The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Stefano Ugel - One of the best experts on this subject based on the ideXlab platform.
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Moonlighting Proteins Are Important Players in Cancer Immunology
Frontiers in Immunology, 2021Co-Authors: Annalisa Adamo, Cristina Frusteri, Maria Teresa Pallotta, Tracey Pirali, Silvia Sartoris, Stefano UgelAbstract:Plasticity and adaptation to environmental stress are the main features that tumor and immune system share. Except for intrinsic and high-defined properties, Cancer and immune cells need to overcome the opponent’s defenses by activating more effective signaling networks, based on common elements such as transcriptional factors, protein-based complexes and receptors. Interestingly, growing evidence point to an increasing number of proteins capable of performing diverse and unpredictable functions. These multifunctional proteins are defined as moonlighting proteins. During Cancer progression, several moonlighting proteins are involved in promoting an immunosuppressive microenvironment by reprogramming immune cells to support tumor growth and metastatic spread. Conversely, other moonlighting proteins support tumor antigen presentation and lymphocytes activation, leading to several anti-Cancer immunological responses. In this light, moonlighting proteins could be used as promising new potential targets for improving current Cancer therapies. In this review, we describe in details 12 unprecedented moonlighting proteins that during Cancer progression play a decisive role in guiding Cancer-associated immunomodulation by shaping innate or adaptive immune response.
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Moonlighting Proteins Are Important Players in Cancer Immunology.
Frontiers in immunology, 2021Co-Authors: Annalisa Adamo, Cristina Frusteri, Maria Teresa Pallotta, Tracey Pirali, Silvia Sartoris, Stefano UgelAbstract:Plasticity and adaptation to environmental stress are the main features that tumor and immune system share. Except for intrinsic and high-defined properties, Cancer and immune cells need to overcome the opponent's defences by activating more effective signaling networks, based on common elements such as transcriptional factors, protein-based complexes and receptors. Interestingly, growing evidence point to an increasing number of proteins capable of performing diverse and unpredictable functions. These multifunctional proteins are defined as moonlighting proteins. During Cancer progression, several moonlighting proteins are involved in promoting an immunosuppressive microenvironment by reprogramming immune cells to support tumor growth and metastatic spread. Conversely, other moonlighting proteins support tumor antigen presentation and lymphocytes activation, leading to several anti-Cancer immunological responses. In this light, moonlighting proteins could be used as promising new potential targets for improving current Cancer therapies. In this review, we describe in details twelve unprecedented moonlighting proteins that during Cancer progression play a decisive role in guiding Cancer-associated immunomodulation by shaping innate or adaptive immune response.
Annalisa Adamo - One of the best experts on this subject based on the ideXlab platform.
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Moonlighting Proteins Are Important Players in Cancer Immunology
Frontiers in Immunology, 2021Co-Authors: Annalisa Adamo, Cristina Frusteri, Maria Teresa Pallotta, Tracey Pirali, Silvia Sartoris, Stefano UgelAbstract:Plasticity and adaptation to environmental stress are the main features that tumor and immune system share. Except for intrinsic and high-defined properties, Cancer and immune cells need to overcome the opponent’s defenses by activating more effective signaling networks, based on common elements such as transcriptional factors, protein-based complexes and receptors. Interestingly, growing evidence point to an increasing number of proteins capable of performing diverse and unpredictable functions. These multifunctional proteins are defined as moonlighting proteins. During Cancer progression, several moonlighting proteins are involved in promoting an immunosuppressive microenvironment by reprogramming immune cells to support tumor growth and metastatic spread. Conversely, other moonlighting proteins support tumor antigen presentation and lymphocytes activation, leading to several anti-Cancer immunological responses. In this light, moonlighting proteins could be used as promising new potential targets for improving current Cancer therapies. In this review, we describe in details 12 unprecedented moonlighting proteins that during Cancer progression play a decisive role in guiding Cancer-associated immunomodulation by shaping innate or adaptive immune response.
