The Experts below are selected from a list of 57 Experts worldwide ranked by ideXlab platform
Dennis W. Dickson - One of the best experts on this subject based on the ideXlab platform.
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Original Article Perivascular Neuritic Dystrophy Associated with Cerebral Amyloid Angiopathy in Alzheimer's Disease
2008Co-Authors: Kenichi Oshima, Hirotake Uchikado, Dennis W. DicksonAbstract:Cerebral amyloid angiopathy (CAA) affects both leptomeningeal and parenchymal blood vessels and is common in Alzheimer's disease (AD). In some vessels, CAA is accompanied by localized neuritic dystrophy around the affected blood vessel. The aim of this study was to assess the distribution and severity of perivascular neuritic dystrophy in primary visual and visual association cortices. The severity of perivascular neuritic dystrophy and Aβ deposition was scored in an association cortex (Brodmann Area 18) and a primary cortex (Brodmann Area 17) with double labeling immunohistochemistry for tau and Aβ in 31 cases of AD with severe CAA. The perivascular tau neuritic dystrophy score was significantly worse in visual association cortex than in primary visual cortex. On the other hand, there was no difference in the perivascular Aβ score between the two cortices. There were positive correlations between the severity of perivascular tau and perivascular Aβ scores for both primary and association cortices. The results suggest that the local neuronal environment determines the severity and nature of the perivascular neuritic pathology more than the severity of the intrinsic vascular disease and suggest a close association between perivascular amyloid deposits, so-called dyshoric angiopathy, and perivascular neuritic
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Perivascular neuritic dystrophy associated with cerebral amyloid angiopathy in Alzheimer's disease.
International journal of clinical and experimental pathology, 2008Co-Authors: Kenichi Oshima, Hirotake Uchikado, Dennis W. DicksonAbstract:Cerebral amyloid angiopathy (CAA) affects both leptomeningeal and parenchymal blood vessels and is common in Alzheimer's disease (AD). In some vessels, CAA is accompanied by localized neuritic dystrophy around the affected blood vessel. The aim of this study was to assess the distribution and severity of perivascular neuritic dystrophy in primary visual and visual association cortices. The severity of perivascular neuritic dystrophy and Aβ deposition was scored in an association cortex (Brodmann Area 18) and a primary cortex (Brodmann Area 17) with double labeling immunohistochemistry for tau and Aβ in 31 cases of AD with severe CAA. The perivascular tau neuritic dystrophy score was significantly worse in visual association cortex than in primary visual cortex. On the other hand, there was no difference in the perivascular Aβ score between the two cortices. There were positive correlations between the severity of perivascular tau and perivascular Aβ scores for both primary and association cortices. The results suggest that the local neuronal environment determines the severity and nature of the perivascular neuritic pathology more than the severity of the intrinsic vascular disease and suggest a close association between perivascular amyloid deposits, so-called dyshoric angiopathy, and perivascular neuritic dystrophy.
Kenichi Oshima - One of the best experts on this subject based on the ideXlab platform.
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Original Article Perivascular Neuritic Dystrophy Associated with Cerebral Amyloid Angiopathy in Alzheimer's Disease
2008Co-Authors: Kenichi Oshima, Hirotake Uchikado, Dennis W. DicksonAbstract:Cerebral amyloid angiopathy (CAA) affects both leptomeningeal and parenchymal blood vessels and is common in Alzheimer's disease (AD). In some vessels, CAA is accompanied by localized neuritic dystrophy around the affected blood vessel. The aim of this study was to assess the distribution and severity of perivascular neuritic dystrophy in primary visual and visual association cortices. The severity of perivascular neuritic dystrophy and Aβ deposition was scored in an association cortex (Brodmann Area 18) and a primary cortex (Brodmann Area 17) with double labeling immunohistochemistry for tau and Aβ in 31 cases of AD with severe CAA. The perivascular tau neuritic dystrophy score was significantly worse in visual association cortex than in primary visual cortex. On the other hand, there was no difference in the perivascular Aβ score between the two cortices. There were positive correlations between the severity of perivascular tau and perivascular Aβ scores for both primary and association cortices. The results suggest that the local neuronal environment determines the severity and nature of the perivascular neuritic pathology more than the severity of the intrinsic vascular disease and suggest a close association between perivascular amyloid deposits, so-called dyshoric angiopathy, and perivascular neuritic
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Perivascular neuritic dystrophy associated with cerebral amyloid angiopathy in Alzheimer's disease.
