The Experts below are selected from a list of 6543 Experts worldwide ranked by ideXlab platform
R Gore - One of the best experts on this subject based on the ideXlab platform.
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effect of a novel temperature controlled laminar airflow device on personal Breathing Zone aeroallergen exposure
Indoor Air, 2015Co-Authors: R Gore, Robe J Oyle, Adna Custovic, Heathe Hanna, P Svensso, Claudia Gore, J O WarneAbstract:Temperature-controlled laminar airflow improves symptoms in atopic asthmatics, but its effects on personal allergen exposure are unknown. We aimed to evaluate its effects on personal cat allergen and particulate exposures in a simulated bedroom environment. Five healthy volunteers lay under an active and an inactive temperature-controlled laminar airflow device for 175 min, in a simulated bedroom containing bedding from a cat owner. Total airborne particles (≥0.5 – ≥10 μm diameter) were quantified with a laser particle counter. Airborne allergen was sampled with Institute of Occupational Medicine filters. Inhaled exposure was sampled with nasal air samplers. Allergen-containing particles were quantified by immunoassay. Treatment reduced total airborne particles (>0.5 μm diameter) by >99% (P < 0.001) and reduced airborne allergen concentration within the Breathing Zone (ratio of median counts = 30, P = 0.043). Treatment reduced inhaled allergen (ratio of median counts = 7, P = 0.043). Treatment was not associated with a change in airborne allergen concentration outside of the Breathing Zone (P = 0.160). Temperature-controlled laminar airflow treatment of individuals in an allergen-rich experimental environment results in significant reductions in Breathing Zone allergenic and non-allergenic particle exposure, and in inhaled cat allergen exposure. These findings may explain the clinical benefits of temperature-controlled laminar airflow.
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p27 personal allergen exposures are increased by changes in sleep position and improved by temperature controlled laminar airflow
Thorax, 2010Co-Authors: R Gore, Robe J Oyle, Adna Custovic, Heathe Hanna, P Svensso, Claudia Gore, J O WarneAbstract:Introduction and Objectives Aeroallergens are released directly from bedding into the Breathing Zone, and contribute importantly to asthma symptoms. Adults change their sleep position between 3 and 45 times per night. The effect of these turns on inhaled particulate exposures is unknown. We aimed to investigate the effects of changing position on Breathing Zone particulate exposures and the effect of a novel Temperature-controlled Laminar Airflow (TLA) device on reducing such exposures. Methods A simulated bedroom was constructed containing bedding from a cat owner. Five healthy volunteers lay recumbent under an active and an inactive TLA device for 175 min. Volunteers made scheduled turns in bed to simulate normal sleep. Real-time total particle levels (≥0·5 μm diametre) within the Breathing Zone were measured by laser particle counting. Inhaled cat allergen exposure was measured by nasal air sampling. Time series analysis was used to evaluate changes in particulate exposures with turning. Results A greater proportion of larger particles than smaller ones were disturbed by turning over (F=20.6, df=5, p 10 μm diametre were accounted for by turning over, compared with 0.2% (95% CI 0.07 to 0.5) of particles >0.5 μm diameter. TLA treatment reduced total particle numbers (size >0.5 μm) by 3010-fold (p Conclusions Turning over in bed causes a significant increase in Breathing Zone exposures to particulates which are within the respirable size range. TLA treatment dramatically reduces overhead Breathing Zone total particulate exposures and also reduces nasal cat allergen exposure. TLA treatment attenuates the increase in particulate exposures caused by turning over. Treatments which result in better sleep quality and a reduced number of bodily turns may result in a reduction in personal Breathing Zone particulate exposures in bed.
J O Warne - One of the best experts on this subject based on the ideXlab platform.
