The Experts below are selected from a list of 270 Experts worldwide ranked by ideXlab platform
Cynthia K Aaron - One of the best experts on this subject based on the ideXlab platform.
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regional intravenous infusion of Calcium Gluconate for hydrofluoric acid burns of the upper extremity
Annals of Emergency Medicine, 1997Co-Authors: Andis Graudins, Michael J Burns, Cynthia K AaronAbstract:Abstract Study objective: To describe regional intravenous infusion of Calcium Gluconate as a therapy for hydrofluoric acid (HF) burns of the forearm, hand, or digits. Methods: This study describes seven patients with HF burns. Calcium Gluconate, 10 mL of 10% solution with 30 to 40 mL normal saline solution, was injected intravenously into the affected limb using a Bier block technique. Ischemia was maintained for 20 to 25 minutes. Therapy was considered successful if significant reduction of pain and tenderness was noted after tourniquet release. Results: Seven patients were treated. HF concentration varied from 5% to 49%. Exposure sites included the forearm (two cases), thenar eminence and digits (two cases), or digits only (three cases). Complete pain resolution occurred on tourniquet release in four patients (two with burns to the forearm, two with burns to digits only). One patient had partial relief (thenar but not digital exposure site), and two had no relief of symptoms. Intraarterial Calcium Gluconate perfusion was subsequently administered to the three patients with persistent subungual and pulp, or thenar pain. Recovery was complete in all cases. No adverse effects were noted. Conclusion: Regional intravenous infusion of Calcium Gluconate should be considered a therapeutic option in HF burns of the forearm, hand, or digits when topical therapy fails. [Graudins A, Burns MJ, Aaron CK, Regional intravenous infusion of Calcium Gluconate for hydrofluoric acid burns of the upper extremity. Ann Emerg Med November 1997;30:604-607.]
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Regional Intravenous Infusion of Calcium Gluconate for Hydrofluoric Acid Burns of the Upper Extremity
Annals of emergency medicine, 1997Co-Authors: Andis Graudins, Michael J Burns, Cynthia K AaronAbstract:Abstract Study objective: To describe regional intravenous infusion of Calcium Gluconate as a therapy for hydrofluoric acid (HF) burns of the forearm, hand, or digits. Methods: This study describes seven patients with HF burns. Calcium Gluconate, 10 mL of 10% solution with 30 to 40 mL normal saline solution, was injected intravenously into the affected limb using a Bier block technique. Ischemia was maintained for 20 to 25 minutes. Therapy was considered successful if significant reduction of pain and tenderness was noted after tourniquet release. Results: Seven patients were treated. HF concentration varied from 5% to 49%. Exposure sites included the forearm (two cases), thenar eminence and digits (two cases), or digits only (three cases). Complete pain resolution occurred on tourniquet release in four patients (two with burns to the forearm, two with burns to digits only). One patient had partial relief (thenar but not digital exposure site), and two had no relief of symptoms. Intraarterial Calcium Gluconate perfusion was subsequently administered to the three patients with persistent subungual and pulp, or thenar pain. Recovery was complete in all cases. No adverse effects were noted. Conclusion: Regional intravenous infusion of Calcium Gluconate should be considered a therapeutic option in HF burns of the forearm, hand, or digits when topical therapy fails. [Graudins A, Burns MJ, Aaron CK, Regional intravenous infusion of Calcium Gluconate for hydrofluoric acid burns of the upper extremity. Ann Emerg Med November 1997;30:604-607.]
Su Jin Kang - One of the best experts on this subject based on the ideXlab platform.
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Protective effects of Calcium Gluconate on osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague–Dawley rats
Journal of Orthopaedic Surgery and Research, 2014Co-Authors: Su Jin Kang, Joo-wan Kim, Ki-young Kim, Young-joon LeeAbstract:Background This study aimed to determine whether Calcium Gluconate exerts protective effects on osteoarthritis (OA) induced by anterior cruciate ligament (ACL) transection and partial medial meniscectomy. Methods Calcium Gluconate was administered by mouth daily for 84 days to male ACL transected and partial medial meniscectomized Sprague–Dawley rats 1 week after operation. Results Eighty-four days of treatment with 50 mg/kg Calcium Gluconate led to a lower degree of articular stiffness and cartilage damage compared to the OA control, possibly through inhibition of overexpressed cyclooxygenase (COX)-2 and related chondrocyte apoptosis. Similar favorable effects on stiffness and cartilage were detected in Calcium Gluconate-administered rats. Additionally, Calcium Gluconate increased 5-bromo-2′-deoxyuridine (BrdU) uptake based on observation of BrdU-immunoreactive cells on both the femur and tibia articular surface cartilages 84 days after intra-joint treatment with Calcium Gluconate. Conclusions Taken together, our results demonstrate that Calcium Gluconate has a protective effect against OA through inhibition of COX-2 and related chondrocyte apoptosis.
