The Experts below are selected from a list of 199005 Experts worldwide ranked by ideXlab platform
Hans Rudolf Bosshard - One of the best experts on this subject based on the ideXlab platform.
-
isothermal titration Calorimetry and differential scanning Calorimetry as complementary tools to investigate the energetics of biomolecular recognition
Journal of Molecular Recognition, 1999Co-Authors: Ilian Jelesarov, Hans Rudolf BosshardAbstract:The principles of isothermal titration Calorimetry (ITC) and differential scanning Calorimetry (DSC) are reviewed together with the basic thermodynamic formalism on which the two techniques are based. Although ITC is particularly suitable to follow the energetics of an association reaction between biomolecules, the combination of ITC and DSC provides a more comprehensive description of the thermodynamics of an associating system. The reason is that the parameters ΔG, ΔH, ΔS, and ΔCp obtained from ITC are global properties of the system under study. They may be composed to varying degrees of contributions from the binding reaction proper, from conformational changes of the component molecules during association, and from changes in molecule/solvent interactions and in the state of protonation. Copyright © 1999 John Wiley & Sons, Ltd.
-
isothermal titration Calorimetry and differential scanning Calorimetry as complementary tools to investigate the energetics of biomolecular recognition
Journal of Molecular Recognition, 1999Co-Authors: Ilian Jelesarov, Hans Rudolf BosshardAbstract:The principles of isothermal titration Calorimetry (ITC) and differential scanning Calorimetry (DSC) are reviewed together with the basic thermodynamic formalism on which the two techniques are based. Although ITC is particularly suitable to follow the energetics of an association reaction between biomolecules, the combination of ITC and DSC provides a more comprehensive description of the thermodynamics of an associating system. The reason is that the parameters DeltaG, DeltaH, DeltaS, and DeltaCp obtained from ITC are global properties of the system under study. They may be composed to varying degrees of contributions from the binding reaction proper, from conformational changes of the component molecules during association, and from changes in molecule/solvent interactions and in the state of protonation.
Yuanzheng Yue - One of the best experts on this subject based on the ideXlab platform.
-
understanding glass through differential scanning Calorimetry
Chemical Reviews, 2019Co-Authors: Qiuju Zheng, Yanfei Zhang, Maziar Montazerian, Ozgur Gulbiten, John C Mauro, Edgar D Zanotto, Yuanzheng YueAbstract:Differential scanning Calorimetry (DSC) is a powerful tool to address some of the most challenging issues in glass science and technology, such as the nonequilibrium nature of the glassy state and the detailed thermodynamics and kinetics of glass-forming systems during glass transition, relaxation, rejuvenation, polyamorphic transition, and crystallization. The utility of the DSC technique spans across all glass-forming chemistries, including oxide, chalcogenide, metallic, and organic systems, as well as recently discovered metal–organic framework glass-forming systems. Here we present a comprehensive review of the many applications of DSC in glass science with focus on glass transition, relaxation, polyamorphism, and crystallization phenomena. We also emphasize recent advances in DSC characterization technology, including flash DSC and temperature-modulated DSC. This review demonstrates how DSC studies have led to a multitude of relevant advances in the understanding of glass physics, chemistry, and even...
Hazreen Abdul Majid - One of the best experts on this subject based on the ideXlab platform.
-
a single center prospective observational study comparing resting energy expenditure in different phases of critical illness indirect Calorimetry versus predictive equations
Critical Care Medicine, 2020Co-Authors: Pei Chien Tah, Zhengyii Lee, Bee Koon Poh, Hazreen Abdul Majid, Vineyarai Hakumatrai, Mohd Basri Mat Nor, Chee Cheong KeeAbstract:Objectives Several predictive equations have been developed for estimation of resting energy expenditure, but no study has been done to compare predictive equations against indirect Calorimetry among critically ill patients at different phases of critical illness. This study aimed to determine the degree of agreement and accuracy of predictive equations among ICU patients during acute phase (≤ 5 d), late phase (6-10 d), and chronic phase (≥ 11 d). Design This was a single-center prospective observational study that compared resting energy expenditure estimated by 15 commonly used predictive equations against resting energy expenditure measured by indirect Calorimetry at different phases. Degree of agreement between resting energy expenditure calculated by predictive equations and resting energy expenditure measured by indirect Calorimetry was analyzed using intraclass correlation coefficient and Bland-Altman analyses. Resting energy expenditure values calculated from predictive equations differing by ± 10% from resting energy expenditure measured by indirect Calorimetry was used to assess accuracy. A score ranking method was developed to determine the best predictive equations. Setting General Intensive Care Unit, University of Malaya Medical Centre. Patients Mechanically ventilated critically ill patients. Interventions None. Measurements and main results Indirect Calorimetry was measured thrice during acute, late, and chronic phases among 305, 180, and 91 ICU patients, respectively. There were significant differences (F= 3.447; p = 0.034) in mean resting energy expenditure measured by indirect Calorimetry among the three phases. Pairwise comparison showed mean resting energy expenditure measured by indirect Calorimetry in late phase (1,878 ± 517 kcal) was significantly higher than during acute phase (1,765 ± 456 kcal) (p = 0.037). The predictive equations with the best agreement and accuracy for acute phase was Swinamer (1990), for late phase was Brandi (1999) and Swinamer (1990), and for chronic phase was Swinamer (1990). None of the resting energy expenditure calculated from predictive equations showed very good agreement or accuracy. Conclusions Predictive equations tend to either over- or underestimate resting energy expenditure at different phases. Predictive equations with "dynamic" variables and respiratory data had better agreement with resting energy expenditure measured by indirect Calorimetry compared with predictive equations developed for healthy adults or predictive equations based on "static" variables. Although none of the resting energy expenditure calculated from predictive equations had very good agreement, Swinamer (1990) appears to provide relatively good agreement across three phases and could be used to predict resting energy expenditure when indirect Calorimetry is not available.