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effect of a novel temperature controlled laminar airflow device on personal Breathing Zone aeroallergen exposure
Indoor Air, 2015Co-Authors: R Gore, Robe J Oyle, Adna Custovic, Heathe Hanna, P Svensso, Claudia Gore, J O WarneAbstract:Temperature-controlled laminar airflow improves symptoms in atopic asthmatics, but its effects on personal allergen exposure are unknown. We aimed to evaluate its effects on personal cat allergen and particulate exposures in a simulated bedroom environment. Five healthy volunteers lay under an active and an inactive temperature-controlled laminar airflow device for 175 min, in a simulated bedroom containing bedding from a cat owner. Total airborne particles (≥0.5 – ≥10 μm diameter) were quantified with a laser particle counter. Airborne allergen was sampled with Institute of Occupational Medicine filters. Inhaled exposure was sampled with nasal air samplers. Allergen-containing particles were quantified by immunoassay. Treatment reduced total airborne particles (>0.5 μm diameter) by >99% (P < 0.001) and reduced airborne allergen concentration within the Breathing Zone (ratio of median counts = 30, P = 0.043). Treatment reduced inhaled allergen (ratio of median counts = 7, P = 0.043). Treatment was not associated with a change in airborne allergen concentration outside of the Breathing Zone (P = 0.160). Temperature-controlled laminar airflow treatment of individuals in an allergen-rich experimental environment results in significant reductions in Breathing Zone allergenic and non-allergenic particle exposure, and in inhaled cat allergen exposure. These findings may explain the clinical benefits of temperature-controlled laminar airflow.
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p27 personal allergen exposures are increased by changes in sleep position and improved by temperature controlled laminar airflow
Thorax, 2010Co-Authors: R Gore, Robe J Oyle, Adna Custovic, Heathe Hanna, P Svensso, Claudia Gore, J O WarneAbstract:Introduction and Objectives Aeroallergens are released directly from bedding into the Breathing Zone, and contribute importantly to asthma symptoms. Adults change their sleep position between 3 and 45 times per night. The effect of these turns on inhaled particulate exposures is unknown. We aimed to investigate the effects of changing position on Breathing Zone particulate exposures and the effect of a novel Temperature-controlled Laminar Airflow (TLA) device on reducing such exposures. Methods A simulated bedroom was constructed containing bedding from a cat owner. Five healthy volunteers lay recumbent under an active and an inactive TLA device for 175 min. Volunteers made scheduled turns in bed to simulate normal sleep. Real-time total particle levels (≥0·5 μm diametre) within the Breathing Zone were measured by laser particle counting. Inhaled cat allergen exposure was measured by nasal air sampling. Time series analysis was used to evaluate changes in particulate exposures with turning. Results A greater proportion of larger particles than smaller ones were disturbed by turning over (F=20.6, df=5, p 10 μm diametre were accounted for by turning over, compared with 0.2% (95% CI 0.07 to 0.5) of particles >0.5 μm diameter. TLA treatment reduced total particle numbers (size >0.5 μm) by 3010-fold (p Conclusions Turning over in bed causes a significant increase in Breathing Zone exposures to particulates which are within the respirable size range. TLA treatment dramatically reduces overhead Breathing Zone total particulate exposures and also reduces nasal cat allergen exposure. TLA treatment attenuates the increase in particulate exposures caused by turning over. Treatments which result in better sleep quality and a reduced number of bodily turns may result in a reduction in personal Breathing Zone particulate exposures in bed.
Otmar Geiss - One of the best experts on this subject based on the ideXlab platform.