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protective effects of Calcium Gluconate on osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in sprague dawley rats
Journal of Orthopaedic Surgery and Research, 2014Co-Authors: Su Jin Kang, Saekwang KuAbstract:This study aimed to determine whether Calcium Gluconate exerts protective effects on osteoarthritis (OA) induced by anterior cruciate ligament (ACL) transection and partial medial meniscectomy. Calcium Gluconate was administered by mouth daily for 84 days to male ACL transected and partial medial meniscectomized Sprague–Dawley rats 1 week after operation. Eighty-four days of treatment with 50 mg/kg Calcium Gluconate led to a lower degree of articular stiffness and cartilage damage compared to the OA control, possibly through inhibition of overexpressed cyclooxygenase (COX)-2 and related chondrocyte apoptosis. Similar favorable effects on stiffness and cartilage were detected in Calcium Gluconate-administered rats. Additionally, Calcium Gluconate increased 5-bromo-2′-deoxyuridine (BrdU) uptake based on observation of BrdU-immunoreactive cells on both the femur and tibia articular surface cartilages 84 days after intra-joint treatment with Calcium Gluconate. Taken together, our results demonstrate that Calcium Gluconate has a protective effect against OA through inhibition of COX-2 and related chondrocyte apoptosis.
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effects of Calcium Gluconate on experimental periodontitis and alveolar bone loss in rats
Basic & Clinical Pharmacology & Toxicology, 2011Co-Authors: Saekwang Ku, Yun Sub Sung, Su Jin KangAbstract:We examined the effects of Calcium Gluconate, an anti-inflammatory Calcium salt, on ligature-induced experimental periodontitis and related alveolar bone loss. Calcium Gluconate was orally administered daily for 10 days at 250, 125 or 62.5 mg/kg, beginning 1 day after ligation. We recorded changes in body-weight and alveolar bone loss and quantified the anti-inflammatory effects of Calcium Gluconate by measuring levels of myeloperoxidase (MPO), IL-1β and TNF-α. We also evaluated inducible nitric oxide synthase (iNOS) activity and malondialdehyde (MDA) concentration as a measure of antioxidant effects. Ligature placement produced a marked decrease in body-weight, increased alveolar bone loss, and led to increased MPO, IL-1β, TNF-α and MDA concentrations, as well as elevated iNOS activity, increased inflammatory cell infiltration and decreased collagen fibre content in gingival tissue. Histopathology revealed decreased alveolar bone volume, increased osteoclast cell numbers and activity, and an elevated percentage of osteclasts on the alveolar bone surface. The effects of ligature placement were significantly and dose-dependently inhibited by 10 days of daily oral treatment with 250 and 125 mg/kg of Calcium Gluconate. The results suggest that 10 days daily oral treatment with Calcium Gluconate effectively inhibits ligature placement-induced periodontitis and related alveolar bone loss via antioxidant effects.
Andis Graudins - One of the best experts on this subject based on the ideXlab platform.
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regional intravenous infusion of Calcium Gluconate for hydrofluoric acid burns of the upper extremity
Annals of Emergency Medicine, 1997Co-Authors: Andis Graudins, Michael J Burns, Cynthia K AaronAbstract:Abstract Study objective: To describe regional intravenous infusion of Calcium Gluconate as a therapy for hydrofluoric acid (HF) burns of the forearm, hand, or digits. Methods: This study describes seven patients with HF burns. Calcium Gluconate, 10 mL of 10% solution with 30 to 40 mL normal saline solution, was injected intravenously into the affected limb using a Bier block technique. Ischemia was maintained for 20 to 25 minutes. Therapy was considered successful if significant reduction of pain and tenderness was noted after tourniquet release. Results: Seven patients were treated. HF concentration varied from 5% to 49%. Exposure sites included the forearm (two cases), thenar eminence and digits (two cases), or digits only (three cases). Complete pain resolution occurred on tourniquet release in four patients (two with burns to the forearm, two with burns to digits only). One patient had partial relief (thenar but not digital exposure site), and two had no relief of symptoms. Intraarterial Calcium Gluconate perfusion was subsequently administered to the three patients with persistent subungual and pulp, or thenar pain. Recovery was complete in all cases. No adverse effects were noted. Conclusion: Regional intravenous infusion of Calcium Gluconate should be considered a therapeutic option in HF burns of the forearm, hand, or digits when topical therapy fails. [Graudins A, Burns MJ, Aaron CK, Regional intravenous infusion of Calcium Gluconate for hydrofluoric acid burns of the upper extremity. Ann Emerg Med November 1997;30:604-607.]
