen J Marx, Hanns Christian Hopf, Peter Stoeter
    Abstract:

    Abstract Background and purpose: diffusion weighted magnetic resonance imaging (MRI) is highly sensitive in detecting acute supratentorial cerebral ischemia and Diffusion Weighted Imaging (DWI) lesion size has been shown to correlate strongly with the neurologic deficit in middle cerebral artery territory stroke. However, data concerning infratentorial strokes are rare. We examined the size and evolution of acute Brain Stem ischemic lesions and their relationship to neurological outcome. Methods: Brain Stem Infarctions of 11 patients were analyzed. We performed DWI in all patients and in 7/11 patients within 24 h, T2W sequences within the first 2 weeks (10/11 patients) and follow-up MRI (MR2) within 3–9 months (median 4.8 months) later (12/12 patients). Lesion volumes were compared with early and follow-up neurologic deficit as determined by National Institutes of Health Stroke Scale (NIHSS) score. Results: the relative infarct volumes—with MR2 lesion size set to 100%—decreased over the time ( P P P P r =0.9, P r =0.71, P r =0.86, P Conclusions: in this study, we saw a shrinking of the Brain Stem infarct volume according to clinical improvement of patients. Great extension of restricted diffusion in the acute stage does not necessarily implicate a large resulting Infarction or a bad clinical outcome.

Sabine Fitzek - One of the best experts on this subject based on the ideXlab platform.

  • a new method to investigate Brain Stem structural functional correlations using digital post processing mri reliability in ischemic internuclear ophthalmoplegia
    European Journal of Neurology, 2001
    Co-Authors: J J Marx, Sabine Fitzek, Clemens Fitzek, P P Urban, Peter Stoeter, F Thoemke, Goran Vucurevic, A Mikagruettner, H C Hopf
    Abstract:

    We investigated the reliability of a new digital post-processing magnetic resonance imaging (MRI) technique in ischemic Brain Stem lesions to identify relations of the lesion to anatomical Brain Stem structures. The target was a medial longitudinal fasciculus (MLF) lesion, which was evident from ipsilateral internuclear ophthalmoplegia (INO). Sixteen patients with acute unilateral INO and an isolated acute Brain Stem lesion in T2- and EPI-diffusion weighted MRI within 2 days after the onset of symptoms were studied. The MRI slice direction was parallel and perpendicular to a slice selection of a stereotactic anatomical atlas. The individual slices were normalized and projected in the digitalized atlas. The eye movement disorder was monitored by electro-oculography. In all patients with clinical or subclinical electro-oculographically documented INO and MRI proven Brain Stem Infarction the lesion covered or at least partially overlapped the ipsilateral MLF at one or more atlas levels. We conclude that digital post-processing MRI with normalizing and projecting Brain Stem lesions in an anatomical atlas is a reliable method to demonstrate the anatomical structures involved by the lesion. Combined with electrophysiological Brain Stem testing, this method may be a useful tool to identify incompletely understood pathways mediating Brain Stem reflexes or the generators of evoked potentials.

  • time course of lesion development in patients with acute Brain Stem Infarction and correlation with nihss score
    European Journal of Radiology, 2001
    Co-Authors: Sabine Fitzek, Clemens Fitzek, P P Urban, Juergen J Marx, Hanns Christian Hopf, Peter Stoeter
    Abstract:

    Abstract Background and purpose: diffusion weighted magnetic resonance imaging (MRI) is highly sensitive in detecting acute supratentorial cerebral ischemia and Diffusion Weighted Imaging (DWI) lesion size has been shown to correlate strongly with the neurologic deficit in middle cerebral artery territory stroke. However, data concerning infratentorial strokes are rare. We examined the size and evolution of acute Brain Stem ischemic lesions and their relationship to neurological outcome. Methods: Brain Stem Infarctions of 11 patients were analyzed. We performed DWI in all patients and in 7/11 patients within 24 h, T2W sequences within the first 2 weeks (10/11 patients) and follow-up MRI (MR2) within 3–9 months (median 4.8 months) later (12/12 patients). Lesion volumes were compared with early and follow-up neurologic deficit as determined by National Institutes of Health Stroke Scale (NIHSS) score. Results: the relative infarct volumes—with MR2 lesion size set to 100%—decreased over the time ( P P P P r =0.9, P r =0.71, P r =0.86, P Conclusions: in this study, we saw a shrinking of the Brain Stem infarct volume according to clinical improvement of patients. Great extension of restricted diffusion in the acute stage does not necessarily implicate a large resulting Infarction or a bad clinical outcome.

Kinji Ohno - One of the best experts on this subject based on the ideXlab platform.

