The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Ashok K Malani - One of the best experts on this subject based on the ideXlab platform.
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pure primary squamous cell carcinoma of the Breast a rare presentation and clinicopathologic comparison with usual ductal carcinoma of the Breast
Pathology Research and Practice, 2006Co-Authors: Chakshu Gupta, Ashok K Malani, Robert T Weigand, Guatam RangineniAbstract:Pure and primary squamous cell carcinomas of the Breast are exceedingly uncommon lesions. To the best of our knowledge, based up on review of the literature, only four studies of patients with these tumors, which presented clinically as Breast Abscess, have been reported previously. We present a woman who sought medical attention for Breast pain and was initially diagnosed with a Breast Abscess. When she did not respond to antibiotic therapy, an incision as well as drainage was performed. Histologic examination of the material revealed a pure squamous cell carcinoma. An extensive work up ruled out other primary sites. She was treated with mastectomy and radiation therapy and has seen disease-free 3 years postdiagnosis. We also review the literature for presenting features, value of imaging studies, role of cytology in diagnosis, and therapy of such tumors in comparison to the usual ductal carcinomas of the Breast.
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Abscess as initial presentation of pure primary squamous cell carcinoma of the Breast
Clinical Breast Cancer, 2006Co-Authors: Chakshu Gupta, Ashok K MalaniAbstract:al.1 Pure primary squamous cell carcinoma of the Breast is indeed an extremely rare tumor. In addition, review of the literature reveals only 4 reports of pure primary squamous cell carcinomas of the Breast presenting as Breast Abscess.2-5 We were involved in the care of a 43-year-old woman who presented with acute onset pain and tenderness in the right Breast. She had not had screening mammograms. Examination revealed erythema and hyperemia of the right Breast. A mass lesion was not palpated. An ultrasound examination of the right Breast revealed a slightly ill-defined 5-cm mass with a thick rind and diminished echogenicity centrally, consistent with an Abscess. A clinical diagnosis of right Breast Abscess was rendered, and aspiration of the possible Abscess was performed under local anesthesia. Brownish fluid was removed by aspiration, and this resulted in symptomatic improvement. The patient was discharged on antibiotics. The fluid was not submitted for cytologic evaluation. She returned a few days later without resolution of her symptoms; an incision and drainage of the Abscess with biopsies of the Abscess wall were performed under general anesthesia. Pathologic examination of the biopsy results revealed an infiltrative, poorly differentiated, squamous cell carcinoma in a background of necrotic debris, fibrosis, and granulation tissue. The patient underwent a modified radical mastectomy of the right Breast, which confirmed the initial biopsy diagnosis. Areas of usual ductal adenocarcinoma were not identified with extensive sampling. There was no involvement of the skin or adenexal elements. Nineteen axillary lymph nodes were dissected and were negative for metastatic disease. Breast tumor profile was negative for estrogen receptor, progesterone receptor, and HER2/neu overexpression. An extensive workup that included computed tomography scans of the neck, chest, abdomen, and pelvis and a whole body [18F]fluorodeoxyglucose–positron emission tomography scan ruled out another primary squamous cell carcinoma. She received postoperative radiation therapy to the mastectomy site and supraclavicular region and has remained disease free for 3 years. Review of the 4 reports of pure primary squamous cell carcinoma presenting as Breast Abscess (total of 6 women) and the clinicopathologic features of our present patient support the observations made by Siegelmann-Danieli et al for all squamous cell carcinoma.1 We also found that the women tend to be older (postmenopausal), the lesions tend to be bigger (range, 2-5 cm), axillary lymph node metastasis is significantly lower, and Breast tumor markers (estrogen receptor, progesterone receptor, and HER2/neu overexpression) are usually negative compared with usual ductal adenocarcinoma of the Breast. Adjuvant chemotherapy with 5-fluorouracil and cisplatin, with or without doxorubicin, has been recommended.3-4 We should add that ultrasound has been reported as more helpful than mammography in the evaluation of these women.3,6 In conclusion, pure primary squamous cell carcinomas of the Breast are rare tumors and can infrequently present as a Breast Abscess. Clinicians should keep this differential in mind, especially in postmenopausal women with large lesions not responding to antibiotics.
Chakshu Gupta - One of the best experts on this subject based on the ideXlab platform.
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pure primary squamous cell carcinoma of the Breast a rare presentation and clinicopathologic comparison with usual ductal carcinoma of the Breast
Pathology Research and Practice, 2006Co-Authors: Chakshu Gupta, Ashok K Malani, Robert T Weigand, Guatam RangineniAbstract:Pure and primary squamous cell carcinomas of the Breast are exceedingly uncommon lesions. To the best of our knowledge, based up on review of the literature, only four studies of patients with these tumors, which presented clinically as Breast Abscess, have been reported previously. We present a woman who sought medical attention for Breast pain and was initially diagnosed with a Breast Abscess. When she did not respond to antibiotic therapy, an incision as well as drainage was performed. Histologic examination of the material revealed a pure squamous cell carcinoma. An extensive work up ruled out other primary sites. She was treated with mastectomy and radiation therapy and has seen disease-free 3 years postdiagnosis. We also review the literature for presenting features, value of imaging studies, role of cytology in diagnosis, and therapy of such tumors in comparison to the usual ductal carcinomas of the Breast.
