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Joanne R Paulmurphy - One of the best experts on this subject based on the ideXlab platform.
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evaluation of the thermal antinociceptive effects of subcutaneous administration of Butorphanol Tartrate or Butorphanol Tartrate in a sustained release poloxamer 407 gel formulation to orange winged amazon parrots amazona amazonica
American Journal of Veterinary Research, 2020Co-Authors: Delphine Laniesse, Dale A Smith, Cornelia Mosley, David Sanchezmigallon Guzman, Hugues Beaufrere, Jamie M Douglas, Joanne R PaulmurphyAbstract:OBJECTIVE To determine the thermal antinociceptive effects of Butorphanol Tartrate and Butorphanol Tartrate in a sustained-release 25% poloxamer 407 (P407) gel formulation (But-P407) in parrots. AN...
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evaluation of thermal antinociceptive effects and pharmacokinetics after intramuscular administration of Butorphanol Tartrate to american kestrels falco sparverius
American Journal of Veterinary Research, 2014Co-Authors: David Sanchezmigallon Guzman, Tracy L Drazenovich, Butch Kukanich, Glenn H Olsen, Neil H Willits, Joanne R PaulmurphyAbstract:Objective—To evaluate antinociceptive effects and pharmacokinetics of Butorphanol Tartrate after IM administration to American kestrels (Falco sparverius). Animals—Fifteen 2- to 3-year-old American kestrels (6 males and 9 females). Procedures—Butorphanol (1, 3, and 6 mg/kg) and saline (0.9% NaCl) solution were administered IM to birds in a crossover experimental design. Agitation-sedation scores and foot withdrawal response to a thermal stimulus were determined 30 to 60 minutes before (baseline) and 0.5, 1.5, 3, and 6 hours after treatment. For the pharmacokinetic analysis, Butorphanol (6 mg/kg, IM) was administered in the pectoral muscles of each of 12 birds. Results—In male kestrels, Butorphanol did not significantly increase thermal thresholds for foot withdrawal, compared with results for saline solution administration. However, at 1.5 hours after administration of 6 mg of Butorphanol/kg, the thermal threshold was significantly decreased, compared with the baseline value. Foot withdrawal threshold for...
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pharmacokinetics of Butorphanol after intravenous intramuscular and oral administration in hispaniolan amazon parrots amazona ventralis
Journal of Avian Medicine and Surgery, 2011Co-Authors: David Sanchezmigallon Guzman, Joanne R Paulmurphy, Keven Flammer, Steven A Barker, Thomas N. TullyAbstract:Abstract Previous studies have validated the clinical use of opioids with κ-receptor affinities for pain management in birds. Butorphanol, a κ opioid receptor agonist and a μ opioid receptor antagonist, is currently considered by many clinicians to be the opioid of choice for this use. However, despite studies reporting the analgesic properties of Butorphanol in psittacine birds, dosing intervals have not been established for any psittacine species. The goals of this study in the Hispaniolan Amazon parrot (Amazona ventralis) were to evaluate the pharmacokinetics of Butorphanol Tartrate after intravenous (IV), intramuscular (IM), and oral (PO) administration and to determine the bioavailability of Butorphanol Tartrate after oral administration. Twelve Hispaniolan Amazon parrots were used in the study, with a complete-crossover experimental design and a 3-month period separating each part of the study. The birds were randomly assigned to 3 groups (n = 4) for each stage. Butorphanol Tartrate was administer...
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pharmacokinetics of Butorphanol after intravenous intramuscular and oral administration in hispaniolan amazon parrots amazona ventralis
Journal of Avian Medicine and Surgery, 2011Co-Authors: David Sanchezmigallon Guzman, Joanne R Paulmurphy, Keven Flammer, Steven A Barker, Thomas N. TullyAbstract:Previous studies have validated the clinical use of opioids with kaap-receptor affinities for pain management in birds. Butorphanol, a kappa opioid receptor agonist and a mu opioid receptor antagonist, is currently considered by many clinicians to be the opioid of choice for this use. However, despite studies reporting the analgesic properties of Butorphanol in psittacine birds, dosing intervals have not been established for any psittacine species. The goals of this study in the Hispaniolan Amazon parrot (Amazona ventralis) were to evaluate the pharmacokinetics of Butorphanol Tartrate after intravenous (IV), intramuscular (IM), and oral (PO) administration and to determine the bioavailability of Butorphanol Tartrate after oral administration. Twelve Hispaniolan Amazon parrots were used in the study, with a complete-crossover experimental design and a 3-month period separating each part of the study. The birds were randomly assigned to 3 groups (n = 4) for each stage. Butorphanol Tartrate was administered once at a dose of 5 mg/kg in the basilic vein or pectoral muscles or as an oral solution delivered via feeding tube into the crop for the IV, IM, and PO studies, respectively. After Butorphanol administration, blood samples were collected at 1, 5, 15, 30, 60, 90, 120, 180, and 240 minutes for the IV and IM studies and at 5, 15, 30, 60, 90, 120, 180, 240, and 300 minutes for the PO study. Because of the size limitation of the birds, naive pooling of datum points was used to generate a mean plasma Butorphanol concentration at each time point. For each study, birds in each group (n = 4) were bled 3 times after dosing. Plasma Butorphanol concentrations were determined by high-performance liquid chromatography/tandem mass spectrometry, and pharmacokinetic parameters were calculated. Butorphanol Tartrate was found to have high bioavailability and rapid elimination following IM administration. In contrast, oral administration resulted in low bioavailability (< 10%), thus precluding the use of this route of administration for clinical purposes. Based on these results, in Hispaniolan Amazon parrots, Butorphanol Tartrate dosed at 5 mg/kg IV or IM would have to be administered every 2 and 3 hours, respectively, to maintain plasma concentrations consistent with published therapeutic levels. To our knowledge, this is the first published study presenting the pharmacokinetic analysis of Butorphanol Tartrate in a psittacine species as well as the first study presenting pharmacokinetic analysis of Butorphanol after oral administration in any avian species.
