The Experts below are selected from a list of 399 Experts worldwide ranked by ideXlab platform
Aamer Saeed - One of the best experts on this subject based on the ideXlab platform.
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(Z)-N-(3-(2-Chloro-4-nitrophenyl)-4-methylthiazol-
2016Co-Authors: Aamer Saeed, Michael BolteAbstract:Synthesis of the title compound was carried out by base-catalyzed cyclization of 1-pivaloyl-3-(2-chloro-4-nitrophenyl) thiourea with α-Bromoacetone produced in situ. The structure was confirmed by the spectroscopic and elemental analy-sis and single crystal X-ray diffraction data. It crystallizes in the triclinic space group P-1 with unit cell dime sions a
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(Z)-N-(3-(2-Chloro-4-nitrophenyl)-4-methylthiazol- 2(3H)-ylidene) Pivalamide: Synthesis and Crystal Structure
Journal of Crystallization Process and Technology, 2011Co-Authors: Aamer Saeed, Michael BolteAbstract:Synthesis of the title compound was carried out by base-catalyzed cyclization of 1-pivaloyl-3-(2-chloro-4-nitrophenyl) thiourea with α-Bromoacetone produced in situ. The structure was confirmed by the spectroscopic and elemental analysis and single crystal X-ray diffraction data. It crystallizes in the triclinic space group P-1 with unit cell dime sions a = 8.7137(10), b = 10.2010(14), c = 10.6593(13), α = 62.671(9), β = 82.701(10), γ = 79.762(10), V = 827.21(8) A³, Z = 2.
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GREEN SYNTHESIS OF SOME NEW (SUBSTITUTED FLUOROBENZOYLIMINO)-3-ARYL-4-METHYL-1,3-THIAZOLINES
Synthetic Communications, 2010Co-Authors: Aamer Saeed, Uzma ShaheenAbstract:A series of 2-, 3-, and 4-substituted (fluorobenzoylimino)-3-aryl-4-methyl-1,3-thiazolines (2a–j) were synthesized in good yields by the base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas (1a–j) with α-Bromoacetone in water. Compared to the reactions in conventional nonaqueous solvents under inert anhydrous conditions, the aqueous medium provides a much cleaner, more efficient, and simpler method for synthesis.
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Synthesis and antimicrobial activity of some novel 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines
Journal of Fluorine Chemistry, 2010Co-Authors: Aamer Saeed, Uzma Shaheen, Abdul Hameed, Faiza KazmiAbstract:Abstract The synthesis of several 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines ( 2a–t ) was carried out by base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas ( 1a–t ) with 2-Bromoacetone in aqueous medium. The structures of the synthesized compounds were confirmed by spectral and elemental analysis. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria ( Staphylococcus aureus , Bacillus subtilis ) and Gram-negative bacteria ( Escherichia coli , Pseudomonas aeruginosa ). The minimum inhibitory concentration (MIC) was determined for the most active compounds. In vitro antifungal activity was also determined against the five fungal species ( Rhizopus oryzae , Fusarium oxysporum , Aspergillus terreus , A. niger and A. fumigatus ).
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Microwave promoted synthesis of some N-(4-methyl-3-tolylthiazol-2(3H)-ylidene) substituted benzamides
Chinese Chemical Letters, 2009Co-Authors: Aamer SaeedAbstract:Abstract N -(4-Methyl-3-tolylthiazol-2(3H)-ylidene) substituted benzamides ( 2a-o ) were synthesized in good to excellent yields by the base-catalyzed direct cyclization of corresponding 1-tolyl-3-aryl thioureas ( 1a-o ) with 2-Bromoacetone through microwave irradiation in a solvent-free medium. Compared to traditional thermal heating, microwave irradiation provides a much more cleaner, efficient and faster method for synthesis of the title compounds.
Polezhaeva N. - One of the best experts on this subject based on the ideXlab platform.
