The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform
Guo’an Luo - One of the best experts on this subject based on the ideXlab platform.
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Arctigenin exhibits relaxation effect on Bronchus by affecting transmembrane flow of calcium.
Biological Trace Element Research, 2013Co-Authors: Zhenying Zhao, Yongqiang Yin, Zengyong Wang, Runping Fang, Min Jiang, Gang Bai, Guo’an LuoAbstract:Arctigenin, a lignan extract from Arctium lappa (L.), exhibits anti-inflammation, antioxidation, vasodilator effects, etc. However, the effects of arctigenin on Bronchus relaxation are not well investigated. This study aimed to investigate how arctigenin regulates Bronchus Tone and calcium ion (Ca(2+)) flow. Trachea strips of guinea pigs were prepared for testing the relaxation effect of arctigenin to acetylcholine, histamine, KCl, and CaCl2, respectively. Furthermore, L-type calcium channel currents were detected by patch-clamp, and intracellular Ca(2+) concentration was detected by confocal microscopy. The results showed that arctigenin exhibited relaxation effect on tracheae to different constrictors, and this was related to decreasing cytoplasmic Ca(2+) concentration by inhibiting Ca(2+) influx partly through L-type calcium channel as well as promoting Ca(2+) efflux. In summary, this study provides new insight into the mechanisms by which arctigenin exhibits relaxation effect on Bronchus and suggests its potential use for airway disease therapy.
Zhenying Zhao - One of the best experts on this subject based on the ideXlab platform.
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Arctigenin exhibits relaxation effect on Bronchus by affecting transmembrane flow of calcium.
Biological Trace Element Research, 2013Co-Authors: Zhenying Zhao, Yongqiang Yin, Zengyong Wang, Runping Fang, Min Jiang, Gang Bai, Guo’an LuoAbstract:Arctigenin, a lignan extract from Arctium lappa (L.), exhibits anti-inflammation, antioxidation, vasodilator effects, etc. However, the effects of arctigenin on Bronchus relaxation are not well investigated. This study aimed to investigate how arctigenin regulates Bronchus Tone and calcium ion (Ca(2+)) flow. Trachea strips of guinea pigs were prepared for testing the relaxation effect of arctigenin to acetylcholine, histamine, KCl, and CaCl2, respectively. Furthermore, L-type calcium channel currents were detected by patch-clamp, and intracellular Ca(2+) concentration was detected by confocal microscopy. The results showed that arctigenin exhibited relaxation effect on tracheae to different constrictors, and this was related to decreasing cytoplasmic Ca(2+) concentration by inhibiting Ca(2+) influx partly through L-type calcium channel as well as promoting Ca(2+) efflux. In summary, this study provides new insight into the mechanisms by which arctigenin exhibits relaxation effect on Bronchus and suggests its potential use for airway disease therapy.
Yongqiang Yin - One of the best experts on this subject based on the ideXlab platform.
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Arctigenin exhibits relaxation effect on Bronchus by affecting transmembrane flow of calcium.
Biological Trace Element Research, 2013Co-Authors: Zhenying Zhao, Yongqiang Yin, Zengyong Wang, Runping Fang, Min Jiang, Gang Bai, Guo’an LuoAbstract:Arctigenin, a lignan extract from Arctium lappa (L.), exhibits anti-inflammation, antioxidation, vasodilator effects, etc. However, the effects of arctigenin on Bronchus relaxation are not well investigated. This study aimed to investigate how arctigenin regulates Bronchus Tone and calcium ion (Ca(2+)) flow. Trachea strips of guinea pigs were prepared for testing the relaxation effect of arctigenin to acetylcholine, histamine, KCl, and CaCl2, respectively. Furthermore, L-type calcium channel currents were detected by patch-clamp, and intracellular Ca(2+) concentration was detected by confocal microscopy. The results showed that arctigenin exhibited relaxation effect on tracheae to different constrictors, and this was related to decreasing cytoplasmic Ca(2+) concentration by inhibiting Ca(2+) influx partly through L-type calcium channel as well as promoting Ca(2+) efflux. In summary, this study provides new insight into the mechanisms by which arctigenin exhibits relaxation effect on Bronchus and suggests its potential use for airway disease therapy.
Zengyong Wang - One of the best experts on this subject based on the ideXlab platform.
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Arctigenin exhibits relaxation effect on Bronchus by affecting transmembrane flow of calcium.
Biological Trace Element Research, 2013Co-Authors: Zhenying Zhao, Yongqiang Yin, Zengyong Wang, Runping Fang, Min Jiang, Gang Bai, Guo’an LuoAbstract:Arctigenin, a lignan extract from Arctium lappa (L.), exhibits anti-inflammation, antioxidation, vasodilator effects, etc. However, the effects of arctigenin on Bronchus relaxation are not well investigated. This study aimed to investigate how arctigenin regulates Bronchus Tone and calcium ion (Ca(2+)) flow. Trachea strips of guinea pigs were prepared for testing the relaxation effect of arctigenin to acetylcholine, histamine, KCl, and CaCl2, respectively. Furthermore, L-type calcium channel currents were detected by patch-clamp, and intracellular Ca(2+) concentration was detected by confocal microscopy. The results showed that arctigenin exhibited relaxation effect on tracheae to different constrictors, and this was related to decreasing cytoplasmic Ca(2+) concentration by inhibiting Ca(2+) influx partly through L-type calcium channel as well as promoting Ca(2+) efflux. In summary, this study provides new insight into the mechanisms by which arctigenin exhibits relaxation effect on Bronchus and suggests its potential use for airway disease therapy.
Runping Fang - One of the best experts on this subject based on the ideXlab platform.
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Arctigenin exhibits relaxation effect on Bronchus by affecting transmembrane flow of calcium.
Biological Trace Element Research, 2013Co-Authors: Zhenying Zhao, Yongqiang Yin, Zengyong Wang, Runping Fang, Min Jiang, Gang Bai, Guo’an LuoAbstract:Arctigenin, a lignan extract from Arctium lappa (L.), exhibits anti-inflammation, antioxidation, vasodilator effects, etc. However, the effects of arctigenin on Bronchus relaxation are not well investigated. This study aimed to investigate how arctigenin regulates Bronchus Tone and calcium ion (Ca(2+)) flow. Trachea strips of guinea pigs were prepared for testing the relaxation effect of arctigenin to acetylcholine, histamine, KCl, and CaCl2, respectively. Furthermore, L-type calcium channel currents were detected by patch-clamp, and intracellular Ca(2+) concentration was detected by confocal microscopy. The results showed that arctigenin exhibited relaxation effect on tracheae to different constrictors, and this was related to decreasing cytoplasmic Ca(2+) concentration by inhibiting Ca(2+) influx partly through L-type calcium channel as well as promoting Ca(2+) efflux. In summary, this study provides new insight into the mechanisms by which arctigenin exhibits relaxation effect on Bronchus and suggests its potential use for airway disease therapy.
