The Experts below are selected from a list of 270 Experts worldwide ranked by ideXlab platform

Graham A Colditz - One of the best experts on this subject based on the ideXlab platform.

  • adolescent alcohol nuts and fiber combined effects on benign Breast Disease risk in young women
    NPJ breast cancer, 2020
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    AbstractAdolescent drinking is associated with higher risks of proliferative benign Breast Disease (BBD) and invasive Breast cancer (BC). Furthermore, adolescent nut and fiber consumptions are associated with lower risks of benign lesions and premenopausal BC. We hypothesize that diet (nuts, fiber) may mitigate the elevated BBD risk associated with alcohol. A prospective cohort of 9031 females, 9–15 years at baseline, completed questionnaires in 1996–2001, 2003, 2005, 2007, 2010, 2013, and 2014. Participants completed food frequency questionnaires in 1996–2001. In 2005, participants (>=18 years) began reporting biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression estimated associations between BBD and cross-classified intakes (14–17 years) of alcohol and peanut butter/nuts (separately, total dietary fiber). Only 19% of participants drank in high school; drinking was associated with elevated BBD risk (OR = 1.75, 95% CI: 1.20–2.56; p = 0.004) compared to nondrinkers. Participants consuming any nuts/butter had lower BBD risk (OR = 0.64, 95% CI: 0.45–0.90; p = 0.01) compared to those consuming none. Participants in top 75% fiber intake had lower risk (OR = 0.57, 95% CI: 0.40–0.81; p = 0.002) compared to bottom quartile. Testing our hypothesis that consuming nuts/butter mitigates the elevated alcohol risk, analyzing alcohol and nuts combined found that those who consumed both had lower risk (RR = 0.47, 95% CI: 0.24–0.89; p = 0.02) compared to drinkers eating no nuts. Our analysis of alcohol and fiber together did not demonstrate risk mitigation by fiber. For high school females who drink, their BBD risk may be attenuated by consuming nuts. Due to modest numbers, future studies need to replicate our findings in adolescent/adult females. However, high school students may be encouraged to eat nuts and fiber, and to avoid alcohol, to reduce risk of BBD and for general health benefits.

  • Dietary intake from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2019
    Co-Authors: Catherine S Berkey, A. Lindsay Frazier, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Graham A Colditz
    Abstract:

    PurposeNutritional factors during different periods in life impact Breast cancer risk. Because benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, we investigated childhood nutrition from birth through age 14 year and subsequent BBD.MethodsA prospective cohort study of 9031 females, 9–15 year at baseline, completed questionnaires (including heights, weights) annually from 1996 to 2001, in 2003, 2005, 2007, 2010, 2013 and 2014. In 1996, mothers reported infant feeding practices during their daughters first year of life. Beginning in 1996, participants completed annual food frequency questionnaires. In 2005, participants (18 year +) began reporting whether they had ever been diagnosed with biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression models estimated associations between childhood nutrition and BBD, adjusted for maternal Breast Disease and childhood body size factors.ResultsAlthough no infant nutrition factors were associated with biopsy-confirmed BBD, certain adolescent dietary factors were. A multivariable model simultaneously included the most important diet and body size factors from different age periods: higher BBD risk was associated with greater age 10 year consumption of animal (non-dairy, energy-adjusted) fat (OR 2.27, p  

  • dietary intake from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2019
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Nutritional factors during different periods in life impact Breast cancer risk. Because benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, we investigated childhood nutrition from birth through age 14 year and subsequent BBD. A prospective cohort study of 9031 females, 9–15 year at baseline, completed questionnaires (including heights, weights) annually from 1996 to 2001, in 2003, 2005, 2007, 2010, 2013 and 2014. In 1996, mothers reported infant feeding practices during their daughters first year of life. Beginning in 1996, participants completed annual food frequency questionnaires. In 2005, participants (18 year +) began reporting whether they had ever been diagnosed with biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression models estimated associations between childhood nutrition and BBD, adjusted for maternal Breast Disease and childhood body size factors. Although no infant nutrition factors were associated with biopsy-confirmed BBD, certain adolescent dietary factors were. A multivariable model simultaneously included the most important diet and body size factors from different age periods: higher BBD risk was associated with greater age 10 year consumption of animal (non-dairy, energy-adjusted) fat (OR 2.27, p < .02, top vs. bottom quartiles) and with lower 14 year consumption of nuts/peanut butter (OR 0.60, p = .033, top vs. bottom quartiles). Greater intake of animal (non-dairy) fat at 10 year and lower intake of nuts/peanut butter at 14 year were independently associated with higher BBD risk. These dietary factors appeared to operate on BBD risk independent of childhood growth (gestational weight gain, childhood BMI and height, adolescent height growth velocity), young adult height and BMI, and family history.

