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Bronchus Disease

The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform

Gmc Guangzhou – 1st expert on this subject based on the ideXlab platform

  • Application of the detection of CK-19 and other assiociated biochemistry items in the diagnosis of lung cancer
    Chinese Journal of Laboratory Diagnosis, 2020
    Co-Authors: Lin Yong-ping, Gmc Guangzhou

    Abstract:

    Objective To detect cytokeratin 19 fragment (CK-19) and other associated biochemical items and analysis their clinical significance for specific diagnosis of the lung cancer in the laboratory.Methods the level of CK-19 in the PE and serum of 45 lung cancer patients, 50 non-cancer lung and Bronchus Disease patients, and the level of CK-19 in the serum of 30 healthy people control were detected by ELISA, and the correlation of these parameters was analysised. Other associated biochemical items including lactate dehydrogenase(LDH), isoenzymes of lactate dehydrogenase(LD-1), adenosine deaminase(ADA), C-response protein(CRP), carcinoembryonic antigen(CEA), immunoglobulin E(IgE), and albumin(ALB) were assayed in the PE and serum of these patients.Results The level of CK-19, CEA, LDH, and LD-1 in lung cancer group were higher than in non-cancer lung and Bronchus Disease group and healthy people control group( P 0 05), but the level of ADA in lung cancer group were lower than in non-cancer lung and Bronchus Disease group and healthy people control group( P 0 05). The level of CRP was increased significantly in the non-cancer lung and Bronchus Disease group( P 0 05). The level of CK-19 in the PE were significantly correlated with that in the serum of patients with lung cancer ( r =0 868) and patients with non-cancer lung and Bronchus Disease( r =0 5462). The sensitivity, specificity, and accuracy of CK-19 in the PE and serum as a diagnostic test for lung cancer were 93 3%, 71 1%, 91 7% and 87 5%, 92%, 81 6% respectively. Conclusion Pleural effusion CK-19 may be a useful test for diagnosing lung cancer. It may be more benificial for diagnosing lung cancer measuring the CK-19 and other associated biochemical items combinatorial optimation.

Lin Yong-ping – 2nd expert on this subject based on the ideXlab platform

  • Application of the detection of CK-19 and other assiociated biochemistry items in the diagnosis of lung cancer
    Chinese Journal of Laboratory Diagnosis, 2020
    Co-Authors: Lin Yong-ping, Gmc Guangzhou

    Abstract:

    Objective To detect cytokeratin 19 fragment (CK-19) and other associated biochemical items and analysis their clinical significance for specific diagnosis of the lung cancer in the laboratory.Methods the level of CK-19 in the PE and serum of 45 lung cancer patients, 50 non-cancer lung and Bronchus Disease patients, and the level of CK-19 in the serum of 30 healthy people control were detected by ELISA, and the correlation of these parameters was analysised. Other associated biochemical items including lactate dehydrogenase(LDH), isoenzymes of lactate dehydrogenase(LD-1), adenosine deaminase(ADA), C-response protein(CRP), carcinoembryonic antigen(CEA), immunoglobulin E(IgE), and albumin(ALB) were assayed in the PE and serum of these patients.Results The level of CK-19, CEA, LDH, and LD-1 in lung cancer group were higher than in non-cancer lung and Bronchus Disease group and healthy people control group( P 0 05), but the level of ADA in lung cancer group were lower than in non-cancer lung and Bronchus Disease group and healthy people control group( P 0 05). The level of CRP was increased significantly in the non-cancer lung and Bronchus Disease group( P 0 05). The level of CK-19 in the PE were significantly correlated with that in the serum of patients with lung cancer ( r =0 868) and patients with non-cancer lung and Bronchus Disease( r =0 5462). The sensitivity, specificity, and accuracy of CK-19 in the PE and serum as a diagnostic test for lung cancer were 93 3%, 71 1%, 91 7% and 87 5%, 92%, 81 6% respectively. Conclusion Pleural effusion CK-19 may be a useful test for diagnosing lung cancer. It may be more benificial for diagnosing lung cancer measuring the CK-19 and other associated biochemical items combinatorial optimation.