The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Matthieu Plichart - One of the best experts on this subject based on the ideXlab platform.
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Can a tablet-based Cancellation Test identify cognitive impairment in older adults?
PLOS ONE, 2017Co-Authors: Ya-huei Wu, Jean-sébastien Vidal, Jocelyne De Rotrou, Sietske A.m. Sikkes, Anne-sophie Rigaud, Matthieu PlichartAbstract:Background and objective There has been a growing interest in using computerized cognitive assessment to detect age-related cognitive disorders. We have developed a tablet-based Cancellation Test (e-CT), previously shown as a reliable measure of executive functions and free of effect of familiarity with computer-based devices in healthy older adults. This study aimed to investigate the influence of demographics and current daily use of computer-based devices in older adults with Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD). We further studied the ability of the e-CT to discriminate MCI and AD patients from older adults with normal cognition (NC). Methods The e-CT was administered to 325 older adults (NC = 112, MCI = 129, AD = 84). Subjects also performed the K-T Test, a paper-and-pencil Cancellation Test from which the e-CT was developed. Multiple linear regression analyses were conducted to assess the contribution of demographics and current daily use of computer-based devices on the e-CT in patient groups. The Receiver Operating Characteristic (ROC) curves and the Area Under the Curve (AUC) were established to compare the efficacy of the e-CT and the K-T Test to classify subjects into diagnostic groups. Results In the MCI group, age (B = -0.37, p
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can a tablet based Cancellation Test identify cognitive impairment in older adults
PLOS ONE, 2017Co-Authors: Ya-huei Wu, Jean-sébastien Vidal, Jocelyne De Rotrou, Sietske A.m. Sikkes, Anne-sophie Rigaud, Matthieu PlichartAbstract:Background and objective There has been a growing interest in using computerized cognitive assessment to detect age-related cognitive disorders. We have developed a tablet-based Cancellation Test (e-CT), previously shown as a reliable measure of executive functions and free of effect of familiarity with computer-based devices in healthy older adults. This study aimed to investigate the influence of demographics and current daily use of computer-based devices in older adults with Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD). We further studied the ability of the e-CT to discriminate MCI and AD patients from older adults with normal cognition (NC). Methods The e-CT was administered to 325 older adults (NC = 112, MCI = 129, AD = 84). Subjects also performed the K-T Test, a paper-and-pencil Cancellation Test from which the e-CT was developed. Multiple linear regression analyses were conducted to assess the contribution of demographics and current daily use of computer-based devices on the e-CT in patient groups. The Receiver Operating Characteristic (ROC) curves and the Area Under the Curve (AUC) were established to compare the efficacy of the e-CT and the K-T Test to classify subjects into diagnostic groups. Results In the MCI group, age (B = -0.37, p<0.001) and current daily use of computer-based devices (B = 5.85, p<0.001) were associated with the number of correct Cancellations of the e-CT. In the AD group, only current daily use of a computer-based device was a significant contributor (B = 6.28, p<0.001). The e-CT (AUC = 0.811; 95% confidence interval [CI]: 0.756–0.867) and the K-T (AUC = 0.837; CI: 0.787–0.887) showed good and comparable diagnostic accuracy to discriminate between MCI and NC subjects. To discriminate between NC and AD, both Tests showed high diagnostic accuracy, with the AUC values of 0.923 (CI: 0.876–0.971) and 0.929 (95%CI: 0.886–0.972) for the e-CT and the K-T, respectively. Conclusion The e-CT presents satisfying discriminative validity and is a promising tool for detection of early cognitive impairment in older adults.