  • body size from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2017
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Purpose Body size, from birth throughout adulthood, is associated with Breast cancer risk, but few studies have investigated early-life body size and benign Breast Disease (BBD), a well-established Breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk.

  • prenatal factors and infant feeding in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2015
    Co-Authors: Catherine S Berkey, Rulla M. Tamimi, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, but little work has considered a girl's early life and her risk for BBD in adulthood. We investigated factors, from pre-conception through infant feeding practices, in relation to subsequent BBD risk in young women. The Growing Up Today Study (GUTS) includes 9032 females, born 1980-1987, who completed questionnaires annually from 1996 through 2001, then 2003, 2005, 2007, 2010, and 2013. In 1996, their mothers provided each participant's birth weight and length, gestational age, biological father's height, and infant feeding factors (e.g., Breast-fed, type of formula). In 1999, their mothers reported maternal pre-pregnancy weight and weight gain during index pregnancy. Beginning in 2005, daughters (18 years+) reported whether they had ever been diagnosed with biopsy-confirmed BBD (n = 142 cases, through 2013). Logistic regression estimated associations between early life factors and biopsy-confirmed BBD. Girls whose mother's BMI prior to pregnancy was 20-25 kg/m(2) were at lower risk of BBD as young women (OR = 0.66, p = 0.04, vs. maternal pre-pregnancy BMI < 20). Girls whose mothers gained 20 + pounds (vs. <20 pounds) during pregnancy were at lower risk (among full-term singleton births: OR = 0.48, p = 0.007, if mother gained 20-35 pounds). However, neither birth weight nor BMI at birth were associated with subsequent BBD risk. We found no evidence that infant feeding practices were linked to BBD. A healthy maternal BMI before pregnancy and sufficient weight gain during pregnancy may produce daughters at lower risk for BBD as young women. Further examination of these findings is needed.

Catherine S Berkey - One of the best experts on this subject based on the ideXlab platform.

  • adolescent alcohol nuts and fiber combined effects on benign Breast Disease risk in young women
    NPJ breast cancer, 2020
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    AbstractAdolescent drinking is associated with higher risks of proliferative benign Breast Disease (BBD) and invasive Breast cancer (BC). Furthermore, adolescent nut and fiber consumptions are associated with lower risks of benign lesions and premenopausal BC. We hypothesize that diet (nuts, fiber) may mitigate the elevated BBD risk associated with alcohol. A prospective cohort of 9031 females, 9–15 years at baseline, completed questionnaires in 1996–2001, 2003, 2005, 2007, 2010, 2013, and 2014. Participants completed food frequency questionnaires in 1996–2001. In 2005, participants (>=18 years) began reporting biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression estimated associations between BBD and cross-classified intakes (14–17 years) of alcohol and peanut butter/nuts (separately, total dietary fiber). Only 19% of participants drank in high school; drinking was associated with elevated BBD risk (OR = 1.75, 95% CI: 1.20–2.56; p = 0.004) compared to nondrinkers. Participants consuming any nuts/butter had lower BBD risk (OR = 0.64, 95% CI: 0.45–0.90; p = 0.01) compared to those consuming none. Participants in top 75% fiber intake had lower risk (OR = 0.57, 95% CI: 0.40–0.81; p = 0.002) compared to bottom quartile. Testing our hypothesis that consuming nuts/butter mitigates the elevated alcohol risk, analyzing alcohol and nuts combined found that those who consumed both had lower risk (RR = 0.47, 95% CI: 0.24–0.89; p = 0.02) compared to drinkers eating no nuts. Our analysis of alcohol and fiber together did not demonstrate risk mitigation by fiber. For high school females who drink, their BBD risk may be attenuated by consuming nuts. Due to modest numbers, future studies need to replicate our findings in adolescent/adult females. However, high school students may be encouraged to eat nuts and fiber, and to avoid alcohol, to reduce risk of BBD and for general health benefits.