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Regional Intravenous Infusion of Calcium Gluconate for Hydrofluoric Acid Burns of the Upper Extremity
Annals of emergency medicine, 1997Co-Authors: Andis Graudins, Michael J Burns, Cynthia K AaronAbstract:Abstract Study objective: To describe regional intravenous infusion of Calcium Gluconate as a therapy for hydrofluoric acid (HF) burns of the forearm, hand, or digits. Methods: This study describes seven patients with HF burns. Calcium Gluconate, 10 mL of 10% solution with 30 to 40 mL normal saline solution, was injected intravenously into the affected limb using a Bier block technique. Ischemia was maintained for 20 to 25 minutes. Therapy was considered successful if significant reduction of pain and tenderness was noted after tourniquet release. Results: Seven patients were treated. HF concentration varied from 5% to 49%. Exposure sites included the forearm (two cases), thenar eminence and digits (two cases), or digits only (three cases). Complete pain resolution occurred on tourniquet release in four patients (two with burns to the forearm, two with burns to digits only). One patient had partial relief (thenar but not digital exposure site), and two had no relief of symptoms. Intraarterial Calcium Gluconate perfusion was subsequently administered to the three patients with persistent subungual and pulp, or thenar pain. Recovery was complete in all cases. No adverse effects were noted. Conclusion: Regional intravenous infusion of Calcium Gluconate should be considered a therapeutic option in HF burns of the forearm, hand, or digits when topical therapy fails. [Graudins A, Burns MJ, Aaron CK, Regional intravenous infusion of Calcium Gluconate for hydrofluoric acid burns of the upper extremity. Ann Emerg Med November 1997;30:604-607.]
Saekwang Ku - One of the best experts on this subject based on the ideXlab platform.
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protective effects of Calcium Gluconate on osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in sprague dawley rats
Journal of Orthopaedic Surgery and Research, 2014Co-Authors: Su Jin Kang, Saekwang KuAbstract:This study aimed to determine whether Calcium Gluconate exerts protective effects on osteoarthritis (OA) induced by anterior cruciate ligament (ACL) transection and partial medial meniscectomy. Calcium Gluconate was administered by mouth daily for 84 days to male ACL transected and partial medial meniscectomized Sprague–Dawley rats 1 week after operation. Eighty-four days of treatment with 50 mg/kg Calcium Gluconate led to a lower degree of articular stiffness and cartilage damage compared to the OA control, possibly through inhibition of overexpressed cyclooxygenase (COX)-2 and related chondrocyte apoptosis. Similar favorable effects on stiffness and cartilage were detected in Calcium Gluconate-administered rats. Additionally, Calcium Gluconate increased 5-bromo-2′-deoxyuridine (BrdU) uptake based on observation of BrdU-immunoreactive cells on both the femur and tibia articular surface cartilages 84 days after intra-joint treatment with Calcium Gluconate. Taken together, our results demonstrate that Calcium Gluconate has a protective effect against OA through inhibition of COX-2 and related chondrocyte apoptosis.
