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Jan Tack - One of the best experts on this subject based on the ideXlab platform.
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higher plasma motilin levels in obese patients decrease after roux en y gastric bypass surgery and regulate hunger
Gut, 2016Co-Authors: Eveline Deloose, Inge Depoortere, Pieter Janssen, Matthias Lannoo, B Van Der Schueren, Jan TackAbstract:Objective Motilin-induced phase III contractions of the migrating motor complex (MMC) signal hunger in healthy volunteers. The current aim was to study the role of motilin as a hunger-inducing factor in obese patients and to evaluate the effect of Roux-en-Y gastric bypass (RYGB) surgery on plasma motilin levels and hunger scores. Design Motilin and ghrelin plasma levels were determined during a complete MMC cycle in controls and obese patients selected for RYGB before, 6 months and 1 year after surgery. 20 min after the end of the second phase III, obese patients received an intravenous infusion of 40 mg erythromycin. Hunger was scored every 5 min. Hedonic hunger was assessed in obese patients with the Power of Food Scale questionnaire. Results Obesity caused a switch in the origin of phase III from antrum to duodenum. Obese patients had significantly higher motilin levels compared with controls during the MMC but tended to lack the motilin peak prior to phase III necessary to trigger hunger. Hunger scores during phase III were significantly lower in obese patients, but could be restored to control levels through the administration of a low dose of the motilin agonist, erythromycin. After RYGB surgery motilin, but not ghrelin, levels decreased in parallel with hedonic hunger scores. Conclusions Motilin may be an important regulator involved in the pathogenesis of obesity.
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the motilin receptor agonist erythromycin stimulates hunger and food intake through a cholinergic pathway
The American Journal of Clinical Nutrition, 2016Co-Authors: Eveline Deloose, Inge Depoortere, Rita Vos, Pieter Janssen, Omer Van Den Bergh, Lukas Van Oudenhove, Jan TackAbstract:BACKGROUND Motilin-induced phase III contractions have been identified as a hunger signal. These phase III contractions occur as part of the migrating motor complex (MMC), a contractility pattern of the gastrointestinal tract during fasting. The mechanism involved in this association between subjective hunger feelings and gastrointestinal motility during the MMC is largely unknown, however, as is its ability to stimulate food intake. OBJECTIVES We sought to 1) investigate the occurrence of hunger peaks and their relation to phase III contractions, 2) evaluate whether this relation was cholinergically driven, and 3) assess the ability of the motilin receptor agonist erythromycin to induce food intake. DESIGN An algorithm was developed to detect hunger peaks. The association with phase III contractions was studied in 14 healthy volunteers [50% men; mean ± SEM age: 25 ± 2 y; mean ± SEM body mass index (BMI; in kg/m(2)): 23 ± 1]. The impact of pharmacologically induced phase III contractions on the occurrence of hunger peaks and the involvement of a cholinergic pathway were assessed in 14 healthy volunteers (43% men; age: 29 ± 3 y; BMI: 23 ± 1). Last, the effect of erythromycin administration on food intake was examined in 15 healthy volunteers (40% men; age: 28 ± 3 y; BMI: 22 ± 1). RESULTS The occurrence of hunger peaks and their significant association with phase III contractions was confirmed (P < 0.0001). Pharmacologically induced phase III contractions were also significantly associated with hunger peaks (P < 0.05), and this association involved a cholinergic pathway. Administering erythromycin significantly stimulated food intake compared with placebo (53% ± 13% compared with 10% ± 5%; P < 0.05). CONCLUSIONS Motilin-induced phase III contractions induced hunger feelings through a cholinergic pathway. Moreover, erythromycin stimulated food intake, suggesting a physiologic role of motilin as an orexigenic signal from the gastrointestinal tract. This trial was registered at www.clinicaltrials.gov as NCT02633579.
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motilin induced gastric contractions signal hunger in man
Gut, 2016Co-Authors: Jan Tack, Eveline Deloose, Lukas Van Oudenhove, Daphne Ang, Emidio Scarpellini, Tim Vanuytsel, Inge DepoortereAbstract:Rationale Hunger is controlled by the brain, which receives input from signals of the GI tract (GIT). During fasting, GIT displays a cyclical motor pattern, the migrating motor complex (MMC), regulated by motilin. Objectives To study the relationship between hunger and MMC phases (I–III), focusing on spontaneous and pharmacologically induced phase III and the correlation with plasma motilin and ghrelin levels. The role of phase III was also studied in the return of hunger after a meal in healthy individuals and in patients with loss of appetite. Findings In fasting healthy volunteers, mean hunger ratings during a gastric (62.5±7.5) but not a duodenal (40.4±5.4) phase III were higher (p Conclusions Motilin-induced gastric phase III is a hunger signal from GIT in man.