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clinical utility of the k t Cancellation Test in a memory clinic population
Journal of Clinical and Experimental Neuropsychology, 2016Co-Authors: Ya-huei Wu, Jocelyne De Rotrou, Sietske A.m. Sikkes, Anne-sophie Rigaud, Matthieu PlichartAbstract:ABSTRACTBackground/Aim: The K-T Cancellation Test (K-T) has been validated as a measure of executive functions (EF) but its clinical utility has not yet been examined. This study aimed to validate K-T in a memory clinic setting by examining its capacity to discriminate older adults with normal cognition (NC) from those with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Method: K-T was administered to 120 NC subjects, 146 patients with MCI, and 93 patients with AD. A one-way analysis of covariance was used to compare the correct Cancellations of K-T between the groups. Linear regressions were run to identify significant demographic predictors of K-T for NC subjects and to determine the equation to calculate z scores for all subjects. The area under the curve (AUC), sensitivity (Se), specificity (Sp), and positive (PPV) and negative (NPV) predictive values were assessed to compare the diagnostic performance between K-T and the Mini-Mental State Examination (MMSE) for discrimination between N...
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a tablet pc based Cancellation Test assessing executive functions in older adults
American Journal of Geriatric Psychiatry, 2015Co-Authors: Ya-huei Wu, Jean-sébastien Vidal, Jocelyne De Rotrou, Sietske A.m. Sikkes, Anne-sophie Rigaud, Matthieu PlichartAbstract:Objective To examine older adults' performance on a newly developed tablet-PC-based Cancellation Test (e-CT) and to study its psychometric properties. Methods 94 older adults with normal cognitive functioning were recruited. The effects of age, education, sex, and experience with computer-based devices on the e-CT were examined. Construct validity was Tested by correlating the e-CT with established measures of executive functions (EF) and episodic memory. Correlation coefficients were used to assess short-term Test–reTest reliablity. Results The mean age of participants was 74.6 (SD: 7.3) years and 78% were women. Sixty-nine percent had higher education level (> high school) and 76% used computer-based devices daily. The correct Cancellations (CC) on the e-CT ranged from 18 to 56, with a mean (SD) of 40.3 (5.7). The CC was inversely correlated with advancing age (r s = −0.59, N = 94, p (94) = 646.5, p = 0.02). No relationship was observed between the e-CT and sex or computer-based device experience. In multivariate analysis, only age remained significantly associated with CC (β = −0.46, SE = 0.07, t = −6.47, df = 93, p s = 0.63, N = 90, p s = −0.41, N = 85, p s = 0.89, N = 13, p Conclusions Results suggested that e-CT has good psychometric properties and may be useful for assessing EF in older adults.
Ya-huei Wu - One of the best experts on this subject based on the ideXlab platform.
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Can a tablet-based Cancellation Test identify cognitive impairment in older adults?
PLOS ONE, 2017Co-Authors: Ya-huei Wu, Jean-sébastien Vidal, Jocelyne De Rotrou, Sietske A.m. Sikkes, Anne-sophie Rigaud, Matthieu PlichartAbstract:Background and objective There has been a growing interest in using computerized cognitive assessment to detect age-related cognitive disorders. We have developed a tablet-based Cancellation Test (e-CT), previously shown as a reliable measure of executive functions and free of effect of familiarity with computer-based devices in healthy older adults. This study aimed to investigate the influence of demographics and current daily use of computer-based devices in older adults with Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD). We further studied the ability of the e-CT to discriminate MCI and AD patients from older adults with normal cognition (NC). Methods The e-CT was administered to 325 older adults (NC = 112, MCI = 129, AD = 84). Subjects also performed the K-T Test, a paper-and-pencil Cancellation Test from which the e-CT was developed. Multiple linear regression analyses were conducted to assess the contribution of demographics and current daily use of computer-based devices on the e-CT in patient groups. The Receiver Operating Characteristic (ROC) curves and the Area Under the Curve (AUC) were established to compare the efficacy of the e-CT and the K-T Test to classify subjects into diagnostic groups. Results In the MCI group, age (B = -0.37, p