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Effect of wearing face masks on the carbon dioxide concentration in the Breathing Zone
Aerosol and Air Quality Research, 2021Co-Authors: Otmar GeissAbstract:The use of face masks is among the measures taken to prevent person-to-person transmission of the virus (SARS-CoV-2) responsible for the coronavirus disease (COVID-19) Lately, concern was expressed about the possibility that carbon dioxide could build up in the mask over time, causing medical issues related to the respiratory system In this study, the carbon dioxide concentration in the Breathing Zone was measured while wearing a surgical mask, a KN95 and a cloth mask For the surgical mask, the concentration was determined under different conditions (office work, slow walking, and fast walking) Measurements were made using a modified indoor air quality meter equipped with a nondispersive infrared (NDIR) CO2 sensor Detected carbon dioxide concentrations ranged from 2150 ± 192 to 2875 ± 323 ppm The concentrations of carbon dioxide while not wearing a face mask varied from 500–900 ppm Doing office work and standing still on the treadmill each resulted in carbon dioxide concentrations of around 2200 ppm A small increase could be observed when walking at a speed of 3 km h–1 (leisurely walking pace) Walking at a speed of 5 km h–1, which corresponds to medium activity with Breathing through the mouth, resulted in an average carbon dioxide concentration of 2875 ppm No differences were observed among the three types of face masks tested According to the literature, these concentrations have no toxicological effect However, concentrations in the detected range can cause undesirable symptoms, such as fatigue, headache, and loss of concentration © 2021, AAGR Aerosol and Air Quality Research All rights reserved
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Effect of Wearing Face Masks on the Carbon Dioxide Concentration in the Breathing Zone
Aerosol and Air Quality Research, 2020Co-Authors: Otmar GeissAbstract:ABSTRACT The use of face masks is among the measures taken to prevent person-to-person transmission of the virus (SARS-CoV-2) responsible for the coronavirus disease (COVID-19). Lately, concern was expressed about the possibility that carbon dioxide could build up in the mask over time, causing medical issues related to the respiratory system. In this study, the carbon dioxide concentration in the Breathing Zone was measured while wearing a surgical mask, a KN95 and a cloth mask. For the surgical mask, the concentration was determined under different conditions (office work, slow walking, and fast walking). Measurements were made using a modified indoor air quality meter equipped with a nondispersive infrared (NDIR) CO2 sensor. Detected carbon dioxide concentrations ranged from 2150 ± 192 to 2875 ± 323 ppm. The concentrations of carbon dioxide while not wearing a face mask varied from 500–900 ppm. Doing office work and standing still on the treadmill each resulted in carbon dioxide concentrations of around 2200 ppm. A small increase could be observed when walking at a speed of 3 km h–1 (leisurely walking pace). Walking at a speed of 5 km h–1, which corresponds to medium activity with Breathing through the mouth, resulted in an average carbon dioxide concentration of 2875 ppm. No differences were observed among the three types of face masks tested. According to the literature, these concentrations have no toxicological effect. However, concentrations in the detected range can cause undesirable symptoms, such as fatigue, headache, and loss of concentration.
Margit Sundgren - One of the best experts on this subject based on the ideXlab platform.
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Development of a miniaturized diffusive sampler for true Breathing-Zone sampling and thermal desorption gas chromatographic analysis
Journal of Environmental Monitoring, 2009Co-Authors: Roger Lindahl, Jan Olof Levin, Margit SundgrenAbstract:Exposure measurements should be performed as close as possible to the nose and mouth for a more correct assessment of exposure. User-friendly sampling equipment, with a minimum of handling before, during and after measurement, should not affect ordinary work. In diffusive (passive) sampling, no extra equipment as sampling pumps is needed, making the measurements more acceptable to the user. The diffusive samplers are normally attached on a shoulder, on a breast-pocket or on the lapel. There are, however, difficulties if true Breathing-Zone sampling is to be performed, since available diffusive samplers normally cannot be arranged close to the nose/mouth. The purpose of this work was to study the performance of a miniaturized tube type diffusive sampler attached to a headset for true Breathing-Zone sampling. The basis for this miniaturization was the Perkin Elmer ATD tube. Both the size of the tube and the amount of adsorbent was decreased for the miniaturized sampler. A special tube holder to be used with a headset was designed for the mini tube. The mini tube is thermally desorbed inside a standard PE tube. The new sampler was evaluated for the determination of styrene, both in laboratory experiments and in field measurements. As reference method, diffusive sampling with standard Perkin Elmer tubes, thermal desorption and gas chromatographic (GC) analysis was used. The sampling rate was determined to 0.356 mL min(-1) (CV 9.6%) and was not significantly affected by concentration, sampling time or relative humidity.