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Moonlighting Proteins Are Important Players in Cancer Immunology.
Frontiers in immunology, 2021Co-Authors: Annalisa Adamo, Cristina Frusteri, Maria Teresa Pallotta, Tracey Pirali, Silvia Sartoris, Stefano UgelAbstract:Plasticity and adaptation to environmental stress are the main features that tumor and immune system share. Except for intrinsic and high-defined properties, Cancer and immune cells need to overcome the opponent's defences by activating more effective signaling networks, based on common elements such as transcriptional factors, protein-based complexes and receptors. Interestingly, growing evidence point to an increasing number of proteins capable of performing diverse and unpredictable functions. These multifunctional proteins are defined as moonlighting proteins. During Cancer progression, several moonlighting proteins are involved in promoting an immunosuppressive microenvironment by reprogramming immune cells to support tumor growth and metastatic spread. Conversely, other moonlighting proteins support tumor antigen presentation and lymphocytes activation, leading to several anti-Cancer immunological responses. In this light, moonlighting proteins could be used as promising new potential targets for improving current Cancer therapies. In this review, we describe in details twelve unprecedented moonlighting proteins that during Cancer progression play a decisive role in guiding Cancer-associated immunomodulation by shaping innate or adaptive immune response.
E. John Wherry - One of the best experts on this subject based on the ideXlab platform.
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Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in Cancer Immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank.
Neuro-oncology, 2020Co-Authors: Pavlina Chuntova, Frances Chow, Payal Watchmaker, Mildred Galvez, Amy B. Heimberger, Evan W. Newell, Aaron Diaz, Ronald A. Depinho, E. John WherryAbstract:Cancer immunotherapy has made remarkable advances with over fifty separate Food and Drug Administration (FDA) approvals as first or second line indications since 2015. These include immune checkpoint blocking antibodies, chimeric antigen receptor-transduced T-cells and bispecific T-cell-engaging antibodies. While multiple Cancer types now benefit from these immunotherapies, notable exceptions thus far include brain tumors, such as glioblastoma. As such, it seems critical to gain a better understanding of unique mechanistic challenges underlying the resistance of malignant gliomas to immunotherapy, as well as to acquire insights in the development of future strategies. An Immuno-Oncology Think Tank Meeting was held during the 2019 Annual Society for Neuro-Oncology Scientific Conference. Discussants in the fields of neuro-oncology, neurosurgery, neuro-imaging, medical oncology, and Cancer Immunology participated in the meeting. Sessions focused on topics such as the tumor microenvironment, myeloid cells and T-cell dysfunction, cellular engineering, and translational aspects that are critical and unique challenges inherent with primary brain tumors. In this review, we summarize the discussions and the key messages from the meeting, which may potentially serve as a basis for advancing the field of immune neuro-oncology in a collaborative manner.
Cristina Frusteri - One of the best experts on this subject based on the ideXlab platform.
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Moonlighting Proteins Are Important Players in Cancer Immunology
Frontiers in Immunology, 2021Co-Authors: Annalisa Adamo, Cristina Frusteri, Maria Teresa Pallotta, Tracey Pirali, Silvia Sartoris, Stefano UgelAbstract:Plasticity and adaptation to environmental stress are the main features that tumor and immune system share. Except for intrinsic and high-defined properties, Cancer and immune cells need to overcome the opponent’s defenses by activating more effective signaling networks, based on common elements such as transcriptional factors, protein-based complexes and receptors. Interestingly, growing evidence point to an increasing number of proteins capable of performing diverse and unpredictable functions. These multifunctional proteins are defined as moonlighting proteins. During Cancer progression, several moonlighting proteins are involved in promoting an immunosuppressive microenvironment by reprogramming immune cells to support tumor growth and metastatic spread. Conversely, other moonlighting proteins support tumor antigen presentation and lymphocytes activation, leading to several anti-Cancer immunological responses. In this light, moonlighting proteins could be used as promising new potential targets for improving current Cancer therapies. In this review, we describe in details 12 unprecedented moonlighting proteins that during Cancer progression play a decisive role in guiding Cancer-associated immunomodulation by shaping innate or adaptive immune response.
