Calcium Ion

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Shunichi Fukuzumi - One of the best experts on this subject based on the ideXlab platform.

  • tuning electron transfer reactivity of a chromium iii superoxo complex enabled by Calcium Ion and other redox inactive metal Ions
    Journal of the American Chemical Society, 2020
    Co-Authors: Tarali Devi, Yongmin Lee, Wonwoo Nam, Shunichi Fukuzumi
    Abstract:

    Calcium Ion plays an indispensable role for water oxidatIon by oxygen-evolving complex (OEC) composed of a manganese–oxo cluster (Mn4CaO5) in Photosystem II. In this context, the effects of Ca2+ io...

  • redox reactivity of a mononuclear manganese oxo complex binding Calcium Ion and other redox inactive metal Ions
    Journal of the American Chemical Society, 2019
    Co-Authors: Muniyandi Sankaralingam, Yongmin Lee, Shunichi Fukuzumi, Yuliana Pinedagalvan, Deepika G Karmalkar, Mi Sook Seo, So Hyun Jeon, Yulia Pushkar, Wonwoo Nam
    Abstract:

    Mononuclear nonheme manganese(IV)-oxo complexes binding Calcium Ion and other redox-inactive metal Ions, [(dpaq)MnIV(O)]+-M n+ (1-Mn+, M n+ = Ca2+, Mg2+, Zn2+, Lu3+, Y3+, Al3+, and Sc3+) (dpaq = 2-[bis(pyridin-2-ylmethyl)]amino- N-quinolin-8-yl-acetamidate), were synthesized by reacting a hydroxomanganese(III) complex, [(dpaq)MnIII(OH)]+, with iodosylbenzene (PhIO) in the presence of redox-inactive metal Ions (M n+). The Mn(IV)-oxo complexes were characterized using various spectroscopic techniques. In reactivity studies, we observed contrasting effects of M n+ on the reactivity of 1-M n+ in redox reactIons such as electron-transfer (ET), oxygen atom transfer (OAT), and hydrogen atom transfer (HAT) reactIons. In the OAT and ET reactIons, the reactivity order of 1-M n+, such as 1-Sc3+ ≈ 1-Al3+ > 1-Y3+ > 1-Lu3+ > 1-Zn2+ > 1-Mg2+ > 1-Ca2+, follows the Lewis acidity of M n+ bound to the Mn-O moiety; that is, the stronger the Lewis acidity of M n+, the higher the reactivity of 1-M n+ becomes. In sharp contrast, the reactivity of 1-M n+ in the HAT reactIon was reversed, giving the reactivity order 1-Ca2+ > 1-Mg2+ > 1-Zn2+ > 1-Lu3+> 1-Y3+> 1-Al3+ ≈ 1-Sc3+; that is, the higher is Lewis acidity of M n+, the lower the reactivity of 1-M n+ in the HAT reactIon. The latter result implies that the Lewis acidity of M n+ bound to the Mn-O moiety can modulate the basicity of the metal-oxo moiety, thus influencing the HAT reactivity of 1-M n+; cytochrome P450 utilizes the axial thiolate ligand to increase the basicity of the iron-oxo moiety, which enhances the reactivity of compound I in C-H bond activatIon reactIons.

Wonwoo Nam - One of the best experts on this subject based on the ideXlab platform.

  • tuning electron transfer reactivity of a chromium iii superoxo complex enabled by Calcium Ion and other redox inactive metal Ions
    Journal of the American Chemical Society, 2020
    Co-Authors: Tarali Devi, Yongmin Lee, Wonwoo Nam, Shunichi Fukuzumi
    Abstract:

    Calcium Ion plays an indispensable role for water oxidatIon by oxygen-evolving complex (OEC) composed of a manganese–oxo cluster (Mn4CaO5) in Photosystem II. In this context, the effects of Ca2+ io...