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analgesic effects of carprofen and liposome encapsulated Butorphanol Tartrate in hispaniolan parrots amazona ventralis with experimentally induced arthritis
American Journal of Veterinary Research, 2009Co-Authors: Joanne R Paulmurphy, Ben Stading, Carolyn S Brown, Lisa Krugnerhigby, Julia M Klauer, Nicholas S. Keuler, Kurt K. Sladky, Timothy D. HeathAbstract:Objective—To evaluate the microcrystalline sodium urate (MSU) method for inducing arthritis in parrots and to compare the analgesic efficacy of long-acting liposome-encapsulated Butorphanol (LEBT), carprofen, or a combination of both. Animals—20 Hispaniolan parrots. Procedures—MSU was injected into a tibiotarsal-tarsometatarsal (intertarsal) joint to induce arthritis (time 0). Four treatments were compared (LEBT [15 mg/kg, SC] administered once at time 0; injections of carprofen [3 mg/kg, IM, q 12 h] starting at time 0; administration of LEBT plus carprofen; and a control treatment of saline [0.9% NaCl] solution). Weight load testing and behavioral scoring were conducted at 0, 2, 6, 26, and 30 hours. Results—Injection of MSU into the intertarsal joint induced arthritis, which resolved within 30 hours. Treatment with LEBT or LEBT plus carprofen resulted in significantly greater weight-bearing load on the limb with induced arthritis, compared with the control treatment. Treatment with carprofen alone caused...
Landoni, María Fabiana - One of the best experts on this subject based on the ideXlab platform.
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Efeito de dois surfactantes na permeação in vitro de butorfanol através da mucosa nasal equina
'Universidad Nacional de Costa Rica', 2021Co-Authors: Velloso, María Inés, Andreeta, Héctor Alfredo, Landoni, María FabianaAbstract:The aim of the present study was to evaluate the effect of two surfactants on in vitro permeation of Butorphanol through equine nasal mucosa. Franz diffusion cells and equine nasal mucosa were used. Three formulations were developed based on citric acid, sodium citrate, sodium chloride, and Butorphanol Tartrate and administered at a 24.4 g cm-3 dose. Control formulation lacked any penetration enhancer. Formulation 1 (F1) had a cationic surfactant (cetrimonium bromide) and formulation 2 (F2) had a non-ionic surfactant (Tween 80). Statistically comparing flux values at the steady state (Jss), apparent permeability coefficient (Kp), and lag-time from control, F1 and F2 for the respiratory region does not show statistically significant differences (α= 0.05). However, statistically significant differences were found on the Jss and Kp, values from control, F1, and F2 in olfactory mucosa. A statistical analysis on the latter showed significant differences between the Jss values of F1 and F2 and between control and F2. Based on this, Tween 80 proved to be a promising excipient in developing intranasal Butorphanol formulations in equines since it increases its passage through the nasal mucosa. These results are very promising to continue with the development of intranasal Butorphanol formulation in equines.El objetivo del trabajo fue estudiar el efecto de dos surfactantes en la permeabilidad in vitro de butorfanol, a través de la mucosa nasal equina. Para ello se utilizaron celdas de difusión de Franz, mucosa nasal equina y fueron desarrolladas tres formulaciones basadas en ácido cítrico, citrato de sodio, cloruro de sodio y tartrato de butorfanol a la dosis de 24.4 g cm-3. La formulación control carecía de mejoradores de permeabilidad; la primera formulación (F1) contenía un surfactante catiónico (cetrimida) y la formulación 2 (F2) un surfactante no iónico (Tween 80). Al comparar estadísticamente los valores del flujo máximo en estado estacionario (Jss), coeficiente de permeabilidad aparente (Kp) y el tiempo lag provenientes de las mucosas nasales respiratorias de las formulaciones control, F1 y F2 no se encontraron diferencias estadísticamente significativas (α= 0.05). Sin embargo, cuando se compararon los valores de Jss y Kp provenientes de la mucosa nasal olfatoria de las formulaciones control, F1 y F2 sí se observaron. Tras realizar un análisis estadístico sobre estos últimos se descubrieron diferencias significativas entre los valores de Jss de F1 y F2 y entre control y F2. Basándonos en esto, se propone que el Tween 80 podría ser un excipiente promisorio en el desarrollo de formulaciones intranasales con aplicación equina, porque incrementa el pasaje del fármaco a través de la mucosa nasal equina. Estos resultados son prometedores para continuar en el desarrollo de formulaciones intranasales de butorfanol para uso en equinos.Este trabalho teve como objetivo estudar o efeito de dois surfactantes na permeabilidade in vitro de butorfanol através da mucosa nasal equina. Para isso, foram utilizadas células de difusão de Franz, mucosa nasal equina, e desenvolvidas três formulações com base em ácido cítrico, citrato de sódio, cloreto de sódio e tartarato de butorfanol na dose de 24,4 g cm-3. A formulação controle carecia de melhoradores de permeação; a primeira formulação (F1) continha um surfactante catiônico (cetrimida) e a formulação 2 (F2) um surfactante não iônico (Tween 80). Ao comparar estatisticamente os valores do fluxo máximo em estado estacionário (Jss), coeficiente de permeabilidade aparente (Kp) e o tempo lag (tlag) provenientes das mucosas nasais respiratórias das formulações controle, F1 e F2, não foram encontradas diferenças estatisticamente significativas (α= 0.05). Entretanto, ao comparar os valores de Jss e Kp provenientes da mucosa nasal olfatória das formulações controle, F1 e F2, sim. Depois de realizar uma análise estatística sobre esses últimos, foram descobertas diferenças significativas entre os valores de Jss de F1 e F2, e entre o controle e F2. Com base nisso, propõe-se que o Tween 80 poderia ser um excipiente promissor no desenvolvimento de formulações intranasais com aplicação equina, já que amplia a passagem do fármaco através da mucosa nasal equina. Estes resultados são prometedores para avançar no desenvolvimento de formulações intranasais de butorfanol para uso em equinos
