The Experts below are selected from a list of 15 Experts worldwide ranked by ideXlab platform
Lineu Cesar Werneck - One of the best experts on this subject based on the ideXlab platform.
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reversible parkinsonian syndrome in systemic and Brain Vasculitis
Movement Disorders, 2002Co-Authors: Giorgio Fabiani, Helio A G Teive, Francisco M B Germiniani, Lineu Cesar WerneckAbstract:A young female patient with chronic renal failure due to a systemic Vasculitis and a parkinsonian syndrome secondary to Brain Vasculitis, most likely systemic lupus erythematosus, is described. The patient had a dramatic response to a pulse of methylprednisolone, with remision of her parkinsonian symptoms. © 2002 Movement Disorder Society.
H. Akaoka - One of the best experts on this subject based on the ideXlab platform.
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A golden hamster model for human acute Nipah virus infection
The American journal of pathology, 2003Co-Authors: K. Thong Wong, I. Grosjean, C. Brisson, B. Blanquier, M. Fevre-montange, A. Bernard, P. Loth, Mc Georges-courbot, M. Chevallier, H. AkaokaAbstract:A predominantly pig-to-human zoonotic infection caused by the novel Nipah virus emerged recently to cause severe morbidity and mortality in both animals and man. Human autopsy studies showed the pathogenesis to be related to systemic Vasculitis that led to widespread thrombotic occlusion and microinfarction in most major organs especially in the central nervous system. There was also evidence of extravascular parenchymal infection, particularly near damaged vessels (Wong KT, Shieh WJ, Kumar S, Norain K, Abdullah W, Guarner J, Goldsmith CS, Chua KB, Lam SK, Tan CT, Goh KJ, Chong HT, Jusoh R, Rollin PE, Ksiazek TG, Zaki SR, Nipah Virus Pathology Working Group: Nipah virus infection: Pathology and pathogenesis of an emerging paramyxoviral zoonosis. Am J Pathol 2002, 161:2153–2167). We describe here a golden hamster (Mesocricetus auratus) model that appears to reproduce the pathology and pathogenesis of acute human Nipah infection. Hamsters infected by intranasal or intraperitoneal routes died within 9 to 29 days or 5 to 9 days, respectively. Pathological lesions were most severe and extensive in the hamster Brain. Vasculitis, thrombosis, and more rarely, multinucleated endothelial syncytia, were found in blood vessels of multiple organs. Viral antigen and RNA were localized in both vascular and extravascular tissues including neurons, lung, kidney, and spleen, as demonstrated by immunohistochemistry and in situ hybridization, respectively. Paramyxoviral-type nucleocapsids were identified in neurons and in vessel walls. At the terminal stage of infection, virus and/or viral RNA could be recovered from most solid organs and urine, but not from serum. The golden hamster is proposed as a suitable model for further studies including pathogenesis studies, anti-viral drug testing, and vaccine development against acute Nipah infection.
Takafumi Yura - One of the best experts on this subject based on the ideXlab platform.
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case of microscopic polyangiitis accompanied by central nervous system symptoms and Brain Vasculitis observed histopathologically
Japanese Journal of Nephrology, 2011Co-Authors: Hiroko Matsuda, Tamaki Harada, Yutaka Ando, Aya Nakamori, Shinichi Nakatsuka, Toshiro Takama, Takafumi YuraAbstract:A 65-year-old-man complained of coughing and fever. The urine showed microscopic hematuria. The level of myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) was 167 EU. Two months later, he was admitted to our hospital with pulmonary hemorrhage and progressive renal dysfunction. He was treated with intravenous methylprednisolone followed by oral prednisolone with plasma exchanges, and his first pulmonary hemorrhage was relieved. Three weeks later, he suffered from a second diffuse pulmonary hemorrhage with central nervous system symptoms. He was treated again with intravenous methylprednisolone, plasma exchanges, and also intravenous pulse cyclophosphamide (IVCY), but he died of respiratory failure. Autopsy findings revealed microscopic polyangiitis (MPA)in the Brain as well as in the lung, kidney and gastrointestinal system. The histopathological findings suggested that cerebral nervous system symptoms could have been caused by Brain Vasculitis in this case.
Giorgio Fabiani - One of the best experts on this subject based on the ideXlab platform.
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reversible parkinsonian syndrome in systemic and Brain Vasculitis
Movement Disorders, 2002Co-Authors: Giorgio Fabiani, Helio A G Teive, Francisco M B Germiniani, Lineu Cesar WerneckAbstract:A young female patient with chronic renal failure due to a systemic Vasculitis and a parkinsonian syndrome secondary to Brain Vasculitis, most likely systemic lupus erythematosus, is described. The patient had a dramatic response to a pulse of methylprednisolone, with remision of her parkinsonian symptoms. © 2002 Movement Disorder Society.
K. Thong Wong - One of the best experts on this subject based on the ideXlab platform.
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A golden hamster model for human acute Nipah virus infection
The American journal of pathology, 2003Co-Authors: K. Thong Wong, I. Grosjean, C. Brisson, B. Blanquier, M. Fevre-montange, A. Bernard, P. Loth, Mc Georges-courbot, M. Chevallier, H. AkaokaAbstract:A predominantly pig-to-human zoonotic infection caused by the novel Nipah virus emerged recently to cause severe morbidity and mortality in both animals and man. Human autopsy studies showed the pathogenesis to be related to systemic Vasculitis that led to widespread thrombotic occlusion and microinfarction in most major organs especially in the central nervous system. There was also evidence of extravascular parenchymal infection, particularly near damaged vessels (Wong KT, Shieh WJ, Kumar S, Norain K, Abdullah W, Guarner J, Goldsmith CS, Chua KB, Lam SK, Tan CT, Goh KJ, Chong HT, Jusoh R, Rollin PE, Ksiazek TG, Zaki SR, Nipah Virus Pathology Working Group: Nipah virus infection: Pathology and pathogenesis of an emerging paramyxoviral zoonosis. Am J Pathol 2002, 161:2153–2167). We describe here a golden hamster (Mesocricetus auratus) model that appears to reproduce the pathology and pathogenesis of acute human Nipah infection. Hamsters infected by intranasal or intraperitoneal routes died within 9 to 29 days or 5 to 9 days, respectively. Pathological lesions were most severe and extensive in the hamster Brain. Vasculitis, thrombosis, and more rarely, multinucleated endothelial syncytia, were found in blood vessels of multiple organs. Viral antigen and RNA were localized in both vascular and extravascular tissues including neurons, lung, kidney, and spleen, as demonstrated by immunohistochemistry and in situ hybridization, respectively. Paramyxoviral-type nucleocapsids were identified in neurons and in vessel walls. At the terminal stage of infection, virus and/or viral RNA could be recovered from most solid organs and urine, but not from serum. The golden hamster is proposed as a suitable model for further studies including pathogenesis studies, anti-viral drug testing, and vaccine development against acute Nipah infection.