  • redox reactivity of a mononuclear manganese oxo complex binding Calcium Ion and other redox inactive metal Ions
    Journal of the American Chemical Society, 2019
    Co-Authors: Muniyandi Sankaralingam, Yongmin Lee, Shunichi Fukuzumi, Yuliana Pinedagalvan, Deepika G Karmalkar, Mi Sook Seo, So Hyun Jeon, Yulia Pushkar, Wonwoo Nam
    Abstract:

    Mononuclear nonheme manganese(IV)-oxo complexes binding Calcium Ion and other redox-inactive metal Ions, [(dpaq)MnIV(O)]+-M n+ (1-Mn+, M n+ = Ca2+, Mg2+, Zn2+, Lu3+, Y3+, Al3+, and Sc3+) (dpaq = 2-[bis(pyridin-2-ylmethyl)]amino- N-quinolin-8-yl-acetamidate), were synthesized by reacting a hydroxomanganese(III) complex, [(dpaq)MnIII(OH)]+, with iodosylbenzene (PhIO) in the presence of redox-inactive metal Ions (M n+). The Mn(IV)-oxo complexes were characterized using various spectroscopic techniques. In reactivity studies, we observed contrasting effects of M n+ on the reactivity of 1-M n+ in redox reactIons such as electron-transfer (ET), oxygen atom transfer (OAT), and hydrogen atom transfer (HAT) reactIons. In the OAT and ET reactIons, the reactivity order of 1-M n+, such as 1-Sc3+ ≈ 1-Al3+ > 1-Y3+ > 1-Lu3+ > 1-Zn2+ > 1-Mg2+ > 1-Ca2+, follows the Lewis acidity of M n+ bound to the Mn-O moiety; that is, the stronger the Lewis acidity of M n+, the higher the reactivity of 1-M n+ becomes. In sharp contrast, the reactivity of 1-M n+ in the HAT reactIon was reversed, giving the reactivity order 1-Ca2+ > 1-Mg2+ > 1-Zn2+ > 1-Lu3+> 1-Y3+> 1-Al3+ ≈ 1-Sc3+; that is, the higher is Lewis acidity of M n+, the lower the reactivity of 1-M n+ in the HAT reactIon. The latter result implies that the Lewis acidity of M n+ bound to the Mn-O moiety can modulate the basicity of the metal-oxo moiety, thus influencing the HAT reactivity of 1-M n+; cytochrome P450 utilizes the axial thiolate ligand to increase the basicity of the iron-oxo moiety, which enhances the reactivity of compound I in C-H bond activatIon reactIons.

Yongmin Lee - One of the best experts on this subject based on the ideXlab platform.

  • tuning electron transfer reactivity of a chromium iii superoxo complex enabled by Calcium Ion and other redox inactive metal Ions
    Journal of the American Chemical Society, 2020
    Co-Authors: Tarali Devi, Yongmin Lee, Wonwoo Nam, Shunichi Fukuzumi
    Abstract:

    Calcium Ion plays an indispensable role for water oxidatIon by oxygen-evolving complex (OEC) composed of a manganese–oxo cluster (Mn4CaO5) in Photosystem II. In this context, the effects of Ca2+ io...

  • redox reactivity of a mononuclear manganese oxo complex binding Calcium Ion and other redox inactive metal Ions
    Journal of the American Chemical Society, 2019
    Co-Authors: Muniyandi Sankaralingam, Yongmin Lee, Shunichi Fukuzumi, Yuliana Pinedagalvan, Deepika G Karmalkar, Mi Sook Seo, So Hyun Jeon, Yulia Pushkar, Wonwoo Nam
    Abstract:

    Mononuclear nonheme manganese(IV)-oxo complexes binding Calcium Ion and other redox-inactive metal Ions, [(dpaq)MnIV(O)]+-M n+ (1-Mn+, M n+ = Ca2+, Mg2+, Zn2+, Lu3+, Y3+, Al3+, and Sc3+) (dpaq = 2-[bis(pyridin-2-ylmethyl)]amino- N-quinolin-8-yl-acetamidate), were synthesized by reacting a hydroxomanganese(III) complex, [(dpaq)MnIII(OH)]+, with iodosylbenzene (PhIO) in the presence of redox-inactive metal Ions (M n+). The Mn(IV)-oxo complexes were characterized using various spectroscopic techniques. In reactivity studies, we observed contrasting effects of M n+ on the reactivity of 1-M n+ in redox reactIons such as electron-transfer (ET), oxygen atom transfer (OAT), and hydrogen atom transfer (HAT) reactIons. In the OAT and ET reactIons, the reactivity order of 1-M n+, such as 1-Sc3+ ≈ 1-Al3+ > 1-Y3+ > 1-Lu3+ > 1-Zn2+ > 1-Mg2+ > 1-Ca2+, follows the Lewis acidity of M n+ bound to the Mn-O moiety; that is, the stronger the Lewis acidity of M n+, the higher the reactivity of 1-M n+ becomes. In sharp contrast, the reactivity of 1-M n+ in the HAT reactIon was reversed, giving the reactivity order 1-Ca2+ > 1-Mg2+ > 1-Zn2+ > 1-Lu3+> 1-Y3+> 1-Al3+ ≈ 1-Sc3+; that is, the higher is Lewis acidity of M n+, the lower the reactivity of 1-M n+ in the HAT reactIon. The latter result implies that the Lewis acidity of M n+ bound to the Mn-O moiety can modulate the basicity of the metal-oxo moiety, thus influencing the HAT reactivity of 1-M n+; cytochrome P450 utilizes the axial thiolate ligand to increase the basicity of the iron-oxo moiety, which enhances the reactivity of compound I in C-H bond activatIon reactIons.

Muniyandi Sankaralingam - One of the best experts on this subject based on the ideXlab platform.

  • redox reactivity of a mononuclear manganese oxo complex binding Calcium Ion and other redox inactive metal Ions
    Journal of the American Chemical Society, 2019
    Co-Authors: Muniyandi Sankaralingam, Yongmin Lee, Shunichi Fukuzumi, Yuliana Pinedagalvan, Deepika G Karmalkar, Mi Sook Seo, So Hyun Jeon, Yulia Pushkar, Wonwoo Nam
    Abstract:

    Mononuclear nonheme manganese(IV)-oxo complexes binding Calcium Ion and other redox-inactive metal Ions, [(dpaq)MnIV(O)]+-M n+ (1-Mn+, M n+ = Ca2+, Mg2+, Zn2+, Lu3+, Y3+, Al3+, and Sc3+) (dpaq = 2-[bis(pyridin-2-ylmethyl)]amino- N-quinolin-8-yl-acetamidate), were synthesized by reacting a hydroxomanganese(III) complex, [(dpaq)MnIII(OH)]+, with iodosylbenzene (PhIO) in the presence of redox-inactive metal Ions (M n+). The Mn(IV)-oxo complexes were characterized using various spectroscopic techniques. In reactivity studies, we observed contrasting effects of M n+ on the reactivity of 1-M n+ in redox reactIons such as electron-transfer (ET), oxygen atom transfer (OAT), and hydrogen atom transfer (HAT) reactIons. In the OAT and ET reactIons, the reactivity order of 1-M n+, such as 1-Sc3+ ≈ 1-Al3+ > 1-Y3+ > 1-Lu3+ > 1-Zn2+ > 1-Mg2+ > 1-Ca2+, follows the Lewis acidity of M n+ bound to the Mn-O moiety; that is, the stronger the Lewis acidity of M n+, the higher the reactivity of 1-M n+ becomes. In sharp contrast, the reactivity of 1-M n+ in the HAT reactIon was reversed, giving the reactivity order 1-Ca2+ > 1-Mg2+ > 1-Zn2+ > 1-Lu3+> 1-Y3+> 1-Al3+ ≈ 1-Sc3+; that is, the higher is Lewis acidity of M n+, the lower the reactivity of 1-M n+ in the HAT reactIon. The latter result implies that the Lewis acidity of M n+ bound to the Mn-O moiety can modulate the basicity of the metal-oxo moiety, thus influencing the HAT reactivity of 1-M n+; cytochrome P450 utilizes the axial thiolate ligand to increase the basicity of the iron-oxo moiety, which enhances the reactivity of compound I in C-H bond activatIon reactIons.