Stephen Majoni - One of the best experts on this subject based on the ideXlab platform.
-
thermal and flammability study of polystyrene composites containing magnesium aluminum layered double hydroxide mgal c16 ldh and an organophosphate
Journal of Thermal Analysis and Calorimetry, 2015Co-Authors: Stephen MajoniAbstract:The flame retardancy and thermal stability of polystyrene compounded with Bis(2,4-dicumylphenyl)pentaerythritol diphosphate (DPP) and or a palmitate containing magnesium aluminum LDH (MgAl–C16 LDH) were investigated via thermogravimetric analysis, cone Calorimetry, and pyrolysis combustion flow Calorimetry. Cone Calorimetry and thermogravimetry measurements revealed that the addition of 5 and 10 mass% of MgAl–C16 LDH to PS resulted in substantial reduction in peak heat release rate (PHRR) (47 and 61 %, respectively) of the polymer and minimal improvements in thermal stability (5 and 2 °C, respectively, for the temperature at which 50 % mass loss occurs, ΔT50). On the other hand, there was insignificant reduction in PHRR for composites containing DPP at loadings of 5 mass%, while loadings of 10 mass% resulted in a relatively low reduction of 22 %. This difference was attributed to the more compact residue formed by the LDH systems during cone Calorimetry analysis. There was substantial improvements in the thermal stability of PS compounded with 10 mass% of DPP with ΔT50 being 21 °C. The combination of DPP and LDH resulted in a negative effect on the flammability performance of the LDH; thus, we did not observe any synergism between the LDH and DPP. Results from micro-scale combustion Calorimetry did not correlate with results from cone Calorimetry.
Ilian Jelesarov - One of the best experts on this subject based on the ideXlab platform.
-
isothermal titration Calorimetry and differential scanning Calorimetry as complementary tools to investigate the energetics of biomolecular recognition
Journal of Molecular Recognition, 1999Co-Authors: Ilian Jelesarov, Hans Rudolf BosshardAbstract:The principles of isothermal titration Calorimetry (ITC) and differential scanning Calorimetry (DSC) are reviewed together with the basic thermodynamic formalism on which the two techniques are based. Although ITC is particularly suitable to follow the energetics of an association reaction between biomolecules, the combination of ITC and DSC provides a more comprehensive description of the thermodynamics of an associating system. The reason is that the parameters ΔG, ΔH, ΔS, and ΔCp obtained from ITC are global properties of the system under study. They may be composed to varying degrees of contributions from the binding reaction proper, from conformational changes of the component molecules during association, and from changes in molecule/solvent interactions and in the state of protonation. Copyright © 1999 John Wiley & Sons, Ltd.
-
isothermal titration Calorimetry and differential scanning Calorimetry as complementary tools to investigate the energetics of biomolecular recognition
Journal of Molecular Recognition, 1999Co-Authors: Ilian Jelesarov, Hans Rudolf BosshardAbstract:The principles of isothermal titration Calorimetry (ITC) and differential scanning Calorimetry (DSC) are reviewed together with the basic thermodynamic formalism on which the two techniques are based. Although ITC is particularly suitable to follow the energetics of an association reaction between biomolecules, the combination of ITC and DSC provides a more comprehensive description of the thermodynamics of an associating system. The reason is that the parameters DeltaG, DeltaH, DeltaS, and DeltaCp obtained from ITC are global properties of the system under study. They may be composed to varying degrees of contributions from the binding reaction proper, from conformational changes of the component molecules during association, and from changes in molecule/solvent interactions and in the state of protonation.