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can a tablet based Cancellation Test identify cognitive impairment in older adults
PLOS ONE, 2017Co-Authors: Ya-huei Wu, Jean-sébastien Vidal, Jocelyne De Rotrou, Sietske A.m. Sikkes, Anne-sophie Rigaud, Matthieu PlichartAbstract:Background and objective There has been a growing interest in using computerized cognitive assessment to detect age-related cognitive disorders. We have developed a tablet-based Cancellation Test (e-CT), previously shown as a reliable measure of executive functions and free of effect of familiarity with computer-based devices in healthy older adults. This study aimed to investigate the influence of demographics and current daily use of computer-based devices in older adults with Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD). We further studied the ability of the e-CT to discriminate MCI and AD patients from older adults with normal cognition (NC). Methods The e-CT was administered to 325 older adults (NC = 112, MCI = 129, AD = 84). Subjects also performed the K-T Test, a paper-and-pencil Cancellation Test from which the e-CT was developed. Multiple linear regression analyses were conducted to assess the contribution of demographics and current daily use of computer-based devices on the e-CT in patient groups. The Receiver Operating Characteristic (ROC) curves and the Area Under the Curve (AUC) were established to compare the efficacy of the e-CT and the K-T Test to classify subjects into diagnostic groups. Results In the MCI group, age (B = -0.37, p<0.001) and current daily use of computer-based devices (B = 5.85, p<0.001) were associated with the number of correct Cancellations of the e-CT. In the AD group, only current daily use of a computer-based device was a significant contributor (B = 6.28, p<0.001). The e-CT (AUC = 0.811; 95% confidence interval [CI]: 0.756–0.867) and the K-T (AUC = 0.837; CI: 0.787–0.887) showed good and comparable diagnostic accuracy to discriminate between MCI and NC subjects. To discriminate between NC and AD, both Tests showed high diagnostic accuracy, with the AUC values of 0.923 (CI: 0.876–0.971) and 0.929 (95%CI: 0.886–0.972) for the e-CT and the K-T, respectively. Conclusion The e-CT presents satisfying discriminative validity and is a promising tool for detection of early cognitive impairment in older adults.
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clinical utility of the k t Cancellation Test in a memory clinic population
Journal of Clinical and Experimental Neuropsychology, 2016Co-Authors: Ya-huei Wu, Jocelyne De Rotrou, Sietske A.m. Sikkes, Anne-sophie Rigaud, Matthieu PlichartAbstract:ABSTRACTBackground/Aim: The K-T Cancellation Test (K-T) has been validated as a measure of executive functions (EF) but its clinical utility has not yet been examined. This study aimed to validate K-T in a memory clinic setting by examining its capacity to discriminate older adults with normal cognition (NC) from those with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Method: K-T was administered to 120 NC subjects, 146 patients with MCI, and 93 patients with AD. A one-way analysis of covariance was used to compare the correct Cancellations of K-T between the groups. Linear regressions were run to identify significant demographic predictors of K-T for NC subjects and to determine the equation to calculate z scores for all subjects. The area under the curve (AUC), sensitivity (Se), specificity (Sp), and positive (PPV) and negative (NPV) predictive values were assessed to compare the diagnostic performance between K-T and the Mini-Mental State Examination (MMSE) for discrimination between N...