  • Dietary intake from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2019
    Co-Authors: Catherine S Berkey, A. Lindsay Frazier, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Graham A Colditz
    Abstract:

    PurposeNutritional factors during different periods in life impact Breast cancer risk. Because benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, we investigated childhood nutrition from birth through age 14 year and subsequent BBD.MethodsA prospective cohort study of 9031 females, 9–15 year at baseline, completed questionnaires (including heights, weights) annually from 1996 to 2001, in 2003, 2005, 2007, 2010, 2013 and 2014. In 1996, mothers reported infant feeding practices during their daughters first year of life. Beginning in 1996, participants completed annual food frequency questionnaires. In 2005, participants (18 year +) began reporting whether they had ever been diagnosed with biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression models estimated associations between childhood nutrition and BBD, adjusted for maternal Breast Disease and childhood body size factors.ResultsAlthough no infant nutrition factors were associated with biopsy-confirmed BBD, certain adolescent dietary factors were. A multivariable model simultaneously included the most important diet and body size factors from different age periods: higher BBD risk was associated with greater age 10 year consumption of animal (non-dairy, energy-adjusted) fat (OR 2.27, p  

  • dietary intake from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2019
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Nutritional factors during different periods in life impact Breast cancer risk. Because benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, we investigated childhood nutrition from birth through age 14 year and subsequent BBD. A prospective cohort study of 9031 females, 9–15 year at baseline, completed questionnaires (including heights, weights) annually from 1996 to 2001, in 2003, 2005, 2007, 2010, 2013 and 2014. In 1996, mothers reported infant feeding practices during their daughters first year of life. Beginning in 1996, participants completed annual food frequency questionnaires. In 2005, participants (18 year +) began reporting whether they had ever been diagnosed with biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression models estimated associations between childhood nutrition and BBD, adjusted for maternal Breast Disease and childhood body size factors. Although no infant nutrition factors were associated with biopsy-confirmed BBD, certain adolescent dietary factors were. A multivariable model simultaneously included the most important diet and body size factors from different age periods: higher BBD risk was associated with greater age 10 year consumption of animal (non-dairy, energy-adjusted) fat (OR 2.27, p < .02, top vs. bottom quartiles) and with lower 14 year consumption of nuts/peanut butter (OR 0.60, p = .033, top vs. bottom quartiles). Greater intake of animal (non-dairy) fat at 10 year and lower intake of nuts/peanut butter at 14 year were independently associated with higher BBD risk. These dietary factors appeared to operate on BBD risk independent of childhood growth (gestational weight gain, childhood BMI and height, adolescent height growth velocity), young adult height and BMI, and family history.

  • body size from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2017
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Purpose Body size, from birth throughout adulthood, is associated with Breast cancer risk, but few studies have investigated early-life body size and benign Breast Disease (BBD), a well-established Breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk.

  • prenatal factors and infant feeding in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2015
    Co-Authors: Catherine S Berkey, Rulla M. Tamimi, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, but little work has considered a girl's early life and her risk for BBD in adulthood. We investigated factors, from pre-conception through infant feeding practices, in relation to subsequent BBD risk in young women. The Growing Up Today Study (GUTS) includes 9032 females, born 1980-1987, who completed questionnaires annually from 1996 through 2001, then 2003, 2005, 2007, 2010, and 2013. In 1996, their mothers provided each participant's birth weight and length, gestational age, biological father's height, and infant feeding factors (e.g., Breast-fed, type of formula). In 1999, their mothers reported maternal pre-pregnancy weight and weight gain during index pregnancy. Beginning in 2005, daughters (18 years+) reported whether they had ever been diagnosed with biopsy-confirmed BBD (n = 142 cases, through 2013). Logistic regression estimated associations between early life factors and biopsy-confirmed BBD. Girls whose mother's BMI prior to pregnancy was 20-25 kg/m(2) were at lower risk of BBD as young women (OR = 0.66, p = 0.04, vs. maternal pre-pregnancy BMI < 20). Girls whose mothers gained 20 + pounds (vs. <20 pounds) during pregnancy were at lower risk (among full-term singleton births: OR = 0.48, p = 0.007, if mother gained 20-35 pounds). However, neither birth weight nor BMI at birth were associated with subsequent BBD risk. We found no evidence that infant feeding practices were linked to BBD. A healthy maternal BMI before pregnancy and sufficient weight gain during pregnancy may produce daughters at lower risk for BBD as young women. Further examination of these findings is needed.