Eveline Deloose - One of the best experts on this subject based on the ideXlab platform.
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higher plasma motilin levels in obese patients decrease after roux en y gastric bypass surgery and regulate hunger
Gut, 2016Co-Authors: Eveline Deloose, Inge Depoortere, Pieter Janssen, Matthias Lannoo, B Van Der Schueren, Jan TackAbstract:Objective Motilin-induced phase III contractions of the migrating motor complex (MMC) signal hunger in healthy volunteers. The current aim was to study the role of motilin as a hunger-inducing factor in obese patients and to evaluate the effect of Roux-en-Y gastric bypass (RYGB) surgery on plasma motilin levels and hunger scores. Design Motilin and ghrelin plasma levels were determined during a complete MMC cycle in controls and obese patients selected for RYGB before, 6 months and 1 year after surgery. 20 min after the end of the second phase III, obese patients received an intravenous infusion of 40 mg erythromycin. Hunger was scored every 5 min. Hedonic hunger was assessed in obese patients with the Power of Food Scale questionnaire. Results Obesity caused a switch in the origin of phase III from antrum to duodenum. Obese patients had significantly higher motilin levels compared with controls during the MMC but tended to lack the motilin peak prior to phase III necessary to trigger hunger. Hunger scores during phase III were significantly lower in obese patients, but could be restored to control levels through the administration of a low dose of the motilin agonist, erythromycin. After RYGB surgery motilin, but not ghrelin, levels decreased in parallel with hedonic hunger scores. Conclusions Motilin may be an important regulator involved in the pathogenesis of obesity.
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the motilin receptor agonist erythromycin stimulates hunger and food intake through a cholinergic pathway
The American Journal of Clinical Nutrition, 2016Co-Authors: Eveline Deloose, Inge Depoortere, Rita Vos, Pieter Janssen, Omer Van Den Bergh, Lukas Van Oudenhove, Jan TackAbstract:BACKGROUND Motilin-induced phase III contractions have been identified as a hunger signal. These phase III contractions occur as part of the migrating motor complex (MMC), a contractility pattern of the gastrointestinal tract during fasting. The mechanism involved in this association between subjective hunger feelings and gastrointestinal motility during the MMC is largely unknown, however, as is its ability to stimulate food intake. OBJECTIVES We sought to 1) investigate the occurrence of hunger peaks and their relation to phase III contractions, 2) evaluate whether this relation was cholinergically driven, and 3) assess the ability of the motilin receptor agonist erythromycin to induce food intake. DESIGN An algorithm was developed to detect hunger peaks. The association with phase III contractions was studied in 14 healthy volunteers [50% men; mean ± SEM age: 25 ± 2 y; mean ± SEM body mass index (BMI; in kg/m(2)): 23 ± 1]. The impact of pharmacologically induced phase III contractions on the occurrence of hunger peaks and the involvement of a cholinergic pathway were assessed in 14 healthy volunteers (43% men; age: 29 ± 3 y; BMI: 23 ± 1). Last, the effect of erythromycin administration on food intake was examined in 15 healthy volunteers (40% men; age: 28 ± 3 y; BMI: 22 ± 1). RESULTS The occurrence of hunger peaks and their significant association with phase III contractions was confirmed (P < 0.0001). Pharmacologically induced phase III contractions were also significantly associated with hunger peaks (P < 0.05), and this association involved a cholinergic pathway. Administering erythromycin significantly stimulated food intake compared with placebo (53% ± 13% compared with 10% ± 5%; P < 0.05). CONCLUSIONS Motilin-induced phase III contractions induced hunger feelings through a cholinergic pathway. Moreover, erythromycin stimulated food intake, suggesting a physiologic role of motilin as an orexigenic signal from the gastrointestinal tract. This trial was registered at www.clinicaltrials.gov as NCT02633579.
