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Michael D. Delp - One of the best experts on this subject based on the ideXlab platform.

  • Acute and chronic head-down tail suspension diminishes cerebral perfusion in rats
    American journal of physiology. Heart and circulatory physiology, 2002
    Co-Authors: M. Keith Wilkerson, Patrick N. Colleran, Michael D. Delp
    Abstract:

    The purpose of this study was to test the hypothesis that regional Brain blood flow and Vascular Resistance are altered by acute and chronic head-down tail suspension (HDT). Regional cerebral blood flow, arterial pressure, heart rate, and Vascular Resistance were measured in a group of control rats during normal standing and following 10 min of HDT and in two other groups of rats after 7 and 28 days of HDT. Heart rate was not different among conditions, whereas mean arterial pressure was elevated at 10 min of HDT relative to the other conditions. Total Brain blood flow was reduced from that during standing by 48, 24, and 27% following 10 min and 7 and 28 days of HDT, respectively. Regional blood flows to all cerebral tissues and the eyes were reduced with 10 min of HDT and remained lower in the eye, olfactory bulbs, left and right cerebrum, thalamic region, and the midBrain with 7 and 28 days of HDT. Total Brain Vascular Resistance was 116, 44, and 38% greater following 10 min and 7 and 28 days of HDT, respectively, relative to that during control standing. Vascular Resistance was elevated in all cerebral regions with 10 min of HDT and remained higher than control levels in most Brain regions. These results demonstrate that HDT results in chronic elevations in total and regional cerebral Vascular Resistance, and this may be the underlying stimulus for the HDT-induced smooth muscle hypertrophy of cerebral Resistance arteries.

M. Keith Wilkerson - One of the best experts on this subject based on the ideXlab platform.

  • Acute and chronic head-down tail suspension diminishes cerebral perfusion in rats
    American journal of physiology. Heart and circulatory physiology, 2002
    Co-Authors: M. Keith Wilkerson, Patrick N. Colleran, Michael D. Delp
    Abstract:

    The purpose of this study was to test the hypothesis that regional Brain blood flow and Vascular Resistance are altered by acute and chronic head-down tail suspension (HDT). Regional cerebral blood flow, arterial pressure, heart rate, and Vascular Resistance were measured in a group of control rats during normal standing and following 10 min of HDT and in two other groups of rats after 7 and 28 days of HDT. Heart rate was not different among conditions, whereas mean arterial pressure was elevated at 10 min of HDT relative to the other conditions. Total Brain blood flow was reduced from that during standing by 48, 24, and 27% following 10 min and 7 and 28 days of HDT, respectively. Regional blood flows to all cerebral tissues and the eyes were reduced with 10 min of HDT and remained lower in the eye, olfactory bulbs, left and right cerebrum, thalamic region, and the midBrain with 7 and 28 days of HDT. Total Brain Vascular Resistance was 116, 44, and 38% greater following 10 min and 7 and 28 days of HDT, respectively, relative to that during control standing. Vascular Resistance was elevated in all cerebral regions with 10 min of HDT and remained higher than control levels in most Brain regions. These results demonstrate that HDT results in chronic elevations in total and regional cerebral Vascular Resistance, and this may be the underlying stimulus for the HDT-induced smooth muscle hypertrophy of cerebral Resistance arteries.

Patrick N. Colleran - One of the best experts on this subject based on the ideXlab platform.

  • Acute and chronic head-down tail suspension diminishes cerebral perfusion in rats
    American journal of physiology. Heart and circulatory physiology, 2002
    Co-Authors: M. Keith Wilkerson, Patrick N. Colleran, Michael D. Delp
    Abstract:

    The purpose of this study was to test the hypothesis that regional Brain blood flow and Vascular Resistance are altered by acute and chronic head-down tail suspension (HDT). Regional cerebral blood flow, arterial pressure, heart rate, and Vascular Resistance were measured in a group of control rats during normal standing and following 10 min of HDT and in two other groups of rats after 7 and 28 days of HDT. Heart rate was not different among conditions, whereas mean arterial pressure was elevated at 10 min of HDT relative to the other conditions. Total Brain blood flow was reduced from that during standing by 48, 24, and 27% following 10 min and 7 and 28 days of HDT, respectively. Regional blood flows to all cerebral tissues and the eyes were reduced with 10 min of HDT and remained lower in the eye, olfactory bulbs, left and right cerebrum, thalamic region, and the midBrain with 7 and 28 days of HDT. Total Brain Vascular Resistance was 116, 44, and 38% greater following 10 min and 7 and 28 days of HDT, respectively, relative to that during control standing. Vascular Resistance was elevated in all cerebral regions with 10 min of HDT and remained higher than control levels in most Brain regions. These results demonstrate that HDT results in chronic elevations in total and regional cerebral Vascular Resistance, and this may be the underlying stimulus for the HDT-induced smooth muscle hypertrophy of cerebral Resistance arteries.

Konstantine Lukashev - One of the best experts on this subject based on the ideXlab platform.

  • Dynamics of ExtraVascular Pulmonary Water and Intracranial Pressure in Patients With Ischemic Stroke
    Seminars in cardiothoracic and vascular anesthesia, 2010
    Co-Authors: Mikhail Verein, Azat Valiahmedov, Yuri Churliaev, Pavel Sitnikov, Larisa Redkokasha, Konstantine Lukashev
    Abstract:

    The objective of the present study was to examine the relationship among extraVascular pulmonary water, intracranial and cerebral perfusion pressure, hemodynamic parameters (eg, cardiac index, system Vascular Resistance index), and Brain stem function during acute ischemic stroke. The subjects were 17 comatose patients with ischemic stroke who were admitted to an intensive care unit. The results revealed an elevation in extraVascular lung water in the absence of cardiac dysfunction. The absence of correlation between indices of Brain Vascular Resistance and mean arterial pressure confirmed that a disturbance of cerebral blood flow was present. There was a correlation between auditory-evoked potential parameters and extraVascular lung water during the study period. The correlation between auditory-evoked potentials and extraVascular lung water may imply that ischemic Brainstem injury plays a significant role in the development of increased pulmonary capillary permeability and the elevation of extraVascular lung water. Brain stem injury is a cause of noncardiogenic lung edema in comatose patients following acute ischemic stroke.

Mikhail Verein - One of the best experts on this subject based on the ideXlab platform.

  • Dynamics of ExtraVascular Pulmonary Water and Intracranial Pressure in Patients With Ischemic Stroke
    Seminars in cardiothoracic and vascular anesthesia, 2010
    Co-Authors: Mikhail Verein, Azat Valiahmedov, Yuri Churliaev, Pavel Sitnikov, Larisa Redkokasha, Konstantine Lukashev
    Abstract:

    The objective of the present study was to examine the relationship among extraVascular pulmonary water, intracranial and cerebral perfusion pressure, hemodynamic parameters (eg, cardiac index, system Vascular Resistance index), and Brain stem function during acute ischemic stroke. The subjects were 17 comatose patients with ischemic stroke who were admitted to an intensive care unit. The results revealed an elevation in extraVascular lung water in the absence of cardiac dysfunction. The absence of correlation between indices of Brain Vascular Resistance and mean arterial pressure confirmed that a disturbance of cerebral blood flow was present. There was a correlation between auditory-evoked potential parameters and extraVascular lung water during the study period. The correlation between auditory-evoked potentials and extraVascular lung water may imply that ischemic Brainstem injury plays a significant role in the development of increased pulmonary capillary permeability and the elevation of extraVascular lung water. Brain stem injury is a cause of noncardiogenic lung edema in comatose patients following acute ischemic stroke.