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Efeito de dois surfactantes na permeação in vitro de butorfanol através da mucosa nasal equina
'Universidad Nacional de Costa Rica', 2021Co-Authors: Velloso, María Inés, Andreeta, Héctor Alfredo, Landoni, María FabianaAbstract:El objetivo del trabajo fue estudiar el efecto de dos surfactantes en la permeabilidad in vitro de butorfanol, a través de la mucosa nasal equina. Para ello se utilizaron celdas de difusión de Franz, mucosa nasal equina y fueron desarrolladas tres formulaciones basadas en ácido cítrico, citrato de sodio, cloruro de sodio y tartrato de butorfanol a la dosis de 24.4 g cm-3 . La formulación control carecía de mejoradores de permeabilidad; la primera formulación (F1) contenía un surfactante catiónico (cetrimida) y la formulación 2 (F2) un surfactante no iónico (Tween 80). Al comparar estadísticamente los valores del flujo máximo en estado estacionario (Jss), coeficiente de permeabilidad aparente (Kp) y el tiempo lag provenientes de las mucosas nasales respiratorias de las formulaciones control, F1 y F2 no se encontraron diferencias estadísticamente significativas (α=0.05). Sin embargo, cuando se compararon los valores de Jss y Kp provenientes de la mucosa nasal olfatoria de las formulaciones control, F1 y F2 sí se observaron. Tras realizar un análisis estadístico sobre estos últimos se descubrieron diferencias significativas entre los valores de Jss de F1 y F2 y entre control y F2. Basándonos en esto, se propone que el Tween 80 podría ser un excipiente promisorio en el desarrollo de formulaciones intranasales con aplicación equina, porque incrementa el pasaje del fármaco a través de la mucosa nasal equina. Estos resultados son prometedores para continuar en el desarrollo de formulaciones intranasales de butorfanol para uso en equinos.Este trabalho teve como objetivo estudar o efeito de dois surfactantes na permeabilidade in vitro de butorfanol através da mucosa nasal equina. Para isso, foram utilizadas células de difusão de Franz, mucosa nasal equina, e desenvolvidas três formulações com base em ácido cítrico, citrato de sódio, cloreto de sódio e tartarato de butorfanol na dose de 24,4 g cm-3 . A formulação controle carecia de melhoradores de permeação; a primeira formulação (F1) continha um surfactante catiônico (cetrimida) e a formulação 2 (F2) um surfactante não iônico (Tween 80). Ao comparar estatisticamente os valores do fluxo máximo em estado estacionário (Jss), coeficiente de permeabilidade aparente (Kp) e o tempo lag (tlag) provenientes das mucosas nasais respiratórias das formulações controle, F1 e F2, não foram encontradas diferenças estatisticamente significativas (α= 0.05). Entretanto, ao comparar os valores de Jss e Kp provenientes da mucosa nasal olfatória das formulações controle, F1 e F2, sim. Depois de realizar uma análise estatística sobre esses últimos, foram descobertas diferenças significativas entre os valores de Jss de F1 e F2, e entre o controle e F2. Com base nisso, propõe-se que o Tween 80 poderia ser um excipiente promissor no desenvolvimento de formulações intranasais com aplicação equina, já que amplia a passagem do fármaco através da mucosa nasal equina. Estes resultados são prometedores para avançar no desenvolvimento de formulações intranasais de butorfanol para uso em equinos.The aim of the present study was to evaluate the effect of two surfactants on in vitro permeation of Butorphanol through equine nasal mucosa. Franz diffusion cells and equine nasal mucosa were used. Three formulations were developed based on citric acid, sodium citrate, sodium chloride, and Butorphanol Tartrate and administered at a 24.4 g cm-3 dose. Control formulation lacked any penetration enhancer. Formulation 1 (F1) had a cationic surfactant (cetrimonium bromide) and formulation 2 (F2) had a non-ionic surfactant (Tween 80). Statistically comparing flux values at the steady state (Jss), apparent permeability coefficient (Kp), and lag-time from control, F1 and F2 for the respiratory region does not show statistically significant differences (α= 0.05). However, statistically significant differences were found on the Jss and Kp, values from control, F1, and F2 in olfactory mucosa. A statistical analysis on the latter showed significant differences between the Jss values of F1 and F2 and between control and F2. Based on this, Tween 80 proved to be a promising excipient in developing intranasal Butorphanol formulations in equines since it increases its passage through the nasal mucosa. These results are very promising to continue with the development of intranasal Butorphanol formulation in equines.Fil: Velloso, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Farmacología, Farmacotecnia y Terapéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Andreeta, Héctor Alfredo. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; ArgentinaFil: Landoni, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Farmacología, Farmacotecnia y Terapéutica; Argentin
Velloso, María Inés - One of the best experts on this subject based on the ideXlab platform.