Walter C Willett - One of the best experts on this subject based on the ideXlab platform.

  • adolescent alcohol nuts and fiber combined effects on benign Breast Disease risk in young women
    NPJ breast cancer, 2020
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    AbstractAdolescent drinking is associated with higher risks of proliferative benign Breast Disease (BBD) and invasive Breast cancer (BC). Furthermore, adolescent nut and fiber consumptions are associated with lower risks of benign lesions and premenopausal BC. We hypothesize that diet (nuts, fiber) may mitigate the elevated BBD risk associated with alcohol. A prospective cohort of 9031 females, 9–15 years at baseline, completed questionnaires in 1996–2001, 2003, 2005, 2007, 2010, 2013, and 2014. Participants completed food frequency questionnaires in 1996–2001. In 2005, participants (>=18 years) began reporting biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression estimated associations between BBD and cross-classified intakes (14–17 years) of alcohol and peanut butter/nuts (separately, total dietary fiber). Only 19% of participants drank in high school; drinking was associated with elevated BBD risk (OR = 1.75, 95% CI: 1.20–2.56; p = 0.004) compared to nondrinkers. Participants consuming any nuts/butter had lower BBD risk (OR = 0.64, 95% CI: 0.45–0.90; p = 0.01) compared to those consuming none. Participants in top 75% fiber intake had lower risk (OR = 0.57, 95% CI: 0.40–0.81; p = 0.002) compared to bottom quartile. Testing our hypothesis that consuming nuts/butter mitigates the elevated alcohol risk, analyzing alcohol and nuts combined found that those who consumed both had lower risk (RR = 0.47, 95% CI: 0.24–0.89; p = 0.02) compared to drinkers eating no nuts. Our analysis of alcohol and fiber together did not demonstrate risk mitigation by fiber. For high school females who drink, their BBD risk may be attenuated by consuming nuts. Due to modest numbers, future studies need to replicate our findings in adolescent/adult females. However, high school students may be encouraged to eat nuts and fiber, and to avoid alcohol, to reduce risk of BBD and for general health benefits.

  • Dietary intake from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2019
    Co-Authors: Catherine S Berkey, A. Lindsay Frazier, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Graham A Colditz
    Abstract:

    PurposeNutritional factors during different periods in life impact Breast cancer risk. Because benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, we investigated childhood nutrition from birth through age 14 year and subsequent BBD.MethodsA prospective cohort study of 9031 females, 9–15 year at baseline, completed questionnaires (including heights, weights) annually from 1996 to 2001, in 2003, 2005, 2007, 2010, 2013 and 2014. In 1996, mothers reported infant feeding practices during their daughters first year of life. Beginning in 1996, participants completed annual food frequency questionnaires. In 2005, participants (18 year +) began reporting whether they had ever been diagnosed with biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression models estimated associations between childhood nutrition and BBD, adjusted for maternal Breast Disease and childhood body size factors.ResultsAlthough no infant nutrition factors were associated with biopsy-confirmed BBD, certain adolescent dietary factors were. A multivariable model simultaneously included the most important diet and body size factors from different age periods: higher BBD risk was associated with greater age 10 year consumption of animal (non-dairy, energy-adjusted) fat (OR 2.27, p  

