The Experts below are selected from a list of 5265 Experts worldwide ranked by ideXlab platform
João Pereira - One of the best experts on this subject based on the ideXlab platform.
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Trophic and reproductive biochemistry of a deep-sea gelatinous octopus, Opisthoteuthis Calypso
Marine Biology, 2013Co-Authors: Rui Rosa, Marta S. Pimentel, Miguel Baptista, Katja Trübenbach, Ricardo Calado, Maria L. Nunes, Ana Moreno, João PereiraAbstract:The present study provides a comprehensive analysis of the biochemical composition (proximate composition, amino acids and fatty acids in gonad, digestive gland and muscle) of the cirrate octopod, Opisthoteuthis Calypso , collected off the coast of Portugal. Protein and energy contents of O. Calypso were significantly lower ( p
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Trophic and reproductive biochemistry of a deep-sea gelatinous octopus, Opisthoteuthis Calypso
Marine Biology, 2012Co-Authors: Rui Rosa, Marta S. Pimentel, Miguel Baptista, Katja Trübenbach, Ricardo Calado, Maria L. Nunes, Ana Moreno, João PereiraAbstract:The present study provides a comprehensive analysis of the biochemical composition (proximate composition, amino acids and fatty acids in gonad, digestive gland and muscle) of the cirrate octopod, Opisthoteuthis Calypso, collected off the coast of Portugal. Protein and energy contents of O. Calypso were significantly lower (p < 0.05) than those observed for coastal octopods, suggesting that the gelatinous musculature of the cirrate octopus may not be a direct consequence of food limitation, but rather associated with reduced selective pressure for strong swimming ability in the deep sea. Moreover, principal component analyses of fatty acid (FA) data clearly separated coastal octopods from O. Calypso. Saturated FA biomarkers (namely 16:0, 17:0, 18:0) and monounsaturated FA 22:1 suggest a higher phytodetrital influence on diet of O. Calypso. A clear separation between groups was also observed with amino acid (AA) data. However, essential AA and non-essential AA designations (based on the flow of carbon through biochemical systems) do not necessarily provide an accurate picture of the origins of amino nitrogen in the deep-sea environment. Consequently, the interpretation of the present data is a challenging task but opens a new window of opportunity to unravel new trophic biomarkers in the deep sea.
Derek F. Ceccarelli - One of the best experts on this subject based on the ideXlab platform.
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Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
Nature Communications, 2018Co-Authors: Salima Daou, Haithem Barbour, Nadine Sen Nkwe, Oumaima Ahmed, Louis Masclef, Damehan Tchelougou, Maxime Uriarte, Caroline Baril, Eric Bonneil, Derek F. CeccarelliAbstract:The tumor suppressor and deubiquitinase (DUB) BAP1 and its Drosophila ortholog Calypso assemble DUB complexes with the transcription regulators Additional sex combs-like (ASXL1, ASXL2, ASXL3) and Asx respectively. ASXLs and Asx use their DEUBiquitinase ADaptor (DEUBAD) domain to stimulate BAP1/Calypso DUB activity. Here we report that monoubiquitination of the DEUBAD is a general feature of ASXLs and Asx. BAP1 promotes DEUBAD monoubiquitination resulting in an increased stability of ASXL2, which in turn stimulates BAP1 DUB activity. ASXL2 monoubiquitination is directly catalyzed by UBE2E family of Ubiquitin-conjugating enzymes and regulates mammalian cell proliferation. Remarkably, Calypso also regulates Asx monoubiquitination and transgenic flies expressing monoubiquitination-defective Asx mutant exhibit developmental defects. Finally, the protein levels of ASXL2, BAP1 and UBE2E enzymes are highly correlated in mesothelioma tumors suggesting the importance of this signaling axis for tumor suppression. We propose that monoubiquitination orchestrates a molecular symbiosis relationship between ASXLs and BAP1.
