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William D Dupont - One of the best experts on this subject based on the ideXlab platform.

  • subsequent Breast carcinoma risk after biopsy with atypia in a Breast Papilloma
    Cancer, 1996
    Co-Authors: L David M D Page, E Kevin M D Salhany, A Roy M D Jensen, William D Dupont
    Abstract:

    BACKGROUND Risk of Breast cancer after biopsy demonstrating a Papilloma has long been variously interpreted on the basis of histologic pattern of multiplicity of Papillomas. METHODS A nested case control study was performed on women with surgical Breast biopsies evidencing Papillomas; cases who subsequently developed invasive carcinoma were compared with controls who did not. Presence of atypical hyperplasia (AH) within the Papilloma as well as areas of AH in the surrounding parenchyma were evaluated in both cases and controls. The entire cohort (not tested) was separately evaluated for all variables except for atypia within Papillomas. RESULTS The relative risk of invasive carcinoma for women with Papillomas containing AH was >4× that of Papillomas without AH within or surrounding the Papilloma. This risk may be greater with added atypical hyperplasia outside the Papilloma and most strikingly, most of the subsequent invasive carcinomas developed in the same Breast and probably near the site of the original Papilloma. However, ordinary patterns of epithelial hyperplasia lacking specific features of AH within the Papilloma do not add to the risk of subsequent carcinoma development over Papillomas without hyperplasia. CONCLUSIONS This study indicates that women having Papillomas with AH have a similar or greater cancer risk than others with specifically defined patterns of atypical hyperplasia within the Breast parenchyma (4–5× relative risk). Most importantly, this risk is largely local, in the region of the original Papilloma. Cancer 1996;78:258-66.

A Roy M D Jensen - One of the best experts on this subject based on the ideXlab platform.

  • subsequent Breast carcinoma risk after biopsy with atypia in a Breast Papilloma
    Cancer, 1996
    Co-Authors: L David M D Page, E Kevin M D Salhany, A Roy M D Jensen, William D Dupont
    Abstract:

    BACKGROUND Risk of Breast cancer after biopsy demonstrating a Papilloma has long been variously interpreted on the basis of histologic pattern of multiplicity of Papillomas. METHODS A nested case control study was performed on women with surgical Breast biopsies evidencing Papillomas; cases who subsequently developed invasive carcinoma were compared with controls who did not. Presence of atypical hyperplasia (AH) within the Papilloma as well as areas of AH in the surrounding parenchyma were evaluated in both cases and controls. The entire cohort (not tested) was separately evaluated for all variables except for atypia within Papillomas. RESULTS The relative risk of invasive carcinoma for women with Papillomas containing AH was >4× that of Papillomas without AH within or surrounding the Papilloma. This risk may be greater with added atypical hyperplasia outside the Papilloma and most strikingly, most of the subsequent invasive carcinomas developed in the same Breast and probably near the site of the original Papilloma. However, ordinary patterns of epithelial hyperplasia lacking specific features of AH within the Papilloma do not add to the risk of subsequent carcinoma development over Papillomas without hyperplasia. CONCLUSIONS This study indicates that women having Papillomas with AH have a similar or greater cancer risk than others with specifically defined patterns of atypical hyperplasia within the Breast parenchyma (4–5× relative risk). Most importantly, this risk is largely local, in the region of the original Papilloma. Cancer 1996;78:258-66.

Lévêque Jean - One of the best experts on this subject based on the ideXlab platform.

  • The Role of Percutaneous Biopsy and Prognostic Factors of Malignancy in Solitary Breast Papilloma: A Retrospective Multicenter Study of 259 Cases
    International Institute of Anticancer Research, 2015
    Co-Authors: Laval Maude, Delangle Romain, Ndoye Aïcha, Sylvestre Emmanuelle, Laviolle Bruno, Lavoué Vincent, Lévêque Jean
    Abstract:

    International audienceAIM: Management of papillary Breast lesions is a controversial issue, as complete excision implies surgery of numerous benign lesions. The purpose of this study was to assess concordance between percutaneous and surgical biopsy of Papillomas along with factors predictive of malignancy. PATIENTS AND METHODS: The study consisted of a retrospective review of Papilloma cases between 2009 and 2013 at three Breast cancer centers. All cases of Papilloma histologically diagnosed by percutaneous biopsy and confirmed by surgical specimen were included. The biopsy results were compared with final surgical pathology. Lesion size and clinical and radiological features were recorded. RESULTS: A total of 259 cases were included (188 simple and 71 complex Papillomas). Concordance between histology after percutaneous and surgical biopsy was lower for complex Papillomas, regardless of type, than for simple Papillomas (p\textless0.001). The risk of having a complex Papilloma was shown to be significantly higher in postmenopausal patients (p=0.023), and was 20 times higher if the percutaneous biopsy was malignant as opposed to benign (p\textless2.10). However, the false-negatives for percutaneous biopsy in complex Papilloma cases were mainly related to atypical and in situ lesions. CONCLUSION: Percutaneous biopsy does not appear adequate for identifying Papillomas requiring surgical excision due to the risk of underestimation of cancerous lesions. However, certain factors predictive of malignancy may assist with surgical management, such as age and menopausal status, lesions peripheral to the nipple, and atypia on percutaneous biops

L David M D Page - One of the best experts on this subject based on the ideXlab platform.

  • subsequent Breast carcinoma risk after biopsy with atypia in a Breast Papilloma
    Cancer, 1996
    Co-Authors: L David M D Page, E Kevin M D Salhany, A Roy M D Jensen, William D Dupont
    Abstract:

    BACKGROUND Risk of Breast cancer after biopsy demonstrating a Papilloma has long been variously interpreted on the basis of histologic pattern of multiplicity of Papillomas. METHODS A nested case control study was performed on women with surgical Breast biopsies evidencing Papillomas; cases who subsequently developed invasive carcinoma were compared with controls who did not. Presence of atypical hyperplasia (AH) within the Papilloma as well as areas of AH in the surrounding parenchyma were evaluated in both cases and controls. The entire cohort (not tested) was separately evaluated for all variables except for atypia within Papillomas. RESULTS The relative risk of invasive carcinoma for women with Papillomas containing AH was >4× that of Papillomas without AH within or surrounding the Papilloma. This risk may be greater with added atypical hyperplasia outside the Papilloma and most strikingly, most of the subsequent invasive carcinomas developed in the same Breast and probably near the site of the original Papilloma. However, ordinary patterns of epithelial hyperplasia lacking specific features of AH within the Papilloma do not add to the risk of subsequent carcinoma development over Papillomas without hyperplasia. CONCLUSIONS This study indicates that women having Papillomas with AH have a similar or greater cancer risk than others with specifically defined patterns of atypical hyperplasia within the Breast parenchyma (4–5× relative risk). Most importantly, this risk is largely local, in the region of the original Papilloma. Cancer 1996;78:258-66.

Laval Maude - One of the best experts on this subject based on the ideXlab platform.

  • The Role of Percutaneous Biopsy and Prognostic Factors of Malignancy in Solitary Breast Papilloma: A Retrospective Multicenter Study of 259 Cases
    International Institute of Anticancer Research, 2015
    Co-Authors: Laval Maude, Delangle Romain, Ndoye Aïcha, Sylvestre Emmanuelle, Laviolle Bruno, Lavoué Vincent, Lévêque Jean
    Abstract:

    International audienceAIM: Management of papillary Breast lesions is a controversial issue, as complete excision implies surgery of numerous benign lesions. The purpose of this study was to assess concordance between percutaneous and surgical biopsy of Papillomas along with factors predictive of malignancy. PATIENTS AND METHODS: The study consisted of a retrospective review of Papilloma cases between 2009 and 2013 at three Breast cancer centers. All cases of Papilloma histologically diagnosed by percutaneous biopsy and confirmed by surgical specimen were included. The biopsy results were compared with final surgical pathology. Lesion size and clinical and radiological features were recorded. RESULTS: A total of 259 cases were included (188 simple and 71 complex Papillomas). Concordance between histology after percutaneous and surgical biopsy was lower for complex Papillomas, regardless of type, than for simple Papillomas (p\textless0.001). The risk of having a complex Papilloma was shown to be significantly higher in postmenopausal patients (p=0.023), and was 20 times higher if the percutaneous biopsy was malignant as opposed to benign (p\textless2.10). However, the false-negatives for percutaneous biopsy in complex Papilloma cases were mainly related to atypical and in situ lesions. CONCLUSION: Percutaneous biopsy does not appear adequate for identifying Papillomas requiring surgical excision due to the risk of underestimation of cancerous lesions. However, certain factors predictive of malignancy may assist with surgical management, such as age and menopausal status, lesions peripheral to the nipple, and atypia on percutaneous biops