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Efeito de dois surfactantes na permeação in vitro de butorfanol através da mucosa nasal equina
'Universidad Nacional de Costa Rica', 2021Co-Authors: Velloso, María Inés, Andreeta, Héctor Alfredo, Landoni, María FabianaAbstract:The aim of the present study was to evaluate the effect of two surfactants on in vitro permeation of Butorphanol through equine nasal mucosa. Franz diffusion cells and equine nasal mucosa were used. Three formulations were developed based on citric acid, sodium citrate, sodium chloride, and Butorphanol Tartrate and administered at a 24.4 g cm-3 dose. Control formulation lacked any penetration enhancer. Formulation 1 (F1) had a cationic surfactant (cetrimonium bromide) and formulation 2 (F2) had a non-ionic surfactant (Tween 80). Statistically comparing flux values at the steady state (Jss), apparent permeability coefficient (Kp), and lag-time from control, F1 and F2 for the respiratory region does not show statistically significant differences (α= 0.05). However, statistically significant differences were found on the Jss and Kp, values from control, F1, and F2 in olfactory mucosa. A statistical analysis on the latter showed significant differences between the Jss values of F1 and F2 and between control and F2. Based on this, Tween 80 proved to be a promising excipient in developing intranasal Butorphanol formulations in equines since it increases its passage through the nasal mucosa. These results are very promising to continue with the development of intranasal Butorphanol formulation in equines.El objetivo del trabajo fue estudiar el efecto de dos surfactantes en la permeabilidad in vitro de butorfanol, a través de la mucosa nasal equina. Para ello se utilizaron celdas de difusión de Franz, mucosa nasal equina y fueron desarrolladas tres formulaciones basadas en ácido cítrico, citrato de sodio, cloruro de sodio y tartrato de butorfanol a la dosis de 24.4 g cm-3. La formulación control carecía de mejoradores de permeabilidad; la primera formulación (F1) contenía un surfactante catiónico (cetrimida) y la formulación 2 (F2) un surfactante no iónico (Tween 80). Al comparar estadísticamente los valores del flujo máximo en estado estacionario (Jss), coeficiente de permeabilidad aparente (Kp) y el tiempo lag provenientes de las mucosas nasales respiratorias de las formulaciones control, F1 y F2 no se encontraron diferencias estadísticamente significativas (α= 0.05). Sin embargo, cuando se compararon los valores de Jss y Kp provenientes de la mucosa nasal olfatoria de las formulaciones control, F1 y F2 sí se observaron. Tras realizar un análisis estadístico sobre estos últimos se descubrieron diferencias significativas entre los valores de Jss de F1 y F2 y entre control y F2. Basándonos en esto, se propone que el Tween 80 podría ser un excipiente promisorio en el desarrollo de formulaciones intranasales con aplicación equina, porque incrementa el pasaje del fármaco a través de la mucosa nasal equina. Estos resultados son prometedores para continuar en el desarrollo de formulaciones intranasales de butorfanol para uso en equinos.Este trabalho teve como objetivo estudar o efeito de dois surfactantes na permeabilidade in vitro de butorfanol através da mucosa nasal equina. Para isso, foram utilizadas células de difusão de Franz, mucosa nasal equina, e desenvolvidas três formulações com base em ácido cítrico, citrato de sódio, cloreto de sódio e tartarato de butorfanol na dose de 24,4 g cm-3. A formulação controle carecia de melhoradores de permeação; a primeira formulação (F1) continha um surfactante catiônico (cetrimida) e a formulação 2 (F2) um surfactante não iônico (Tween 80). Ao comparar estatisticamente os valores do fluxo máximo em estado estacionário (Jss), coeficiente de permeabilidade aparente (Kp) e o tempo lag (tlag) provenientes das mucosas nasais respiratórias das formulações controle, F1 e F2, não foram encontradas diferenças estatisticamente significativas (α= 0.05). Entretanto, ao comparar os valores de Jss e Kp provenientes da mucosa nasal olfatória das formulações controle, F1 e F2, sim. Depois de realizar uma análise estatística sobre esses últimos, foram descobertas diferenças significativas entre os valores de Jss de F1 e F2, e entre o controle e F2. Com base nisso, propõe-se que o Tween 80 poderia ser um excipiente promissor no desenvolvimento de formulações intranasais com aplicação equina, já que amplia a passagem do fármaco através da mucosa nasal equina. Estes resultados são prometedores para avançar no desenvolvimento de formulações intranasais de butorfanol para uso em equinos
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Efeito de dois surfactantes na permeação in vitro de butorfanol através da mucosa nasal equina
