Calvaria

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Jeffrey L. Ebersole - One of the best experts on this subject based on the ideXlab platform.

  • tannerella forsythia infection induced Calvarial bone and soft tissue transcriptional profiles
    Molecular Oral Microbiology, 2010
    Co-Authors: Vasudevan Bakthavatchalu, Maria-cecilia Lopez, Jeffrey J. Mans, Sabapathi Sathishkumar, Richard J Lamont, Brendan F. Boyce, Indraneel Bhattacharyya, Henry V. Baker, Ao Meka, Jeffrey L. Ebersole
    Abstract:

    Summary Tannerella forsythia is associated with subgingival biofilms in adult periodontitis, although the molecular mechanisms contributing to chronic inflammation and loss of periodontal bone remain unclear. We examined changes in the host transcriptional profiles during a T. forsythia infection using a murine Calvarial model of inflammation and bone resorption. Tannerella forsythia was injected into the subcutaneous soft tissue over Calvariae of BALB/c mice for 3 days, after which the soft tissues and Calvarial bones were excised. RNA was isolated and Murine GeneChip® (Affymetrix, Santa Clara, CA) array analysis of transcript profiles showed that 3226 genes were differentially expressed in the infected soft tissues (P < 0.05) and 2586 genes were differentially transcribed in Calvarial bones after infection. Quantitative real-time reverse transcription-polymerase chain reaction analysis of transcription levels of selected genes corresponded well with the microarray results. Biological pathways significantly impacted by T. forsythia infection in Calvarial bone and soft tissue included leukocyte transendothelial migration, cell adhesion molecules (immune system), extracellular matrix–receptor interaction, adherens junction, and antigen processing and presentation. Histologic examination revealed intense inflammation and increased osteoclasts in Calvariae compared with controls. In conclusion, localized T. forsythia infection differentially induces transcription of a broad array of host genes, and the profiles differ between inflamed soft tissues and Calvarial bone.

  • Tannerella forsythia infection-induced Calvarial bone and soft tissue transcriptional profiles.
    Molecular Oral Microbiology, 2010
    Co-Authors: Vasudevan Bakthavatchalu, Maria-cecilia Lopez, Jeffrey J. Mans, Sabapathi Sathishkumar, Richard J Lamont, Brendan F. Boyce, Indraneel Bhattacharyya, Henry V. Baker, Ao Meka, Jeffrey L. Ebersole
    Abstract:

    Summary Tannerella forsythia is associated with subgingival biofilms in adult periodontitis, although the molecular mechanisms contributing to chronic inflammation and loss of periodontal bone remain unclear. We examined changes in the host transcriptional profiles during a T. forsythia infection using a murine Calvarial model of inflammation and bone resorption. Tannerella forsythia was injected into the subcutaneous soft tissue over Calvariae of BALB/c mice for 3 days, after which the soft tissues and Calvarial bones were excised. RNA was isolated and Murine GeneChip® (Affymetrix, Santa Clara, CA) array analysis of transcript profiles showed that 3226 genes were differentially expressed in the infected soft tissues (P 

Vasudevan Bakthavatchalu - One of the best experts on this subject based on the ideXlab platform.

  • tannerella forsythia infection induced Calvarial bone and soft tissue transcriptional profiles
    Molecular Oral Microbiology, 2010
    Co-Authors: Vasudevan Bakthavatchalu, Maria-cecilia Lopez, Jeffrey J. Mans, Sabapathi Sathishkumar, Richard J Lamont, Brendan F. Boyce, Indraneel Bhattacharyya, Henry V. Baker, Ao Meka, Jeffrey L. Ebersole
    Abstract:

    Summary Tannerella forsythia is associated with subgingival biofilms in adult periodontitis, although the molecular mechanisms contributing to chronic inflammation and loss of periodontal bone remain unclear. We examined changes in the host transcriptional profiles during a T. forsythia infection using a murine Calvarial model of inflammation and bone resorption. Tannerella forsythia was injected into the subcutaneous soft tissue over Calvariae of BALB/c mice for 3 days, after which the soft tissues and Calvarial bones were excised. RNA was isolated and Murine GeneChip® (Affymetrix, Santa Clara, CA) array analysis of transcript profiles showed that 3226 genes were differentially expressed in the infected soft tissues (P < 0.05) and 2586 genes were differentially transcribed in Calvarial bones after infection. Quantitative real-time reverse transcription-polymerase chain reaction analysis of transcription levels of selected genes corresponded well with the microarray results. Biological pathways significantly impacted by T. forsythia infection in Calvarial bone and soft tissue included leukocyte transendothelial migration, cell adhesion molecules (immune system), extracellular matrix–receptor interaction, adherens junction, and antigen processing and presentation. Histologic examination revealed intense inflammation and increased osteoclasts in Calvariae compared with controls. In conclusion, localized T. forsythia infection differentially induces transcription of a broad array of host genes, and the profiles differ between inflamed soft tissues and Calvarial bone.

