The Experts below are selected from a list of 102 Experts worldwide ranked by ideXlab platform
Oliver W - One of the best experts on this subject based on the ideXlab platform.
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The relative bioavailability of paracetamol and codeine after oral administration of a combination of Buclizine, paracetamol and codeine, with or without docusate, and of paracetamol alone in healthy volunteers
Current Medical Research and Opinion, 2008Co-Authors: Persaud N, Johnson Es, Merrington D, Oliver WAbstract:SummaryA randomized, double-blind, crossover study was carried out in 10 healthy volunteers to investigate whether the inclusion of the wetting agent docusate sodium (10 mg) in a combined oral formulation (‘Migraleve’) with Buclizine hydrochloride (6.25 mg), codeine phosphate (8 mg) and paracetamol (500 mg) had any effect on the bioavailability of the analgesics. On 3 occasions at weekly intervals, the subjects were given 2 tablets of the standard formulation, the combination without docusate or 500 mg paracetamol alone. Blood samples were taken before and at fixed times during the 4 hours after administration of each preparation for estimation of plasma concentrations of paracetamol, by gas-liquid chromatography, and of codeine, by radioimmunoassay. The results showed that there were no significant differences between the mean paracetamol concentrations achieved after administration of each of the 3 preparations at any of the time points. Peak paracetamol plasma concentrations were 11.25±1.74ng/ml at 0.5...
Farhan Ahmed Siddiqui - One of the best experts on this subject based on the ideXlab platform.
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Simultaneous determination of antihistamine anti-allergic drugs, cetirizine, domperidone, chlorphenamine maleate, loratadine, meclizine and Buclizine in pharmaceutical formulations, human serum and pharmacokinetics application
Analytical Methods, 2014Co-Authors: Nawab Sher, Farhan Ahmed Siddiqui, Najmul Hasan, Nighat Shafi, Arif Zubair, Agha Zeeshan MirzaAbstract:This article describes a new, accurate and highly specific high performance liquid chromatographic method with UV detection (HPLC-UV) for the simultaneous determination of cetirizine HCl (CZ), chlorphenamine maleate (CPM), loratadine (LTD), domperidone (DP), Buclizine (BZ) and meclizine (MZ) in pharmaceutical dosage form and human serum, involving pyridoxine (PYD) as the internal standard. The mobile phase consists of heptane sulphonic acid salt buffer and acetonitrile, drawn at a flow rate of 1.0 mL min−1 using a symmetry C18 column with UV detection at 230 nm. The intraday and inter-day precision measurements showed coefficients of variation always less than one. The calibration curve was tested in the range of 10–2150 ng mL−1 and the correlation coefficient of >0.9990 in all cases was obtained. The averages of the absolute and relative recoveries were found to be in the range of 98 to 102%. Up to six antihistamines were separated in the same chromatogram with good resolution. The proposed HPLC method has reasonable applications in pharmaceutical tablet dosage form and pharmacokinetics studies.
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optimization of quantitative analysis of Buclizine hydrochloride using uv spectrophotometry in bulk drug and dosage formulations
Medicinal Chemistry Research, 2011Co-Authors: Farhan Ahmed Siddiqui, Agha Zeeshan Mirza, Hashim M Zuberi, Faiza QureshiAbstract:Development and validation of an analytical spectral calibration method to quantify Buclizine hydrochloride, which is a piperazine derivative and used as a single active principle in pharmaceutical forms were done. The quantification of Buclizine hydrochloride was performed in the wavelength range of 218–226 nm at N = 6. The linear regression equation has been constructed using relationship between concentration and absorbance at 218, 220, 222, 224, and 226 nm. The developed method was applied directly and easily to the analysis of the pharmaceutical tablet preparations. Mean %RSD was found to be 0.6231% (Longifene® tablet 25 mg). The method was completely validated and proven to be rugged. This validated UV spectrophotometric method is potentially useful for a routine laboratory analysis because of its simplicity, rapidity, sensitivity, precision, and accuracy.