  • M (2012) Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxid Med Cell Longev doi: 10.1155/2012/353152
    2020
    Co-Authors: Kinji Ohno, Mikako Ito, Masatoshi Ichihara, Masafumi Ito, Marcos Dias Pereira
    Abstract:

    Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson's disease and three models of Alzheimer's disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson's disease; ischemia/reperfusion of spinal cord, heart, lung, liver, kidney, and intestine; transplantation of lung, heart, kidney, and intestine. Six human diseases have been studied to date: diabetes mellitus type 2, metabolic syndrome, hemodialysis, inflammatory and mitochondrial myopathies, Brain Stem Infarction, and radiation-induced adverse effects. Two enigmas, however, remain to be solved. First, no dose-response effect is observed. Rodents and humans are able to take a small amount of hydrogen by drinking hydrogen-rich water, but marked effects are observed. Second, intestinal bacteria in humans and rodents produce a large amount of hydrogen, but an addition of a small amount of hydrogen exhibits marked effects. Further studies are required to elucidate molecular bases of prominent hydrogen effects and to determine the optimal frequency, amount, and method of hydrogen administration for each human disease

  • molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases
    Oxidative Medicine and Cellular Longevity, 2012
    Co-Authors: Kinji Ohno, Mikako Ito, Masatoshi Ichihara, Masafumi Ito
    Abstract:

    Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson's disease and three models of Alzheimer's disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson's disease; ischemia/reperfusion of spinal cord, heart, lung, liver, kidney, and intestine; transplantation of lung, heart, kidney, and intestine. Six human diseases have been studied to date: diabetes mellitus type 2, metabolic syndrome, hemodialysis, inflammatory and mitochondrial myopathies, Brain Stem Infarction, and radiation-induced adverse effects. Two enigmas, however, remain to be solved. First, no dose-response effect is observed. Rodents and humans are able to take a small amount of hydrogen by drinking hydrogen-rich water, but marked effects are observed. Second, intestinal bacteria in humans and rodents produce a large amount of hydrogen, but an addition of a small amount of hydrogen exhibits marked effects. Further studies are required to elucidate molecular bases of prominent hydrogen effects and to determine the optimal frequency, amount, and method of hydrogen administration for each human disease.

Clemens Fitzek - One of the best experts on this subject based on the ideXlab platform.

  • a new method to investigate Brain Stem structural functional correlations using digital post processing mri reliability in ischemic internuclear ophthalmoplegia
    European Journal of Neurology, 2001
    Co-Authors: J J Marx, Sabine Fitzek, Clemens Fitzek, P P Urban, Peter Stoeter, F Thoemke, Goran Vucurevic, A Mikagruettner, H C Hopf
    Abstract:

    We investigated the reliability of a new digital post-processing magnetic resonance imaging (MRI) technique in ischemic Brain Stem lesions to identify relations of the lesion to anatomical Brain Stem structures. The target was a medial longitudinal fasciculus (MLF) lesion, which was evident from ipsilateral internuclear ophthalmoplegia (INO). Sixteen patients with acute unilateral INO and an isolated acute Brain Stem lesion in T2- and EPI-diffusion weighted MRI within 2 days after the onset of symptoms were studied. The MRI slice direction was parallel and perpendicular to a slice selection of a stereotactic anatomical atlas. The individual slices were normalized and projected in the digitalized atlas. The eye movement disorder was monitored by electro-oculography. In all patients with clinical or subclinical electro-oculographically documented INO and MRI proven Brain Stem Infarction the lesion covered or at least partially overlapped the ipsilateral MLF at one or more atlas levels. We conclude that digital post-processing MRI with normalizing and projecting Brain Stem lesions in an anatomical atlas is a reliable method to demonstrate the anatomical structures involved by the lesion. Combined with electrophysiological Brain Stem testing, this method may be a useful tool to identify incompletely understood pathways mediating Brain Stem reflexes or the generators of evoked potentials.

  • time course of lesion development in patients with acute Brain Stem Infarction and correlation with nihss score
    European Journal of Radiology, 2001
    Co-Authors: Sabine Fitzek, Clemens Fitzek, P P Urban, Juergen J Marx, Hanns Christian Hopf, Peter Stoeter
    Abstract:

    Abstract Background and purpose: diffusion weighted magnetic resonance imaging (MRI) is highly sensitive in detecting acute supratentorial cerebral ischemia and Diffusion Weighted Imaging (DWI) lesion size has been shown to correlate strongly with the neurologic deficit in middle cerebral artery territory stroke. However, data concerning infratentorial strokes are rare. We examined the size and evolution of acute Brain Stem ischemic lesions and their relationship to neurological outcome. Methods: Brain Stem Infarctions of 11 patients were analyzed. We performed DWI in all patients and in 7/11 patients within 24 h, T2W sequences within the first 2 weeks (10/11 patients) and follow-up MRI (MR2) within 3–9 months (median 4.8 months) later (12/12 patients). Lesion volumes were compared with early and follow-up neurologic deficit as determined by National Institutes of Health Stroke Scale (NIHSS) score. Results: the relative infarct volumes—with MR2 lesion size set to 100%—decreased over the time ( P P P P r =0.9, P r =0.71, P r =0.86, P Conclusions: in this study, we saw a shrinking of the Brain Stem infarct volume according to clinical improvement of patients. Great extension of restricted diffusion in the acute stage does not necessarily implicate a large resulting Infarction or a bad clinical outcome.