Claudia Gore - One of the best experts on this subject based on the ideXlab platform.
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effect of a novel temperature controlled laminar airflow device on personal Breathing Zone aeroallergen exposure
Indoor Air, 2015Co-Authors: R Gore, Robe J Oyle, Adna Custovic, Heathe Hanna, P Svensso, Claudia Gore, J O WarneAbstract:Temperature-controlled laminar airflow improves symptoms in atopic asthmatics, but its effects on personal allergen exposure are unknown. We aimed to evaluate its effects on personal cat allergen and particulate exposures in a simulated bedroom environment. Five healthy volunteers lay under an active and an inactive temperature-controlled laminar airflow device for 175 min, in a simulated bedroom containing bedding from a cat owner. Total airborne particles (≥0.5 – ≥10 μm diameter) were quantified with a laser particle counter. Airborne allergen was sampled with Institute of Occupational Medicine filters. Inhaled exposure was sampled with nasal air samplers. Allergen-containing particles were quantified by immunoassay. Treatment reduced total airborne particles (>0.5 μm diameter) by >99% (P < 0.001) and reduced airborne allergen concentration within the Breathing Zone (ratio of median counts = 30, P = 0.043). Treatment reduced inhaled allergen (ratio of median counts = 7, P = 0.043). Treatment was not associated with a change in airborne allergen concentration outside of the Breathing Zone (P = 0.160). Temperature-controlled laminar airflow treatment of individuals in an allergen-rich experimental environment results in significant reductions in Breathing Zone allergenic and non-allergenic particle exposure, and in inhaled cat allergen exposure. These findings may explain the clinical benefits of temperature-controlled laminar airflow.
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p27 personal allergen exposures are increased by changes in sleep position and improved by temperature controlled laminar airflow
Thorax, 2010Co-Authors: R Gore, Robe J Oyle, Adna Custovic, Heathe Hanna, P Svensso, Claudia Gore, J O WarneAbstract:Introduction and Objectives Aeroallergens are released directly from bedding into the Breathing Zone, and contribute importantly to asthma symptoms. Adults change their sleep position between 3 and 45 times per night. The effect of these turns on inhaled particulate exposures is unknown. We aimed to investigate the effects of changing position on Breathing Zone particulate exposures and the effect of a novel Temperature-controlled Laminar Airflow (TLA) device on reducing such exposures. Methods A simulated bedroom was constructed containing bedding from a cat owner. Five healthy volunteers lay recumbent under an active and an inactive TLA device for 175 min. Volunteers made scheduled turns in bed to simulate normal sleep. Real-time total particle levels (≥0·5 μm diametre) within the Breathing Zone were measured by laser particle counting. Inhaled cat allergen exposure was measured by nasal air sampling. Time series analysis was used to evaluate changes in particulate exposures with turning. Results A greater proportion of larger particles than smaller ones were disturbed by turning over (F=20.6, df=5, p 10 μm diametre were accounted for by turning over, compared with 0.2% (95% CI 0.07 to 0.5) of particles >0.5 μm diameter. TLA treatment reduced total particle numbers (size >0.5 μm) by 3010-fold (p Conclusions Turning over in bed causes a significant increase in Breathing Zone exposures to particulates which are within the respirable size range. TLA treatment dramatically reduces overhead Breathing Zone total particulate exposures and also reduces nasal cat allergen exposure. TLA treatment attenuates the increase in particulate exposures caused by turning over. Treatments which result in better sleep quality and a reduced number of bodily turns may result in a reduction in personal Breathing Zone particulate exposures in bed.