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simultaneous determination of gliquidone fexofenadine Buclizine and levocetirizine in dosage formulation and human serum by rp hplc
Journal of Chromatographic Science, 2010Co-Authors: Saeed M Arayne, Mirza Agha Zeeshan, Najma Sultana, Farhan Ahmed SiddiquiAbstract:: In the present paper, a simultaneous method has been developed and validated for estimation of gliquidone in the presence of H(1)-receptor antagonists (fexofenadine hydrochloride, Buclizine hydrochloride, and levocetirizine dihydrochloride) using reversed-phase high-performance liquid chromatographic technique. A good chromatographic separation between these drugs was achieved using a mobile phase containing methanol-water (80:20 v/v) at pH 3.5 with a flow rate of 1.0 mL/min; and detection was performed at 230 nm with a UV detector. Validation of the method was performed in terms of linearity, accuracy, precision, and limit of detection and quantification. The linearity of the calibration curves for gliquidone, fexofenadine hydrochloride, Buclizine hydrochloride, and levocetirizine dihydrochloride were found to be 0.338-50 microg/mL (r = 0.9964), 5-50 microg/mL (r = 0.9956), 0.325-50 microg/mL (r = 0.9967), and 0.553-50 microg/mL (r = 0.9950), respectively. There was no significant difference between the amount of drug spiked in serum and the amount recovered, and serum did not interfere in simultaneous estimation. Thus, the proposed method is suitable for the simultaneous analysis of active ingredients in tablet dosage forms and human serum.
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Simultaneous Determination of Pyridoxine, Meclizine and Buclizine in Dosage Formulations and Human Serum by RP-LC
Chromatographia, 2008Co-Authors: Muhammad Saeed Arayne, Najma Sultana, Farhan Ahmed SiddiquiAbstract:Rapid liquid chromatographic procedures for analytical quality control of pharmaceutical preparations and human serum containing antihistamine drugs, meclizine and Buclizine alone or in combination with pyridoxine are proposed, using acetonitrile:water (80:20) as a mobile phase (pH adjusted to 2.6), methylparaben as internal standard and UV detection was made at 230 nm. The results obtained showed a good agreement with the declared content. The method shows good linearity in the range of 30–10,000 ng mL−1 for pyridoxine and 25–10,000 ng mL−1 for meclizine and Buclizine serum concentrations with a correlation coefficient 0.9999 (inter- and intra-day CV 97.8%. The proposed method may be used for the quantitative analysis of meclizine and Buclizine alone or in combination with pyridoxine from raw materials, in bulk drugs, dosage formulations and in serum.
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quantitation of Buclizine hydrochloride in pharmaceutical formulations and human serum by rp hplc
Pakistan Journal of Pharmaceutical Sciences, 2006Co-Authors: Saeed M Arayne, Najma Sultana, Farhan Ahmed SiddiquiAbstract:An isocratic reversed phase high-performance liquid chromatographic (HPLC) method with ultraviolet detection at 230 nm has been developed for the determination of Buclizine hydrochloride in human serum and dosage formulation. Methylparaben was successfully used as an internal standard. Good chromatographic separation between Buclizine and internal standard peaks was achieved by using a stainless steel analytical column Nucleosil, C18 (10 microm, 25 cm x 0.46 cm). The system was operated at room temperature using a mobile phase consisting of acetonitrile-water (1:1) (pH 2.6) with phosphoric acid 85% at a flow rate of 2 ml/min. The calibration curve for Buclizine hydrochloride in human serum was linear over the tested concentration range of 10, 3, 1.5, 0.5, 0.15, 0.05, and 0.025 microg/ml with a correlation coefficient of 0.9999. The intra- and inter-run precision and accuracy results were 98.07 to 100.34. The proposed method was validated for selectivity, linearity, accuracy, and precision. The method was found to be suitable for the quality control of Buclizine hydrochloride in bulk drug as well as in human serum.