'Universidad Nacional de Costa Rica', 2021Co-Authors: Velloso, María Inés, Andreeta, Héctor Alfredo, Landoni, María FabianaAbstract:El objetivo del trabajo fue estudiar el efecto de dos surfactantes en la permeabilidad in vitro de butorfanol, a través de la mucosa nasal equina. Para ello se utilizaron celdas de difusión de Franz, mucosa nasal equina y fueron desarrolladas tres formulaciones basadas en ácido cítrico, citrato de sodio, cloruro de sodio y tartrato de butorfanol a la dosis de 24.4 g cm-3 . La formulación control carecía de mejoradores de permeabilidad; la primera formulación (F1) contenía un surfactante catiónico (cetrimida) y la formulación 2 (F2) un surfactante no iónico (Tween 80). Al comparar estadísticamente los valores del flujo máximo en estado estacionario (Jss), coeficiente de permeabilidad aparente (Kp) y el tiempo lag provenientes de las mucosas nasales respiratorias de las formulaciones control, F1 y F2 no se encontraron diferencias estadísticamente significativas (α=0.05). Sin embargo, cuando se compararon los valores de Jss y Kp provenientes de la mucosa nasal olfatoria de las formulaciones control, F1 y F2 sí se observaron. Tras realizar un análisis estadístico sobre estos últimos se descubrieron diferencias significativas entre los valores de Jss de F1 y F2 y entre control y F2. Basándonos en esto, se propone que el Tween 80 podría ser un excipiente promisorio en el desarrollo de formulaciones intranasales con aplicación equina, porque incrementa el pasaje del fármaco a través de la mucosa nasal equina. Estos resultados son prometedores para continuar en el desarrollo de formulaciones intranasales de butorfanol para uso en equinos.Este trabalho teve como objetivo estudar o efeito de dois surfactantes na permeabilidade in vitro de butorfanol através da mucosa nasal equina. Para isso, foram utilizadas células de difusão de Franz, mucosa nasal equina, e desenvolvidas três formulações com base em ácido cítrico, citrato de sódio, cloreto de sódio e tartarato de butorfanol na dose de 24,4 g cm-3 . A formulação controle carecia de melhoradores de permeação; a primeira formulação (F1) continha um surfactante catiônico (cetrimida) e a formulação 2 (F2) um surfactante não iônico (Tween 80). Ao comparar estatisticamente os valores do fluxo máximo em estado estacionário (Jss), coeficiente de permeabilidade aparente (Kp) e o tempo lag (tlag) provenientes das mucosas nasais respiratórias das formulações controle, F1 e F2, não foram encontradas diferenças estatisticamente significativas (α= 0.05). Entretanto, ao comparar os valores de Jss e Kp provenientes da mucosa nasal olfatória das formulações controle, F1 e F2, sim. Depois de realizar uma análise estatística sobre esses últimos, foram descobertas diferenças significativas entre os valores de Jss de F1 e F2, e entre o controle e F2. Com base nisso, propõe-se que o Tween 80 poderia ser um excipiente promissor no desenvolvimento de formulações intranasais com aplicação equina, já que amplia a passagem do fármaco através da mucosa nasal equina. Estes resultados são prometedores para avançar no desenvolvimento de formulações intranasais de butorfanol para uso em equinos.The aim of the present study was to evaluate the effect of two surfactants on in vitro permeation of Butorphanol through equine nasal mucosa. Franz diffusion cells and equine nasal mucosa were used. Three formulations were developed based on citric acid, sodium citrate, sodium chloride, and Butorphanol Tartrate and administered at a 24.4 g cm-3 dose. Control formulation lacked any penetration enhancer. Formulation 1 (F1) had a cationic surfactant (cetrimonium bromide) and formulation 2 (F2) had a non-ionic surfactant (Tween 80). Statistically comparing flux values at the steady state (Jss), apparent permeability coefficient (Kp), and lag-time from control, F1 and F2 for the respiratory region does not show statistically significant differences (α= 0.05). However, statistically significant differences were found on the Jss and Kp, values from control, F1, and F2 in olfactory mucosa. A statistical analysis on the latter showed significant differences between the Jss values of F1 and F2 and between control and F2. Based on this, Tween 80 proved to be a promising excipient in developing intranasal Butorphanol formulations in equines since it increases its passage through the nasal mucosa. These results are very promising to continue with the development of intranasal Butorphanol formulation in equines.Fil: Velloso, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Farmacología, Farmacotecnia y Terapéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Andreeta, Héctor Alfredo. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; ArgentinaFil: Landoni, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Farmacología, Farmacotecnia y Terapéutica; Argentin
David Sanchezmigallon Guzman - One of the best experts on this subject based on the ideXlab platform.
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evaluation of the thermal antinociceptive effects of subcutaneous administration of Butorphanol Tartrate or Butorphanol Tartrate in a sustained release poloxamer 407 gel formulation to orange winged amazon parrots amazona amazonica
American Journal of Veterinary Research, 2020Co-Authors: Delphine Laniesse, Dale A Smith, Cornelia Mosley, David Sanchezmigallon Guzman, Hugues Beaufrere, Jamie M Douglas, Joanne R PaulmurphyAbstract:OBJECTIVE To determine the thermal antinociceptive effects of Butorphanol Tartrate and Butorphanol Tartrate in a sustained-release 25% poloxamer 407 (P407) gel formulation (But-P407) in parrots. AN...