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Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
Nature Communications, 2018Co-Authors: Salima Daou, Haithem Barbour, Nadine Sen Nkwe, Oumaima Ahmed, Louis Masclef, Damehan Tchelougou, Maxime Uriarte, Caroline Baril, Eric Bonneil, Derek F. CeccarelliAbstract:The tumor suppressor and deubiquitinase (DUB) BAP1 and its Drosophila ortholog Calypso assemble DUB complexes with the transcription regulators Additional sex combs-like (ASXL1, ASXL2, ASXL3) and Asx respectively. ASXLs and Asx use their DEUBiquitinase ADaptor (DEUBAD) domain to stimulate BAP1/Calypso DUB activity. Here we report that monoubiquitination of the DEUBAD is a general feature of ASXLs and Asx. BAP1 promotes DEUBAD monoubiquitination resulting in an increased stability of ASXL2, which in turn stimulates BAP1 DUB activity. ASXL2 monoubiquitination is directly catalyzed by UBE2E family of Ubiquitin-conjugating enzymes and regulates mammalian cell proliferation. Remarkably, Calypso also regulates Asx monoubiquitination and transgenic flies expressing monoubiquitination-defective Asx mutant exhibit developmental defects. Finally, the protein levels of ASXL2, BAP1 and UBE2E enzymes are highly correlated in mesothelioma tumors suggesting the importance of this signaling axis for tumor suppression. We propose that monoubiquitination orchestrates a molecular symbiosis relationship between ASXLs and BAP1.
Rui Rosa - One of the best experts on this subject based on the ideXlab platform.
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Trophic and reproductive biochemistry of a deep-sea gelatinous octopus, Opisthoteuthis Calypso
Marine Biology, 2013Co-Authors: Rui Rosa, Marta S. Pimentel, Miguel Baptista, Katja Trübenbach, Ricardo Calado, Maria L. Nunes, Ana Moreno, João PereiraAbstract:The present study provides a comprehensive analysis of the biochemical composition (proximate composition, amino acids and fatty acids in gonad, digestive gland and muscle) of the cirrate octopod, Opisthoteuthis Calypso , collected off the coast of Portugal. Protein and energy contents of O. Calypso were significantly lower ( p
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Trophic and reproductive biochemistry of a deep-sea gelatinous octopus, Opisthoteuthis Calypso
Marine Biology, 2012Co-Authors: Rui Rosa, Marta S. Pimentel, Miguel Baptista, Katja Trübenbach, Ricardo Calado, Maria L. Nunes, Ana Moreno, João PereiraAbstract:The present study provides a comprehensive analysis of the biochemical composition (proximate composition, amino acids and fatty acids in gonad, digestive gland and muscle) of the cirrate octopod, Opisthoteuthis Calypso, collected off the coast of Portugal. Protein and energy contents of O. Calypso were significantly lower (p < 0.05) than those observed for coastal octopods, suggesting that the gelatinous musculature of the cirrate octopus may not be a direct consequence of food limitation, but rather associated with reduced selective pressure for strong swimming ability in the deep sea. Moreover, principal component analyses of fatty acid (FA) data clearly separated coastal octopods from O. Calypso. Saturated FA biomarkers (namely 16:0, 17:0, 18:0) and monounsaturated FA 22:1 suggest a higher phytodetrital influence on diet of O. Calypso. A clear separation between groups was also observed with amino acid (AA) data. However, essential AA and non-essential AA designations (based on the flow of carbon through biochemical systems) do not necessarily provide an accurate picture of the origins of amino nitrogen in the deep-sea environment. Consequently, the interpretation of the present data is a challenging task but opens a new window of opportunity to unravel new trophic biomarkers in the deep sea.
Yoshinobu Sato - One of the best experts on this subject based on the ideXlab platform.
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realtime organ tracking for endoscopic augmented reality visualization using miniature wireless magnetic tracker
international conference on Medical Imaging and Augmented Reality, 2008Co-Authors: Masahiko Nakamoto, Osamu Ukimura, Inderbir S Gill, A Mahadevan, Tsuneharu Miki, Makoto Hashizume, Yoshinobu SatoAbstract:Organ motion is one of the problems on augmented reality (AR) visualization for endoscopic surgical navigation system. However, the conventional optical and magnetic trackers are not suitable for tracking of internal organ motion. Recently, a wireless magnetic tracker, which is called the Calypso 4-D localization system has been developed. Since the sensor of the Calypso system is miniature and implantable, position of the internal organ can be measured directly. This paper describes AR system using the Calypso system and preliminary experiments to evaluate the AR system. We evaluated distortion error caused by the surgical instruments and misalignment error of superimposition. Results of the experiments shows potential feasibility and usefulness of AR visualization of moving organ using the Calypso system.