Yong Qian - One of the best experts on this subject based on the ideXlab platform.

  • improved genetically encoded near infrared fluorescent Calcium Ion indicators for in vivo imaging
    PLOS Biology, 2020
    Co-Authors: Yong Qian, Kiryl D Piatkevich, Danielle Orozco M Cosio, Sarah Aufmkolk, Orhan T Celiker, Anne Schohl
    Abstract:

    Near-infrared (NIR) genetically encoded Calcium Ion (Ca2+) indicators (GECIs) can provide advantages over visible wavelength fluorescent GECIs in terms of reduced phototoxicity, minimal spectral cross talk with visible light excitable optogenetic tools and fluorescent probes, and decreased scattering and absorptIon in mammalian tissues. Our previously reported NIR GECI, NIR-GECO1, has these advantages but also has several disadvantages including lower brightness and limited fluorescence response compared to state-of-the-art visible wavelength GECIs, when used for imaging of neuronal activity. Here, we report 2 improved NIR GECI variants, designated NIR-GECO2 and NIR-GECO2G, derived from NIR-GECO1. We characterized the performance of the new NIR GECIs in cultured cells, acute mouse brain slices, and Caenorhabditis elegans and Xenopus laevis in vivo. Our results demonstrate that NIR-GECO2 and NIR-GECO2G provide substantial improvements over NIR-GECO1 for imaging of neuronal Ca2+ dynamics.

  • improved genetically encoded near infrared fluorescent Calcium Ion indicators for in vivo imaging
    bioRxiv, 2020
    Co-Authors: Yong Qian, Kiryl D Piatkevich, Mitchell H Murdock, Danielle Orozco M Cosio, Sarah Aufmkolk, Orhan T Celiker, Anne Schohl, Abhi Aggarwal, Yufen Chang, Paul W Wiseman
    Abstract:

    Near-infrared (NIR) genetically-encoded Calcium Ion (Ca2+) indicators (GECIs) can provide advantages over visible wavelength fluorescent GECIs in terms of reduced phototoxicity, minimal spectral cross-talk with visible-light excitable optogenetic tools and fluorescent probes, and decreased scattering and absorptIon in mammalian tissues. Our previously reported NIR GECI, NIR-GECO1, has these advantages but also has several disadvantages including lower brightness and limited fluorescence response compared to state-of-the-art visible wavelength GECIs, when used for imaging of neuronal activity. Here, we report two improved NIR GECI variants, designated NIR-GECO2 and NIR-GECO2G, derived from NIR-GECO1. We characterized the performance of the new NIR GECIs in cultured cells, acute mouse brain slices, and C. elegans and Xenopus laevis in vivo. Our results demonstrate that NIR-GECO2 and NIR-GECO2G provide substantial improvements over NIR-GECO1 for imaging of neuronal Ca2+ dynamics

  • a genetically encoded near infrared fluorescent Calcium Ion indicator
    Nature Methods, 2019
    Co-Authors: Yong Qian, Kiryl D Piatkevich, Benedict Mc Larney, Ahmed S Abdelfattah, Sohum Mehta, Mitchell H Murdock, Sven Gottschalk, Rosana S Molina, Wei Zhang, Yingche Chen
    Abstract:

    We report an intensiometric, near-infrared fluorescent, genetically encoded Calcium Ion (Ca2+) indicator (GECI) with excitatIon and emissIon maxima at 678 and 704 nm, respectively. This GECI, designated NIR-GECO1, enables imaging of Ca2+ transients in cultured mammalian cells and brain tissue with sensitivity comparable to that of currently available visible-wavelength GECIs. We demonstrate that NIR-GECO1 opens up new vistas for multicolor Ca2+ imaging in combinatIon with other optogenetic indicators and actuators. NIR-GECO1, the first near-infrared genetically encoded Calcium Ion (Ca2+) indicator, enables improved Ca2+ imaging in conjunctIon with blue-light-activated optogenetic tools and multiplexed imaging in cell cultures and tissue slices.

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