The Experts below are selected from a list of 96 Experts worldwide ranked by ideXlab platform

Dai Ayusawa - One of the best experts on this subject based on the ideXlab platform.

  • Cardiolipin activates MAP Kinases during premature senescence in normal human fibroblasts
    Biogerontology, 2007
    Co-Authors: Palaniyappan Arivazhagan, Dai Ayusawa
    Abstract:

    Lipids are major structural components of cellular membranes and regulate various signaling pathways as a mediator of the signals or a source of new signals. Our earlier studies show that cardiolipin very sensitively induces premature senescence in normal human fibroblasts. To understand a molecular basis for the action of cardiolipin, we tested whether the mitogen-activated protein (MAP) kinase cascades have a role in the above phenomenon. As expected, cardiolipin activated phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), C-Jun N-Terminal Kinases (JNK), and p38 map kinase (p38) of the MAP kinase family as in replicatively senesced cells. These results suggest that cardiolipin uses signaling pathways similar to those in replicative senescence to lead to premature senescence.

Maria Angelica Selim - One of the best experts on this subject based on the ideXlab platform.

  • The role of the C-Jun N-Terminal Kinase signaling pathway in skin cancer
    American Journal of Cancer Research, 2012
    Co-Authors: Jennifer Y. Zhang, Maria Angelica Selim
    Abstract:

    The C-Jun N-Terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for cancer type-specific applications have been summarized in this review.

  • Review Article The role of the C-Jun N-Terminal Kinase signaling pathway in skin cancer
    2012
    Co-Authors: Jennifer Y. Zhang, Maria Angelica Selim
    Abstract:

    The C-Jun N-Terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for cancer type-specific applications have been summarized in this review.

Palaniyappan Arivazhagan - One of the best experts on this subject based on the ideXlab platform.

  • Cardiolipin activates MAP Kinases during premature senescence in normal human fibroblasts
    Biogerontology, 2007
    Co-Authors: Palaniyappan Arivazhagan, Dai Ayusawa
    Abstract:

    Lipids are major structural components of cellular membranes and regulate various signaling pathways as a mediator of the signals or a source of new signals. Our earlier studies show that cardiolipin very sensitively induces premature senescence in normal human fibroblasts. To understand a molecular basis for the action of cardiolipin, we tested whether the mitogen-activated protein (MAP) kinase cascades have a role in the above phenomenon. As expected, cardiolipin activated phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), C-Jun N-Terminal Kinases (JNK), and p38 map kinase (p38) of the MAP kinase family as in replicatively senesced cells. These results suggest that cardiolipin uses signaling pathways similar to those in replicative senescence to lead to premature senescence.

James M. Trevillyan - One of the best experts on this subject based on the ideXlab platform.

  • C-Jun N-Terminal kinase pathways in diabetes
    The International Journal of Biochemistry & Cell Biology, 2008
    Co-Authors: Ruojing Yang, James M. Trevillyan
    Abstract:

    Type 2 diabetes develops from insulin resistance and has become a worldwide epidemic. The C-Jun N-Terminal Kinases have been considered as signaling molecules linking inflammation and insulin resistance. Genetic disruption of C-Jun N-Terminal kinase-1 gene prevents the development of insulin resistance in obese and diabetic mice. Inhibition of C-Jun N-Terminal Kinases by a small cell-permeable peptide improves insulin sensitivity in mice. Hepatic inhibition of C-Jun N-Terminal Kinases using a dominant-negative protein or knockdown of C-Jun N-Terminal kinase-1 gene by RNA interference reduces blood glucose and insulin levels and enhances hepatic insulin signaling in mice. Recent evidence demonstrates that the hepatic C-Jun N-Terminal kinase pathway plays an important role in lipid and lipoprotein homeostasis in mice. This review discusses recent advances in our understanding of the role of C-Jun N-Terminal kinase pathway in metabolic control and its potential as a target for the treatment of type 2 diabetes.

Jennifer Y. Zhang - One of the best experts on this subject based on the ideXlab platform.

  • The role of the C-Jun N-Terminal Kinase signaling pathway in skin cancer
    American Journal of Cancer Research, 2012
    Co-Authors: Jennifer Y. Zhang, Maria Angelica Selim
    Abstract:

    The C-Jun N-Terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for cancer type-specific applications have been summarized in this review.

  • Review Article The role of the C-Jun N-Terminal Kinase signaling pathway in skin cancer
    2012
    Co-Authors: Jennifer Y. Zhang, Maria Angelica Selim
    Abstract:

    The C-Jun N-Terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for cancer type-specific applications have been summarized in this review.