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β-Keto phosphonic esters Communication 3. Structures of the products of the reaction of some halo ketones with triethyl phosphite and with sodium diethyl phosphite
2020Co-Authors: Arbuzov B., Polezhaeva N.Abstract:1. Reaction of triethyl phosphite with chloro- and bromo-acetones* and 1-bromo-2-butanone gives the corresponding β-keto phosphonic esters. 2. The products obtained by methylating the potassium derivatives of diethyl acetonylphosphonate and of diethyl 1-methylacetonylphosphonate with methyl iodide are sB-keto phosphonic esters. 3. Reaction of sodium diethyl phosphite with chloro- and bromo-acetones and 3~bromo-2-butanone gives epoxy phosphonic esters. The structures of these were proved by confirmatory synthesis and by analysis of their Raman spectra. 4. In spite of Kreutzkamp and Kayser's results, reaction of sodium diethyl phosphite with chloro- or Bromoacetone does not give an unsaturated ester (diethyl isopropenyl phosphate); the products are diethyl epoxy-1-methylethylphosphonate and diethyl acetonylphosphonate. 5. The product of the reaction of 5-chloro-2-pentanone with sodium diethyl phosphite is diethyl tetrahydro2-methyl-2-furylphosphonate. © 1959 Consultants Bureau Inc
E R Anabha - One of the best experts on this subject based on the ideXlab platform.
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a facile method for the synthesis of substituted 2 ylidene 1 3 oxathioles from acetophenones
Tetrahedron Letters, 2007Co-Authors: Reichel Samuel, C V Asokan, S Suma, Prakash Chandran, S Retnamma, E R AnabhaAbstract:Compounds incorporating 1,3-oxathiole moieties in their frameworks are biologically active. Active methylene ketones can be easily converted to the corresponding dithiocarboxylates by treatment with trithiocarbonate in the presence of sodium hydride. The reactions of aroyl dithiocarboxylates with α-haloketones such as phenacyl bromide or Bromoacetone afford substituted 2-ylidene-1,3-oxathioles in good yields.
Arbuzov B. - One of the best experts on this subject based on the ideXlab platform.
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β-Keto phosphonic esters Communication 3. Structures of the products of the reaction of some halo ketones with triethyl phosphite and with sodium diethyl phosphite
2020Co-Authors: Arbuzov B., Polezhaeva N.Abstract:1. Reaction of triethyl phosphite with chloro- and bromo-acetones* and 1-bromo-2-butanone gives the corresponding β-keto phosphonic esters. 2. The products obtained by methylating the potassium derivatives of diethyl acetonylphosphonate and of diethyl 1-methylacetonylphosphonate with methyl iodide are sB-keto phosphonic esters. 3. Reaction of sodium diethyl phosphite with chloro- and bromo-acetones and 3~bromo-2-butanone gives epoxy phosphonic esters. The structures of these were proved by confirmatory synthesis and by analysis of their Raman spectra. 4. In spite of Kreutzkamp and Kayser's results, reaction of sodium diethyl phosphite with chloro- or Bromoacetone does not give an unsaturated ester (diethyl isopropenyl phosphate); the products are diethyl epoxy-1-methylethylphosphonate and diethyl acetonylphosphonate. 5. The product of the reaction of 5-chloro-2-pentanone with sodium diethyl phosphite is diethyl tetrahydro2-methyl-2-furylphosphonate. © 1959 Consultants Bureau Inc
Uzma Shaheen - One of the best experts on this subject based on the ideXlab platform.
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GREEN SYNTHESIS OF SOME NEW (SUBSTITUTED FLUOROBENZOYLIMINO)-3-ARYL-4-METHYL-1,3-THIAZOLINES
Synthetic Communications, 2010Co-Authors: Aamer Saeed, Uzma ShaheenAbstract:A series of 2-, 3-, and 4-substituted (fluorobenzoylimino)-3-aryl-4-methyl-1,3-thiazolines (2a–j) were synthesized in good yields by the base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas (1a–j) with α-Bromoacetone in water. Compared to the reactions in conventional nonaqueous solvents under inert anhydrous conditions, the aqueous medium provides a much cleaner, more efficient, and simpler method for synthesis.
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Synthesis and antimicrobial activity of some novel 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines
Journal of Fluorine Chemistry, 2010Co-Authors: Aamer Saeed, Uzma Shaheen, Abdul Hameed, Faiza KazmiAbstract:Abstract The synthesis of several 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines ( 2a–t ) was carried out by base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas ( 1a–t ) with 2-Bromoacetone in aqueous medium. The structures of the synthesized compounds were confirmed by spectral and elemental analysis. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria ( Staphylococcus aureus , Bacillus subtilis ) and Gram-negative bacteria ( Escherichia coli , Pseudomonas aeruginosa ). The minimum inhibitory concentration (MIC) was determined for the most active compounds. In vitro antifungal activity was also determined against the five fungal species ( Rhizopus oryzae , Fusarium oxysporum , Aspergillus terreus , A. niger and A. fumigatus ).