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effects of Calcium Gluconate on experimental periodontitis and alveolar bone loss in rats
Basic & Clinical Pharmacology & Toxicology, 2011Co-Authors: Saekwang Ku, Yun Sub Sung, Su Jin KangAbstract:We examined the effects of Calcium Gluconate, an anti-inflammatory Calcium salt, on ligature-induced experimental periodontitis and related alveolar bone loss. Calcium Gluconate was orally administered daily for 10 days at 250, 125 or 62.5 mg/kg, beginning 1 day after ligation. We recorded changes in body-weight and alveolar bone loss and quantified the anti-inflammatory effects of Calcium Gluconate by measuring levels of myeloperoxidase (MPO), IL-1β and TNF-α. We also evaluated inducible nitric oxide synthase (iNOS) activity and malondialdehyde (MDA) concentration as a measure of antioxidant effects. Ligature placement produced a marked decrease in body-weight, increased alveolar bone loss, and led to increased MPO, IL-1β, TNF-α and MDA concentrations, as well as elevated iNOS activity, increased inflammatory cell infiltration and decreased collagen fibre content in gingival tissue. Histopathology revealed decreased alveolar bone volume, increased osteoclast cell numbers and activity, and an elevated percentage of osteclasts on the alveolar bone surface. The effects of ligature placement were significantly and dose-dependently inhibited by 10 days of daily oral treatment with 250 and 125 mg/kg of Calcium Gluconate. The results suggest that 10 days daily oral treatment with Calcium Gluconate effectively inhibits ligature placement-induced periodontitis and related alveolar bone loss via antioxidant effects.
Michael J Burns - One of the best experts on this subject based on the ideXlab platform.
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regional intravenous infusion of Calcium Gluconate for hydrofluoric acid burns of the upper extremity
Annals of Emergency Medicine, 1997Co-Authors: Andis Graudins, Michael J Burns, Cynthia K AaronAbstract:Abstract Study objective: To describe regional intravenous infusion of Calcium Gluconate as a therapy for hydrofluoric acid (HF) burns of the forearm, hand, or digits. Methods: This study describes seven patients with HF burns. Calcium Gluconate, 10 mL of 10% solution with 30 to 40 mL normal saline solution, was injected intravenously into the affected limb using a Bier block technique. Ischemia was maintained for 20 to 25 minutes. Therapy was considered successful if significant reduction of pain and tenderness was noted after tourniquet release. Results: Seven patients were treated. HF concentration varied from 5% to 49%. Exposure sites included the forearm (two cases), thenar eminence and digits (two cases), or digits only (three cases). Complete pain resolution occurred on tourniquet release in four patients (two with burns to the forearm, two with burns to digits only). One patient had partial relief (thenar but not digital exposure site), and two had no relief of symptoms. Intraarterial Calcium Gluconate perfusion was subsequently administered to the three patients with persistent subungual and pulp, or thenar pain. Recovery was complete in all cases. No adverse effects were noted. Conclusion: Regional intravenous infusion of Calcium Gluconate should be considered a therapeutic option in HF burns of the forearm, hand, or digits when topical therapy fails. [Graudins A, Burns MJ, Aaron CK, Regional intravenous infusion of Calcium Gluconate for hydrofluoric acid burns of the upper extremity. Ann Emerg Med November 1997;30:604-607.]
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Regional Intravenous Infusion of Calcium Gluconate for Hydrofluoric Acid Burns of the Upper Extremity
Annals of emergency medicine, 1997Co-Authors: Andis Graudins, Michael J Burns, Cynthia K AaronAbstract:Abstract Study objective: To describe regional intravenous infusion of Calcium Gluconate as a therapy for hydrofluoric acid (HF) burns of the forearm, hand, or digits. Methods: This study describes seven patients with HF burns. Calcium Gluconate, 10 mL of 10% solution with 30 to 40 mL normal saline solution, was injected intravenously into the affected limb using a Bier block technique. Ischemia was maintained for 20 to 25 minutes. Therapy was considered successful if significant reduction of pain and tenderness was noted after tourniquet release. Results: Seven patients were treated. HF concentration varied from 5% to 49%. Exposure sites included the forearm (two cases), thenar eminence and digits (two cases), or digits only (three cases). Complete pain resolution occurred on tourniquet release in four patients (two with burns to the forearm, two with burns to digits only). One patient had partial relief (thenar but not digital exposure site), and two had no relief of symptoms. Intraarterial Calcium Gluconate perfusion was subsequently administered to the three patients with persistent subungual and pulp, or thenar pain. Recovery was complete in all cases. No adverse effects were noted. Conclusion: Regional intravenous infusion of Calcium Gluconate should be considered a therapeutic option in HF burns of the forearm, hand, or digits when topical therapy fails. [Graudins A, Burns MJ, Aaron CK, Regional intravenous infusion of Calcium Gluconate for hydrofluoric acid burns of the upper extremity. Ann Emerg Med November 1997;30:604-607.]