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a tablet pc based Cancellation Test assessing executive functions in older adults
American Journal of Geriatric Psychiatry, 2015Co-Authors: Ya-huei Wu, Jean-sébastien Vidal, Jocelyne De Rotrou, Sietske A.m. Sikkes, Anne-sophie Rigaud, Matthieu PlichartAbstract:Objective To examine older adults' performance on a newly developed tablet-PC-based Cancellation Test (e-CT) and to study its psychometric properties. Methods 94 older adults with normal cognitive functioning were recruited. The effects of age, education, sex, and experience with computer-based devices on the e-CT were examined. Construct validity was Tested by correlating the e-CT with established measures of executive functions (EF) and episodic memory. Correlation coefficients were used to assess short-term Test–reTest reliablity. Results The mean age of participants was 74.6 (SD: 7.3) years and 78% were women. Sixty-nine percent had higher education level (> high school) and 76% used computer-based devices daily. The correct Cancellations (CC) on the e-CT ranged from 18 to 56, with a mean (SD) of 40.3 (5.7). The CC was inversely correlated with advancing age (r s = −0.59, N = 94, p (94) = 646.5, p = 0.02). No relationship was observed between the e-CT and sex or computer-based device experience. In multivariate analysis, only age remained significantly associated with CC (β = −0.46, SE = 0.07, t = −6.47, df = 93, p s = 0.63, N = 90, p s = −0.41, N = 85, p s = 0.89, N = 13, p Conclusions Results suggested that e-CT has good psychometric properties and may be useful for assessing EF in older adults.
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the k t Cancellation Test in the older adults normative data and construct validity
Aging Neuropsychology and Cognition, 2013Co-Authors: Ya-huei Wu, Jean-sébastien Vidal, Jocelyne De Rotrou, Anne-sophie Rigaud, Claude Jeandel, Emmanuelle Kesseguyot, Olivier HanonAbstract:ABSTRACT Since cutoff scores are necessary for differentiating normal cognitive functioning from dementia, the main objective of this study was to establish normative data of the K-T Test, a standardized Cancellation Test. The construct validity of K-T Test was also investigated. In total, 2471 cognitively intact elderly subjects from the SU.VI.MAX 2 study were included in the present study. Younger subjects, women and subjects with higher education had a higher number of correct answers and fewer omission errors. Participants made few commission errors and only the educational level was found to have a significant effect. Normative data for correct responses and efficiency were stratified by age, education, and gender. Correlation analysis showed that the K-T Test was significantly correlated to validated neuropsychological Tests assessing executive functions. This study permits to strengthen the utility of the K-T Test to detect impairment of the executive components involved in the task.
Han Eun Young - One of the best experts on this subject based on the ideXlab platform.
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The Effect of Virtual Reality Training on Unilateral Spatial Neglect in Stroke Patients
Annals of Rehabilitation Medicine, 2011Co-Authors: Yong Mi Kim, Gi Jeong Yun, Young-jin Song, Min Ho Chun, Han Eun YoungAbstract:OBJECTIVE: To investigate the effect of virtual reality training on unilateral spatial neglect in stroke patients. METHOD: Twenty-four stroke patients (14 males and 10 females, mean age=64.7) who had unilateral spatial neglect as a result of right hemisphere stroke were recruited. All patients were randomly assigned to either the virtual reality (VR) group (n=12) or the control group (n=12). The VR group received VR training, which stimulated the left side of their bodies. The control group received conventional neglect therapy such as visual scanning training. Both groups received therapy for 30 minutes a day, five days per week for three weeks. Outcome measurements included star Cancellation Test, line bisection Test, Catherine Bergego scale (CBS), and the Korean version of modified Barthel index (K-MBI). These measurements were taken before and after treatment. RESULTS: There were no significant differences in the baseline characteristics and initial values between the two groups. The changes in star Cancellation Test results and CBS in the VR group were significantly higher than those of the control group after treatment. The changes in line bisection Test score and the K-MBI in the VR group were not statistically significant. CONCLUSION: This study suggests that virtual reality training may be a beneficial therapeutic technique on unilateral spatial neglect in stroke patients.
Paul J Friedman - One of the best experts on this subject based on the ideXlab platform.