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motilin induced gastric contractions signal hunger in man
Gut, 2016Co-Authors: Jan Tack, Eveline Deloose, Lukas Van Oudenhove, Daphne Ang, Emidio Scarpellini, Tim Vanuytsel, Inge DepoortereAbstract:Rationale Hunger is controlled by the brain, which receives input from signals of the GI tract (GIT). During fasting, GIT displays a cyclical motor pattern, the migrating motor complex (MMC), regulated by motilin. Objectives To study the relationship between hunger and MMC phases (I–III), focusing on spontaneous and pharmacologically induced phase III and the correlation with plasma motilin and ghrelin levels. The role of phase III was also studied in the return of hunger after a meal in healthy individuals and in patients with loss of appetite. Findings In fasting healthy volunteers, mean hunger ratings during a gastric (62.5±7.5) but not a duodenal (40.4±5.4) phase III were higher (p Conclusions Motilin-induced gastric phase III is a hunger signal from GIT in man.
Inge Depoortere - One of the best experts on this subject based on the ideXlab platform.
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higher plasma motilin levels in obese patients decrease after roux en y gastric bypass surgery and regulate hunger
Gut, 2016Co-Authors: Eveline Deloose, Inge Depoortere, Pieter Janssen, Matthias Lannoo, B Van Der Schueren, Jan TackAbstract:Objective Motilin-induced phase III contractions of the migrating motor complex (MMC) signal hunger in healthy volunteers. The current aim was to study the role of motilin as a hunger-inducing factor in obese patients and to evaluate the effect of Roux-en-Y gastric bypass (RYGB) surgery on plasma motilin levels and hunger scores. Design Motilin and ghrelin plasma levels were determined during a complete MMC cycle in controls and obese patients selected for RYGB before, 6 months and 1 year after surgery. 20 min after the end of the second phase III, obese patients received an intravenous infusion of 40 mg erythromycin. Hunger was scored every 5 min. Hedonic hunger was assessed in obese patients with the Power of Food Scale questionnaire. Results Obesity caused a switch in the origin of phase III from antrum to duodenum. Obese patients had significantly higher motilin levels compared with controls during the MMC but tended to lack the motilin peak prior to phase III necessary to trigger hunger. Hunger scores during phase III were significantly lower in obese patients, but could be restored to control levels through the administration of a low dose of the motilin agonist, erythromycin. After RYGB surgery motilin, but not ghrelin, levels decreased in parallel with hedonic hunger scores. Conclusions Motilin may be an important regulator involved in the pathogenesis of obesity.
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the motilin receptor agonist erythromycin stimulates hunger and food intake through a cholinergic pathway
The American Journal of Clinical Nutrition, 2016Co-Authors: Eveline Deloose, Inge Depoortere, Rita Vos, Pieter Janssen, Omer Van Den Bergh, Lukas Van Oudenhove, Jan TackAbstract:BACKGROUND Motilin-induced phase III contractions have been identified as a hunger signal. These phase III contractions occur as part of the migrating motor complex (MMC), a contractility pattern of the gastrointestinal tract during fasting. The mechanism involved in this association between subjective hunger feelings and gastrointestinal motility during the MMC is largely unknown, however, as is its ability to stimulate food intake. OBJECTIVES We sought to 1) investigate the occurrence of hunger peaks and their relation to phase III contractions, 2) evaluate whether this relation was cholinergically driven, and 3) assess the ability of the motilin receptor agonist erythromycin to induce food intake. DESIGN An algorithm was developed to detect hunger peaks. The association with phase III contractions was studied in 14 healthy volunteers [50% men; mean ± SEM age: 25 ± 2 y; mean ± SEM body mass index (BMI; in kg/m(2)): 23 ± 1]. The impact of pharmacologically induced phase III contractions on the occurrence of hunger peaks and the involvement of a cholinergic pathway were assessed in 14 healthy volunteers (43% men; age: 29 ± 3 y; BMI: 23 ± 1). Last, the effect of erythromycin administration on food intake was examined in 15 healthy volunteers (40% men; age: 28 ± 3 y; BMI: 22 ± 1). RESULTS The occurrence of hunger peaks and their significant association with phase III contractions was confirmed (P < 0.0001). Pharmacologically induced phase III contractions were also significantly associated with hunger peaks (P < 0.05), and this association involved a cholinergic pathway. Administering erythromycin significantly stimulated food intake compared with placebo (53% ± 13% compared with 10% ± 5%; P < 0.05). CONCLUSIONS Motilin-induced phase III contractions induced hunger feelings through a cholinergic pathway. Moreover, erythromycin stimulated food intake, suggesting a physiologic role of motilin as an orexigenic signal from the gastrointestinal tract. This trial was registered at www.clinicaltrials.gov as NCT02633579.