  • dietary intake from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2019
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Nutritional factors during different periods in life impact Breast cancer risk. Because benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, we investigated childhood nutrition from birth through age 14 year and subsequent BBD. A prospective cohort study of 9031 females, 9–15 year at baseline, completed questionnaires (including heights, weights) annually from 1996 to 2001, in 2003, 2005, 2007, 2010, 2013 and 2014. In 1996, mothers reported infant feeding practices during their daughters first year of life. Beginning in 1996, participants completed annual food frequency questionnaires. In 2005, participants (18 year +) began reporting whether they had ever been diagnosed with biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression models estimated associations between childhood nutrition and BBD, adjusted for maternal Breast Disease and childhood body size factors. Although no infant nutrition factors were associated with biopsy-confirmed BBD, certain adolescent dietary factors were. A multivariable model simultaneously included the most important diet and body size factors from different age periods: higher BBD risk was associated with greater age 10 year consumption of animal (non-dairy, energy-adjusted) fat (OR 2.27, p < .02, top vs. bottom quartiles) and with lower 14 year consumption of nuts/peanut butter (OR 0.60, p = .033, top vs. bottom quartiles). Greater intake of animal (non-dairy) fat at 10 year and lower intake of nuts/peanut butter at 14 year were independently associated with higher BBD risk. These dietary factors appeared to operate on BBD risk independent of childhood growth (gestational weight gain, childhood BMI and height, adolescent height growth velocity), young adult height and BMI, and family history.

  • body size from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2017
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Purpose Body size, from birth throughout adulthood, is associated with Breast cancer risk, but few studies have investigated early-life body size and benign Breast Disease (BBD), a well-established Breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk.

  • prenatal factors and infant feeding in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2015
    Co-Authors: Catherine S Berkey, Rulla M. Tamimi, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, but little work has considered a girl's early life and her risk for BBD in adulthood. We investigated factors, from pre-conception through infant feeding practices, in relation to subsequent BBD risk in young women. The Growing Up Today Study (GUTS) includes 9032 females, born 1980-1987, who completed questionnaires annually from 1996 through 2001, then 2003, 2005, 2007, 2010, and 2013. In 1996, their mothers provided each participant's birth weight and length, gestational age, biological father's height, and infant feeding factors (e.g., Breast-fed, type of formula). In 1999, their mothers reported maternal pre-pregnancy weight and weight gain during index pregnancy. Beginning in 2005, daughters (18 years+) reported whether they had ever been diagnosed with biopsy-confirmed BBD (n = 142 cases, through 2013). Logistic regression estimated associations between early life factors and biopsy-confirmed BBD. Girls whose mother's BMI prior to pregnancy was 20-25 kg/m(2) were at lower risk of BBD as young women (OR = 0.66, p = 0.04, vs. maternal pre-pregnancy BMI < 20). Girls whose mothers gained 20 + pounds (vs. <20 pounds) during pregnancy were at lower risk (among full-term singleton births: OR = 0.48, p = 0.007, if mother gained 20-35 pounds). However, neither birth weight nor BMI at birth were associated with subsequent BBD risk. We found no evidence that infant feeding practices were linked to BBD. A healthy maternal BMI before pregnancy and sufficient weight gain during pregnancy may produce daughters at lower risk for BBD as young women. Further examination of these findings is needed.

Rulla M. Tamimi - One of the best experts on this subject based on the ideXlab platform.

