The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Hai-tao Gao - One of the best experts on this subject based on the ideXlab platform.
-
Total Synthesis of (+)-Iresin
2015Co-Authors: Bian-lin Wang, Hai-tao GaoAbstract:The first asymmetric total synthesis of (+)-iresin (4), an historically important ent-Drimane sesquiterpene lactone, was realized from aldehyde 3 via cyclic orthoester 6 in 5 steps. Notable transformations in this synthesis include a tandem trifluoroperacetic acid (TFPAA)-mediated Baeyer–Villiger oxidation–olefin epoxidation–epoxy ester cyclization, regioselective Burgess Dehydration, and regioselective Fétizon oxidative lactonization
Bian-lin Wang - One of the best experts on this subject based on the ideXlab platform.
-
Total Synthesis of (+)-Iresin
2015Co-Authors: Bian-lin Wang, Hai-tao GaoAbstract:The first asymmetric total synthesis of (+)-iresin (4), an historically important ent-Drimane sesquiterpene lactone, was realized from aldehyde 3 via cyclic orthoester 6 in 5 steps. Notable transformations in this synthesis include a tandem trifluoroperacetic acid (TFPAA)-mediated Baeyer–Villiger oxidation–olefin epoxidation–epoxy ester cyclization, regioselective Burgess Dehydration, and regioselective Fétizon oxidative lactonization
Georg Manolikakes - One of the best experts on this subject based on the ideXlab platform.
-
Modular Regiospecific Synthesis of Nitrated Fatty Acids
Synthesis, 2016Co-Authors: Katharina J. Hock, Jennifer Grimmer, Dominik Göbel, George Gichogo T. Gasaya, Jessica Roos, Isabelle V. Maucher, Benjamin Kühn, Jasmin Fettel, Thorsten J. Maier, Georg ManolikakesAbstract:Endogenous nitrated fatty acids are an important class of signaling molecules. Herein a modular route for the efficient and regiospecific preparation of nitrooleic acids as well as various analogues is described. The approach is based on a simple set of alkyl halides as common building blocks and a Henry reaction/Burgess Dehydration sequence for the formation of the key nitroalkene moiety.
Kenichi Nihei - One of the best experts on this subject based on the ideXlab platform.
-
stereochemical investigation and total synthesis of inuloidin a biologically active sesquiterpenoid from heterotheca inuloides
Tetrahedron, 2014Co-Authors: Jumpei Kamatani, Takehiro Iwadate, Reiko Tajima, Hideaki Kimoto, Yoichi Yamada, Noriyoshi Masuoka, Isao Kubo, Kenichi NiheiAbstract:Abstract The stereochemistry of inuloidin (1), which was a sesquiterpenoid that was characterized as a plant growth inhibitory substance from Heterotheca inuloides, was investigated. The modified Mosher's method coupled with a total synthetic study using osmium oxidation and Burgess Dehydration as key steps were performed to clarify the stereochemistry of 1, which was determined to be a 2S,4R isomer.
Katharina J. Hock - One of the best experts on this subject based on the ideXlab platform.
-
Modular Regiospecific Synthesis of Nitrated Fatty Acids
Synthesis, 2016Co-Authors: Katharina J. Hock, Jennifer Grimmer, Dominik Göbel, George Gichogo T. Gasaya, Jessica Roos, Isabelle V. Maucher, Benjamin Kühn, Jasmin Fettel, Thorsten J. Maier, Georg ManolikakesAbstract:Endogenous nitrated fatty acids are an important class of signaling molecules. Herein a modular route for the efficient and regiospecific preparation of nitrooleic acids as well as various analogues is described. The approach is based on a simple set of alkyl halides as common building blocks and a Henry reaction/Burgess Dehydration sequence for the formation of the key nitroalkene moiety.