International journal of clinical and experimental pathology, 2008Co-Authors: Kenichi Oshima, Hirotake Uchikado, Dennis W. DicksonAbstract:Cerebral amyloid angiopathy (CAA) affects both leptomeningeal and parenchymal blood vessels and is common in Alzheimer's disease (AD). In some vessels, CAA is accompanied by localized neuritic dystrophy around the affected blood vessel. The aim of this study was to assess the distribution and severity of perivascular neuritic dystrophy in primary visual and visual association cortices. The severity of perivascular neuritic dystrophy and Aβ deposition was scored in an association cortex (Brodmann Area 18) and a primary cortex (Brodmann Area 17) with double labeling immunohistochemistry for tau and Aβ in 31 cases of AD with severe CAA. The perivascular tau neuritic dystrophy score was significantly worse in visual association cortex than in primary visual cortex. On the other hand, there was no difference in the perivascular Aβ score between the two cortices. There were positive correlations between the severity of perivascular tau and perivascular Aβ scores for both primary and association cortices. The results suggest that the local neuronal environment determines the severity and nature of the perivascular neuritic pathology more than the severity of the intrinsic vascular disease and suggest a close association between perivascular amyloid deposits, so-called dyshoric angiopathy, and perivascular neuritic dystrophy.
Hirotake Uchikado - One of the best experts on this subject based on the ideXlab platform.
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Original Article Perivascular Neuritic Dystrophy Associated with Cerebral Amyloid Angiopathy in Alzheimer's Disease
2008Co-Authors: Kenichi Oshima, Hirotake Uchikado, Dennis W. DicksonAbstract:Cerebral amyloid angiopathy (CAA) affects both leptomeningeal and parenchymal blood vessels and is common in Alzheimer's disease (AD). In some vessels, CAA is accompanied by localized neuritic dystrophy around the affected blood vessel. The aim of this study was to assess the distribution and severity of perivascular neuritic dystrophy in primary visual and visual association cortices. The severity of perivascular neuritic dystrophy and Aβ deposition was scored in an association cortex (Brodmann Area 18) and a primary cortex (Brodmann Area 17) with double labeling immunohistochemistry for tau and Aβ in 31 cases of AD with severe CAA. The perivascular tau neuritic dystrophy score was significantly worse in visual association cortex than in primary visual cortex. On the other hand, there was no difference in the perivascular Aβ score between the two cortices. There were positive correlations between the severity of perivascular tau and perivascular Aβ scores for both primary and association cortices. The results suggest that the local neuronal environment determines the severity and nature of the perivascular neuritic pathology more than the severity of the intrinsic vascular disease and suggest a close association between perivascular amyloid deposits, so-called dyshoric angiopathy, and perivascular neuritic
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Perivascular neuritic dystrophy associated with cerebral amyloid angiopathy in Alzheimer's disease.
International journal of clinical and experimental pathology, 2008Co-Authors: Kenichi Oshima, Hirotake Uchikado, Dennis W. DicksonAbstract:Cerebral amyloid angiopathy (CAA) affects both leptomeningeal and parenchymal blood vessels and is common in Alzheimer's disease (AD). In some vessels, CAA is accompanied by localized neuritic dystrophy around the affected blood vessel. The aim of this study was to assess the distribution and severity of perivascular neuritic dystrophy in primary visual and visual association cortices. The severity of perivascular neuritic dystrophy and Aβ deposition was scored in an association cortex (Brodmann Area 18) and a primary cortex (Brodmann Area 17) with double labeling immunohistochemistry for tau and Aβ in 31 cases of AD with severe CAA. The perivascular tau neuritic dystrophy score was significantly worse in visual association cortex than in primary visual cortex. On the other hand, there was no difference in the perivascular Aβ score between the two cortices. There were positive correlations between the severity of perivascular tau and perivascular Aβ scores for both primary and association cortices. The results suggest that the local neuronal environment determines the severity and nature of the perivascular neuritic pathology more than the severity of the intrinsic vascular disease and suggest a close association between perivascular amyloid deposits, so-called dyshoric angiopathy, and perivascular neuritic dystrophy.