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MIAR - Realtime Organ Tracking for Endoscopic Augmented Reality Visualization Using Miniature Wireless Magnetic Tracker
Lecture Notes in Computer Science, 1Co-Authors: Masahiko Nakamoto, Osamu Ukimura, Inderbir S Gill, A Mahadevan, Tsuneharu Miki, Makoto Hashizume, Yoshinobu SatoAbstract:Organ motion is one of the problems on augmented reality (AR) visualization for endoscopic surgical navigation system. However, the conventional optical and magnetic trackers are not suitable for tracking of internal organ motion. Recently, a wireless magnetic tracker, which is called the Calypso 4-D localization system has been developed. Since the sensor of the Calypso system is miniature and implantable, position of the internal organ can be measured directly. This paper describes AR system using the Calypso system and preliminary experiments to evaluate the AR system. We evaluated distortion error caused by the surgical instruments and misalignment error of superimposition. Results of the experiments shows potential feasibility and usefulness of AR visualization of moving organ using the Calypso system.
Salima Daou - One of the best experts on this subject based on the ideXlab platform.
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Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
Nature Communications, 2018Co-Authors: Salima Daou, Haithem Barbour, Nadine Sen Nkwe, Oumaima Ahmed, Louis Masclef, Damehan Tchelougou, Maxime Uriarte, Caroline Baril, Eric Bonneil, Derek F. CeccarelliAbstract:The tumor suppressor and deubiquitinase (DUB) BAP1 and its Drosophila ortholog Calypso assemble DUB complexes with the transcription regulators Additional sex combs-like (ASXL1, ASXL2, ASXL3) and Asx respectively. ASXLs and Asx use their DEUBiquitinase ADaptor (DEUBAD) domain to stimulate BAP1/Calypso DUB activity. Here we report that monoubiquitination of the DEUBAD is a general feature of ASXLs and Asx. BAP1 promotes DEUBAD monoubiquitination resulting in an increased stability of ASXL2, which in turn stimulates BAP1 DUB activity. ASXL2 monoubiquitination is directly catalyzed by UBE2E family of Ubiquitin-conjugating enzymes and regulates mammalian cell proliferation. Remarkably, Calypso also regulates Asx monoubiquitination and transgenic flies expressing monoubiquitination-defective Asx mutant exhibit developmental defects. Finally, the protein levels of ASXL2, BAP1 and UBE2E enzymes are highly correlated in mesothelioma tumors suggesting the importance of this signaling axis for tumor suppression. We propose that monoubiquitination orchestrates a molecular symbiosis relationship between ASXLs and BAP1.
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Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
Nature Communications, 2018Co-Authors: Salima Daou, Haithem Barbour, Nadine Sen Nkwe, Oumaima Ahmed, Louis Masclef, Damehan Tchelougou, Maxime Uriarte, Caroline Baril, Eric Bonneil, Derek F. CeccarelliAbstract:The tumor suppressor and deubiquitinase (DUB) BAP1 and its Drosophila ortholog Calypso assemble DUB complexes with the transcription regulators Additional sex combs-like (ASXL1, ASXL2, ASXL3) and Asx respectively. ASXLs and Asx use their DEUBiquitinase ADaptor (DEUBAD) domain to stimulate BAP1/Calypso DUB activity. Here we report that monoubiquitination of the DEUBAD is a general feature of ASXLs and Asx. BAP1 promotes DEUBAD monoubiquitination resulting in an increased stability of ASXL2, which in turn stimulates BAP1 DUB activity. ASXL2 monoubiquitination is directly catalyzed by UBE2E family of Ubiquitin-conjugating enzymes and regulates mammalian cell proliferation. Remarkably, Calypso also regulates Asx monoubiquitination and transgenic flies expressing monoubiquitination-defective Asx mutant exhibit developmental defects. Finally, the protein levels of ASXL2, BAP1 and UBE2E enzymes are highly correlated in mesothelioma tumors suggesting the importance of this signaling axis for tumor suppression. We propose that monoubiquitination orchestrates a molecular symbiosis relationship between ASXLs and BAP1.