  • adolescent alcohol nuts and fiber combined effects on benign Breast Disease risk in young women
    NPJ breast cancer, 2020
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    AbstractAdolescent drinking is associated with higher risks of proliferative benign Breast Disease (BBD) and invasive Breast cancer (BC). Furthermore, adolescent nut and fiber consumptions are associated with lower risks of benign lesions and premenopausal BC. We hypothesize that diet (nuts, fiber) may mitigate the elevated BBD risk associated with alcohol. A prospective cohort of 9031 females, 9–15 years at baseline, completed questionnaires in 1996–2001, 2003, 2005, 2007, 2010, 2013, and 2014. Participants completed food frequency questionnaires in 1996–2001. In 2005, participants (>=18 years) began reporting biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression estimated associations between BBD and cross-classified intakes (14–17 years) of alcohol and peanut butter/nuts (separately, total dietary fiber). Only 19% of participants drank in high school; drinking was associated with elevated BBD risk (OR = 1.75, 95% CI: 1.20–2.56; p = 0.004) compared to nondrinkers. Participants consuming any nuts/butter had lower BBD risk (OR = 0.64, 95% CI: 0.45–0.90; p = 0.01) compared to those consuming none. Participants in top 75% fiber intake had lower risk (OR = 0.57, 95% CI: 0.40–0.81; p = 0.002) compared to bottom quartile. Testing our hypothesis that consuming nuts/butter mitigates the elevated alcohol risk, analyzing alcohol and nuts combined found that those who consumed both had lower risk (RR = 0.47, 95% CI: 0.24–0.89; p = 0.02) compared to drinkers eating no nuts. Our analysis of alcohol and fiber together did not demonstrate risk mitigation by fiber. For high school females who drink, their BBD risk may be attenuated by consuming nuts. Due to modest numbers, future studies need to replicate our findings in adolescent/adult females. However, high school students may be encouraged to eat nuts and fiber, and to avoid alcohol, to reduce risk of BBD and for general health benefits.

  • Dietary intake from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2019
    Co-Authors: Catherine S Berkey, A. Lindsay Frazier, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Graham A Colditz
    Abstract:

    PurposeNutritional factors during different periods in life impact Breast cancer risk. Because benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, we investigated childhood nutrition from birth through age 14 year and subsequent BBD.MethodsA prospective cohort study of 9031 females, 9–15 year at baseline, completed questionnaires (including heights, weights) annually from 1996 to 2001, in 2003, 2005, 2007, 2010, 2013 and 2014. In 1996, mothers reported infant feeding practices during their daughters first year of life. Beginning in 1996, participants completed annual food frequency questionnaires. In 2005, participants (18 year +) began reporting whether they had ever been diagnosed with biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression models estimated associations between childhood nutrition and BBD, adjusted for maternal Breast Disease and childhood body size factors.ResultsAlthough no infant nutrition factors were associated with biopsy-confirmed BBD, certain adolescent dietary factors were. A multivariable model simultaneously included the most important diet and body size factors from different age periods: higher BBD risk was associated with greater age 10 year consumption of animal (non-dairy, energy-adjusted) fat (OR 2.27, p  

  • dietary intake from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2019
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Nutritional factors during different periods in life impact Breast cancer risk. Because benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, we investigated childhood nutrition from birth through age 14 year and subsequent BBD. A prospective cohort study of 9031 females, 9–15 year at baseline, completed questionnaires (including heights, weights) annually from 1996 to 2001, in 2003, 2005, 2007, 2010, 2013 and 2014. In 1996, mothers reported infant feeding practices during their daughters first year of life. Beginning in 1996, participants completed annual food frequency questionnaires. In 2005, participants (18 year +) began reporting whether they had ever been diagnosed with biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression models estimated associations between childhood nutrition and BBD, adjusted for maternal Breast Disease and childhood body size factors. Although no infant nutrition factors were associated with biopsy-confirmed BBD, certain adolescent dietary factors were. A multivariable model simultaneously included the most important diet and body size factors from different age periods: higher BBD risk was associated with greater age 10 year consumption of animal (non-dairy, energy-adjusted) fat (OR 2.27, p < .02, top vs. bottom quartiles) and with lower 14 year consumption of nuts/peanut butter (OR 0.60, p = .033, top vs. bottom quartiles). Greater intake of animal (non-dairy) fat at 10 year and lower intake of nuts/peanut butter at 14 year were independently associated with higher BBD risk. These dietary factors appeared to operate on BBD risk independent of childhood growth (gestational weight gain, childhood BMI and height, adolescent height growth velocity), young adult height and BMI, and family history.

  • body size from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2017
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Purpose Body size, from birth throughout adulthood, is associated with Breast cancer risk, but few studies have investigated early-life body size and benign Breast Disease (BBD), a well-established Breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk.