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Abscess as initial presentation of pure primary squamous cell carcinoma of the Breast
Clinical Breast Cancer, 2006Co-Authors: Chakshu Gupta, Ashok K MalaniAbstract:al.1 Pure primary squamous cell carcinoma of the Breast is indeed an extremely rare tumor. In addition, review of the literature reveals only 4 reports of pure primary squamous cell carcinomas of the Breast presenting as Breast Abscess.2-5 We were involved in the care of a 43-year-old woman who presented with acute onset pain and tenderness in the right Breast. She had not had screening mammograms. Examination revealed erythema and hyperemia of the right Breast. A mass lesion was not palpated. An ultrasound examination of the right Breast revealed a slightly ill-defined 5-cm mass with a thick rind and diminished echogenicity centrally, consistent with an Abscess. A clinical diagnosis of right Breast Abscess was rendered, and aspiration of the possible Abscess was performed under local anesthesia. Brownish fluid was removed by aspiration, and this resulted in symptomatic improvement. The patient was discharged on antibiotics. The fluid was not submitted for cytologic evaluation. She returned a few days later without resolution of her symptoms; an incision and drainage of the Abscess with biopsies of the Abscess wall were performed under general anesthesia. Pathologic examination of the biopsy results revealed an infiltrative, poorly differentiated, squamous cell carcinoma in a background of necrotic debris, fibrosis, and granulation tissue. The patient underwent a modified radical mastectomy of the right Breast, which confirmed the initial biopsy diagnosis. Areas of usual ductal adenocarcinoma were not identified with extensive sampling. There was no involvement of the skin or adenexal elements. Nineteen axillary lymph nodes were dissected and were negative for metastatic disease. Breast tumor profile was negative for estrogen receptor, progesterone receptor, and HER2/neu overexpression. An extensive workup that included computed tomography scans of the neck, chest, abdomen, and pelvis and a whole body [18F]fluorodeoxyglucose–positron emission tomography scan ruled out another primary squamous cell carcinoma. She received postoperative radiation therapy to the mastectomy site and supraclavicular region and has remained disease free for 3 years. Review of the 4 reports of pure primary squamous cell carcinoma presenting as Breast Abscess (total of 6 women) and the clinicopathologic features of our present patient support the observations made by Siegelmann-Danieli et al for all squamous cell carcinoma.1 We also found that the women tend to be older (postmenopausal), the lesions tend to be bigger (range, 2-5 cm), axillary lymph node metastasis is significantly lower, and Breast tumor markers (estrogen receptor, progesterone receptor, and HER2/neu overexpression) are usually negative compared with usual ductal adenocarcinoma of the Breast. Adjuvant chemotherapy with 5-fluorouracil and cisplatin, with or without doxorubicin, has been recommended.3-4 We should add that ultrasound has been reported as more helpful than mammography in the evaluation of these women.3,6 In conclusion, pure primary squamous cell carcinomas of the Breast are rare tumors and can infrequently present as a Breast Abscess. Clinicians should keep this differential in mind, especially in postmenopausal women with large lesions not responding to antibiotics.
Elvira Mustać - One of the best experts on this subject based on the ideXlab platform.
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Breast Abscess in a Man Due to Salmonella enterica Serotype Enteritidis
Journal of Clinical Microbiology, 2011Co-Authors: Nada Brnčić, Lari Gorup, Miroslav Strčić, Maja Abram, Elvira MustaćAbstract:Nontyphoidal salmonellae can cause Breast infection only exceptionally. A case of Breast Abscess in a 70-year-old man due to Salmonella enterica serotype Enteritidis (Salmonella Enteritidis) is reported. The infection was successfully treated with a combination of surgical and antibiotic treatment.
Guatam Rangineni - One of the best experts on this subject based on the ideXlab platform.
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pure primary squamous cell carcinoma of the Breast a rare presentation and clinicopathologic comparison with usual ductal carcinoma of the Breast
Pathology Research and Practice, 2006Co-Authors: Chakshu Gupta, Ashok K Malani, Robert T Weigand, Guatam RangineniAbstract:Pure and primary squamous cell carcinomas of the Breast are exceedingly uncommon lesions. To the best of our knowledge, based up on review of the literature, only four studies of patients with these tumors, which presented clinically as Breast Abscess, have been reported previously. We present a woman who sought medical attention for Breast pain and was initially diagnosed with a Breast Abscess. When she did not respond to antibiotic therapy, an incision as well as drainage was performed. Histologic examination of the material revealed a pure squamous cell carcinoma. An extensive work up ruled out other primary sites. She was treated with mastectomy and radiation therapy and has seen disease-free 3 years postdiagnosis. We also review the literature for presenting features, value of imaging studies, role of cytology in diagnosis, and therapy of such tumors in comparison to the usual ductal carcinomas of the Breast.
Rajeev Atri - One of the best experts on this subject based on the ideXlab platform.
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pure squamous cell carcinoma of the Breast presenting as a pyogenic Abscess a case report
Clinical Breast Cancer, 2007Co-Authors: Vimoj Nair, Vivek Kaushal, Rajeev AtriAbstract:The field of oncology is studded with fascinating case reports of rarities, and management of Breast cancer by the oncologist has, at times, resulted in the surfacing of such instances of rarities. Pure squamous cell carcinoma (SCC) of the Breast is such an example of a rare and generally aggressive malignancy constituting < 0.1% of invasive Breast cancers. To the best of our knowledge, until 2006, only 5 patients of primary SCC of the Breast, which presented clinically as Breast Abscess, have been reported in medical literature. We report the sixth worldwide case of pure primary SCC of the Breast presenting as an Abscess. In this report, we highlight the fact that a benign lesion like Breast Abscess can harbor such a rare malignancy. Clinicians should be aware of that fact, and adequate investigations should be done to rule out that possibility. Extensive literature review has been done to discuss the clinical and radiologic features as well as management of this rare lesion.