  • Tannerella forsythia infection-induced Calvarial bone and soft tissue transcriptional profiles.
    Molecular Oral Microbiology, 2010
    Co-Authors: Vasudevan Bakthavatchalu, Maria-cecilia Lopez, Jeffrey J. Mans, Sabapathi Sathishkumar, Richard J Lamont, Brendan F. Boyce, Indraneel Bhattacharyya, Henry V. Baker, Ao Meka, Jeffrey L. Ebersole
    Abstract:

    Summary Tannerella forsythia is associated with subgingival biofilms in adult periodontitis, although the molecular mechanisms contributing to chronic inflammation and loss of periodontal bone remain unclear. We examined changes in the host transcriptional profiles during a T. forsythia infection using a murine Calvarial model of inflammation and bone resorption. Tannerella forsythia was injected into the subcutaneous soft tissue over Calvariae of BALB/c mice for 3 days, after which the soft tissues and Calvarial bones were excised. RNA was isolated and Murine GeneChip® (Affymetrix, Santa Clara, CA) array analysis of transcript profiles showed that 3226 genes were differentially expressed in the infected soft tissues (P 

Ao Meka - One of the best experts on this subject based on the ideXlab platform.

  • tannerella forsythia infection induced Calvarial bone and soft tissue transcriptional profiles
    Molecular Oral Microbiology, 2010
    Co-Authors: Vasudevan Bakthavatchalu, Maria-cecilia Lopez, Jeffrey J. Mans, Sabapathi Sathishkumar, Richard J Lamont, Brendan F. Boyce, Indraneel Bhattacharyya, Henry V. Baker, Ao Meka, Jeffrey L. Ebersole
    Abstract:

    Summary Tannerella forsythia is associated with subgingival biofilms in adult periodontitis, although the molecular mechanisms contributing to chronic inflammation and loss of periodontal bone remain unclear. We examined changes in the host transcriptional profiles during a T. forsythia infection using a murine Calvarial model of inflammation and bone resorption. Tannerella forsythia was injected into the subcutaneous soft tissue over Calvariae of BALB/c mice for 3 days, after which the soft tissues and Calvarial bones were excised. RNA was isolated and Murine GeneChip® (Affymetrix, Santa Clara, CA) array analysis of transcript profiles showed that 3226 genes were differentially expressed in the infected soft tissues (P < 0.05) and 2586 genes were differentially transcribed in Calvarial bones after infection. Quantitative real-time reverse transcription-polymerase chain reaction analysis of transcription levels of selected genes corresponded well with the microarray results. Biological pathways significantly impacted by T. forsythia infection in Calvarial bone and soft tissue included leukocyte transendothelial migration, cell adhesion molecules (immune system), extracellular matrix–receptor interaction, adherens junction, and antigen processing and presentation. Histologic examination revealed intense inflammation and increased osteoclasts in Calvariae compared with controls. In conclusion, localized T. forsythia infection differentially induces transcription of a broad array of host genes, and the profiles differ between inflamed soft tissues and Calvarial bone.

  • Tannerella forsythia infection-induced Calvarial bone and soft tissue transcriptional profiles.
    Molecular Oral Microbiology, 2010
    Co-Authors: Vasudevan Bakthavatchalu, Maria-cecilia Lopez, Jeffrey J. Mans, Sabapathi Sathishkumar, Richard J Lamont, Brendan F. Boyce, Indraneel Bhattacharyya, Henry V. Baker, Ao Meka, Jeffrey L. Ebersole
    Abstract:

    Summary Tannerella forsythia is associated with subgingival biofilms in adult periodontitis, although the molecular mechanisms contributing to chronic inflammation and loss of periodontal bone remain unclear. We examined changes in the host transcriptional profiles during a T. forsythia infection using a murine Calvarial model of inflammation and bone resorption. Tannerella forsythia was injected into the subcutaneous soft tissue over Calvariae of BALB/c mice for 3 days, after which the soft tissues and Calvarial bones were excised. RNA was isolated and Murine GeneChip® (Affymetrix, Santa Clara, CA) array analysis of transcript profiles showed that 3226 genes were differentially expressed in the infected soft tissues (P 

Jeffrey J. Mans - One of the best experts on this subject based on the ideXlab platform.

  • tannerella forsythia infection induced Calvarial bone and soft tissue transcriptional profiles
    Molecular Oral Microbiology, 2010
    Co-Authors: Vasudevan Bakthavatchalu, Maria-cecilia Lopez, Jeffrey J. Mans, Sabapathi Sathishkumar, Richard J Lamont, Brendan F. Boyce, Indraneel Bhattacharyya, Henry V. Baker, Ao Meka, Jeffrey L. Ebersole
    Abstract:

    Summary Tannerella forsythia is associated with subgingival biofilms in adult periodontitis, although the molecular mechanisms contributing to chronic inflammation and loss of periodontal bone remain unclear. We examined changes in the host transcriptional profiles during a T. forsythia infection using a murine Calvarial model of inflammation and bone resorption. Tannerella forsythia was injected into the subcutaneous soft tissue over Calvariae of BALB/c mice for 3 days, after which the soft tissues and Calvarial bones were excised. RNA was isolated and Murine GeneChip® (Affymetrix, Santa Clara, CA) array analysis of transcript profiles showed that 3226 genes were differentially expressed in the infected soft tissues (P < 0.05) and 2586 genes were differentially transcribed in Calvarial bones after infection. Quantitative real-time reverse transcription-polymerase chain reaction analysis of transcription levels of selected genes corresponded well with the microarray results. Biological pathways significantly impacted by T. forsythia infection in Calvarial bone and soft tissue included leukocyte transendothelial migration, cell adhesion molecules (immune system), extracellular matrix–receptor interaction, adherens junction, and antigen processing and presentation. Histologic examination revealed intense inflammation and increased osteoclasts in Calvariae compared with controls. In conclusion, localized T. forsythia infection differentially induces transcription of a broad array of host genes, and the profiles differ between inflamed soft tissues and Calvarial bone.

  • Tannerella forsythia infection-induced Calvarial bone and soft tissue transcriptional profiles.
    Molecular Oral Microbiology, 2010
    Co-Authors: Vasudevan Bakthavatchalu, Maria-cecilia Lopez, Jeffrey J. Mans, Sabapathi Sathishkumar, Richard J Lamont, Brendan F. Boyce, Indraneel Bhattacharyya, Henry V. Baker, Ao Meka, Jeffrey L. Ebersole
    Abstract:

    Summary Tannerella forsythia is associated with subgingival biofilms in adult periodontitis, although the molecular mechanisms contributing to chronic inflammation and loss of periodontal bone remain unclear. We examined changes in the host transcriptional profiles during a T. forsythia infection using a murine Calvarial model of inflammation and bone resorption. Tannerella forsythia was injected into the subcutaneous soft tissue over Calvariae of BALB/c mice for 3 days, after which the soft tissues and Calvarial bones were excised. RNA was isolated and Murine GeneChip® (Affymetrix, Santa Clara, CA) array analysis of transcript profiles showed that 3226 genes were differentially expressed in the infected soft tissues (P 

Sabapathi Sathishkumar - One of the best experts on this subject based on the ideXlab platform.

  • tannerella forsythia infection induced Calvarial bone and soft tissue transcriptional profiles
    Molecular Oral Microbiology, 2010
    Co-Authors: Vasudevan Bakthavatchalu, Maria-cecilia Lopez, Jeffrey J. Mans, Sabapathi Sathishkumar, Richard J Lamont, Brendan F. Boyce, Indraneel Bhattacharyya, Henry V. Baker, Ao Meka, Jeffrey L. Ebersole
    Abstract:

    Summary Tannerella forsythia is associated with subgingival biofilms in adult periodontitis, although the molecular mechanisms contributing to chronic inflammation and loss of periodontal bone remain unclear. We examined changes in the host transcriptional profiles during a T. forsythia infection using a murine Calvarial model of inflammation and bone resorption. Tannerella forsythia was injected into the subcutaneous soft tissue over Calvariae of BALB/c mice for 3 days, after which the soft tissues and Calvarial bones were excised. RNA was isolated and Murine GeneChip® (Affymetrix, Santa Clara, CA) array analysis of transcript profiles showed that 3226 genes were differentially expressed in the infected soft tissues (P < 0.05) and 2586 genes were differentially transcribed in Calvarial bones after infection. Quantitative real-time reverse transcription-polymerase chain reaction analysis of transcription levels of selected genes corresponded well with the microarray results. Biological pathways significantly impacted by T. forsythia infection in Calvarial bone and soft tissue included leukocyte transendothelial migration, cell adhesion molecules (immune system), extracellular matrix–receptor interaction, adherens junction, and antigen processing and presentation. Histologic examination revealed intense inflammation and increased osteoclasts in Calvariae compared with controls. In conclusion, localized T. forsythia infection differentially induces transcription of a broad array of host genes, and the profiles differ between inflamed soft tissues and Calvarial bone.

  • Tannerella forsythia infection-induced Calvarial bone and soft tissue transcriptional profiles.
    Molecular Oral Microbiology, 2010
    Co-Authors: Vasudevan Bakthavatchalu, Maria-cecilia Lopez, Jeffrey J. Mans, Sabapathi Sathishkumar, Richard J Lamont, Brendan F. Boyce, Indraneel Bhattacharyya, Henry V. Baker, Ao Meka, Jeffrey L. Ebersole
    Abstract:

    Summary Tannerella forsythia is associated with subgingival biofilms in adult periodontitis, although the molecular mechanisms contributing to chronic inflammation and loss of periodontal bone remain unclear. We examined changes in the host transcriptional profiles during a T. forsythia infection using a murine Calvarial model of inflammation and bone resorption. Tannerella forsythia was injected into the subcutaneous soft tissue over Calvariae of BALB/c mice for 3 days, after which the soft tissues and Calvarial bones were excised. RNA was isolated and Murine GeneChip® (Affymetrix, Santa Clara, CA) array analysis of transcript profiles showed that 3226 genes were differentially expressed in the infected soft tissues (P 

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