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Moonlighting Proteins Are Important Players in Cancer Immunology.
Frontiers in immunology, 2021Co-Authors: Annalisa Adamo, Cristina Frusteri, Maria Teresa Pallotta, Tracey Pirali, Silvia Sartoris, Stefano UgelAbstract:Plasticity and adaptation to environmental stress are the main features that tumor and immune system share. Except for intrinsic and high-defined properties, Cancer and immune cells need to overcome the opponent's defences by activating more effective signaling networks, based on common elements such as transcriptional factors, protein-based complexes and receptors. Interestingly, growing evidence point to an increasing number of proteins capable of performing diverse and unpredictable functions. These multifunctional proteins are defined as moonlighting proteins. During Cancer progression, several moonlighting proteins are involved in promoting an immunosuppressive microenvironment by reprogramming immune cells to support tumor growth and metastatic spread. Conversely, other moonlighting proteins support tumor antigen presentation and lymphocytes activation, leading to several anti-Cancer immunological responses. In this light, moonlighting proteins could be used as promising new potential targets for improving current Cancer therapies. In this review, we describe in details twelve unprecedented moonlighting proteins that during Cancer progression play a decisive role in guiding Cancer-associated immunomodulation by shaping innate or adaptive immune response.
Tracey Pirali - One of the best experts on this subject based on the ideXlab platform.
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Moonlighting Proteins Are Important Players in Cancer Immunology
Frontiers in Immunology, 2021Co-Authors: Annalisa Adamo, Cristina Frusteri, Maria Teresa Pallotta, Tracey Pirali, Silvia Sartoris, Stefano UgelAbstract:Plasticity and adaptation to environmental stress are the main features that tumor and immune system share. Except for intrinsic and high-defined properties, Cancer and immune cells need to overcome the opponent’s defenses by activating more effective signaling networks, based on common elements such as transcriptional factors, protein-based complexes and receptors. Interestingly, growing evidence point to an increasing number of proteins capable of performing diverse and unpredictable functions. These multifunctional proteins are defined as moonlighting proteins. During Cancer progression, several moonlighting proteins are involved in promoting an immunosuppressive microenvironment by reprogramming immune cells to support tumor growth and metastatic spread. Conversely, other moonlighting proteins support tumor antigen presentation and lymphocytes activation, leading to several anti-Cancer immunological responses. In this light, moonlighting proteins could be used as promising new potential targets for improving current Cancer therapies. In this review, we describe in details 12 unprecedented moonlighting proteins that during Cancer progression play a decisive role in guiding Cancer-associated immunomodulation by shaping innate or adaptive immune response.
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Moonlighting Proteins Are Important Players in Cancer Immunology.
Frontiers in immunology, 2021Co-Authors: Annalisa Adamo, Cristina Frusteri, Maria Teresa Pallotta, Tracey Pirali, Silvia Sartoris, Stefano UgelAbstract:Plasticity and adaptation to environmental stress are the main features that tumor and immune system share. Except for intrinsic and high-defined properties, Cancer and immune cells need to overcome the opponent's defences by activating more effective signaling networks, based on common elements such as transcriptional factors, protein-based complexes and receptors. Interestingly, growing evidence point to an increasing number of proteins capable of performing diverse and unpredictable functions. These multifunctional proteins are defined as moonlighting proteins. During Cancer progression, several moonlighting proteins are involved in promoting an immunosuppressive microenvironment by reprogramming immune cells to support tumor growth and metastatic spread. Conversely, other moonlighting proteins support tumor antigen presentation and lymphocytes activation, leading to several anti-Cancer immunological responses. In this light, moonlighting proteins could be used as promising new potential targets for improving current Cancer therapies. In this review, we describe in details twelve unprecedented moonlighting proteins that during Cancer progression play a decisive role in guiding Cancer-associated immunomodulation by shaping innate or adaptive immune response.