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in vitro characterization of a formulation of Butorphanol Tartrate in a poloxamer 407 base intended for use as a parenterally administered slow release analgesic agent
American Journal of Veterinary Research, 2017Co-Authors: Delphine Laniesse, Dale A Smith, Heather K Knych, Cornelia Mosley, David Sanchezmigallon Guzman, Hugues BeaufrereAbstract:OBJECTIVE To assess rheological properties and in vitro diffusion of poloxamer 407 (P407) and Butorphanol-P407 (But-P407) hydrogels and to develop a sustained-release opioid formulation for use in birds. SAMPLE P407 powder and a commercially available injectable Butorphanol Tartrate formulation (10 mg/mL). PROCEDURES P407 and But-P407 gels were compounded by adding water or Butorphanol to P407 powder. Effects of various concentrations of P407 (20%, 25% and 30% [{weight of P407/weight of diluent} × 100]), addition of Butorphanol, and sterilization through a microfilter on rheological properties of P407 were measured by use of a rheometer. In vitro diffusion of Butorphanol from But-P407 25% through a biological membrane was compared with that of a Butorphanol solution. RESULTS P407 20% and 25% formulations were easily compounded, whereas it was difficult to obtain a homogenous P407 30% formulation. The P407 was a gel at avian body temperature, although its viscosity was lower than that at mammalian body temperature. The But-P407 25% formulation (Butorphanol concentration, 8.3 mg/mL) was used for subsequent experiments. Addition of Butorphanol to P407 as well as microfiltration did not significantly affect viscosity. Butorphanol diffused in vitro from But-P407, and its diffusion was slower than that from a Butorphanol solution. CONCLUSIONS AND CLINICAL RELEVANCE But-P407 25% had in vitro characteristics that would make it a good candidate for use as a sustained-release analgesic medication. Further studies are needed to characterize the pharmacokinetic and pharmacodynamic properties of But-P407 25% in vivo before it can be recommended for use in birds.
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evaluation of thermal antinociceptive effects and pharmacokinetics after intramuscular administration of Butorphanol Tartrate to american kestrels falco sparverius
American Journal of Veterinary Research, 2014Co-Authors: David Sanchezmigallon Guzman, Tracy L Drazenovich, Butch Kukanich, Glenn H Olsen, Neil H Willits, Joanne R PaulmurphyAbstract:Objective—To evaluate antinociceptive effects and pharmacokinetics of Butorphanol Tartrate after IM administration to American kestrels (Falco sparverius). Animals—Fifteen 2- to 3-year-old American kestrels (6 males and 9 females). Procedures—Butorphanol (1, 3, and 6 mg/kg) and saline (0.9% NaCl) solution were administered IM to birds in a crossover experimental design. Agitation-sedation scores and foot withdrawal response to a thermal stimulus were determined 30 to 60 minutes before (baseline) and 0.5, 1.5, 3, and 6 hours after treatment. For the pharmacokinetic analysis, Butorphanol (6 mg/kg, IM) was administered in the pectoral muscles of each of 12 birds. Results—In male kestrels, Butorphanol did not significantly increase thermal thresholds for foot withdrawal, compared with results for saline solution administration. However, at 1.5 hours after administration of 6 mg of Butorphanol/kg, the thermal threshold was significantly decreased, compared with the baseline value. Foot withdrawal threshold for...
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pharmacokinetics of Butorphanol after intravenous intramuscular and oral administration in hispaniolan amazon parrots amazona ventralis
Journal of Avian Medicine and Surgery, 2011Co-Authors: David Sanchezmigallon Guzman, Joanne R Paulmurphy, Keven Flammer, Steven A Barker, Thomas N. TullyAbstract:Abstract Previous studies have validated the clinical use of opioids with κ-receptor affinities for pain management in birds. Butorphanol, a κ opioid receptor agonist and a μ opioid receptor antagonist, is currently considered by many clinicians to be the opioid of choice for this use. However, despite studies reporting the analgesic properties of Butorphanol in psittacine birds, dosing intervals have not been established for any psittacine species. The goals of this study in the Hispaniolan Amazon parrot (Amazona ventralis) were to evaluate the pharmacokinetics of Butorphanol Tartrate after intravenous (IV), intramuscular (IM), and oral (PO) administration and to determine the bioavailability of Butorphanol Tartrate after oral administration. Twelve Hispaniolan Amazon parrots were used in the study, with a complete-crossover experimental design and a 3-month period separating each part of the study. The birds were randomly assigned to 3 groups (n = 4) for each stage. Butorphanol Tartrate was administer...