  • prenatal factors and infant feeding in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2015
    Co-Authors: Catherine S Berkey, Rulla M. Tamimi, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, but little work has considered a girl's early life and her risk for BBD in adulthood. We investigated factors, from pre-conception through infant feeding practices, in relation to subsequent BBD risk in young women. The Growing Up Today Study (GUTS) includes 9032 females, born 1980-1987, who completed questionnaires annually from 1996 through 2001, then 2003, 2005, 2007, 2010, and 2013. In 1996, their mothers provided each participant's birth weight and length, gestational age, biological father's height, and infant feeding factors (e.g., Breast-fed, type of formula). In 1999, their mothers reported maternal pre-pregnancy weight and weight gain during index pregnancy. Beginning in 2005, daughters (18 years+) reported whether they had ever been diagnosed with biopsy-confirmed BBD (n = 142 cases, through 2013). Logistic regression estimated associations between early life factors and biopsy-confirmed BBD. Girls whose mother's BMI prior to pregnancy was 20-25 kg/m(2) were at lower risk of BBD as young women (OR = 0.66, p = 0.04, vs. maternal pre-pregnancy BMI < 20). Girls whose mothers gained 20 + pounds (vs. <20 pounds) during pregnancy were at lower risk (among full-term singleton births: OR = 0.48, p = 0.007, if mother gained 20-35 pounds). However, neither birth weight nor BMI at birth were associated with subsequent BBD risk. We found no evidence that infant feeding practices were linked to BBD. A healthy maternal BMI before pregnancy and sufficient weight gain during pregnancy may produce daughters at lower risk for BBD as young women. Further examination of these findings is needed.

Bernard Rosner - One of the best experts on this subject based on the ideXlab platform.

  • adolescent alcohol nuts and fiber combined effects on benign Breast Disease risk in young women
    NPJ breast cancer, 2020
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    AbstractAdolescent drinking is associated with higher risks of proliferative benign Breast Disease (BBD) and invasive Breast cancer (BC). Furthermore, adolescent nut and fiber consumptions are associated with lower risks of benign lesions and premenopausal BC. We hypothesize that diet (nuts, fiber) may mitigate the elevated BBD risk associated with alcohol. A prospective cohort of 9031 females, 9–15 years at baseline, completed questionnaires in 1996–2001, 2003, 2005, 2007, 2010, 2013, and 2014. Participants completed food frequency questionnaires in 1996–2001. In 2005, participants (>=18 years) began reporting biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression estimated associations between BBD and cross-classified intakes (14–17 years) of alcohol and peanut butter/nuts (separately, total dietary fiber). Only 19% of participants drank in high school; drinking was associated with elevated BBD risk (OR = 1.75, 95% CI: 1.20–2.56; p = 0.004) compared to nondrinkers. Participants consuming any nuts/butter had lower BBD risk (OR = 0.64, 95% CI: 0.45–0.90; p = 0.01) compared to those consuming none. Participants in top 75% fiber intake had lower risk (OR = 0.57, 95% CI: 0.40–0.81; p = 0.002) compared to bottom quartile. Testing our hypothesis that consuming nuts/butter mitigates the elevated alcohol risk, analyzing alcohol and nuts combined found that those who consumed both had lower risk (RR = 0.47, 95% CI: 0.24–0.89; p = 0.02) compared to drinkers eating no nuts. Our analysis of alcohol and fiber together did not demonstrate risk mitigation by fiber. For high school females who drink, their BBD risk may be attenuated by consuming nuts. Due to modest numbers, future studies need to replicate our findings in adolescent/adult females. However, high school students may be encouraged to eat nuts and fiber, and to avoid alcohol, to reduce risk of BBD and for general health benefits.

  • Dietary intake from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2019
    Co-Authors: Catherine S Berkey, A. Lindsay Frazier, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Graham A Colditz
    Abstract:

    PurposeNutritional factors during different periods in life impact Breast cancer risk. Because benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, we investigated childhood nutrition from birth through age 14 year and subsequent BBD.MethodsA prospective cohort study of 9031 females, 9–15 year at baseline, completed questionnaires (including heights, weights) annually from 1996 to 2001, in 2003, 2005, 2007, 2010, 2013 and 2014. In 1996, mothers reported infant feeding practices during their daughters first year of life. Beginning in 1996, participants completed annual food frequency questionnaires. In 2005, participants (18 year +) began reporting whether they had ever been diagnosed with biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression models estimated associations between childhood nutrition and BBD, adjusted for maternal Breast Disease and childhood body size factors.ResultsAlthough no infant nutrition factors were associated with biopsy-confirmed BBD, certain adolescent dietary factors were. A multivariable model simultaneously included the most important diet and body size factors from different age periods: higher BBD risk was associated with greater age 10 year consumption of animal (non-dairy, energy-adjusted) fat (OR 2.27, p  