Marc Levivier - One of the best experts on this subject based on the ideXlab platform.
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Right Brodmann Area 18 predicts tremor arrest after Vim radiosurgery: a voxel-based morphometry study
Acta Neurochirurgica, 2018Co-Authors: Constantin Tuleasca, Tatiana Witjas, Dimitri Ville, Elena Najdenovska, Antoine Verger, Nadine Girard, Jerome Champoudry, Jean-philippe Thiran, Meritxell Bach Cuadra, Marc LevivierAbstract:Introduction Drug-resistant essential tremor (ET) can benefit from open standard stereotactic procedures, such as deep-brain stimulation or radiofrequency thalamotomy. Non-surgical candidates can be offered either high-focused ultrasound (HIFU) or radiosurgery (RS). All procedures aim to target the same thalamic site, the ventro-intermediate nucleus (e.g., Vim). The mechanisms by which tremor stops after Vim RS or HIFU remain unknown. We used voxel-based morphometry (VBM) on pretherapeutic neuroimaging data and assessed which anatomical site would best correlate with tremor arrest 1 year after Vim RS. Methods Fifty-two patients (30 male, 22 female; mean age 71.6 years, range 49–82) with right-sided ET benefited from left unilateral Vim RS in Marseille, France. Targeting was performed in a uniform manner, using 130 Gy and a single 4-mm collimator. Neurological (pretherapeutic and 1 year after) and neuroimaging (baseline) assessments were completed. Tremor score on the treated hand (TSTH) at 1 year after Vim RS was included in a statistical parametric mapping analysis of variance (ANOVA) model as a continuous variable with pretherapeutic neuroimaging data. Pretherapeutic gray matter density (GMD) was further correlated with TSTH improvement. No a priori hypothesis was used in the statistical model. Results The only statistically significant region was right Brodmann Area (BA) 18 (visual association Area V2, p = 0.05, cluster size K_c = 71). Higher baseline GMD correlated with better TSTH improvement at 1 year after Vim RS (Spearman’s rank correlation coefficient = 0.002). Conclusions Routine baseline structural neuroimaging predicts TSTH improvement 1 year after Vim RS. The relevant anatomical Area is the right visual association cortex (BA 18, V2). The question whether visual Areas should be included in the targeting remains open.
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Right Brodmann Area 18 predicts tremor arrest after Vim radiosurgery: a voxel-based morphometry study.
Acta neurochirurgica, 2017Co-Authors: Constantin Tuleasca, Tatiana Witjas, Elena Najdenovska, Antoine Verger, Nadine Girard, Jerome Champoudry, Jean-philippe Thiran, Meritxell Bach Cuadra, Dimitri Van De Ville, Marc LevivierAbstract:Drug-resistant essential tremor (ET) can benefit from open standard stereotactic procedures, such as deep-brain stimulation or radiofrequency thalamotomy. Non-surgical candidates can be offered either high-focused ultrasound (HIFU) or radiosurgery (RS). All procedures aim to target the same thalamic site, the ventro-intermediate nucleus (e.g., Vim). The mechanisms by which tremor stops after Vim RS or HIFU remain unknown. We used voxel-based morphometry (VBM) on pretherapeutic neuroimaging data and assessed which anatomical site would best correlate with tremor arrest 1 year after Vim RS. Fifty-two patients (30 male, 22 female; mean age 71.6 years, range 49-82) with right-sided ET benefited from left unilateral Vim RS in Marseille, France. Targeting was performed in a uniform manner, using 130 Gy and a single 4-mm collimator. Neurological (pretherapeutic and 1 year after) and neuroimaging (baseline) assessments were completed. Tremor score on the treated hand (TSTH) at 1 year after Vim RS was included in a statistical parametric mapping analysis of variance (ANOVA) model as a continuous variable with pretherapeutic neuroimaging data. Pretherapeutic gray matter density (GMD) was further correlated with TSTH improvement. No a priori hypothesis was used in the statistical model. The only statistically significant region was right Brodmann Area (BA) 18 (visual association Area V2, p = 0.05, cluster size K c = 71). Higher baseline GMD correlated with better TSTH improvement at 1 year after Vim RS (Spearman's rank correlation coefficient = 0.002). Routine baseline structural neuroimaging predicts TSTH improvement 1 year after Vim RS. The relevant anatomical Area is the right visual association cortex (BA 18, V2). The question whether visual Areas should be included in the targeting remains open.