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pharmacokinetics of Butorphanol after intravenous intramuscular and oral administration in hispaniolan amazon parrots amazona ventralis
Journal of Avian Medicine and Surgery, 2011Co-Authors: David Sanchezmigallon Guzman, Joanne R Paulmurphy, Keven Flammer, Steven A Barker, Thomas N. TullyAbstract:Previous studies have validated the clinical use of opioids with kaap-receptor affinities for pain management in birds. Butorphanol, a kappa opioid receptor agonist and a mu opioid receptor antagonist, is currently considered by many clinicians to be the opioid of choice for this use. However, despite studies reporting the analgesic properties of Butorphanol in psittacine birds, dosing intervals have not been established for any psittacine species. The goals of this study in the Hispaniolan Amazon parrot (Amazona ventralis) were to evaluate the pharmacokinetics of Butorphanol Tartrate after intravenous (IV), intramuscular (IM), and oral (PO) administration and to determine the bioavailability of Butorphanol Tartrate after oral administration. Twelve Hispaniolan Amazon parrots were used in the study, with a complete-crossover experimental design and a 3-month period separating each part of the study. The birds were randomly assigned to 3 groups (n = 4) for each stage. Butorphanol Tartrate was administered once at a dose of 5 mg/kg in the basilic vein or pectoral muscles or as an oral solution delivered via feeding tube into the crop for the IV, IM, and PO studies, respectively. After Butorphanol administration, blood samples were collected at 1, 5, 15, 30, 60, 90, 120, 180, and 240 minutes for the IV and IM studies and at 5, 15, 30, 60, 90, 120, 180, 240, and 300 minutes for the PO study. Because of the size limitation of the birds, naive pooling of datum points was used to generate a mean plasma Butorphanol concentration at each time point. For each study, birds in each group (n = 4) were bled 3 times after dosing. Plasma Butorphanol concentrations were determined by high-performance liquid chromatography/tandem mass spectrometry, and pharmacokinetic parameters were calculated. Butorphanol Tartrate was found to have high bioavailability and rapid elimination following IM administration. In contrast, oral administration resulted in low bioavailability (< 10%), thus precluding the use of this route of administration for clinical purposes. Based on these results, in Hispaniolan Amazon parrots, Butorphanol Tartrate dosed at 5 mg/kg IV or IM would have to be administered every 2 and 3 hours, respectively, to maintain plasma concentrations consistent with published therapeutic levels. To our knowledge, this is the first published study presenting the pharmacokinetic analysis of Butorphanol Tartrate in a psittacine species as well as the first study presenting pharmacokinetic analysis of Butorphanol after oral administration in any avian species.
Andreeta, Héctor Alfredo - One of the best experts on this subject based on the ideXlab platform.
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Efeito de dois surfactantes na permeação in vitro de butorfanol através da mucosa nasal equina
'Universidad Nacional de Costa Rica', 2021Co-Authors: Velloso, María Inés, Andreeta, Héctor Alfredo, Landoni, María FabianaAbstract:The aim of the present study was to evaluate the effect of two surfactants on in vitro permeation of Butorphanol through equine nasal mucosa. Franz diffusion cells and equine nasal mucosa were used. Three formulations were developed based on citric acid, sodium citrate, sodium chloride, and Butorphanol Tartrate and administered at a 24.4 g cm-3 dose. Control formulation lacked any penetration enhancer. Formulation 1 (F1) had a cationic surfactant (cetrimonium bromide) and formulation 2 (F2) had a non-ionic surfactant (Tween 80). Statistically comparing flux values at the steady state (Jss), apparent permeability coefficient (Kp), and lag-time from control, F1 and F2 for the respiratory region does not show statistically significant differences (α= 0.05). However, statistically significant differences were found on the Jss and Kp, values from control, F1, and F2 in olfactory mucosa. A statistical analysis on the latter showed significant differences between the Jss values of F1 and F2 and between control and F2. Based on this, Tween 80 proved to be a promising excipient in developing intranasal Butorphanol formulations in equines since it increases its passage through the nasal mucosa. These results are very promising to continue with the development of intranasal Butorphanol formulation in equines.El objetivo del trabajo fue estudiar el efecto de dos surfactantes en la permeabilidad in vitro de butorfanol, a través de la mucosa nasal equina. Para ello se utilizaron celdas de difusión de Franz, mucosa nasal equina y fueron desarrolladas tres formulaciones basadas en ácido cítrico, citrato de sodio, cloruro de sodio y tartrato de butorfanol a la dosis de 24.4 g cm-3. La formulación control carecía de mejoradores de permeabilidad; la primera formulación (F1) contenía un surfactante catiónico (cetrimida) y la formulación 2 (F2) un surfactante no iónico (Tween 80). Al comparar estadísticamente los valores del flujo máximo en estado estacionario (Jss), coeficiente de permeabilidad aparente (Kp) y el tiempo lag provenientes de las mucosas nasales respiratorias de las formulaciones control, F1 y F2 no se encontraron diferencias estadísticamente significativas (α= 0.05). Sin embargo, cuando se compararon los valores de Jss y Kp provenientes de la mucosa nasal olfatoria de las formulaciones control, F1 y F2 sí se observaron. Tras realizar un análisis estadístico sobre estos últimos se descubrieron diferencias significativas entre los valores de Jss de F1 y F2 y entre control y F2. Basándonos en esto, se propone que el Tween 80 podría ser un excipiente promisorio en el desarrollo de formulaciones intranasales con aplicación equina, porque incrementa el pasaje del fármaco a través de la mucosa nasal equina. Estos resultados son prometedores para continuar en el desarrollo de formulaciones intranasales de butorfanol para uso en equinos.Este trabalho teve como objetivo estudar o efeito de dois surfactantes na permeabilidade in vitro de butorfanol através da mucosa nasal equina. Para isso, foram utilizadas