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the star Cancellation Test in acute stroke
Clinical Rehabilitation, 1992Co-Authors: Paul J FriedmanAbstract:Forty-one right-handed elderly subjects performed star Cancellation within 30 days of stroke. Eighteen subjects had impaired star Cancellation as defined by star score ≤44/54. Fourteen of these 18 subjects had a lateralizing defect based on the star ratio (ratio of stars cancelled in the left half of the stimulus sheet divided by star score). Thirteen of the 14 with lateralizing spatial neglect had left spatial neglect. Star score was significantly correlated to other Tests of spatial neglect, but not to limb power, cognitive score or age. Star score and star ratio were useful predictors of functional outcome as measured by Barthel ADL score at hospital discharge. Multivariate models of functional outcome included leg power and either star score, star ratio or ability to draw pentagons.
Anne-sophie Rigaud - One of the best experts on this subject based on the ideXlab platform.
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Can a tablet-based Cancellation Test identify cognitive impairment in older adults?
PLOS ONE, 2017Co-Authors: Ya-huei Wu, Jean-sébastien Vidal, Jocelyne De Rotrou, Sietske A.m. Sikkes, Anne-sophie Rigaud, Matthieu PlichartAbstract:Background and objective There has been a growing interest in using computerized cognitive assessment to detect age-related cognitive disorders. We have developed a tablet-based Cancellation Test (e-CT), previously shown as a reliable measure of executive functions and free of effect of familiarity with computer-based devices in healthy older adults. This study aimed to investigate the influence of demographics and current daily use of computer-based devices in older adults with Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD). We further studied the ability of the e-CT to discriminate MCI and AD patients from older adults with normal cognition (NC). Methods The e-CT was administered to 325 older adults (NC = 112, MCI = 129, AD = 84). Subjects also performed the K-T Test, a paper-and-pencil Cancellation Test from which the e-CT was developed. Multiple linear regression analyses were conducted to assess the contribution of demographics and current daily use of computer-based devices on the e-CT in patient groups. The Receiver Operating Characteristic (ROC) curves and the Area Under the Curve (AUC) were established to compare the efficacy of the e-CT and the K-T Test to classify subjects into diagnostic groups. Results In the MCI group, age (B = -0.37, p
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can a tablet based Cancellation Test identify cognitive impairment in older adults
PLOS ONE, 2017Co-Authors: Ya-huei Wu, Jean-sébastien Vidal, Jocelyne De Rotrou, Sietske A.m. Sikkes, Anne-sophie Rigaud, Matthieu PlichartAbstract:Background and objective There has been a growing interest in using computerized cognitive assessment to detect age-related cognitive disorders. We have developed a tablet-based Cancellation Test (e-CT), previously shown as a reliable measure of executive functions and free of effect of familiarity with computer-based devices in healthy older adults. This study aimed to investigate the influence of demographics and current daily use of computer-based devices in older adults with Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD). We further studied the ability of the e-CT to discriminate MCI and AD patients from older adults with normal cognition (NC). Methods The e-CT was administered to 325 older adults (NC = 112, MCI = 129, AD = 84). Subjects also performed the K-T Test, a paper-and-pencil Cancellation Test from which the e-CT was developed. Multiple linear regression analyses were conducted to assess the contribution of demographics and current daily use of computer-based devices on the e-CT in patient groups. The Receiver Operating Characteristic (ROC) curves and the Area Under the Curve (AUC) were established to compare the efficacy of the e-CT and the K-T Test to classify subjects into diagnostic groups. Results In the MCI group, age (B = -0.37, p<0.001) and current daily use of computer-based devices (B = 5.85, p<0.001) were associated with the number of correct Cancellations of the e-CT. In the AD group, only current daily use of a computer-based device was a significant contributor (B = 6.28, p<0.001). The e-CT (AUC = 0.811; 95% confidence interval [CI]: 0.756–0.867) and the K-T (AUC = 0.837; CI: 0.787–0.887) showed good and comparable diagnostic accuracy to discriminate between MCI and NC subjects. To discriminate between NC and AD, both Tests showed high diagnostic accuracy, with the AUC values of 0.923 (CI: 0.876–0.971) and 0.929 (95%CI: 0.886–0.972) for the e-CT and the K-T, respectively. Conclusion The e-CT presents satisfying discriminative validity and is a promising tool for detection of early cognitive impairment in older adults.