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motilin induced gastric contractions signal hunger in man
Gut, 2016Co-Authors: Jan Tack, Eveline Deloose, Lukas Van Oudenhove, Daphne Ang, Emidio Scarpellini, Tim Vanuytsel, Inge DepoortereAbstract:Rationale Hunger is controlled by the brain, which receives input from signals of the GI tract (GIT). During fasting, GIT displays a cyclical motor pattern, the migrating motor complex (MMC), regulated by motilin. Objectives To study the relationship between hunger and MMC phases (I–III), focusing on spontaneous and pharmacologically induced phase III and the correlation with plasma motilin and ghrelin levels. The role of phase III was also studied in the return of hunger after a meal in healthy individuals and in patients with loss of appetite. Findings In fasting healthy volunteers, mean hunger ratings during a gastric (62.5±7.5) but not a duodenal (40.4±5.4) phase III were higher (p Conclusions Motilin-induced gastric phase III is a hunger signal from GIT in man.
Laure Martin - One of the best experts on this subject based on the ideXlab platform.
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proterozoic reworking of archean yilgarn basement in the Bunger hills east antarctica
Precambrian Research, 2017Co-Authors: Naomi M Tucker, Martin Hand, Chris D Clark, Justin L Payne, Richard J M Taylor, Andrew R C Kylanderclark, Laure MartinAbstract:The Bunger Hills in East Antarctica occupy a pivotal location as the westernmost continuation of the Albany–Fraser Orogen in southwestern Australia. Combined U–Pb, Lu–Hf and oxygen isotope data from the Bunger Hills reveal a previously unrecognised Archean basement (ca. 2800–2700 Ma) of Yilgarn Craton affinity. Results also reveal a Paleo–Mesoproterozoic (ca. 1700–1500 Ma) volcano-clastic sequence and late Mesoproterozoic magmatic intrusives (ca. 1260 Ma and 1200 Ma) that were coeval with high grade metamorphism. Isotopic data reflect the influence of an Archean crustal component in Proterozoic magmatism. Paleoproterozoic magmatism was characterised by voluminous juvenile input and minor recycling of Archean crust. In contrast, Mesoproterozoic magmatism is isotopically evolved, and is interpreted to have been derived largely from reworking of the Paleoproterozoic crust and Archean basement. Strong parallels between the age and isotopic composition of igneous rocks over time from the Bunger Hills and Albany–Fraser Orogen in southwest Australia suggest that the Paleo–Mesoproterozoic tectonic evolution of these two elements of the orogen is linked. Specifically, the Bunger Hills are interpreted to represent the Paleo–Mesoproterozoic (para)autochthonous modification of a reworked fragment of the Archean Yilgarn Craton that was extended during the late Paleoproterozoic.
Justin L Payne - One of the best experts on this subject based on the ideXlab platform.
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proterozoic reworking of archean yilgarn basement in the Bunger hills east antarctica
Precambrian Research, 2017Co-Authors: Naomi M Tucker, Martin Hand, Chris D Clark, Justin L Payne, Richard J M Taylor, Andrew R C Kylanderclark, Laure MartinAbstract:The Bunger Hills in East Antarctica occupy a pivotal location as the westernmost continuation of the Albany–Fraser Orogen in southwestern Australia. Combined U–Pb, Lu–Hf and oxygen isotope data from the Bunger Hills reveal a previously unrecognised Archean basement (ca. 2800–2700 Ma) of Yilgarn Craton affinity. Results also reveal a Paleo–Mesoproterozoic (ca. 1700–1500 Ma) volcano-clastic sequence and late Mesoproterozoic magmatic intrusives (ca. 1260 Ma and 1200 Ma) that were coeval with high grade metamorphism. Isotopic data reflect the influence of an Archean crustal component in Proterozoic magmatism. Paleoproterozoic magmatism was characterised by voluminous juvenile input and minor recycling of Archean crust. In contrast, Mesoproterozoic magmatism is isotopically evolved, and is interpreted to have been derived largely from reworking of the Paleoproterozoic crust and Archean basement. Strong parallels between the age and isotopic composition of igneous rocks over time from the Bunger Hills and Albany–Fraser Orogen in southwest Australia suggest that the Paleo–Mesoproterozoic tectonic evolution of these two elements of the orogen is linked. Specifically, the Bunger Hills are interpreted to represent the Paleo–Mesoproterozoic (para)autochthonous modification of a reworked fragment of the Archean Yilgarn Craton that was extended during the late Paleoproterozoic.