células de difusão de Franz, mucosa nasal equina, e desenvolvidas três formulações com base em ácido cítrico, citrato de sódio, cloreto de sódio e tartarato de butorfanol na dose de 24,4 g cm-3. A formulação controle carecia de melhoradores de permeação; a primeira formulação (F1) continha um surfactante catiônico (cetrimida) e a formulação 2 (F2) um surfactante não iônico (Tween 80). Ao comparar estatisticamente os valores do fluxo máximo em estado estacionário (Jss), coeficiente de permeabilidade aparente (Kp) e o tempo lag (tlag) provenientes das mucosas nasais respiratórias das formulações controle, F1 e F2, não foram encontradas diferenças estatisticamente significativas (α= 0.05). Entretanto, ao comparar os valores de Jss e Kp provenientes da mucosa nasal olfatória das formulações controle, F1 e F2, sim. Depois de realizar uma análise estatística sobre esses últimos, foram descobertas diferenças significativas entre os valores de Jss de F1 e F2, e entre o controle e F2. Com base nisso, propõe-se que o Tween 80 poderia ser um excipiente promissor no desenvolvimento de formulações intranasais com aplicação equina, já que amplia a passagem do fármaco através da mucosa nasal equina. Estes resultados são prometedores para avançar no desenvolvimento de formulações intranasais de butorfanol para uso em equinos
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Efeito de dois surfactantes na permeação in vitro de butorfanol através da mucosa nasal equina
'Universidad Nacional de Costa Rica', 2021Co-Authors: Velloso, María Inés, Andreeta, Héctor Alfredo, Landoni, María FabianaAbstract:El objetivo del trabajo fue estudiar el efecto de dos surfactantes en la permeabilidad in vitro de butorfanol, a través de la mucosa nasal equina. Para ello se utilizaron celdas de difusión de Franz, mucosa nasal equina y fueron desarrolladas tres formulaciones basadas en ácido cítrico, citrato de sodio, cloruro de sodio y tartrato de butorfanol a la dosis de 24.4 g cm-3 . La formulación control carecía de mejoradores de permeabilidad; la primera formulación (F1) contenía un surfactante catiónico (cetrimida) y la formulación 2 (F2) un surfactante no iónico (Tween 80). Al comparar estadísticamente los valores del flujo máximo en estado estacionario (Jss), coeficiente de permeabilidad aparente (Kp) y el tiempo lag provenientes de las mucosas nasales respiratorias de las formulaciones control, F1 y F2 no se encontraron diferencias estadísticamente significativas (α=0.05). Sin embargo, cuando se compararon los valores de Jss y Kp provenientes de la mucosa nasal olfatoria de las formulaciones control, F1 y F2 sí se observaron. Tras realizar un análisis estadístico sobre estos últimos se descubrieron diferencias significativas entre los valores de Jss de F1 y F2 y entre control y F2. Basándonos en esto, se propone que el Tween 80 podría ser un excipiente promisorio en el desarrollo de formulaciones intranasales con aplicación equina, porque incrementa el pasaje del fármaco a través de la mucosa nasal equina. Estos resultados son prometedores para continuar en el desarrollo de formulaciones intranasales de butorfanol para uso en equinos.Este trabalho teve como objetivo estudar o efeito de dois surfactantes na permeabilidade in vitro de butorfanol através da mucosa nasal equina. Para isso, foram utilizadas células de difusão de Franz, mucosa nasal equina, e desenvolvidas três formulações com base em ácido cítrico, citrato de sódio, cloreto de sódio e tartarato de butorfanol na dose de 24,4 g cm-3 . A formulação controle carecia de melhoradores de permeação; a primeira formulação (F1) continha um surfactante catiônico (cetrimida) e a formulação 2 (F2) um surfactante não iônico (Tween 80). Ao comparar estatisticamente os valores do fluxo máximo em estado estacionário (Jss), coeficiente de permeabilidade aparente (Kp) e o tempo lag (tlag) provenientes das mucosas nasais respiratórias das formulações controle, F1 e F2, não foram encontradas diferenças estatisticamente significativas (α= 0.05). Entretanto, ao comparar os valores de Jss e Kp provenientes da mucosa nasal olfatória das formulações controle, F1 e F2, sim. Depois de realizar uma análise estatística sobre esses últimos, foram descobertas diferenças significativas entre os valores de Jss de F1 e F2, e entre o controle e F2. Com base nisso, propõe-se que o Tween 80 poderia ser um excipiente promissor no desenvolvimento de formulações intranasais com aplicação equina, já que amplia a passagem do fármaco através da mucosa nasal equina. Estes resultados são prometedores para avançar no desenvolvimento de formulações intranasais de butorfanol para uso em equinos.The aim of the present study was to evaluate the effect of two surfactants on in vitro permeation of Butorphanol through equine nasal mucosa. Franz diffusion cells and equine nasal mucosa were used. Three formulations were developed based on citric acid, sodium citrate, sodium chloride, and Butorphanol Tartrate and administered at a 24.4 g cm-3 dose. Control formulation lacked any penetration enhancer. Formulation 1 (F1) had a cationic surfactant (cetrimonium bromide) and formulation 2 (F2) had a non-ionic surfactant (Tween 80). Statistically comparing flux values at the steady state (Jss), apparent permeability coefficient (Kp), and lag-time from control, F1 and F2 for the respiratory region does not show statistically significant differences (α= 0.05). However, statistically significant differences were found on the Jss and Kp, values from control, F1, and F2 in olfactory mucosa. A statistical analysis on the latter showed significant differences between the Jss values of F1 and F2 and between control and F2. Based on this, Tween 80 proved to be a promising excipient in developing intranasal Butorphanol formulations in equines since it increases its passage through the nasal mucosa. These results are very promising to continue with the development of intranasal Butorphanol formulation in equines.Fil: Velloso, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Farmacología, Farmacotecnia y Terapéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Andreeta, Héctor Alfredo. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; ArgentinaFil: Landoni, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Farmacología, Farmacotecnia y Terapéutica; Argentin