Chunzhi Tang - One of the best experts on this subject based on the ideXlab platform.
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Brain activation and inhibition after acupuncture at Taichong and Taixi: resting-state functional magnetic resonance imaging.
Neural regeneration research, 2015Co-Authors: Shaoqun Zhang, Junqi Chen, Yong Huang, Yanjie Wang, Jiping Zhang, Jiarong Chen, Huailiang Ouyang, Chunzhi TangAbstract:Acupuncture can induce changes in the brain. However, the majority of studies to date have focused on a single acupoint at a time. In the present study, we observed activity changes in the brains of healthy volunteers before and after acupuncture at Taichong (LR3) and Taixi (KI3) using resting-state functional magnetic resonance imaging. Fifteen healthy volunteers underwent resting-state functional magnetic resonance imaging of the brain 15 minutes before acupuncture, then received acupuncture at Taichong and Taixi using the nail-pressing needle insertion method, after which the needle was retained in place for 30 minutes. Fifteen minutes after withdrawal of the needle, the volunteers underwent a further session of resting-state functional magnetic resonance imaging, which revealed that the amplitude of low-frequency fluctuation, a measure of spontaneous neuronal activity, increased mainly in the cerebral occipital lobe and middle occipital gyrus (Brodmann Area 18/19), inferior occipital gyrus (Brodmann Area 18) and cuneus (Brodmann Area 18), but decreased mainly in the gyrus rectus of the frontal lobe (Brodmann Area 11), inferior frontal gyrus (Brodmann Area 44) and the center of the posterior lobe of the cerebellum. The present findings indicate that acupuncture at Taichong and Taixi specifically promote blood flow and activation in the brain Areas related to vision, emotion and cognition, and inhibit brain Areas related to emotion, attention, phonological and semantic processing, and memory.
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Acupuncture at Waiguan (SJ5) and sham points influences activation of functional brain Areas of ischemic stroke patients: a functional magnetic resonance imaging study.
Neural regeneration research, 2014Co-Authors: Junqi Chen, Yong Huang, Xinsheng Lai, Chunzhi Tang, Junjun Yang, Hua ChenAbstract:Most studies addressing the specificity of meridians and acupuncture points have focused mainly on the different neural effects of acupuncture at different points in healthy individuals. This study examined the effects of acupuncture on brain function in a pathological context. Sixteen patients with ischemic stroke were randomly assigned to true point group (true acupuncture at right Waiguan (SJ5)) and sham point group (sham acupuncture). Results of functional magnetic resonance imaging revealed activation in right parietal lobe (Brodmann Areas 7 and 19), the right temporal lobe (Brodmann Area 39), the right limbic lobe (Brodmann Area 23) and bilateral occipital lobes (Brodmann Area 18). Furthermore, inhibition of bilateral frontal lobes (Brodmann Area 4, 6, and 45), right parietal lobe (Brodmann Areas 1 and 5) and left temporal lobe (Brodmann Area 21) were observed in the true point group. Activation in the precuneus of right parietal lobe (Brodmann Area 7) and inhibition of the left superior frontal gyrus (Brodmann Area 10) was observed in the sham group. Compared with sham acupuncture, acupuncture at Waiguan in stroke patients inhibited Brodmann Area 5 on the healthy side. Results indicated that the altered specificity of sensation-associated cortex (Brodmann Area 5) is possibly associated with a central mechanism of acupuncture at Waiguan for stroke patients.