Persaud N - One of the best experts on this subject based on the ideXlab platform.
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The relative bioavailability of paracetamol and codeine after oral administration of a combination of Buclizine, paracetamol and codeine, with or without docusate, and of paracetamol alone in healthy volunteers
Current Medical Research and Opinion, 2008Co-Authors: Persaud N, Johnson Es, Merrington D, Oliver WAbstract:SummaryA randomized, double-blind, crossover study was carried out in 10 healthy volunteers to investigate whether the inclusion of the wetting agent docusate sodium (10 mg) in a combined oral formulation (‘Migraleve’) with Buclizine hydrochloride (6.25 mg), codeine phosphate (8 mg) and paracetamol (500 mg) had any effect on the bioavailability of the analgesics. On 3 occasions at weekly intervals, the subjects were given 2 tablets of the standard formulation, the combination without docusate or 500 mg paracetamol alone. Blood samples were taken before and at fixed times during the 4 hours after administration of each preparation for estimation of plasma concentrations of paracetamol, by gas-liquid chromatography, and of codeine, by radioimmunoassay. The results showed that there were no significant differences between the mean paracetamol concentrations achieved after administration of each of the 3 preparations at any of the time points. Peak paracetamol plasma concentrations were 11.25±1.74ng/ml at 0.5...
Merrington D - One of the best experts on this subject based on the ideXlab platform.
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The relative bioavailability of paracetamol and codeine after oral administration of a combination of Buclizine, paracetamol and codeine, with or without docusate, and of paracetamol alone in healthy volunteers
Current Medical Research and Opinion, 2008Co-Authors: Persaud N, Johnson Es, Merrington D, Oliver WAbstract:SummaryA randomized, double-blind, crossover study was carried out in 10 healthy volunteers to investigate whether the inclusion of the wetting agent docusate sodium (10 mg) in a combined oral formulation (‘Migraleve’) with Buclizine hydrochloride (6.25 mg), codeine phosphate (8 mg) and paracetamol (500 mg) had any effect on the bioavailability of the analgesics. On 3 occasions at weekly intervals, the subjects were given 2 tablets of the standard formulation, the combination without docusate or 500 mg paracetamol alone. Blood samples were taken before and at fixed times during the 4 hours after administration of each preparation for estimation of plasma concentrations of paracetamol, by gas-liquid chromatography, and of codeine, by radioimmunoassay. The results showed that there were no significant differences between the mean paracetamol concentrations achieved after administration of each of the 3 preparations at any of the time points. Peak paracetamol plasma concentrations were 11.25±1.74ng/ml at 0.5...
Johnson Es - One of the best experts on this subject based on the ideXlab platform.
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The relative bioavailability of paracetamol and codeine after oral administration of a combination of Buclizine, paracetamol and codeine, with or without docusate, and of paracetamol alone in healthy volunteers
Current Medical Research and Opinion, 2008Co-Authors: Persaud N, Johnson Es, Merrington D, Oliver WAbstract:SummaryA randomized, double-blind, crossover study was carried out in 10 healthy volunteers to investigate whether the inclusion of the wetting agent docusate sodium (10 mg) in a combined oral formulation (‘Migraleve’) with Buclizine hydrochloride (6.25 mg), codeine phosphate (8 mg) and paracetamol (500 mg) had any effect on the bioavailability of the analgesics. On 3 occasions at weekly intervals, the subjects were given 2 tablets of the standard formulation, the combination without docusate or 500 mg paracetamol alone. Blood samples were taken before and at fixed times during the 4 hours after administration of each preparation for estimation of plasma concentrations of paracetamol, by gas-liquid chromatography, and of codeine, by radioimmunoassay. The results showed that there were no significant differences between the mean paracetamol concentrations achieved after administration of each of the 3 preparations at any of the time points. Peak paracetamol plasma concentrations were 11.25±1.74ng/ml at 0.5...