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clinical utility of the k t Cancellation Test in a memory clinic population
Journal of Clinical and Experimental Neuropsychology, 2016Co-Authors: Ya-huei Wu, Jocelyne De Rotrou, Sietske A.m. Sikkes, Anne-sophie Rigaud, Matthieu PlichartAbstract:ABSTRACTBackground/Aim: The K-T Cancellation Test (K-T) has been validated as a measure of executive functions (EF) but its clinical utility has not yet been examined. This study aimed to validate K-T in a memory clinic setting by examining its capacity to discriminate older adults with normal cognition (NC) from those with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Method: K-T was administered to 120 NC subjects, 146 patients with MCI, and 93 patients with AD. A one-way analysis of covariance was used to compare the correct Cancellations of K-T between the groups. Linear regressions were run to identify significant demographic predictors of K-T for NC subjects and to determine the equation to calculate z scores for all subjects. The area under the curve (AUC), sensitivity (Se), specificity (Sp), and positive (PPV) and negative (NPV) predictive values were assessed to compare the diagnostic performance between K-T and the Mini-Mental State Examination (MMSE) for discrimination between N...
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a tablet pc based Cancellation Test assessing executive functions in older adults
American Journal of Geriatric Psychiatry, 2015Co-Authors: Ya-huei Wu, Jean-sébastien Vidal, Jocelyne De Rotrou, Sietske A.m. Sikkes, Anne-sophie Rigaud, Matthieu PlichartAbstract:Objective To examine older adults' performance on a newly developed tablet-PC-based Cancellation Test (e-CT) and to study its psychometric properties. Methods 94 older adults with normal cognitive functioning were recruited. The effects of age, education, sex, and experience with computer-based devices on the e-CT were examined. Construct validity was Tested by correlating the e-CT with established measures of executive functions (EF) and episodic memory. Correlation coefficients were used to assess short-term Test–reTest reliablity. Results The mean age of participants was 74.6 (SD: 7.3) years and 78% were women. Sixty-nine percent had higher education level (> high school) and 76% used computer-based devices daily. The correct Cancellations (CC) on the e-CT ranged from 18 to 56, with a mean (SD) of 40.3 (5.7). The CC was inversely correlated with advancing age (r s = −0.59, N = 94, p (94) = 646.5, p = 0.02). No relationship was observed between the e-CT and sex or computer-based device experience. In multivariate analysis, only age remained significantly associated with CC (β = −0.46, SE = 0.07, t = −6.47, df = 93, p s = 0.63, N = 90, p s = −0.41, N = 85, p s = 0.89, N = 13, p Conclusions Results suggested that e-CT has good psychometric properties and may be useful for assessing EF in older adults.
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the k t Cancellation Test in the older adults normative data and construct validity
Aging Neuropsychology and Cognition, 2013Co-Authors: Ya-huei Wu, Jean-sébastien Vidal, Jocelyne De Rotrou, Anne-sophie Rigaud, Claude Jeandel, Emmanuelle Kesseguyot, Olivier HanonAbstract:ABSTRACT Since cutoff scores are necessary for differentiating normal cognitive functioning from dementia, the main objective of this study was to establish normative data of the K-T Test, a standardized Cancellation Test. The construct validity of K-T Test was also investigated. In total, 2471 cognitively intact elderly subjects from the SU.VI.MAX 2 study were included in the present study. Younger subjects, women and subjects with higher education had a higher number of correct answers and fewer omission errors. Participants made few commission errors and only the educational level was found to have a significant effect. Normative data for correct responses and efficiency were stratified by age, education, and gender. Correlation analysis showed that the K-T Test was significantly correlated to validated neuropsychological Tests assessing executive functions. This study permits to strengthen the utility of the K-T Test to detect impairment of the executive components involved in the task.