  • dietary intake from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2019
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Nutritional factors during different periods in life impact Breast cancer risk. Because benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, we investigated childhood nutrition from birth through age 14 year and subsequent BBD. A prospective cohort study of 9031 females, 9–15 year at baseline, completed questionnaires (including heights, weights) annually from 1996 to 2001, in 2003, 2005, 2007, 2010, 2013 and 2014. In 1996, mothers reported infant feeding practices during their daughters first year of life. Beginning in 1996, participants completed annual food frequency questionnaires. In 2005, participants (18 year +) began reporting whether they had ever been diagnosed with biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression models estimated associations between childhood nutrition and BBD, adjusted for maternal Breast Disease and childhood body size factors. Although no infant nutrition factors were associated with biopsy-confirmed BBD, certain adolescent dietary factors were. A multivariable model simultaneously included the most important diet and body size factors from different age periods: higher BBD risk was associated with greater age 10 year consumption of animal (non-dairy, energy-adjusted) fat (OR 2.27, p < .02, top vs. bottom quartiles) and with lower 14 year consumption of nuts/peanut butter (OR 0.60, p = .033, top vs. bottom quartiles). Greater intake of animal (non-dairy) fat at 10 year and lower intake of nuts/peanut butter at 14 year were independently associated with higher BBD risk. These dietary factors appeared to operate on BBD risk independent of childhood growth (gestational weight gain, childhood BMI and height, adolescent height growth velocity), young adult height and BMI, and family history.

  • body size from birth through adolescence in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2017
    Co-Authors: Catherine S Berkey, Adetunji T Toriola, Rulla M. Tamimi, Martha Hickey, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Purpose Body size, from birth throughout adulthood, is associated with Breast cancer risk, but few studies have investigated early-life body size and benign Breast Disease (BBD), a well-established Breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk.

  • prenatal factors and infant feeding in relation to risk of benign Breast Disease in young women
    Breast Cancer Research and Treatment, 2015
    Co-Authors: Catherine S Berkey, Rulla M. Tamimi, Walter C Willett, Bernard Rosner, Lindsay A Frazier, Graham A Colditz
    Abstract:

    Benign Breast Disease (BBD) is a well-established risk factor for Breast cancer, but little work has considered a girl's early life and her risk for BBD in adulthood. We investigated factors, from pre-conception through infant feeding practices, in relation to subsequent BBD risk in young women. The Growing Up Today Study (GUTS) includes 9032 females, born 1980-1987, who completed questionnaires annually from 1996 through 2001, then 2003, 2005, 2007, 2010, and 2013. In 1996, their mothers provided each participant's birth weight and length, gestational age, biological father's height, and infant feeding factors (e.g., Breast-fed, type of formula). In 1999, their mothers reported maternal pre-pregnancy weight and weight gain during index pregnancy. Beginning in 2005, daughters (18 years+) reported whether they had ever been diagnosed with biopsy-confirmed BBD (n = 142 cases, through 2013). Logistic regression estimated associations between early life factors and biopsy-confirmed BBD. Girls whose mother's BMI prior to pregnancy was 20-25 kg/m(2) were at lower risk of BBD as young women (OR = 0.66, p = 0.04, vs. maternal pre-pregnancy BMI < 20). Girls whose mothers gained 20 + pounds (vs. <20 pounds) during pregnancy were at lower risk (among full-term singleton births: OR = 0.48, p = 0.007, if mother gained 20-35 pounds). However, neither birth weight nor BMI at birth were associated with subsequent BBD risk. We found no evidence that infant feeding practices were linked to BBD. A healthy maternal BMI before pregnancy and sufficient weight gain during pregnancy may produce daughters at lower risk for BBD as young women. Further examination of these findings is needed.